Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.008 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | 0.008 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | 0.008 | 0.5 | 0.5 | |
Brugia malayi | Peroxidasin | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.008 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.008 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.008 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.008 | 0.5 | 0.5 |
Onchocerca volvulus | 0.008 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Average change in body weight (functional) | = -3.1 % | Average change in body weight from onset to termination of drug therapy in mice bearing the P388 Leukemia at 80 mg / kg | ChEMBL. | 7392030 |
Average change in body weight (functional) | = -3.1 % | Average change in body weight from onset to termination of drug therapy in mice bearing the P388 Leukemia at 80 mg / kg | ChEMBL. | 7392030 |
Average change in body weight (functional) | = 8.1 % | Average change in body weight from onset to termination of drug therapy in mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
Average change in body weight (functional) | = 8.1 % | Average change in body weight from onset to termination of drug therapy in mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
Average survival (functional) | = 11.6 day | The average survival time (days) of mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
Average survival (functional) | = 11.6 day | The average survival time (days) of mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
Average survival (functional) | = 15 day | The average survival time(days) of mice bearing the P388 Leukemia at 80 mg / kg (Mice that survived more than 50 days) | ChEMBL. | 7392030 |
Average survival (functional) | = 15 day | The average survival time(days) of mice bearing the P388 Leukemia at 80 mg / kg (Mice that survived more than 50 days) | ChEMBL. | 7392030 |
Survivors (functional) | = 0 | At the 50 day survivors of mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
Survivors (functional) | = 20 | At the 50 day survivors of mice bearing the P388 Leukemia at 80 mg / kg | ChEMBL. | 7392030 |
T/C (functional) | = 129 % | Average survival time (treated / control) x100 was calculated in mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
T/C (functional) | = 129 % | Average survival time (treated / control) x100 was calculated in mice bearing the L1210 Leukemia at 100 mg / kg | ChEMBL. | 7392030 |
T/C (functional) | = 160 % | Average survival time (treated / control) x100 was calculated in mice bearing the P388 Leukemia at 80 mg / kg (Mice that survived more than 50 days) | ChEMBL. | 7392030 |
T/C (functional) | = 160 % | Average survival time (treated / control) x100 was calculated in mice bearing the P388 Leukemia at 80 mg / kg (Mice that survived more than 50 days) | ChEMBL. | 7392030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.