Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0994 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.064 | 0.5499 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.1074 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1074 | 0.1074 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0994 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.1074 | 0.1074 |
Onchocerca volvulus | 0.0292 | 0.1074 | 1 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.064 | 0.5499 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.1074 | 0.1074 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.064 | 0.5499 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0994 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0994 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.064 | 0.5499 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0994 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.1074 | 0.1074 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0994 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.064 | 0.5499 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.064 | 0.5499 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.1074 | 0.1074 |
Echinococcus granulosus | dihydrofolate reductase | 0.0994 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.1074 | 0.1074 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.1074 | 0.1074 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0994 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0994 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.68 nM | Inhibition of [3H]- DA (Dopamine) uptake in rat striatal synaptosomes | ChEMBL. | 11806716 |
IC50 (binding) | = 19.6 nM | Inhibition of 3[H] WIN 35 428 binding to Dopamine transporter (DAT) | ChEMBL. | 11806716 |
IC50 (binding) | = 19.6 nM | Inhibition of 3[H] WIN 35 428 binding to Dopamine transporter (DAT) | ChEMBL. | 11806716 |
IC50 (binding) | = 472 nM | Inhibition of [3H]- nisoxatine binding to Norepinephrine transporter | ChEMBL. | 11806716 |
IC50 (binding) | = 472 nM | Inhibition of [3H]- nisoxatine binding to Norepinephrine transporter | ChEMBL. | 11806716 |
IC50 (binding) | = 1080 nM | Inhibition of [3H]- citalopram binding to Serotonin transporter | ChEMBL. | 11806716 |
IC50 (binding) | = 1080 nM | Inhibition of [3H]- citalopram binding to Serotonin transporter | ChEMBL. | 11806716 |
Ratio (binding) | = 0.34 | Selectivity ratio of the compound 3[H]DA uptake /DAT binding | ChEMBL. | 11806716 |
Ratio (binding) | = 24 | Selectivity ratio against dopamine and norepinephrine transporter binding | ChEMBL. | 11806716 |
Ratio (binding) | = 55 | Relative binding to serotonin and dopamine transporters | ChEMBL. | 11806716 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.