TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 315.476 | Formula: C18H25N3S
H donors: 0 H acceptors: 1 LogP: 3.49 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)C(c1ccc(cc1C)C)c1snc(c1)C
InChi: 1S/C18H25N3S/c1-13-5-6-16(14(2)11-13)18(17-12-15(3)19-22-17)21-9-7-20(4)8-10-21/h5-6,11-12,18H,7-10H2,1-4H3
InChiKey: FUXWOJLIVIFGOK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0035	0.0035
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0016	0.0022	0.0022
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0035	0.2398
Entamoeba histolytica	hypothetical protein	0.0038	0.0117	0.2949
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0145	0.0145
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.2372	1	1
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0001	0.0001
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0035	0.0004
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.0398	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0001	0.0001
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0062	0.2836
Entamoeba histolytica	hypothetical protein	0.0038	0.0117	0.2949
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0001	0.0001
Schistosoma mansoni	ap endonuclease	0.0019	0.0035	0.0035
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0062	0.0062
Echinococcus granulosus	neutral amino acid transporter A	0.2372	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0022	0.0022
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.2372	1	1
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0172	0.0172
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0035	0.0004
Echinococcus multilocularis	excitatory amino acid transporter 2	0.2372	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0001	0.0001
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0035	0.0035
Echinococcus multilocularis	protein patched	0.0045	0.0145	0.0145
Echinococcus granulosus	excitatory amino acid transporter 2	0.2372	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0035	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0001	0.0001
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.0398	0.0398
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0001	0.0001
Brugia malayi	nuclear hormone receptor	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0165	0.0165
Brugia malayi	steroid hormone receptor	0.0011	0.0001	0.0001
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1665	0.7006	0.7006
Brugia malayi	ecdysteroid receptor	0.0011	0.0001	0.0001
Brugia malayi	CHE-14 protein	0.0045	0.0145	0.0145
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0001	0.0001
Echinococcus granulosus	GPCR family 2	0.0016	0.0022	0.0022
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.00000024171	0.00000024171
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0001	0.0001
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0165	0.0165
Echinococcus granulosus	replication factor c subunit 1	0.001	0.00000024171	0.00000024171
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0145	0.0145
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.2372	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0001	0.0001
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0001	0.0001
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0035	0.0035
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0001	0.0001
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0035	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.0219	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0001	0.0001
Schistosoma mansoni	patched 1	0.0045	0.0145	0.0145
Echinococcus multilocularis	excitatory amino acid transporter 3	0.2372	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Echinococcus granulosus	expressed conserved protein	0.0098	0.0371	0.0371
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0117	0.0117
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0001	0.0001
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0035	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0188	0.0188
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0219	1
Echinococcus granulosus	Excitatory amino acid transporter	0.2372	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0001	0.0001
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0035	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0022	0.0022
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0062	0.1482
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0062	0.0031
Schistosoma mansoni	hypothetical protein	0.0043	0.0139	0.0139
Echinococcus multilocularis	Excitatory amino acid transporter	0.2372	1	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0062	0.1565
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0035	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0062	0.0062
Treponema pallidum	glutamate transporter	0.1051	0.4408	1
Echinococcus multilocularis	Excitatory amino acid transporter	0.2372	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0001	0.0001
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0001	0.0001
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0034	0.0099	0.0099
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0062	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0035	0.161
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0062	0.1565
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0062	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0035	0.159
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0022	0.0022
Onchocerca volvulus		0.0011	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0016	0.0022	0.0022
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0001	0.0001
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0035	0.9875
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0001	0.0001
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0062	0.0031
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0035	0.0035
Chlamydia trachomatis	glutamate symporter	0.2372	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0001	0.0001
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0062	0.1482
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0001	0.0001
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0165	0.0165
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0001	0.0001
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0099	0.0099
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0001	0.0001
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.1051	0.4408	0.4408
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0035	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0035	0.2398
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.0219	0.0189
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0001	0.0001
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0062	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0035	0.0035
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.0405	0.0405
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.0398	0.0398
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0062	0.2836
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.0219	0.0219
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0038	0.0117	0.0117
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.1051	0.4408	0.4408
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0001	0.0001
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0165	0.0165
Echinococcus granulosus	Excitatory amino acid transporter	0.2372	1	1
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.2372	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0001	0.0001
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0062	0.1565
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0001	0.0001
Chlamydia trachomatis	neutral amino acid transporter	0.1051	0.4408	0.4408
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0001	0.0001
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0022	0.0022
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0022	0.0022
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.2372	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0001	0.0001
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0001	0.0001
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0062	0.2836
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0022	0.0022
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0001	0.0001
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0062	0.2836
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0016	0.0022	0.0022
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0001	0.0001
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0035	0.9875
Entamoeba histolytica	hypothetical protein	0.0038	0.0117	0.2949
Echinococcus multilocularis	expressed conserved protein	0.0098	0.0371	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0398	0.0398
Brugia malayi	hypothetical protein	0.0038	0.0117	0.0117
Onchocerca volvulus		0.0025	0.0062	0.0062
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0062	0.1482
Echinococcus multilocularis	neutral amino acid transporter A	0.2372	1	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0139	0.0139
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0001	0.0001
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0022	0.0022
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0219	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.00000024171	0.0000060763
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0062	0.2836
Echinococcus multilocularis	neutral amino acid transporter A	0.2372	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0001	0.0001
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0145	0.0145
Echinococcus multilocularis	excitatory amino acid transporter 2	0.2372	1	1
Echinococcus granulosus	excitatory amino acid transporter 3	0.2372	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0062	0.0062
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Echinococcus granulosus	excitatory amino acid transporter 2	0.2372	1	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0145	0.0145
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0062	0.0062
Toxoplasma gondii	exonuclease III APE	0.0019	0.0035	0.159
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0001	0.0001
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0001	0.0001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0001
Echinococcus multilocularis	neutral amino acid transporter A	0.2372	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0219	0.0219
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0001	0.0001
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0001	0.0001
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0001	0.0001
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.0219	0.0219
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0001	0.0001
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.0587	0.0587
Loa Loa (eye worm)	excitatory amino acid transporter	0.2372	1	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0139	0.0139
Schistosoma mansoni	hypothetical protein	0.0043	0.0139	0.0139
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0062	0.0219	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0117	0.0117
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.1051	0.4408	0.4408
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0001	0.0001
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0117	0.0117
Treponema pallidum	glutamate/aspartate transporter	0.1051	0.4408	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.0219	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0035	0.0035
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0022	0.0022
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0035	0.0079
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0062	0.2836
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.2372	1	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0001	0.0001
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.00000024171	0.00000024171
Entamoeba histolytica	hypothetical protein	0.0038	0.0117	0.2949
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0001
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0035	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0035	0.0035
Echinococcus granulosus	neutral amino acid transporter A	0.2372	1	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0001	0.0001
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.0219	0.0219
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0145	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0001	0.0001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0001	0.0001
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0062	0.2836
Echinococcus granulosus	sodium:dicarboxylate symporter	0.2372	1	1
Echinococcus granulosus	neutral amino acid transporter	0.2372	1	1
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.1051	0.4408	0.4408
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0001	0.0001

Activities

Activity type	Activity value	Assay description	Source	Reference
Reduction (functional)	= 1 %	Hypolipidemic activity was measured as reduction in rat serum cholesterol after oral administration in male Wistar rats at 30 mg / (kg day)	ChEMBL.	6148419
Reduction (functional)	= 31 %	Hypolipidemic activity was measured as reduction in rat serum triglyceride after oral administration in male Wistar rats at 30 mg / (kg day)	ChEMBL.	6148419
Reduction (functional)	= 52 %	Hypolipidemic activity was measured as reduction in rat serum triglyceride after oral administration in male Wistar rats at 200 mg / (kg day)	ChEMBL.	6148419
Reduction (functional)	= 56 %	Hypolipidemic activity was measured as reduction in rat serum cholesterol after oral administration in male Wistar rats at 200 mg / (kg day)	ChEMBL.	6148419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL25162

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 27025