TDR Targets

Basic information

Technical information

TDR Targets ID: 271255
Name: 2-[4-[2-[(3-hydroxy-3-oxopropanoyl)amino]-3-o xo-3-(pentylamino)propyl]phenoxy]propanedioic acid
MW: 438.428 | Formula: C20H26N2O9
H donors: 5 H acceptors: 8 LogP: 1.73 Rotable bonds: 16
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCNC(=O)C(Cc1ccc(cc1)OC(C(=O)O)C(=O)O)NC(=O)CC(=O)O
InChi: 1S/C20H26N2O9/c1-2-3-4-9-21-18(26)14(22-15(23)11-16(24)25)10-12-5-7-13(8-6-12)31-17(19(27)28)20(29)30/h5-8,14,17H,2-4,9-11H2,1H3,(H,21,26)(H,22,23)(H,24,25)(H,27,28)(H,29,30)
InChiKey: QTZZUVLATBLDIM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[2-[(3-hydroxy-3-oxo-propanoyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid
2-[4-[2-[(3-hydroxy-1,3-dioxopropyl)amino]-3-oxo-3-(pentylamino)propyl]phenoxy]propanedioic acid
2-[4-[3-(amylamino)-2-[(3-hydroxy-3-keto-propanoyl)amino]-3-keto-propyl]phenoxy]malonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0146	0.5
Schistosoma mansoni	cpg binding protein	0.003	0.0107	0.0136
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0126	0.0553	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0113	0.0491	0.0395
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Schistosoma mansoni	cpg binding protein	0.0028	0.01	0.0127
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0113	0.0491	0.0395
Mycobacterium leprae	putative cytochrome p450	0.0007	0.0003	0.5
Brugia malayi	nuclear receptor NHR-88	0.0239	0.1073	0.1136
Brugia malayi	nuclear receptor RXR	0.0113	0.0491	0.0518
Schistosoma mansoni	nuclear hormone receptor	0.0113	0.0491	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0553	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Schistosoma mansoni	nuclear hormone receptor	0.0113	0.0491	0.0637
Brugia malayi	CXXC zinc finger family protein	0.0028	0.01	0.0103
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0239	0.1073	0.1511
Brugia malayi	photoreceptor-specific nuclear receptor	0.0239	0.1073	0.1136
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0007	0.0003	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0235	0.1053	0.1116
Brugia malayi	nuclear receptor NHR-67	0.0113	0.0491	0.0518
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0113	0.0491	0.0637
Schistosoma mansoni	thyroid hormone receptor	0.0239	0.1073	0.1396
Trypanosoma cruzi	cytochrome P450, putative	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0126	0.0553	0.0718
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0126	0.0553	0.0718
Schistosoma mansoni	retinoic acid receptor RXR	0.167	0.7666	1
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0007	0.0003	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.0239	0.1073	0.1396
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0007	0.0003	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0239	0.1073	0.1511
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0239	0.1073	0.1396
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0239	0.1073	0.1136
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0602	0.0782
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0126	0.0553	0.0584
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0239	0.1073	0.1136
Loa Loa (eye worm)	steroid hormone receptor	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0553	0.0584
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0007	0.0003	0.5
Leishmania major	cytochrome p450-like protein	0.0007	0.0003	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0113	0.0491	0.0637
Schistosoma mansoni	coup transcription factor	0.0239	0.1073	0.1396
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0244	0.0315
Schistosoma mansoni	hypothetical protein	0.005	0.0203	0.0261
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0113	0.0491	0.0689
Echinococcus multilocularis	dnaJ subfamily B	0.0398	0.1804	0.2544
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0553	0.0584
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0239	0.1073	0.1396
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0007	0.0003	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0239	0.1073	0.1511
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0007	0.0003	0.5
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0007	0.0003	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0231	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0007	0.0003	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0132	0.0169
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0007	0.0003	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0007	0.0003	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0239	0.1073	0.0983
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0239	0.1073	0.1136
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0239	0.1073	0.1396
Schistosoma mansoni	hypothetical protein	0.0398	0.1804	0.2351
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0239	0.1073	0.1136
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.062	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Brugia malayi	steroid hormone receptor	0.0239	0.1073	0.1136
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0162	0.6986
Brugia malayi	orphan nuclear receptor NR2E1	0.0113	0.0491	0.0518
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0239	0.1073	0.1396
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0007	0.0003	0.5
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0007	0.0003	0.5
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0007	0.0003	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0239	0.1073	0.1511
Brugia malayi	nuclear hormone receptor	0.205	0.9418	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0146	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0113	0.0491	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0553	0.0584
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0239	0.1073	0.1396
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0007	0.0003	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0239	0.1073	0.1511
Echinococcus granulosus	dnaJ subfamily B	0.0398	0.1804	0.2351
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Brugia malayi	Steroid receptor seven-up type 2	0.0239	0.1073	0.1136
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0132	0.0183
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1053	0.1116
Brugia malayi	Nuclear hormone receptor-like 1	0.0126	0.0553	0.0584
Brugia malayi	nuclear receptor NHR-88	0.0113	0.0491	0.0518
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0007	0.0003	0.5
Trypanosoma brucei	cytochrome P450, putative	0.0007	0.0003	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0239	0.1073	0.1511
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0113	0.0491	0.0637
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0239	0.1073	0.1396
Brugia malayi	Nuclear hormone receptor E75	0.0113	0.0491	0.0518
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0007	0.0003	0.5
Brugia malayi	hypothetical protein	0.0126	0.0553	0.0584
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0007	0.0003	0.5
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0007	0.0003	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0239	0.1073	0.1396
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0162	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0113	0.0491	0.0518
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0239	0.1073	0.1136
Onchocerca volvulus		0.0113	0.0491	0.0395
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0113	0.0491	0.0689
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0007	0.0003	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0239	0.1073	0.1136
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0007	0.0003	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0007	0.0003	0.5
Echinococcus multilocularis	nuclear receptor nhr 48	0.0113	0.0491	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.205	0.9418	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0239	0.1073	0.1136
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0007	0.0003	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0113	0.0491	0.0518
Brugia malayi	hypothetical protein	0.0113	0.0491	0.0518
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0007	0.0003	0.5
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Brugia malayi	conserved hypotetical protein	0.0113	0.0491	0.0518
Loa Loa (eye worm)	DR-78	0.0113	0.0491	0.0518
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.01	0.0103
Echinococcus granulosus	FTZ F1 alpha	0.0239	0.1073	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0553	0.0584
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0239	0.1073	0.1136
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0007	0.0003	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0239	0.1073	0.1136
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0007	0.0003	0.5
Mycobacterium leprae	Conserved hypothetical protein	0.0007	0.0003	0.5
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0011	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0533	0.0564
Brugia malayi	hypothetical protein	0.0113	0.0491	0.0518
Brugia malayi	tailless protein	0.0113	0.0491	0.0518
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0113	0.0491	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0239	0.1073	0.1511
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0007	0.0003	0.5
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0007	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0113	0.0491	0.0689
Echinococcus multilocularis	cpg binding protein	0.003	0.0107	0.0147
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0113	0.0491	0.0689
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0007	0.0003	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.062	0.0806
Loa Loa (eye worm)	acetyltransferase	0.0141	0.062	0.0656
Brugia malayi	ecdysteroid receptor	0.0239	0.1073	0.1136
Brugia malayi	Nuclear hormone receptor E75	0.0113	0.0491	0.0518
Echinococcus multilocularis	ecdysone induced protein 78C	0.0239	0.1073	0.1511
Schistosoma mansoni	nuclear receptor	0.0113	0.0491	0.0637
Loa Loa (eye worm)	nuclear hormone receptor	0.0113	0.0491	0.0518
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0113	0.0491	0.0637
Schistosoma mansoni	nuclear receptor	0.0113	0.0491	0.0637
Schistosoma mansoni	RAR-like nuclear receptor	0.0239	0.1073	0.1396
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0007	0.0003	0.5
Echinococcus granulosus	thyroid hormone receptor alpha	0.0113	0.0491	0.0637
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0007	0.0003	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0239	0.1073	0.1396
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0239	0.1073	0.1396
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0007	0.0003	0.5
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0162	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0239	0.1073	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.167	0.7666	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0239	0.1073	0.1396
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0007	0.0003	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.062	0.0656
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0239	0.1073	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0491	0.0518
Brugia malayi	hypothetical protein	0.0126	0.0553	0.0584
Loa Loa (eye worm)	hypothetical protein	0.1937	0.8898	0.9448
Schistosoma mansoni	nuclear receptor nhr-48	0.0113	0.0491	0.0637
Schistosoma mansoni	cpg binding protein	0.003	0.0107	0.0136
Onchocerca volvulus	Protein ultraspiracle homolog	0.0239	0.1073	0.0983
Echinococcus granulosus	cpg binding protein	0.003	0.0107	0.0136
Brugia malayi	nuclear hormone receptor	0.0239	0.1073	0.1136
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0162	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0011	0.0011
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0239	0.1073	0.1396
Leishmania major	cytochrome p450-like protein	0.0007	0.0003	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0132	0.0169
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.001	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0239	0.1073	0.1136
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0011	0.0011
Schistosoma mansoni	hypothetical protein	0.0035	0.0132	0.0169
Leishmania major	cytochrome p450-like protein	0.0007	0.0003	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0113	0.0491	0.0637
Schistosoma mansoni	nuclear hormone receptor	0.0239	0.1073	0.1396
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0239	0.1073	0.1511
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0007	0.0003	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0007	0.0003	0.5
Brugia malayi	ecdysone receptor	0.0113	0.0491	0.0518
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0007	0.0003	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0007	0.0003	0.5
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1543	0.7084	1
Onchocerca volvulus		0.0239	0.1073	0.0983
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0126	0.0553	0.0718
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0007	0.0003	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0239	0.1073	0.1136
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0007	0.0003	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0239	0.1073	0.1136
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0162	0.0208
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0239	0.1073	0.1396
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0239	0.1073	0.1136
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0239	0.1073	0.1136
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0007	0.0003	0.5
Onchocerca volvulus		0.0113	0.0491	0.0395
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0162	0.6986
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0007	0.0003	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0007	0.0003	0.5
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0146	0.5
Schistosoma mansoni	zinc finger protein	0.0113	0.0491	0.0637
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0239	0.1073	0.1396
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0113	0.0491	0.0637
Brugia malayi	Nuclear hormone receptor-like 1	0.0126	0.0553	0.0584
Brugia malayi	nuclear receptor RXR	0.0126	0.0553	0.0584
Brugia malayi	hypothetical protein	0.0035	0.0132	0.0138

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 7 %	Percent inhibition of Protein-tyrosine phosphatase Lar assayed at 100 microM	ChEMBL.	11806712
Inhibition (binding)	= 7 %	Percent inhibition of Protein-tyrosine phosphatase Lar assayed at 100 microM	ChEMBL.	11806712
Inhibition (binding)	= 13 %	Percent inhibition of Tyrosine phosphatase SHP2 SH2 domain containing PTP involved in insulin microM	ChEMBL.	11806712
Inhibition (binding)	= 13 %	Percent inhibition of Tyrosine phosphatase SHP2 SH2 domain containing PTP involved in insulin microM	ChEMBL.	11806712
Inhibition (binding)	= 74 %	Percent inhibition of Protein-tyrosine phosphatase 1 (PTP) assayed at 100 microM	ChEMBL.	11806712
Inhibition (binding)	= 74 %	Percent inhibition of Protein-tyrosine phosphatase 1 (PTP) assayed at 100 microM	ChEMBL.	11806712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL156503
PubChem: 18476702

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 271255