Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0023 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0028 | 0.2407 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0046 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0041 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0046 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0041 | 0.7743 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0046 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0046 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0046 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0046 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0046 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0046 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0046 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0046 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0046 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0046 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0046 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0028 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0046 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0046 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0046 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0046 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0023 | 0.0151 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0046 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0046 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0046 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -8.602 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.602 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.602 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.602 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.295 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.193 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -8.148 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.961 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.784 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -7.683 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.485 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.876 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Ratio (functional) | = 0.81 | Ability to induce the formation of microtubules using microtubule assembly assay in vitro relative to paclitaxel ED50 = 1 | ChEMBL. | No reference |
Ratio (functional) | = 2.6 | In vitro cytotoxicity against B16 melanoma cells relative to paclitaxel ED50 = 1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.