Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL060W and BDH1 (YAL060W) butanediol dehydrogenase | Alcohol dehydrogenase | 374 aa | 366 aa | 24.6 % |
Toxoplasma gondii | quinone oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 323 aa | 23.8 % |
Trypanosoma cruzi | oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 318 aa | 20.1 % |
Mycobacterium tuberculosis | Possible dehydrogenase | Alcohol dehydrogenase | 374 aa | 350 aa | 26.0 % |
Onchocerca volvulus | Alcohol dehydrogenase | 374 aa | 376 aa | 48.9 % | |
Onchocerca volvulus | Putative ATP-dependent RNA helicase DDX52 | Alcohol dehydrogenase | 374 aa | 337 aa | 21.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0088 | 0.5216 | 0.5 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0088 | 0.5216 | 0.5 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0088 | 0.5216 | 0.266 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1404 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0088 | 0.5216 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0088 | 0.5216 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0123 | 0.7833 | 1 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0055 | 0.2719 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0057 | 0.2867 | 0.4938 |
Schistosoma mansoni | ryanodine receptor related | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.078 | 0.1344 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0088 | 0.5216 | 0.5 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0047 | 0.2094 | 0.2094 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1421 | 0.1421 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0088 | 0.5216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.069 | 0.1189 |
Loa Loa (eye worm) | ryanodine receptor | 0.0036 | 0.13 | 0.224 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0088 | 0.5216 | 0.5 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0055 | 0.2719 | 0.5 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0088 | 0.5216 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0088 | 0.5216 | 0.8985 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0088 | 0.5216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5805 | 1 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0088 | 0.5216 | 0.5216 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0123 | 0.7833 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.