TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 257.76 | Formula: C12H20ClN3O
H donors: 3 H acceptors: 1 LogP: 1.44 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NCCCCNC(=O)NCc1ccccc1.Cl
InChi: 1S/C12H19N3O.ClH/c13-8-4-5-9-14-12(16)15-10-11-6-2-1-3-7-11;/h1-3,6-7H,4-5,8-10,13H2,(H2,14,15,16);1H
InChiKey: FOEWKXXAIULRTI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-1	0.0579	0.5068	0.4934
Trypanosoma cruzi	cysteine proteinase, putative	0.0579	0.5068	0.4934
Plasmodium falciparum	serine repeat antigen 2	0.0207	0.1705	0.148
Leishmania major	cathepsin L-like protease	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1705	0.148
Plasmodium vivax	serine-repeat antigen (SERA)	0.0207	0.1705	0.148
Echinococcus multilocularis	cyclin dependent kinase 1	0.0048	0.0264	0.0264
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0579	0.5068	0.5068
Echinococcus multilocularis	cathepsin L	0.0579	0.5068	0.5068
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0144	0.0144
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0207	0.1705	0.148
Onchocerca volvulus	Cathepsin F homolog	0.1124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.045	0.0441
Entamoeba histolytica	cysteine proteinase, putative	0.1124	1	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0026	0.0026
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0752	0.6637	0.6546
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0207	0.1705	0.1666
Echinococcus granulosus	biogenic amine 5HT receptor	0.0123	0.0944	0.0944
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Echinococcus granulosus	cathepsin L	0.0579	0.5068	0.5068
Loa Loa (eye worm)	hypothetical protein	0.004	0.0186	0.0177
Echinococcus granulosus	cyclin dependent kinase 5	0.0048	0.0264	0.0264
Giardia lamblia	Hypothetical protein	0.0207	0.1705	1
Schistosoma mansoni	cathepsin s	0.0372	0.3191	0.3191
Loa Loa (eye worm)	cathepsin B	0.0207	0.1705	0.1697
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0264	0.0264
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1705	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0207	0.1705	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0207	0.1705	0.1666
Giardia lamblia	Cysteine protease	0.0207	0.1705	1
Entamoeba histolytica	hypothetical protein	0.0207	0.1705	0.148
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0207	0.1705	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0123	0.0944	0.0944
Brugia malayi	cathepsin F-like cysteine proteinase	0.0372	0.3191	0.3158
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0207	0.1705	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0207	0.1705	0.148
Echinococcus multilocularis	cathepsin L cysteine protease	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Echinococcus multilocularis	cathepsin L	0.0207	0.1705	0.1705
Brugia malayi	cathepsin L precursor	0.0207	0.1705	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0752	0.6637	0.6634
Echinococcus multilocularis	cyclin dependent kinase 1	0.0048	0.0264	0.0264
Echinococcus granulosus	cathepsin l1	0.0752	0.6637	0.6637
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0372	0.3191	0.3158
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Plasmodium falciparum	serine repeat antigen 3	0.0207	0.1705	0.148
Plasmodium vivax	vivapain-2	0.1124	1	1
Brugia malayi	Cathepsin L-like precursor	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0207	0.1705	0.148
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0207	0.1705	0.148
Giardia lamblia	Cathepsin L precursor	0.0207	0.1705	1
Leishmania major	cathepsin L-like protease	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Brugia malayi	Papain family cysteine protease containing protein	0.0579	0.5068	0.5045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0207	0.1705	0.148
Echinococcus multilocularis	cysteine protease	0.1124	1	1
Toxoplasma gondii	cathepsin CPL	0.1124	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0371	0.3189	0.3189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.1124	1	1
Echinococcus multilocularis	cathepsin b	0.0207	0.1705	0.1705
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0207	0.1705	0.148
Schistosoma mansoni	hypothetical protein	0.0165	0.1319	0.1319
Schistosoma mansoni	cathepsin B (C01 family)	0.0207	0.1705	0.1705
Echinococcus multilocularis	serotonin receptor	0.0123	0.0944	0.0944
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Trypanosoma cruzi	cysteine peptidase, putative	0.0579	0.5068	0.4934
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1705	0.148
Loa Loa (eye worm)	hypothetical protein	0.0372	0.3191	0.3184
Trypanosoma cruzi	cruzipain precursor, putative	0.0372	0.3191	0.3006
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0264	0.0264
Brugia malayi	Cathepsin L-like precursor	0.0752	0.6637	0.6621
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1124	1	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0353	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0207	0.1705	0.148
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Schistosoma mansoni	cathepsin C	0.0207	0.1705	0.1705
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0752	0.6637	0.6546
Onchocerca volvulus		0.1124	1	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0207	0.1705	0.1705
Plasmodium falciparum	serine repeat antigen 5	0.0207	0.1705	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Echinococcus multilocularis	cathepsin b	0.0207	0.1705	0.1705
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Onchocerca volvulus		0.1124	1	1
Giardia lamblia	Cysteine protease	0.0207	0.1705	1
Echinococcus granulosus	cysteine protease	0.0579	0.5068	0.5068
Brugia malayi	cathepsin B-like cysteine proteinase	0.0207	0.1705	0.1666
Entamoeba histolytica	cysteine proteinase, putative	0.0579	0.5068	0.4934
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0207	0.1705	0.148
Plasmodium vivax	serine-repeat antigen (SERA)	0.0207	0.1705	0.148
Brugia malayi	Cathepsin L-like precursor	0.0752	0.6637	0.6621
Entamoeba histolytica	cysteine proteinase 1, putative	0.0579	0.5068	0.4934
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0048	0.0264	0.0255
Onchocerca volvulus		0.0752	0.6637	0.5946
Toxoplasma gondii	cathepsin B	0.0207	0.1705	0.148
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0579	0.5068	0.4934
Brugia malayi	Cathepsin L-like precursor	0.1124	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0207	0.1705	0.148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Echinococcus multilocularis	serotonin receptor	0.0123	0.0944	0.0944
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0207	0.1705	0.148
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Brugia malayi	Papain family cysteine protease containing protein	0.0579	0.5068	0.5045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Onchocerca volvulus		0.1124	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0207	0.1705	0.148
Schistosoma mansoni	cathepsin F (C01 family)	0.1124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Leishmania major	cathepsin L-like protease	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0048	0.0264	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1124	1	1
Echinococcus multilocularis	geminin	0.0165	0.1319	0.1319
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0752	0.6637	0.6621
Loa Loa (eye worm)	ctsf protein	0.1124	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0207	0.1705	1
Entamoeba histolytica	cysteine proteinase, putative	0.0579	0.5068	0.4934
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0207	0.1705	0.1697
Brugia malayi	Papain family cysteine protease containing protein	0.1124	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0579	0.5068	0.4934
Brugia malayi	fibroinase precursor	0.0207	0.1705	0.1666
Giardia lamblia	Hypothetical protein	0.0207	0.1705	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0372	0.3191	0.3184
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0203	0.0194
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0207	0.1705	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0944	0.0935
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0207	0.1705	0.148
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0026	0.0026
Loa Loa (eye worm)	fibroinase	0.1124	1	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0207	0.1705	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0579	0.5068	0.4934
Onchocerca volvulus		0.1124	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Leishmania major	cathepsin L-like protease	0.1124	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0207	0.1705	0.1666
Entamoeba histolytica	cysteine proteinase 2	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0207	0.1705	0.148
Echinococcus granulosus	geminin	0.0165	0.1319	0.1319
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0207	0.1705	0.148
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0207	0.1705	0.148
Echinococcus granulosus	cathepsin b	0.0207	0.1705	0.1705
Brugia malayi	Bromodomain containing protein	0.0073	0.0488	0.0443
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0207	0.1705	0.148
Brugia malayi	Papain family cysteine protease containing protein	0.0207	0.1705	0.1666
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1705	0.148
Echinococcus multilocularis	cyclin dependent kinase	0.0048	0.0264	0.0264
Plasmodium falciparum	serine repeat antigen 1	0.0207	0.1705	0.148
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0207	0.1705	0.1666
Trypanosoma cruzi	cysteine peptidase, putative	0.1124	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.1705	0.148
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0264	0.0218
Plasmodium falciparum	serine repeat antigen 4	0.0207	0.1705	0.148
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1124	1	1
Giardia lamblia	Cathepsin L precursor	0.0207	0.1705	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0579	0.5068	0.4934
Plasmodium vivax	unspecified product	0.0579	0.5068	0.4934
Schistosoma mansoni	bromodomain containing protein	0.0062	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0207	0.1705	0.148
Plasmodium vivax	unspecified product	0.0207	0.1705	0.148
Plasmodium falciparum	serine repeat antigen 6	0.0207	0.1705	0.148
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0579	0.5068	0.5068
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0207	0.1705	0.148
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0207	0.1705	0.148
Echinococcus granulosus	cathepsin b	0.0207	0.1705	0.1705
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0207	0.1705	0.1697
Echinococcus multilocularis	cathepsin L cysteine protease	0.1124	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0207	0.1705	0.1705
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0371	0.3189	0.3189
Brugia malayi	Cathepsin L-like precursor	0.0372	0.3191	0.3158
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Echinococcus granulosus	cyclin dependent kinase	0.0048	0.0264	0.0264
Schistosoma mansoni	cathepsin F (C01 family)	0.0752	0.6637	0.6637
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Trypanosoma cruzi	cysteine peptidase, putative	0.1124	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0207	0.1705	0.1705
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1705	0.148
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0353	0.0353
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0048	0.0264	0.0255
Brugia malayi	Cathepsin L-like precursor	0.1124	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0207	0.1705	0.148
Loa Loa (eye worm)	cysteine protease	0.1124	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1124	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Plasmodium vivax	vivapain-3	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0207	0.1705	0.148
Brugia malayi	Cathepsin L-like precursor	0.1124	1	1
Plasmodium vivax	unspecified product	0.0372	0.3191	0.3006
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0207	0.1705	0.1705
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1124	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0371	0.3189	0.3189
Onchocerca volvulus	Cathepsin L homolog	0.1124	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0207	0.1705	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0752	0.6637	0.6634
Echinococcus granulosus	cyclin dependent kinase 1	0.0048	0.0264	0.0264
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0207	0.1705	0.148
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Loa Loa (eye worm)	hypothetical protein	0.1124	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1124	1	1
Giardia lamblia	Cathepsin L precursor	0.0207	0.1705	1
Giardia lamblia	Cysteine protease	0.0207	0.1705	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0207	0.1705	0.148
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0207	0.1705	0.1705
Giardia lamblia	Cysteine protease	0.0207	0.1705	1
Giardia lamblia	Cathepsin L-like protease	0.0207	0.1705	1
Giardia lamblia	Cathepsin L precursor	0.0207	0.1705	1
Leishmania major	cysteine peptidase A (CPA)	0.1124	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Leishmania major	cathepsin L-like protease	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0207	0.1705	0.148
Entamoeba histolytica	cysteine proteinase, putative	0.0579	0.5068	0.4934
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Schistosoma mansoni	hypothetical protein	0.0165	0.1319	0.1319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Toxoplasma gondii	cathepsin CPC1	0.0207	0.1705	0.148
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0207	0.1705	0.148
Onchocerca volvulus		0.1124	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0579	0.5068	0.5068
Schistosoma mansoni	cathepsin F (C01 family)	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0207	0.1705	0.148
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0165	0.0156
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0207	0.1705	0.148
Entamoeba histolytica	cysteine protease, putative	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Echinococcus multilocularis	cyclin dependent kinase 5	0.0048	0.0264	0.0264
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0048	0.0264	0.0264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Brugia malayi	Papain family cysteine protease containing protein	0.0207	0.1705	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0944	0.0935
Trypanosoma cruzi	cruzipain precursor, putative	0.1124	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0207	0.1705	0.148
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1124	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0207	0.1705	0.148
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Leishmania major	cathepsin L-like protease	0.1124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0752	0.6637	0.6634
Echinococcus granulosus	cathepsin L	0.0207	0.1705	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0255	0.0246
Echinococcus multilocularis	cysteine protease	0.1124	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0752	0.6637	0.6546
Trypanosoma cruzi	cysteine peptidase, putative	0.0372	0.3191	0.3006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0207	0.1705	0.148
Brugia malayi	cathepsin L-like cysteine proteinase	0.0207	0.1705	0.1666
Trypanosoma cruzi	major cysteine proteinase, putative	0.0207	0.1705	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0579	0.5068	0.4934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1124	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0207	0.1705	0.148
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0752	0.6637	0.6546
Brugia malayi	cathepsin F-like cysteine proteinase	0.0207	0.1705	0.1666
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0207	0.1705	1
Entamoeba histolytica	cysteine protease, putative	0.0207	0.1705	0.148
Plasmodium falciparum	serine repeat antigen 8	0.0207	0.1705	0.148
Brugia malayi	cell division control protein 2 homolog	0.0048	0.0264	0.0218
Leishmania major	cathepsin L-like protease	0.1124	1	1
Giardia lamblia	Cathepsin L-like protease	0.0207	0.1705	1
Onchocerca volvulus		0.1124	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0579	0.5068	0.4934
Giardia lamblia	Cathepsin B precursor	0.0207	0.1705	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0207	0.1705	0.1705
Trypanosoma cruzi	cysteine peptidase, putative	0.1124	1	1
Entamoeba histolytica	cysteine protease, putative	0.0207	0.1705	0.148
Plasmodium falciparum	serine repeat antigen 9	0.0207	0.1705	0.148
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0579	0.5068	0.5068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0579	0.5068	0.4934
Brugia malayi	cathepsin L-like precursor	0.0752	0.6637	0.6621
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Loa Loa (eye worm)	hypothetical protein	0.0207	0.1705	0.1697
Brugia malayi	Bromodomain containing protein	0.0037	0.0165	0.0118
Giardia lamblia	Encystation-specific protease	0.0207	0.1705	1
Giardia lamblia	Cathepsin L precursor	0.0207	0.1705	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.3191	0.3184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Giardia lamblia	Cathepsin L precursor	0.0207	0.1705	1
Brugia malayi	Cathepsin L-like precursor	0.1124	1	1
Plasmodium vivax	vivapain-2	0.1124	1	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0207	0.1705	0.148
Leishmania major	cathepsin L-like protease	0.1124	1	1
Onchocerca volvulus		0.1124	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0207	0.1705	0.148
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0144	0.0144
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0207	0.1705	0.148
Trypanosoma cruzi	cysteine peptidase, putative	0.1124	1	1
Loa Loa (eye worm)	hypothetical protein	0.0372	0.3191	0.3184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1124	1	1
Toxoplasma gondii	cathepsin CPC2	0.0207	0.1705	0.148
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0207	0.1705	0.148
Plasmodium falciparum	serine repeat antigen 7	0.0207	0.1705	0.148
Entamoeba histolytica	cysteine proteinase, putative	0.0579	0.5068	0.4934
Echinococcus granulosus	cathepsin l1	0.1124	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0207	0.1705	0.148
Schistosoma mansoni	hypothetical protein	0.002	0.0009	0.0009
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0207	0.1705	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1124	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Fluorescence intensity (binding)	= 44	Oxidative desamination of the compound by bovine serum amine oxidase and expressed in terms of fluorescence intensity.	ChEMBL.	9871574
Fluorescence intensity (binding)	= 44	Oxidative desamination of the compound by bovine serum amine oxidase and expressed in terms of fluorescence intensity.	ChEMBL.	9871574
IC50 (functional)	> 170 uM	Compound was tested for inhibitory concentration required to inhibit 50% of [14C]- putrescine uptake.	ChEMBL.	9871574
IC50 (functional)	> 170 uM	Compound was tested for inhibitory concentration required to inhibit 50% of [14C]- putrescine uptake.	ChEMBL.	9871574
IC50 (functional)	> 200 uM	Cytotoxic effect on L1210 leukemia cells.	ChEMBL.	9871574
IC50 (functional)	> 200 uM	Cytotoxic effect on L1210 leukemia cells.	ChEMBL.	9871574

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL156805

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 270494