Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0119 | 0.2289 | 0.2167 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.0739 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0119 | 0.2289 | 0.2167 |
Echinococcus multilocularis | dihydrofolate reductase | 0.043 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0639 | 0.0491 |
Echinococcus granulosus | thymidylate synthase | 0.0119 | 0.2289 | 0.2167 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0639 | 0.0491 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.7113 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0138 | 0.2764 | 0.2186 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0119 | 0.2289 | 0.1674 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.7113 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0037 | 0.0248 | 0.0349 |
Mycobacterium ulcerans | hypothetical protein | 0.0138 | 0.2764 | 0.0615 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.043 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0639 | 0.0491 |
Toxoplasma gondii | hypothetical protein | 0.0042 | 0.0383 | 0.0326 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0037 | 0.0248 | 0.0132 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0104 | 0.1907 | 0.1779 |
Brugia malayi | MH2 domain containing protein | 0.0104 | 0.1907 | 0.1779 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0037 | 0.0248 | 0.0349 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0262 | 0.5847 | 0.822 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0124 | 0.2415 | 0.3395 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0354 | 0.8129 | 0.8099 |
Echinococcus granulosus | dihydrofolate reductase | 0.043 | 1 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.1675 | 0.1543 |
Loa Loa (eye worm) | thymidylate synthase | 0.0119 | 0.2289 | 0.2167 |
Echinococcus granulosus | tumor protein p63 | 0.0294 | 0.6621 | 0.6568 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.7113 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.8129 | 0.8099 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0639 | 0.0491 |
Brugia malayi | thymidylate synthase | 0.0119 | 0.2289 | 0.2167 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0043 | 0.0399 | 0.0247 |
Schistosoma mansoni | dihydrofolate reductase | 0.043 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.043 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.7113 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.043 | 1 | 0.5 |
Onchocerca volvulus | 0.0119 | 0.2289 | 1 | |
Echinococcus multilocularis | snurportin 1 | 0.0354 | 0.8129 | 0.8099 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0124 | 0.2415 | 0.3395 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0104 | 0.1907 | 0.1779 |
Brugia malayi | follicle stimulating hormone receptor | 0.0267 | 0.5951 | 0.5887 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0262 | 0.5847 | 0.822 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0037 | 0.0248 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0399 | 0.0247 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0639 | 0.0491 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0057 | 0.0739 | 0.1039 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0262 | 0.5847 | 0.822 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0739 | 0.0592 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | expressed protein | 0.0324 | 0.7384 | 0.7343 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0313 | 0.7113 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0124 | 0.2415 | 0.3248 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0267 | 0.5951 | 0.5887 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0639 | 0.0491 |
Echinococcus multilocularis | tumor protein p63 | 0.0294 | 0.6621 | 0.6568 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0262 | 0.5847 | 0.818 |
Echinococcus granulosus | snurportin 1 | 0.0354 | 0.8129 | 0.8099 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.7113 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.043 | 1 | 1 |
Echinococcus granulosus | expressed protein | 0.0324 | 0.7384 | 0.7343 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.043 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0448 | 0.063 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0639 | 0.0491 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0639 | 0.0491 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.043 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0639 | 0.0491 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha; ND means no data | ChEMBL. | 11266159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.