Detailed information for compound 269829

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.488 | Formula: C22H22N2OS
  • H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC[C@@H](Cc1cccnc1)NC(=O)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C22H22N2OS/c25-22(24-21(16-26)13-18-5-4-12-23-15-18)14-17-8-10-20(11-9-17)19-6-2-1-3-7-19/h1-12,15,21,26H,13-14,16H2,(H,24,25)/t21-/m1/s1
  • InChiKey: JIEYFJMFLWBNBY-OAQYLSRUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin converting enzyme 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus granulosus endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium leprae probable zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) Get druggable targets OG5_127344 All targets in OG5_127344
Neospora caninum hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum IPR000718,Peptidase M13, neprilysin,domain-containing Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium ulcerans zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Toxoplasma gondii peptidase family M13 protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor HR96 0.0293 0.0369 0.0535
Echinococcus multilocularis cyclin dependent kinase 0.0098 0.0083 0.013
Onchocerca volvulus Bile acid receptor homolog 0.0621 0.0852 0.0852
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0293 0.0369 0.0575
Trypanosoma brucei cdc2-related kinase 3 0.0098 0.0083 0.2514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0621 0.0852 0.0895
Brugia malayi ecdysone receptor 0.0293 0.0369 0.0388
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0098 0.0083 0.0121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0621 0.0852 0.1235
Entamoeba histolytica hypothetical protein 0.0199 0.0231 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0267 0.0331 1
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0058 0.0023 0.0033
Echinococcus multilocularis dual specificity 0.012 0.0115 0.018
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0279 0.0349 0.0544
Loa Loa (eye worm) nuclear receptor NHR-67 0.0293 0.0369 0.0388
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0098 0.0083 0.2514
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.012 0.0115 0.0121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0621 0.0852 0.1327
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0098 0.0083 0.0088
Brugia malayi tailless protein 0.0293 0.0369 0.0388
Brugia malayi nuclear receptor NHR-67 0.0293 0.0369 0.0388
Echinococcus multilocularis cyclin dependent kinase 1 0.0098 0.0083 0.013
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0293 0.0369 0.0535
Loa Loa (eye worm) hypothetical protein 0.0328 0.0421 0.0442
Loa Loa (eye worm) steroid hormone receptor 0.0621 0.0852 0.0895
Brugia malayi cyclin-dependent kinase 9 0.0054 0.0018 0.0019
Echinococcus multilocularis 0.0262 0.0323 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Giardia lamblia Kinase, CMGC CDK 0.0098 0.0083 0.2514
Trichomonas vaginalis CMGC family protein kinase 0.0267 0.0331 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0621 0.0852 0.0895
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0621 0.0852 0.1327
Loa Loa (eye worm) nuclear hormone receptor 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0114 0.0106 0.0112
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0621 0.0852 0.0895
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0115 0.0167
Giardia lamblia Kinase, CMGC CLK 0.0267 0.0331 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0621 0.0852 0.0895
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0621 0.0852 0.1327
Echinococcus granulosus retinoic acid receptor rxr beta a 0.4732 0.6898 1
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0115 0.3485
Brugia malayi nuclear hormone receptor family member nhr-6 0.0293 0.0369 0.0388
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0279 0.0349 0.0506
Loa Loa (eye worm) hypothetical protein 0.0084 0.0062 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0621 0.0852 0.1327
Loa Loa (eye worm) hypothetical protein 0.0262 0.0323 0.034
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0062 0.0066
Echinococcus multilocularis cyclin dependent kinase 9 0.0063 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0086 0.0065 0.0069
Schistosoma mansoni coup transcription factor 0.0621 0.0852 0.1235
Echinococcus granulosus dual specificity 0.012 0.0115 0.0167
Echinococcus granulosus dual specificity 0.012 0.0115 0.0167
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0098 0.0083 0.2514
Schistosoma mansoni steroid hormone receptor ad4bp 0.0621 0.0852 0.1235
Echinococcus multilocularis dual specificity 0.012 0.0115 0.018
Giardia lamblia Kinase, CMGC CDK 0.0098 0.0083 0.2514
Brugia malayi nuclear receptor RXR 0.0328 0.0421 0.0442
Brugia malayi ecdysteroid receptor 0.0621 0.0852 0.0895
Mycobacterium ulcerans zinc metalloprotease 0.0114 0.0106 0.5
Plasmodium vivax serine/threonine kinase-1, putative 0.0267 0.0331 1
Schistosoma mansoni nuclear hormone receptor 0.0293 0.0369 0.0535
Loa Loa (eye worm) hypothetical protein 0.0328 0.0421 0.0442
Echinococcus multilocularis ecdysone induced protein 78C 0.0621 0.0852 0.1327
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.0231 0.0335
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0621 0.0852 0.1235
Brugia malayi nuclear hormone receptor family member odr-7 0.0293 0.0369 0.0388
Echinococcus granulosus thyroid hormone receptor alpha 0.0293 0.0369 0.0535
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0114 0.0106 0.0112
Schistosoma mansoni nuclear receptor 0.0293 0.0369 0.0535
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Toxoplasma gondii peptidase family M13 protein 0.0114 0.0106 0.0923
Echinococcus multilocularis cyclin dependent kinase 9 0.0054 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0328 0.0421 0.0442
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0293 0.0369 0.0575
Brugia malayi Protein kinase domain containing protein 0.0098 0.0083 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0115 0.3485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0621 0.0852 0.0895
Echinococcus granulosus Nuclear hormone receptor HR96 0.0293 0.0369 0.0535
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0267 0.0331 1
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0331 0.048
Echinococcus granulosus dual specificity 0.012 0.0115 0.0167
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0054 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0282 0.0353 0.0371
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0199 0.0231 0.6977
Brugia malayi cell division control protein 2 homolog 0.0098 0.0083 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0083 0.2514
Brugia malayi Nuclear hormone receptor-like 1 0.0328 0.0421 0.0442
Onchocerca volvulus 0.0293 0.0369 0.0369
Schistosoma mansoni RAR-like nuclear receptor 0.0621 0.0852 0.1235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0621 0.0852 0.0895
Echinococcus granulosus cyclin dependent kinase 1 0.0098 0.0083 0.0121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0621 0.0852 0.1235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0621 0.0852 0.0895
Echinococcus granulosus cyclin dependent kinase 9 0.0063 0.0031 0.0045
Loa Loa (eye worm) hypothetical protein 0.0056 0.0022 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0293 0.0369 0.0535
Entamoeba histolytica protein kinase, putative 0.012 0.0115 0.4995
Brugia malayi Steroid receptor seven-up type 2 0.0621 0.0852 0.0895
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0621 0.0852 0.0895
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Brugia malayi nuclear receptor NHR-88 0.0621 0.0852 0.0895
Trypanosoma cruzi cdc2-related kinase 3 0.0098 0.0083 0.2514
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0621 0.0852 0.0895
Echinococcus multilocularis endothelin converting enzyme 1 0.0114 0.0106 0.0166
Trypanosoma cruzi cdc2-related kinase 1 0.0098 0.0083 0.2514
Schistosoma mansoni neprilysin-2 (M13 family) 0.0058 0.0023 0.0033
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0267 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0065 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0621 0.0852 0.0895
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0621 0.0852 0.1235
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0293 0.0369 0.0535
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0115 0.3485
Loa Loa (eye worm) hypothetical protein 0.0134 0.0135 0.0142
Brugia malayi hypothetical protein 0.0328 0.0421 0.0442
Trypanosoma cruzi cdc2-related kinase 3 0.0098 0.0083 0.2514
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0621 0.0852 0.0895
Echinococcus granulosus nuclear receptor nhr 48 0.0293 0.0369 0.0535
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.012 0.0115 0.1297
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0621 0.0852 0.1327
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0114 0.0106 0.5
Brugia malayi nuclear hormone receptor 0.6513 0.9518 1
Brugia malayi Nuclear hormone receptor E75 0.0293 0.0369 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0083 0.0121
Loa Loa (eye worm) hypothetical protein 0.0134 0.0135 0.0142
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Brugia malayi hypothetical protein 0.0293 0.0369 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0621 0.0852 0.0895
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0098 0.0083 0.0088
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0083 0.0121
Giardia lamblia Kinase, CMGC DYRK 0.012 0.0115 0.3485
Loa Loa (eye worm) nuclear receptor nhr-7B 0.6513 0.9518 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0098 0.0083 0.013
Brugia malayi steroid hormone receptor 0.0621 0.0852 0.0895
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.012 0.0115 0.3485
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0621 0.0852 0.1235
Brugia malayi orphan nuclear receptor NR2E1 0.0293 0.0369 0.0388
Mycobacterium leprae probable zinc metalloprotease 0.0114 0.0106 0.5
Echinococcus granulosus cyclin dependent kinase 0.0098 0.0083 0.0121
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0199 0.0231 0.0243
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0093 0.0075 0.0079
Onchocerca volvulus Protein ultraspiracle homolog 0.0621 0.0852 0.0852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0621 0.0852 0.0895
Brugia malayi hypothetical protein 0.0293 0.0369 0.0388
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0199 0.0231 0.6977
Loa Loa (eye worm) hypothetical protein 0.0086 0.0065 0.0069
Loa Loa (eye worm) hypothetical protein 0.0194 0.0223 0.0235
Echinococcus granulosus ecdysone induced protein 78C 0.0621 0.0852 0.1235
Loa Loa (eye worm) hypothetical protein 0.0084 0.0062 0.0066
Entamoeba histolytica cell division protein kinase 2, putative 0.0107 0.0096 0.4149
Echinococcus multilocularis dual specificity 0.0199 0.0231 0.036
Echinococcus granulosus FTZ F1 alpha 0.0621 0.0852 0.1235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0293 0.0369 0.0575
Entamoeba histolytica protein kinase, putative 0.0199 0.0231 1
Leishmania major protein kinase, putative 0.0267 0.0331 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0199 0.0231 0.6977
Brugia malayi hypothetical protein 0.0134 0.0135 0.0142
Echinococcus granulosus hypothetical protein 0.0262 0.0323 0.0469
Entamoeba histolytica protein kinase domain containing protein 0.0199 0.0231 1
Echinococcus multilocularis FTZ F1 alpha 0.0621 0.0852 0.1327
Loa Loa (eye worm) hypothetical protein 0.622 0.9087 0.9547
Brugia malayi Protein kinase domain containing protein 0.0199 0.0231 0.0243
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0328 0.0421 0.061
Schistosoma mansoni kinase 0.0054 0.0018 0.0027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0621 0.0852 0.1235
Brugia malayi conserved hypotetical protein 0.0293 0.0369 0.0388
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0621 0.0852 0.1235
Trypanosoma cruzi cdc2-related kinase 1 0.0098 0.0083 0.2514
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0114 0.0106 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0621 0.0852 0.1235
Schistosoma mansoni nuclear receptor 0.0293 0.0369 0.0535
Brugia malayi Nuclear hormone receptor E75 0.0293 0.0369 0.0388
Entamoeba histolytica protein kinase domain containing protein 0.0054 0.0018 0.0793
Brugia malayi nuclear receptor RXR 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0328 0.0421 0.0442
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0023 0.0033
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0621 0.0852 0.1327
Brugia malayi Nuclear hormone receptor-like 1 0.0328 0.0421 0.0442
Loa Loa (eye worm) DR-78 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0293 0.0369 0.0369
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0062 0.0066
Brugia malayi Protein kinase domain containing protein 0.0267 0.0331 0.0348
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0267 0.0331 1
Echinococcus multilocularis dual specificity 0.012 0.0115 0.018
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0328 0.0421 0.061
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0267 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0621 0.0852 0.1235
Echinococcus multilocularis cyclin dependent kinase 1 0.0098 0.0083 0.013
Brugia malayi Nuclear hormone receptor-like 1 0.0621 0.0852 0.0895
Plasmodium falciparum protein serine/threonine kinase-1 0.0267 0.0331 1
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.012 0.0115 0.3485
Schistosoma mansoni nuclear hormone receptor 0.0293 0.0369 0.0535
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0083 0.2514
Brugia malayi photoreceptor-specific nuclear receptor 0.0621 0.0852 0.0895
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.4404 0.6416 1
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.012 0.0115 0.0121
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0621 0.0852 0.0895
Entamoeba histolytica protein kinase domain containing protein 0.012 0.0115 0.4995
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0293 0.0369 0.0575
Loa Loa (eye worm) hypothetical protein 0.0114 0.0106 0.0112
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0621 0.0852 0.1235
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0621 0.0852 0.1235
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0098 0.0083 0.0088
Schistosoma mansoni zinc finger protein 0.0293 0.0369 0.0535
Entamoeba histolytica cell division protein kinase 2, putative 0.0098 0.0083 0.3603
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.012 0.0115 0.3485
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0267 0.0331 0.0348
Loa Loa (eye worm) hypothetical protein 0.0328 0.0421 0.0442
Loa Loa (eye worm) hypothetical protein 0.0293 0.0369 0.0388
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0279 0.0349 0.0506
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0328 0.0421 0.0656
Entamoeba histolytica protein kinase, putative 0.0199 0.0231 1
Onchocerca volvulus 0.0621 0.0852 0.0852
Echinococcus granulosus dual specificity 0.0199 0.0231 0.0335
Echinococcus granulosus dual specificity protein kinase clk2 0.0267 0.0331 0.048
Echinococcus granulosus cyclin dependent kinase 9 0.0054 0.0018 0.0027
Loa Loa (eye worm) hypothetical protein 0.0086 0.0065 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0621 0.0852 0.0895
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0621 0.0852 0.1235
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0293 0.0369 0.0535
Loa Loa (eye worm) hypothetical protein 0.0086 0.0065 0.0069
Loa Loa (eye worm) hypothetical protein 0.0084 0.0062 0.0066
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0293 0.0369 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0621 0.0852 0.0895
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0621 0.0852 0.1235
Brugia malayi hypothetical protein 0.0328 0.0421 0.0442
Loa Loa (eye worm) hypothetical protein 0.0086 0.0065 0.0069
Schistosoma mansoni retinoic acid receptor RXR 0.4732 0.6898 1
Echinococcus granulosus endothelin converting enzyme 1 0.0114 0.0106 0.0154
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0328 0.0421 0.061
Echinococcus granulosus cyclin dependent kinase 5 0.0098 0.0083 0.0121
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0267 0.0331 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0328 0.0421 0.0442
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0083 0.2514
Loa Loa (eye worm) hypothetical protein 0.0194 0.0223 0.0235
Schistosoma mansoni nuclear hormone receptor 0.0621 0.0852 0.1235
Brugia malayi nuclear hormone receptor 0.0621 0.0852 0.0895
Echinococcus multilocularis thyroid hormone receptor alpha 0.0621 0.0852 0.1327
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0114 0.0106 0.0154
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0023 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.0331 0.048
Echinococcus multilocularis nuclear receptor nhr 48 0.0293 0.0369 0.0575
Schistosoma mansoni thyroid hormone receptor 0.0621 0.0852 0.1235
Loa Loa (eye worm) hypothetical protein 0.0084 0.0062 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0115 0.3485
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0621 0.0852 0.0895
Brugia malayi Peptidase family M13 containing protein 0.0114 0.0106 0.0112
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0199 0.0231 0.6977
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0621 0.0852 0.0895
Onchocerca volvulus 0.0293 0.0369 0.0369
Brugia malayi nuclear receptor NHR-88 0.0293 0.0369 0.0388
Loa Loa (eye worm) hypothetical protein 0.0279 0.0349 0.0367
Trypanosoma brucei cdc2-related kinase 1 0.0098 0.0083 0.2514
Onchocerca volvulus 0.0056 0.0022 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0293 0.0369 0.0535
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0115 0.3485
Echinococcus multilocularis dual specificity protein kinase clk2 0.0267 0.0331 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0621 0.0852 0.0895
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0058 0.0023 0.0033
Loa Loa (eye worm) hypothetical protein 0.0621 0.0852 0.0895
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0267 0.0331 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0621 0.0852 0.0895
Leishmania major protein kinase, putative 0.0267 0.0331 1
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0115 0.3485

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.2 uM Compound was evaluated for inhibition of Endothelin-converting enzyme 1 partially purified from porcine primary aortic endothelial cells ChEMBL. No reference
IC50 (binding) = 5.2 uM Compound was evaluated for inhibition of Endothelin-converting enzyme 1 partially purified from porcine primary aortic endothelial cells ChEMBL. No reference
Inhibition (binding) = 91 % Inhibition of endothelin-converting enzyme 1 partially purified from porcine primary aortic endothelial cells at 20 microM ChEMBL. No reference
Inhibition (binding) = 91 % Inhibition of endothelin-converting enzyme 1 partially purified from porcine primary aortic endothelial cells at 20 microM ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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