Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1205 | 1 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.1205 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0891 | 0.5353 | 0.5353 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5663 | 0.5663 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5663 | 0.5663 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0891 | 0.5353 | 0.5353 |
Onchocerca volvulus | 0.0825 | 0.4384 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.5353 | 0.5353 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0848 | 0.4714 | 0.0589 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0848 | 0.4714 | 0.4008 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0672 | 0.2123 | 0.2123 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5663 | 0.5663 |
Loa Loa (eye worm) | hypothetical protein | 0.0597 | 0.1016 | 0.1016 |
Loa Loa (eye worm) | hypothetical protein | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.5353 | 0.5353 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0659 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5663 | 0.5663 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5663 | 0.5663 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 0.2457 | 0.2457 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1205 | 1 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1205 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1205 | 1 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1205 | 1 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0912 | 0.5663 | 0.5663 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0848 | 0.4714 | 0.4714 |
Brugia malayi | Peptidase family M1 containing protein | 0.0825 | 0.4384 | 0.287 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.5353 | 0.5353 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0848 | 0.4714 | 0.0589 |
Loa Loa (eye worm) | hypothetical protein | 0.0891 | 0.5353 | 0.5353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Enhancement (binding) | = 7 % | Maximum percent of enhancement of binding. | ChEMBL. | 4032427 |
Enhancement (binding) | = 7 % | Maximum percent of enhancement of binding. | ChEMBL. | 4032427 |
Inhibition (binding) | = 109 % | Maximum percent of inhibition of binding was determined | ChEMBL. | 4032427 |
Inhibition (binding) | = 109 % | Maximum percent of inhibition of binding was determined | ChEMBL. | 4032427 |
Kd (binding) | < 0 M | Compound was evaluated for ability to enhance the binding of (+/-)-[3H]-nicotine to the rat brain P2 fraction at binding site 1; 10e-10-10e-5 | ChEMBL. | 4032427 |
Kd (binding) | = 0.00089 M | Ability to enhance the binding of (+/-)-[3H]-nicotine to the rat brain P2 fraction at binding site 2 | ChEMBL. | 4032427 |
Kd (binding) | = 0.00089 M | Ability to enhance the binding of (+/-)-[3H]-nicotine to the rat brain P2 fraction at binding site 2 | ChEMBL. | 4032427 |
Mean enhancement of binding (binding) | = 5.2 | Compounds was evaluate for their ability to enhance (+/-)-[3H]-nicotine binding at a dose range 10 E -10 - 10 E -4 M was reported | ChEMBL. | 4032427 |
Potency (functional) | 38.0877 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 60.3649 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 60.3649 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 60.3649 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 60.3649 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 67.1274 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.