Detailed information for compound 271304

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 516.524 | Formula: C14H20N4O11S3
  • H donors: 0 H acceptors: 9 LogP: -1.48 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ncnc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@@H]1OS(=O)(=O)C)OS(=O)(=O)C)COS(=O)(=O)C
  • InChi: 1S/C14H20N4O11S3/c1-25-13-9-12(15-6-16-13)18(7-17-9)14-11(29-32(4,23)24)10(28-31(3,21)22)8(27-14)5-26-30(2,19)20/h6-8,10-11,14H,5H2,1-4H3/t8-,10-,11+,14-/m1/s1
  • InChiKey: STGFIUNTLDZKNB-GCDPNZCJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0706 0.8593 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0139 0.0439
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0038
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0099 0.0112
Loa Loa (eye worm) histone methyltransferase 0.001 0.0061 0.0068
Onchocerca volvulus 0.0706 0.8593 1
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0033 0.0035
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0006 0.0011 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0065 0.0073
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0458 0.0531
Echinococcus granulosus cpg binding protein 0.003 0.0308 0.0355
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0006 0.0004
Brugia malayi steroid hormone receptor 0.001 0.0065 0.0073
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0514 0.0562
Mycobacterium leprae Probable lipase LipE 0.0036 0.0376 0.039
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.04 0.4226
Trichomonas vaginalis ferritin, putative 0.0008 0.0042 0.0037
Plasmodium falciparum aldo-keto reductase, putative 0.0204 0.2446 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0204 0.2446 0.2444
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.04 0.0429
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0008 0.0033 0.0038
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0204 0.2446 1
Schistosoma mansoni hypothetical protein 0.0672 0.8184 0.9524
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Brugia malayi nuclear hormone receptor 0.001 0.0065 0.0073
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0378 0.0437
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0008 0.0033 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0354 0.0409
Trichomonas vaginalis aldo/keto reductase, putative 0.0706 0.8593 1
Schistosoma mansoni DNA helicase recq1 0.001 0.0063 0.007
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0008 0.0033 0.0035
Onchocerca volvulus 0.0149 0.1771 0.2051
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0562 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0033 0.0133
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0006 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0139 0.0566
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0065 0.0064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0039 0.0043
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0065 0.0073
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0065 0.0073
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Mycobacterium leprae Conserved hypothetical protein 0.0501 0.6086 0.7069
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0415 0.1585
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0039 0.0037
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0132 0.015
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0033 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0009
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0706 0.8593 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0139 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0132 0.0151
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0011 0.001
Onchocerca volvulus 0.0706 0.8593 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Echinococcus granulosus ferritin 0.0008 0.0042 0.0046
Echinococcus multilocularis GPCR, family 2 0.0016 0.0132 0.0129
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0065 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0006 0.0004
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0065 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0378 0.0436
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0288 0.0332
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0033 0.0026
Echinococcus granulosus synaptojanin 1 0.0008 0.0033 0.0035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0003 0.0001
Entamoeba histolytica alcohol dehydrogenase, putative 0.0204 0.2446 0.2847
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0458 0.0531
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Brugia malayi Pre-SET motif family protein 0.003 0.0309 0.0357
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0063 0.0124
Echinococcus granulosus neutral sphingomyelinase 0.0008 0.0033 0.0035
Trypanosoma brucei prostaglandin f synthase 0.0706 0.8593 1
Echinococcus multilocularis geminin 0.0672 0.8184 0.8183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0139 0.0159
Schistosoma mansoni ferritin 0.0008 0.0042 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0159
Onchocerca volvulus 0.001 0.0065 0.0064
Schistosoma mansoni cpg binding protein 0.003 0.0308 0.0355
Schistosoma mansoni ferritin light chain 0.0008 0.0042 0.0047
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0204 0.2446 0.2845
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1395 0.1591
Loa Loa (eye worm) glutathione reductase 0.0047 0.0514 0.0595
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0065 0.0064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0139 0.0124
Brugia malayi hypothetical protein 0.0036 0.0378 0.0436
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0033 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0033 0.0026
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.04 0.0462
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0546 0.0633
Giardia lamblia Aldose reductase 0.0706 0.8593 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.04 0.1522
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0038
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0238 0.0264
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0065 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0009
Schistosoma mansoni potassium channel beta 0.0204 0.2446 0.2845
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0086 0.0097
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0139 0.1136
Schistosoma mansoni cpg binding protein 0.0028 0.0288 0.0332
Giardia lamblia Aldose reductase 0.0706 0.8593 1
Onchocerca volvulus 0.0008 0.0033 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0132 0.015
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.0151
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Mycobacterium tuberculosis Conserved protein 0.0036 0.0376 0.0401
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0139 0.0149
Onchocerca volvulus 0.0028 0.0288 0.0323
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0124
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0435
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0011 0.001
Echinococcus granulosus geminin 0.0672 0.8184 0.9524
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0011 0.001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0376 0.0401
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.0439
Brugia malayi CCR4 0.0008 0.0033 0.0035
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0033 0.0035
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0042 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0132 0.015
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0415 0.0483
Echinococcus granulosus hypothetical protein 0.0706 0.8593 1
Trypanosoma cruzi mitochondrial protein 99, putative 0.0008 0.0033 0.0035
Onchocerca volvulus 0.0706 0.8593 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0065 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0159
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0011 0.0009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1395 0.1591
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0065 0.0073
Loa Loa (eye worm) oxidoreductase 0.0706 0.8593 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0065 0.0063
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0008 0.0033 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Brugia malayi Probable ClpP-like protease 0.0077 0.0889 0.1031
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0006 0.0011 0.0009
Echinococcus granulosus voltage gated potassium channel subunit 0.0204 0.2446 0.2844
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0006 0.0011 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0065 0.0073
Schistosoma mansoni apoferritin-2 0.0008 0.0042 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0889 0.3633
Brugia malayi hypothetical protein 0.0006 0.0011 0.0009
Mycobacterium ulcerans beta-lactamase 0.0036 0.0376 0.039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0435
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.829 0.8289
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0139 0.0124
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Brugia malayi Pre-SET motif family protein 0.0206 0.2469 0.2871
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0376 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0065 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0065 0.0073
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0376 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0009
Brugia malayi CXXC zinc finger family protein 0.0028 0.0288 0.0332
Schistosoma mansoni hypothetical protein 0.0672 0.8184 0.9524
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.04 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0006 0.0011 0.001
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0204 0.2446 0.2838
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0141 0.0577
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0124
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0238 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0065 0.0073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0065 0.0073
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0376 0.0401
Schistosoma mansoni ferritin 0.0008 0.0042 0.0047
Schistosoma mansoni aldo-keto reductase 0.0706 0.8593 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0099 0.0115
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0033 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0006 0.0004
Brugia malayi beta-lactamase family protein 0.0036 0.0376 0.0435
Schistosoma mansoni ferritin 0.0008 0.0042 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0139 0.0149
Onchocerca volvulus 0.0706 0.8593 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Schistosoma mansoni carbon catabolite repressor protein 0.0008 0.0033 0.0035
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.04 0.0462
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0065 0.0063
Onchocerca volvulus Putative neutral sphingomyelinase 0.0008 0.0033 0.0026
Plasmodium vivax SET domain protein, putative 0.003 0.0309 0.1264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2727 0.3148
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.829 0.9648
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1249 0.1421
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0458 0.053
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.001
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0006 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0435
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0065 0.0073
Trichomonas vaginalis aldo/keto reductase, putative 0.0706 0.8593 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.04 0.0463
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0011 0.001
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0889 0.1032
Schistosoma mansoni hypothetical protein 0.0034 0.0354 0.041
Echinococcus multilocularis aldo keto reductase 0.0706 0.8593 0.8592
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1249 0.1421
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0139 0.0124
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0033 0.0035
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0011 0.001
Echinococcus granulosus expressed protein 0.0006 0.0011 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.1589 0.1847
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.2446 0.2838
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0065 0.0073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.04 0.0429
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0063 0.006
Echinococcus multilocularis aldehyde reductase 0.0501 0.6086 0.6085
Toxoplasma gondii ABC1 family protein 0.0036 0.0376 0.0435
Schistosoma mansoni thyroid hormone receptor 0.001 0.0065 0.0073
Plasmodium falciparum thioredoxin reductase 0.0016 0.0139 0.0439
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0006 0.0011 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0706 0.8593 1
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0033 0.0026
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.04 0.0429
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.04 0.0429
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0376 0.0426
Plasmodium vivax aldehyde reductase, putative 0.0204 0.2446 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0706 0.8593 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0139 0.0124
Echinococcus granulosus microtubule associated protein 2 0.0681 0.829 0.9648
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0006 0.0011 0.001
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 0.3547
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.04 0.4487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.001
Schistosoma mansoni neutral sphingomyelinase 0.0008 0.0033 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0514 0.0595
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0042 0.0011
Schistosoma mansoni ap endonuclease 0.0038 0.04 0.0463
Onchocerca volvulus 0.0036 0.0376 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0065 0.0073
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0008 0.0033 0.003
Trypanosoma brucei aldo-keto reductase, putative 0.0706 0.8593 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0065 0.0073
Trichomonas vaginalis esterase, putative 0.0036 0.0376 0.0426
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0546 0.0633
Mycobacterium ulcerans hypothetical protein 0.0204 0.2446 0.2811
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0019 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0033 0.0035
Entamoeba histolytica aldose reductase, putative 0.0706 0.8593 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0061 0.0058
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0562 0.0618
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0035
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0204 0.2446 0.2844
Schistosoma mansoni DNA helicase recq5 0.001 0.0063 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.1589 0.1587
Echinococcus multilocularis expressed protein 0.0006 0.0011 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0065 0.0073
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0139 0.0124
Echinococcus granulosus aldo keto reductase 0.0706 0.8593 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0061 0.0067
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0063 0.007
Mycobacterium tuberculosis Conserved protein 0.0204 0.2446 0.2819
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0204 0.2446 0.2845
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0011 0.0008
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0011 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0309 0.0357
Brugia malayi beta-lactamase family protein 0.0036 0.0376 0.0435
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0011 0.0008
Plasmodium falciparum glutathione reductase 0.0016 0.0139 0.0439
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0309 0.0306
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0267 0.0262
Plasmodium vivax glutathione reductase, putative 0.0047 0.0514 0.2099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0309 0.0306
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0376 0.0401
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.1589 0.1587
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Echinococcus granulosus GPCR family 2 0.0016 0.0132 0.015
Mycobacterium ulcerans hypothetical protein 0.0036 0.0376 0.039
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0458 0.1874
Leishmania major aldo-keto reductase-like protein 0.0706 0.8593 1
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.2446 0.2838
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0238 0.0273
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0376 0.039
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0033 0.0035
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0033 0.0035
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0033 0.0035
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0065 0.0073
Trypanosoma cruzi aldo-keto reductase 0.0706 0.8593 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0889 0.0886
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0514 0.0595
Leishmania major prostaglandin f synthase, putative 0.0706 0.8593 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Plasmodium falciparum thioredoxin reductase 0.0047 0.0514 0.1993
Entamoeba histolytica G protein alpha subunit, putative 0.0006 0.0011 0.0012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2469 0.2872
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0063 0.007
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0006 0.0011 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0065 0.0073
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.04 0.1635
Schistosoma mansoni nuclear hormone receptor 0.001 0.0065 0.0073
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0008 0.0033 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0376 0.0426
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Echinococcus multilocularis aldo keto reductase 0.0706 0.8593 0.8592
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1771 0.2059
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0034 0.0354 0.041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0546 0.0633
Schistosoma mansoni synaptojanin 0.0008 0.0033 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2818 0.3271
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0065 0.0073
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0008 0.0033 0.003
Treponema pallidum NADH oxidase 0.0016 0.0139 0.1536
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0656 0.076
Echinococcus multilocularis neutral sphingomyelinase 0.0008 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0077 0.0889 0.1032
Echinococcus multilocularis synaptojanin 1 0.0008 0.0033 0.003
Schistosoma mansoni ap endonuclease 0.0038 0.04 0.0463
Echinococcus granulosus aldo keto reductase 0.0706 0.8593 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0139 0.0124
Onchocerca volvulus 0.0204 0.2446 0.2838
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0706 0.8593 1
Onchocerca volvulus 0.0036 0.0376 0.0426
Mycobacterium ulcerans lipase LipD 0.0036 0.0376 0.039
Loa Loa (eye worm) beta-lactamase 0.0036 0.0376 0.0435
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0376 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Mycobacterium tuberculosis Probable reductase 0.0107 0.1249 0.1421
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1249 0.1411
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0132 0.0129
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0006 0.0011 0.0008
Onchocerca volvulus 0.0235 0.2818 0.3271
Loa Loa (eye worm) hypothetical protein 0.0706 0.8593 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0159
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0008 0.0033 0.0035
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0267 0.109
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0063 0.007
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0033 0.0133
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0288 0.0332
Plasmodium falciparum glutathione reductase 0.0047 0.0514 0.1993
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0122 0.1439 0.1672
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0132 0.0151
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0175 0.0201
Plasmodium falciparum aldehyde reductase, putative 0.0204 0.2446 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.1589 0.1847
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0011 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0376 0.0401
Brugia malayi nuclear receptor NHR-88 0.001 0.0065 0.0073
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0011 0.0009
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0139 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0065 0.0073
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0065 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0033 0.0133
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0008 0.0033 0.0035
Toxoplasma gondii aldose reductase, putative 0.0706 0.8593 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0065 0.0073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0139 0.0158
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0065 0.0073
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.04 0.0463
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0033 0.0026
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0514 0.2099
Echinococcus multilocularis ferritin 0.0008 0.0042 0.004
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0415 0.0447
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.1589 0.1847
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0063 0.007
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0376 0.0401
Loa Loa (eye worm) hypothetical protein 0.003 0.0309 0.0357
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0139 0.0159
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0099 0.0077
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0008 0.0033 0.003
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.0439
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1249 0.1421
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0435
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0435
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.04 0.0454
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0204 0.2446 0.2845
Echinococcus multilocularis expressed protein 0.0008 0.0042 0.004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0065 0.0073
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0011 0.0009
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0033 0.0026
Schistosoma mansoni cpg binding protein 0.003 0.0308 0.0355
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0006 0.0004
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0706 0.8593 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1589 0.1847
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0065 0.0073
Plasmodium vivax SET domain containing protein 0.0005 0.0004 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0139 0.0112
Brugia malayi hypothetical protein 0.0005 0.0006 0.0004
Onchocerca volvulus 0.0706 0.8593 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0063 0.007
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0309 0.0357
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0267 0.2982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0309 0.0357
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.001
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0204 0.2446 0.2844
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0376 0.039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0159
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0139 0.0566
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0376 0.0435
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0099 0.0103
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0038
Loa Loa (eye worm) RecQ helicase 0.0024 0.0238 0.0274
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1589 0.1847
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0065 0.0073
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1654 0.1922
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0889 0.1032
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0006 0.0011 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0238 0.0264
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0042 0.0452
Treponema pallidum hypothetical protein 0.0008 0.0033 0.0342
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0376 0.0426
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0033 0.0035
Loa Loa (eye worm) G protein alpha subunit 3 0.0006 0.0011 0.001
Schistosoma mansoni pol-related 0.0706 0.8593 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0378 0.0375
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.2446 0.2838
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0063 0.007
Entamoeba histolytica alcohol dehydrogenase, putative 0.0204 0.2446 0.2847
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0376 0.0373
Loa Loa (eye worm) oxidoreductase 0.0706 0.8593 1
Brugia malayi glutathione reductase 0.0047 0.0514 0.0595
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0065 0.0063
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.0151
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Toxoplasma gondii aldo-keto reductase 0.0204 0.2446 0.2845
Trichomonas vaginalis helicase, putative 0.0006 0.0019 0.0009
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1249 0.1421
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0033 0.0035
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.04 0.0466
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0139 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0159
Onchocerca volvulus 0.0036 0.0376 0.0426
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 0.099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0065 0.0073
Brugia malayi Thioredoxin reductase 0.0047 0.0514 0.0595
Trypanosoma brucei trypanothione reductase 0.0047 0.0514 0.0562
Schistosoma mansoni GTP-binding protein alpha subunit 0.0006 0.0011 0.001
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0706 0.8593 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0006 0.0011 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0039 0.0043
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0889 0.1032
Onchocerca volvulus 0.0706 0.8593 1
Brugia malayi G-protein alpha subunit 0.0006 0.0011 0.0009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0458 0.0522
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0086 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.04 0.0463
Echinococcus multilocularis cpg binding protein 0.003 0.0308 0.0305
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0376 0.0435
Loa Loa (eye worm) oxidoreductase 0.0706 0.8593 1
Brugia malayi hypothetical protein 0.0149 0.1771 0.2058
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0033 0.0035
Echinococcus granulosus traf and tnf receptor associated protein 0.0008 0.0033 0.0035
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0033 0.0038
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0011 0.001
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0376 0.039
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0033 0.0026
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0008 0.0033 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0376 0.0435
Schistosoma mansoni aldo-keto reductase 0.0706 0.8593 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0132 0.015
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0006 0.0011 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0309 0.0357
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0006 0.0011 0.0009
Schistosoma mansoni cript-related 0.0008 0.0033 0.0035
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0006 0.0011 0.0009
Schistosoma mansoni ferritin light chain 0.0008 0.0042 0.0047
Schistosoma mansoni hypothetical protein 0.0016 0.0132 0.0151
Trypanosoma cruzi aldo/keto reductase, putative 0.0706 0.8593 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0065 0.0064
Echinococcus granulosus aldo keto reductase 0.0706 0.8593 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0706 0.8593 1
Schistosoma mansoni hypothetical protein 0.0036 0.0378 0.0437
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0006 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Schistosoma mansoni nocturnin 0.0008 0.0033 0.0035
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0562 0.0618
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0035
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0006 0.0011 0.001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1395 0.1591
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0376 0.0401
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0005 0.0006 0.0004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0889 0.099
Brugia malayi ecdysteroid receptor 0.001 0.0065 0.0073
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0099 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0065 0.0073
Echinococcus granulosus FTZ F1 alpha 0.001 0.0065 0.0073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0691 0.0802
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0132 0.0129
Entamoeba histolytica aldose reductase, putative 0.0706 0.8593 1
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.0439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.1589 0.1847
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0139 0.0158
Trypanosoma brucei aldo/keto reductase, putative 0.0204 0.2446 0.2819
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0008 0.0033 0.0035
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0006 0.0004
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0008 0.0033 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0065 0.0073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0376 0.0401
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Echinococcus multilocularis deoxyribonuclease 1 2 0.0008 0.0033 0.003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Schistosoma mansoni synaptojanin 0.0008 0.0033 0.0035
Schistosoma mansoni thyroid hormone receptor 0.001 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0008 0.0033 0.0035
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0706 0.8593 1
Onchocerca volvulus 0.0008 0.0033 0.0026
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0139 0.0112
Brugia malayi beta-lactamase 0.0036 0.0376 0.0435
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0139 0.0112
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1395 0.1582
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0006 0.0004
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0006 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0546 0.0633
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0006 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0889 0.1031
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0033 0.0026
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0008 0.0033 0.0035
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0033 0.0133
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0039 0.0043
Echinococcus granulosus expressed protein 0.0008 0.0042 0.0046
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 0.099
Brugia malayi hypothetical protein 0.0005 0.0006 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0376 0.0426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0139 0.0159
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0008 0.0033 0.0038
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0139 0.0159
Loa Loa (eye worm) oxidoreductase 0.0706 0.8593 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0139 0.0159
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0038
Entamoeba histolytica hypothetical protein 0.0036 0.0378 0.0439
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0033 0.0035
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0065 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0065 0.0073
Echinococcus multilocularis aldo keto reductase 0.0706 0.8593 0.8592
Trichomonas vaginalis aldo-keto reductase, putative 0.0706 0.8593 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0267 0.097
Schistosoma mansoni hypothetical protein 0.0008 0.0033 0.0035
Leishmania major trypanothione reductase 0.0047 0.0514 0.0562
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0063 0.0035
Schistosoma mansoni coup transcription factor 0.001 0.0065 0.0073
Mycobacterium tuberculosis Conserved protein 0.0036 0.0376 0.0401
Schistosoma mansoni apoferritin-2 0.0008 0.0042 0.0047
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 1
Onchocerca volvulus 0.003 0.0309 0.0348
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0065 0.0063
Schistosoma mansoni ferritin 0.0008 0.0042 0.0047
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0002 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0309 0.0357
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0706 0.8593 1
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1704 0.198
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0008 0.0033 0.0035
Echinococcus multilocularis traf and tnf receptor associated protein 0.0008 0.0033 0.003
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0019 0.0009
Brugia malayi nuclear receptor RXR 0.0005 0.0006 0.0004
Toxoplasma gondii thioredoxin reductase 0.0047 0.0514 0.0595
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0706 0.8593 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0065 0.0073
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0006 0.0011 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0065 0.0073
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0059 0.0066
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0063 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.04 0.0454
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0376 0.1537
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1704 0.198
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0065 0.0073
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0204 0.2446 0.2819
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0065 0.0073
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0039 0.0037
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0139 0.0124
Mycobacterium tuberculosis Conserved protein 0.0036 0.0376 0.0401
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0033 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0019 0.0009
Echinococcus multilocularis aldo keto reductase 0.0706 0.8593 0.8592
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0063 0.007
Toxoplasma gondii exonuclease III APE 0.0038 0.04 0.0463
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0065 0.0073
Entamoeba histolytica aldose reductase, putative 0.0706 0.8593 1
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0006 0.0011 0.0009
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0006 0.0011 0.0009
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0514 0.0511
Toxoplasma gondii hypothetical protein 0.0027 0.0267 0.0308
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0073
Echinococcus granulosus bloom syndrome protein 0.0024 0.0238 0.0273
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0033 0.0038
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0458 0.0522
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.04 0.0397
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.1589 0.1847
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0201 0.0699
Echinococcus granulosus aldehyde reductase 0.0501 0.6086 0.7082
Trichomonas vaginalis aldo-keto reductase, putative 0.0204 0.2446 0.2838
Loa Loa (eye worm) hypothetical protein 0.0036 0.0376 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0065 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0065 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0019 0.0009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1249 0.1421
Leishmania major hypothetical protein, conserved 0.0036 0.0376 0.0401
Trypanosoma cruzi aldo/keto reductase, putative 0.0204 0.2446 0.2845
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0376 0.0401
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0706 0.8593 1
Mycobacterium leprae Possible oxidoreductase 0.0204 0.2446 0.2811
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0706 0.8593 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0376 0.0435
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0139 0.1136
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0706 0.8593 0.8592
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0139 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0376 0.0435
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1704 0.1701
Brugia malayi NADH-dependent xylose reductase 0.0204 0.2446 0.2844
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0006 0.0011 0.001
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0033 0.0026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0139 0.0159
Mycobacterium ulcerans oxidoreductase 0.0706 0.8593 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0309 0.0357
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0514 0.0595
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0562 0.0559
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0889 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0065 0.0073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0065 0.0063
Loa Loa (eye worm) acetyltransferase 0.0144 0.1704 0.198
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0562 0.0651
Trichomonas vaginalis aldo/keto reductase, putative 0.0706 0.8593 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0139 0.0439

Activities

Activity type Activity value Assay description Source Reference
clogP = 0.58 Calculated partition coefficient (clogP) ChEMBL. 1732533
S = 3.22 mM Solubility (phosphate buffered saline) ChEMBL. 1732533
T1/2 > 70 day Ester prodrugs: stability in buffer (pH 7) ChEMBL. 1732533
Urinary recovery (ADMET) = 4.4 % Ester prodrugs: recovery of parent compound in rat urine ChEMBL. 1732533

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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