TDR Targets

Basic information

Technical information

TDR Targets ID: 270523
Name: 3-(3,5-dichloro-4-hydroxyanilino)-4-(3-methox yphenyl)pyrrole-2,5-dione
MW: 379.194 | Formula: C17H12Cl2N2O4
H donors: 3 H acceptors: 3 LogP: 3.56 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C1=C(Nc2cc(Cl)c(c(c2)Cl)O)C(=O)NC1=O
InChi: 1S/C17H12Cl2N2O4/c1-25-10-4-2-3-8(5-10)13-14(17(24)21-16(13)23)20-9-6-11(18)15(22)12(19)7-9/h2-7,22H,1H3,(H2,20,21,23,24)
InChiKey: SDCHARFPZYFAKJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(3,5-dichloro-4-hydroxy-anilino)-4-(3-methoxyphenyl)pyrrole-2,5-dione
3-[(3,5-dichloro-4-hydroxy-phenyl)amino]-4-(3-methoxyphenyl)pyrrole-2,5-dione
3-(3,5-dichloro-4-hydroxy-anilino)-4-(3-methoxyphenyl)-3-pyrroline-2,5-quinone
3-[(3,5-dichloro-4-hydroxyphenyl)amino]-4-(3-methoxyphenyl)pyrrole-2,5-dione
3-[(3,5-dichloro-4-hydroxy-phenyl)amino]-4-(3-methoxyphenyl)-3-pyrroline-2,5-quinone
4-arylmaleimide deriv. 6-k

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0017	0.0335	0.0308
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Echinococcus multilocularis	dnaJ subfamily B	0.0395	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.1909	0.1848
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0129	0.0033
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0008	0.0104	0.003
Echinococcus multilocularis	serotonin receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	opsin-like receptor	0.0079	0.1909	0.1909
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0335	0.0308
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0335	0.0308
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Schistosoma mansoni	cpg binding protein	0.0029	0.0648	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0608	0.0672
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0079	0.1909	0.1848
Echinococcus multilocularis	neuropeptide s receptor	0.0079	0.1909	0.1848
Plasmodium falciparum	glycogen synthase kinase 3	0.0058	0.1382	0.5
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Echinococcus granulosus	G protein coupled receptor 139	0.0079	0.1909	0.1848
Echinococcus granulosus	hypothetical protein	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0008	0.0104	0.003
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0608	0.0672
Echinococcus granulosus	fmrfamide receptor	0.0079	0.1909	0.1848
Brugia malayi	putative neuropeptide receptor	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Onchocerca volvulus		0.0028	0.0608	0.2788
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.1909	0.1848
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0009	0.0129	0.0129
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0008	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0079	0.1909	0.1848
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0017	0.0335	0.0335
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.1909	0.1848
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.1909	0.1848
Brugia malayi	G-protein coupled receptor	0.0079	0.1909	0.2411
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0017	0.0335	0.0335
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.1382	0.1706
Onchocerca volvulus		0.0079	0.1909	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0079	0.1909	0.1909
Echinococcus granulosus	biogenic amine 5HT receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.0008	0.0104	0.003
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0104	0.003
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Onchocerca volvulus		0.0079	0.1909	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Brugia malayi	hypothetical protein	0.0009	0.0129	0.0033
Brugia malayi	steroid hormone receptor	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0079	0.1909	0.2411
Brugia malayi	follicle stimulating hormone receptor	0.0301	0.759	1
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	cpg binding protein	0.0029	0.0648	0.0578
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0079	0.1909	0.1848
Brugia malayi	G-protein coupled receptor	0.0079	0.1909	0.2411
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0079	0.1909	0.2411
Schistosoma mansoni	nuclear receptor nhr-48	0.0008	0.0104	0.0104
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.1382	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0079	0.1909	0.2411
Brugia malayi	intracellular kinase	0.0058	0.1382	0.1706
Echinococcus granulosus	7tm_1 domain containing protein	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0017	0.0335	0.0263
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.1909	0.2411
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0335	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.1909	0.1848
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0079	0.1909	0.2411
Echinococcus granulosus	orexin receptor type 2	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	opsin-like receptor	0.0079	0.1909	0.1909
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.1909	0.1848
Brugia malayi	ecdysteroid receptor	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Giardia lamblia	Kinase, CMGC GSK	0.0058	0.1382	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0017	0.0335	0.0308
Brugia malayi	sulfakinin receptor protein	0.0079	0.1909	0.2411
Brugia malayi	GnHR receptor homolog	0.0079	0.1909	0.2411
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0079	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	g protein coupled receptor	0.0079	0.1909	0.1848
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0017	0.0335	0.0308
Trypanosoma brucei	protein kinase, putative	0.0058	0.1382	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0079	0.1909	0.1848
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0017	0.0335	0.0308
Brugia malayi	RE15519p	0.0079	0.1909	0.2411
Schistosoma mansoni	nuclear receptor	0.0008	0.0104	0.0104
Brugia malayi	photoreceptor-specific nuclear receptor	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0139	0.3444	0.3395
Brugia malayi	neuropeptide F receptor	0.0079	0.1909	0.2411
Onchocerca volvulus		0.0079	0.1909	1
Schistosoma mansoni	adenoreceptor	0.0079	0.1909	0.1909
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Brugia malayi	G protein-coupled receptor	0.0079	0.1909	0.2411
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0008	0.0104	0.003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Brugia malayi	neuropeptide F receptor	0.0079	0.1909	0.2411
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.1909	0.1848
Echinococcus granulosus	tm gpcr rhodopsin	0.0079	0.1909	0.1848
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0079	0.1909	0.2411
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0079	0.1909	0.2411
Schistosoma mansoni	myosin xvIII	0.0079	0.1909	0.1909
Brugia malayi	larval opioid receptor	0.0079	0.1909	0.2411
Schistosoma mansoni	hypothetical protein	0.0079	0.1909	0.1909
Brugia malayi	Serotonin receptor	0.0079	0.1909	0.2411
Brugia malayi	hypothetical protein	0.0009	0.0129	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0457	0.0471
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0079	0.1909	0.1848
Schistosoma mansoni	hypothetical protein	0.0079	0.1909	0.1909
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0009	0.0129	0.0033
Echinococcus multilocularis	sex peptide receptor	0.0079	0.1909	0.1848
Echinococcus granulosus	protein kinase shaggy	0.0058	0.1382	0.1317
Schistosoma mansoni	neuropeptide f receptor 76f	0.0079	0.1909	0.1909
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0335	0.0308
Echinococcus granulosus	sex peptide receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Brugia malayi	ORL1-like opioid receptor	0.0079	0.1909	0.2411
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0129	0.0033
Loa Loa (eye worm)	melatonin receptor type 1A	0.0079	0.1909	0.2411
Schistosoma mansoni	hypothetical protein	0.0079	0.1909	0.1909
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0017	0.0335	0.0263
Echinococcus multilocularis	FTZ F1 alpha	0.0017	0.0335	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0008	0.0104	0.003
Echinococcus granulosus	dro:myosuppressin receptor	0.0079	0.1909	0.1848
Entamoeba histolytica	protein kinase, putative	0.0058	0.1382	0.5
Schistosoma mansoni	nuclear receptor	0.0008	0.0104	0.0104
Onchocerca volvulus	Bile acid receptor homolog	0.0017	0.0335	0.1279
Echinococcus multilocularis	neuropeptides capa receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0079	0.1909	0.1848
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0301	0.759	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0129	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0335	0.0335
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0079	0.1909	0.1909
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.1909	0.1848
Brugia malayi	nuclear receptor RXR	0.0009	0.0129	0.0033
Echinococcus granulosus	g-protein coupled receptor	0.0079	0.1909	0.1848
Echinococcus granulosus	g protein coupled receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0104	0.003
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.1909	0.1909
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0079	0.1909	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	hypothetical protein	0.0122	0.3007	0.3007
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0017	0.0335	0.0308
Schistosoma mansoni	amine GPCR	0.0079	0.1909	0.1909
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.0115	0.0014
Brugia malayi	Melatonin receptor type 1A	0.0079	0.1909	0.2411
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.1909	0.1909
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0017	0.0335	0.0335
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0079	0.1909	0.1909
Echinococcus granulosus	ecdysone induced protein 78C	0.0017	0.0335	0.0263
Echinococcus granulosus	neuropeptide receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	opsin-like receptor	0.0079	0.1909	0.1909
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0079	0.1909	0.1909
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0017	0.0335	0.0335
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0079	0.1909	0.1848
Echinococcus granulosus	allatostatin A receptor	0.0079	0.1909	0.1848
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0058	0.1382	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0017	0.0335	0.0308
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.0104	0.0104
Schistosoma mansoni	biogenic amine receptor	0.0079	0.1909	0.1909
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1382	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0129	0.0033
Echinococcus multilocularis	g-protein coupled receptor	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0129	0.0033
Echinococcus multilocularis	allatostatin A receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Brugia malayi	putative neuropeptide receptor NPR1	0.0079	0.1909	0.2411
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0335	0.0308
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0079	0.1909	0.1909
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0079	0.1909	0.1909
Onchocerca volvulus		0.0079	0.1909	1
Brugia malayi	Dopamine receptor	0.0079	0.1909	0.2411
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0058	0.1382	0.5
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0058	0.1382	0.1317
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.1909	0.1909
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.1909	0.1848
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.3444	0.3444
Echinococcus granulosus	nuclear receptor nhr 48	0.0008	0.0104	0.003
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0335	0.0263
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0079	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0017	0.0335	0.0335
Echinococcus granulosus	g protein coupled receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0079	0.1909	0.1848
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0079	0.1909	0.1848
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0009	0.0129	0.0055
Onchocerca volvulus		0.0058	0.1382	0.7078
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0335	0.0308
Schistosoma mansoni	amine GPCR	0.0079	0.1909	0.1909
Onchocerca volvulus	Protein ultraspiracle homolog	0.0017	0.0335	0.1279
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Schistosoma mansoni	amine GPCR	0.0079	0.1909	0.1909
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0129	0.0033
Schistosoma mansoni	growth hormone secretagogue receptor	0.0079	0.1909	0.1909
Schistosoma mansoni	hypothetical protein	0.0079	0.1909	0.1909
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.1909	0.1848
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0017	0.0335	0.1279
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0017	0.0335	0.0263
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0118	0.0018
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0079	0.1909	0.1848
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0079	0.1909	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.1909	0.1848
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0017	0.0335	0.0308
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0335	0.0263
Brugia malayi	Steroid receptor seven-up type 2	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	G-protein coupled receptor	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	biogenic amine receptor	0.0079	0.1909	0.1909
Schistosoma mansoni	cpg binding protein	0.0029	0.0648	0.0648
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0079	0.1909	0.1848
Echinococcus multilocularis	ecdysone induced protein 78C	0.0017	0.0335	0.0263
Brugia malayi	AKH receptor	0.0079	0.1909	0.2411
Schistosoma mansoni	neuropeptide F-like receptor	0.0079	0.1909	0.1909
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0457	0.0471
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.1909	0.1909
Echinococcus granulosus	thyroid hormone receptor alpha	0.0008	0.0104	0.003
Schistosoma mansoni	histamine h1 receptor	0.0079	0.1909	0.1909
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0058	0.1382	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0079	0.1909	0.1848
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1382	0.5
Onchocerca volvulus		0.0079	0.1909	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1403	0.1403
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	neuropeptide receptor A26	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	thyroid hormone receptor	0.0139	0.3444	0.3444
Brugia malayi	Dopamine receptor protein 1	0.0079	0.1909	0.2411
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	serotonin receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	somatostatin receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1909	0.1909
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0017	0.0335	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0008	0.0104	0.0104
Schistosoma mansoni	biogenic amine receptor	0.0079	0.1909	0.1909
Onchocerca volvulus		0.0079	0.1909	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0017	0.0335	0.0263
Onchocerca volvulus		0.0079	0.1909	1
Echinococcus multilocularis	fmrfamide receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.1909	0.1848
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Echinococcus multilocularis	orexin receptor type 2	0.0079	0.1909	0.1848
Schistosoma mansoni	amine GPCR	0.0079	0.1909	0.1909
Echinococcus multilocularis	protein kinase shaggy	0.0058	0.1382	0.1317
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0017	0.0335	0.0308
Onchocerca volvulus		0.0079	0.1909	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0017	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Loa Loa (eye worm)	neuropeptide F receptor	0.0079	0.1909	0.2411
Brugia malayi	Serotonin receptor	0.0079	0.1909	0.2411
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0008	0.0104	0.003
Echinococcus multilocularis	G protein coupled receptor 139	0.0079	0.1909	0.1848
Echinococcus granulosus	7TM GPCR rhodopsin	0.0079	0.1909	0.1848
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Echinococcus granulosus	neuropeptide Y receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0017	0.0335	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	neuropeptide receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0058	0.1382	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0079	0.1909	0.1848
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1909	0.1909
Entamoeba histolytica	protein kinase domain containing protein	0.0058	0.1382	0.5
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0017	0.0335	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.1909	0.1909
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0009	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Brugia malayi	Dopamine receptor protein 2	0.0079	0.1909	0.2411
Brugia malayi	nuclear hormone receptor	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0079	0.1909	0.1909
Schistosoma mansoni	RAR-like nuclear receptor	0.0017	0.0335	0.0335
Onchocerca volvulus		0.0079	0.1909	1
Echinococcus multilocularis	cpg binding protein	0.0029	0.0648	0.0578
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0058	0.1382	0.1317
Onchocerca volvulus		0.0079	0.1909	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0335	0.0308
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.3007	0.2955
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	neuropeptide Y receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0017	0.0335	0.0263
Echinococcus multilocularis	g protein coupled receptor	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0017	0.0335	0.1279
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0058	0.1382	0.1706
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.1382	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.3007	0.2955
Schistosoma mansoni	amine GPCR	0.0079	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus granulosus	neuropeptides capa receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	dro:myosuppressin receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	coup transcription factor	0.0017	0.0335	0.0335
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0335	0.0263
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0079	0.1909	0.1909
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0079	0.1909	0.1848
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0079	0.1909	0.2411
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0017	0.0335	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0017	0.0335	0.0308
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0335	0.0308
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Schistosoma mansoni	cpg binding protein	0.0028	0.0608	0.0608
Echinococcus granulosus	neuropeptide receptor A26	0.0079	0.1909	0.1848
Echinococcus granulosus	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Onchocerca volvulus		0.0079	0.1909	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0079	0.1909	0.2411
Echinococcus multilocularis	serotonin receptor	0.0079	0.1909	0.1848
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.1909	0.1848
Schistosoma mansoni	zinc finger protein	0.0008	0.0104	0.0104
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0058	0.1382	0.1382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0079	0.1909	0.1909
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0017	0.0335	0.0308
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0008	0.0104	0.003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0335	0.0335
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0017	0.0335	0.0308
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0129	0.0033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0017	0.0335	0.0308
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0079	0.1909	0.1909
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0008	0.0104	0.003
Echinococcus granulosus	somatostatin receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0079	0.1909	0.1909
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0079	0.1909	0.1848
Echinococcus granulosus	FTZ F1 alpha	0.0017	0.0335	0.0263
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0017	0.0335	0.0263
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0017	0.0335	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0074	0.0074
Echinococcus multilocularis	neuropeptide receptor	0.0079	0.1909	0.1848
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0079	0.1909	0.1848
Brugia malayi	G protein-coupled receptor F59B2.13	0.0079	0.1909	0.2411
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1909	0.1909
Brugia malayi	hypothetical protein	0.0079	0.1909	0.2411
Schistosoma mansoni	hypothetical protein	0.0395	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0079	0.1909	0.1848
Schistosoma mansoni	neuropeptide receptor	0.0079	0.1909	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1909	0.2411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0079	0.1909	0.1848
Schistosoma mansoni	retinoic acid receptor RXR	0.0017	0.0335	0.0335
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0009	0.0129	0.0055
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.0104	0.0104

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 142 nM	Inhibition of recombinant GSK3beta (unknown origin)	ChEMBL.	18324764
IC50 (binding)	= 142 nM	Inhibition of recombinant GSK3beta (unknown origin)	ChEMBL.	18324764
IC50 (binding)	= 142 uM	Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha	ChEMBL.	11266159
IC50 (binding)	= 142 uM	Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha	ChEMBL.	11266159

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL157348
PubChem: 6539486

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 270523