Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0149 | 0.0135 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0013 | 0.0149 | 0.0306 |
Schistosoma mansoni | hypothetical protein | 0.0418 | 1 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Onchocerca volvulus | 0.0028 | 0.0508 | 0.0499 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0013 | 0.0149 | 0.0306 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Loa Loa (eye worm) | spectraplakin | 0.0054 | 0.1153 | 0.1553 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0059 | 0.0045 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0013 | 0.0149 | 0.0135 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0508 | 0.0495 |
Leishmania major | oxidoreductase-like protein | 0.0013 | 0.0149 | 1 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0508 | 0.0674 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0197 | 0.025 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0593 | 0.0579 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0508 | 0.0495 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1153 | 0.1553 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4048 | 0.404 |
Echinococcus multilocularis | smad | 0.0008 | 0.004 | 0.0026 |
Schistosoma mansoni | smad | 0.0008 | 0.004 | 0.0026 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0059 | 0.0045 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.004 | 0.0026 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0197 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0508 | 0.0674 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.004 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1153 | 0.114 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0593 | 0.0579 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.004 | 0.0036 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0016 | 0.0001 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.004 | 0.0036 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.119 | 0.2663 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0552 | 0.0538 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.004 | 0.0026 |
Trypanosoma brucei | pteridine reductase 1 | 0.0013 | 0.0149 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0189 | 0.4429 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0162 | 0.0201 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0508 | 0.0495 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.004 | 0.0026 |
Mycobacterium leprae | 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | Spectrin alpha actinin | 0.0054 | 0.1153 | 0.114 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0013 | 0.0149 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.004 | 0.0026 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Schistosoma mansoni | dihydropteridine reductase | 0.0013 | 0.0149 | 0.0135 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0508 | 0.0495 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0508 | 0.0674 |
Echinococcus granulosus | smad | 0.0008 | 0.004 | 0.0026 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus granulosus | geminin | 0.0173 | 0.4048 | 0.404 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0149 | 0.0184 |
Echinococcus multilocularis | geminin | 0.0173 | 0.4048 | 0.404 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0149 | 0.0135 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0418 | 1 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0059 | 0.0061 |
Schistosoma mansoni | lamin | 0.0028 | 0.0508 | 0.0495 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0593 | 0.0579 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.004 | 0.0036 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.004 | 0.0026 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0013 | 0.0149 | 0.0306 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.004 | 0.0036 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0.0149 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.1187 |
Leishmania major | pteridine reductase 1 | 0.0013 | 0.0149 | 1 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium ulcerans | oxidoreductase | 0.0013 | 0.0149 | 0.0306 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.1187 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Onchocerca volvulus | 0.0309 | 0.7346 | 1 | |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0013 | 0.0149 | 0.0306 |
Schistosoma mansoni | lamin | 0.0028 | 0.0508 | 0.0495 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0508 | 0.0674 |
Onchocerca volvulus | 0.0029 | 0.0552 | 0.0559 | |
Onchocerca volvulus | 0.0028 | 0.0508 | 0.0499 | |
Echinococcus multilocularis | musashi | 0.0028 | 0.0508 | 0.0495 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0016 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0149 | 0.0184 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0013 | 0.0149 | 0.0184 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4048 | 0.404 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.004 | 0.0026 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0189 | 0.4429 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0189 | 0.4429 | 1 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0189 | 0.4429 | 1 |
Brugia malayi | hypothetical protein | 0.0309 | 0.7346 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.004 | 0.0036 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Brugia malayi | VAB-10A protein | 0.0054 | 0.1153 | 0.1553 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0593 | 0.0579 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0162 | 0.0148 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1153 | 0.114 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0149 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0496 | 0.0657 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.2804 | 0.3805 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0508 | 0.0674 |
Mycobacterium ulcerans | 3-oxoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Loa Loa (eye worm) | oxidoreductase | 0.0013 | 0.0149 | 0.0184 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.004 | 0.0026 |
Brugia malayi | Growth-Arrest-Specific Protein 2 Domain containing protein | 0.0054 | 0.1153 | 0.1553 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0552 | 0.0733 |
Mycobacterium ulcerans | 20-beta-hydroxysteroid dehydrogenase FabG3 | 0.0013 | 0.0149 | 0.0306 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0013 | 0.0149 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0016 | 0.0001 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0508 | 0.0495 |
Brugia malayi | Smad1 | 0.0008 | 0.004 | 0.0036 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0016 | 0.0001 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0189 | 0.4429 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.0508 | 0.0495 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0.0149 | 0.1187 |
Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 0.0306 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0056 | 0.0057 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0013 | 0.0149 | 0.0306 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0149 | 0.0184 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.2804 | 0.3805 |
Loa Loa (eye worm) | hypothetical protein | 0.0309 | 0.7346 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0189 | 0.4429 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0189 | 0.4429 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0189 | 0.4429 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0016 | 0.0001 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0.0149 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0189 | 0.4429 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0013 | 0.0149 | 0.0306 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.004 | 0.0036 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.1352 | 0.1339 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.004 | 0.0036 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.004 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0149 | 0.0184 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0013 | 0.0149 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0013 | 0.0149 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.2804 | 0.3805 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0162 | 0.0148 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0552 | 0.0733 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0013 | 0.0149 | 0.0184 |
Echinococcus granulosus | Spectrin alpha actinin | 0.0054 | 0.1153 | 0.114 |
Trypanosoma cruzi | kinetoplast DNA-associated protein, putative | 0.0054 | 0.1153 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.004 | 0.0026 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0013 | 0.0149 | 0.0306 |
Mycobacterium leprae | POSSIBLE OXIDOREDUCTASE | 0.0013 | 0.0149 | 0.0306 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.004 | 0.0026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MISS T/C (functional) | = 1 | In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days | ChEMBL. | 11312923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.