Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0034 | 0.1071 | 0.1071 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0064 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0064 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0064 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0064 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0064 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0034 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0064 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0064 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0064 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0034 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0064 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0064 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 1 | 1 |
Onchocerca volvulus | 0.0064 | 1 | 1 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0064 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0064 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0064 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0064 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0064 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0064 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0064 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0064 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0064 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 0.1071 | 0.1071 |
Schistosoma mansoni | coup transcription factor | 0.0064 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0064 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0365 | 0.0365 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0034 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0064 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0064 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0064 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0064 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.0064 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0064 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0034 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0064 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0064 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0064 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0064 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | = 15 % | Compound was evaluated for the percent reduction of carrageenin induced edema in mice at dose of 200 mg/kg | ChEMBL. | 6972450 |
Reduction (functional) | = 15 % | Compound was evaluated for the percent reduction of carrageenin induced edema in mice at dose of 200 mg/kg | ChEMBL. | 6972450 |
Reduction (functional) | = 30 % | Compound was evaluated for the percent reduction of carrageenin induced edema in mice at dose of 200 mg/kg | ChEMBL. | 6972450 |
Reduction (functional) | = 30 % | Compound was evaluated for the percent reduction of carrageenin induced edema in mice at dose of 200 mg/kg | ChEMBL. | 6972450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.