Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.3763 | 0.8914 | 0.8914 |
Schistosoma mansoni | serine/threonine protein kinase | 0.4106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2244 | 0.4102 | 0.4102 |
Echinococcus granulosus | protein kinase c epsilon type | 0.4106 | 1 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.3763 | 0.8914 | 0.8914 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.4106 | 1 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.2042 | 0.3464 | 0.3463 |
Brugia malayi | Hr1 repeat family protein | 0.0949 | 0.0001 | 0.0001 |
Echinococcus multilocularis | serine threonine protein kinase | 0.31 | 0.6813 | 0.6812 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0949 | 0.0001 | 0.0001 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2706 | 0.5565 | 0.5565 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.3334 | 0.7555 | 0.7555 |
Toxoplasma gondii | AGC kinase | 0.0949 | 0.0001 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3193 | 0.7107 | 0.7107 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.2416 | 0.4647 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Onchocerca volvulus | 0.2244 | 0.4102 | 0.5 | |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.3763 | 0.8914 | 0.8914 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2244 | 0.4102 | 0.4102 |
Brugia malayi | Protein kinase domain containing protein | 0.0949 | 0.0001 | 0.0001 |
Echinococcus granulosus | protein kinase c iota type | 0.1867 | 0.2908 | 0.2907 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2042 | 0.3464 | 0.3463 |
Loa Loa (eye worm) | hypothetical protein | 0.2907 | 0.6203 | 0.6203 |
Echinococcus granulosus | protein kinase C gamma type | 0.31 | 0.6813 | 0.6812 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.2042 | 0.3464 | 0.3463 |
Echinococcus multilocularis | protein kinase c iota type | 0.1867 | 0.2908 | 0.2907 |
Brugia malayi | Protein kinase domain containing protein | 0.0949 | 0.0001 | 0.0001 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.2416 | 0.4647 | 0.4647 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.1885 | 0.2967 | 0.2967 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.4106 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0967 | 0.0059 | 0.0058 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3763 | 0.8914 | 0.8914 |
Trichomonas vaginalis | AGC family protein kinase | 0.0949 | 0.0001 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.2181 | 0.3905 | 0.3904 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0949 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2244 | 0.4102 | 0.4102 |
Brugia malayi | Protein kinase c protein 2 | 0.2845 | 0.6006 | 0.6006 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.2042 | 0.3464 | 0.3463 |
Brugia malayi | Protein kinase domain containing protein | 0.0949 | 0.0001 | 0.0001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of mouse brain MAOA | ChEMBL. | 18834112 | |
Activity (binding) | Inhibition of mouse brain MAOB | ChEMBL. | 18834112 | |
Control (ADMET) | = 69 % | Effect on Aryl hydrocarbon hydroxylase activity in 3-methylcolanthrene-induced rat liver microsomes at 8x10E-4M | ChEMBL. | 7097715 |
Control (ADMET) | = 69 % | Effect on Aryl hydrocarbon hydroxylase activity in 3-methylcolanthrene-induced rat liver microsomes at 8x10E-4M | ChEMBL. | 7097715 |
GI (functional) | = 64.66 % | Antiproliferative activity against human CCRF-CEM cells at 10'5 M | ChEMBL. | No reference |
GI50 (functional) | = 20 uM | Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay | ChEMBL. | 22225635 |
GI50 (functional) | = 51 uM | Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay | ChEMBL. | 22225635 |
I50 (ADMET) | = 970000 M | Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats | ChEMBL. | 7097715 |
I50 (ADMET) | = 1800000 M | Inhibition of Aminopyrine N-demethylase in Phenobarbitone-treated rats | ChEMBL. | 7097715 |
IC50 (ADMET) | = 3.74 | Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats. | ChEMBL. | 7120277 |
IC50 (ADMET) | = 4.01 | Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats | ChEMBL. | 7097715 |
IC50 (ADMET) | = 0.000097 M | Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats | ChEMBL. | 7097715 |
IC50 (ADMET) | = 0.00018 M | Inhibition of Aminopyrine N-demethylase in Phenobarbitone-treated rats | ChEMBL. | 7097715 |
IC50 (binding) | > 200 uM | Inhibition of human xanthine oxidase | ChEMBL. | 17379526 |
IC50 (binding) | > 200 uM | Inhibition of human xanthine oxidase | ChEMBL. | 17379526 |
Ks (ADMET) | = 0.000062 M | Interaction with cytochrome P450 in Phenobarbitone-induced rat hepatic microsomes | ChEMBL. | 7097715 |
Ks (ADMET) | = 0.000062 M | Interaction with cytochrome P450 in Phenobarbitone-induced rat hepatic microsomes | ChEMBL. | 7097715 |
Ks (ADMET) | = 0.00032 M | Interaction with cytochrome P450 in 3-methylcholanthrene-induced rat hepatic microsomes | ChEMBL. | 7097715 |
Ks (ADMET) | = 0.00032 M | Interaction with cytochrome P450 in 3-methylcholanthrene-induced rat hepatic microsomes | ChEMBL. | 7097715 |
logP (ADMET) | = 2.35 | Partition coefficient (logP) | ChEMBL. | 7120277 |
logP (ADMET) | = 2.35 | Partition coefficient (logP) | ChEMBL. | 7097715 |
pI50 (ADMET) | = 3.74 | Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats. | ChEMBL. | 7120277 |
pI50 (ADMET) | = 4.01 | Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated rats | ChEMBL. | 7097715 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.