TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 298.379 | Formula: C18H22N2O2
H donors: 0 H acceptors: 1 LogP: 3.01 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1cncc(c1)OC[C@@H]1CCCN1C
InChi: 1S/C18H22N2O2/c1-20-9-3-4-16(20)13-22-18-10-15(11-19-12-18)14-5-7-17(21-2)8-6-14/h5-8,10-12,16H,3-4,9,13H2,1-2H3/t16-/m0/s1
InChiKey: QWPKKGKNBWKYGZ-INIZCTEOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Neuronal acetylcholine receptor; alpha4/beta2	Starlite/ChEMBL	References
Homo sapiens	cholinergic receptor, nicotinic, alpha 3 (neuronal)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Onchocerca volvulus	Putative nachr subunit	Get druggable targets OG5_128160	All targets in OG5_128160
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	Get druggable targets OG5_128160	All targets in OG5_128160
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Get druggable targets OG5_128160	All targets in OG5_128160
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Get druggable targets OG5_128160	All targets in OG5_128160

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cation transporter family protein	cholinergic receptor, nicotinic, alpha 3 (neuronal)	505 aa	486 aa	34.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0022	0.0028
Schistosoma mansoni	opsin-like receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.001	0.000000000031783	0.000000000039612
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0123	0.0453	0.0561
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.2016	0.8023	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	neuropeptide F receptor	0.0123	0.0451	0.0562
Echinococcus granulosus	serotonin receptor	0.0123	0.0451	0.0559
Chlamydia trachomatis	dihydrofolate reductase	0.2016	0.8023	0.5
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0038	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0038	0.0038
Echinococcus granulosus	thymidylate synthase	0.139	0.5518	0.6876
Loa Loa (eye worm)	dihydrofolate reductase	0.2016	0.8023	1
Onchocerca volvulus		0.002	0.0042	0.007
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.0004
Echinococcus granulosus	dro:myosuppressin receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	G-protein coupled receptor	0.0123	0.0451	0.0562
Echinococcus multilocularis	neuropeptide s receptor	0.0123	0.0451	0.0559
Brugia malayi	Cation transporter family protein	0.0038	0.0111	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Echinococcus granulosus	G protein coupled receptor 139	0.0123	0.0451	0.0559
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.2511	1	1
Onchocerca volvulus		0.0019	0.0037	0.0062
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0209	0.0209
Echinococcus granulosus	neuropeptide Y receptor	0.0123	0.0451	0.0559
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0019	0.0038	0.0043
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0037	0.0043
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0038	0.0111	0.0135
Brugia malayi	hypothetical protein	0.0017	0.003	0.0034
Schistosoma mansoni	amine GPCR	0.0123	0.0451	0.0562
Echinococcus granulosus	hypothetical protein	0.0123	0.0451	0.0559
Schistosoma mansoni	amine GPCR	0.0123	0.0451	0.0562
Echinococcus granulosus	fmrfamide receptor	0.0123	0.0451	0.0559
Onchocerca volvulus		0.0123	0.0451	0.0812
Echinococcus granulosus	7tm_1 domain containing protein	0.0123	0.0451	0.0559
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0111	0.0135
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0123	0.0453	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0003	0.0004
Schistosoma mansoni	biogenic amine receptor	0.0123	0.0451	0.0562
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0111	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Leishmania major	cathepsin L-like protease	0.0016	0.0026	0.0023
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0123	0.0451	0.0562
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0042	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0123	0.0451	0.0562
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Echinococcus multilocularis	g protein coupled receptor	0.0123	0.0451	0.0559
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0293	0.113	0.1406
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0037	0.0043
Onchocerca volvulus		0.0123	0.0451	0.0812
Onchocerca volvulus		0.0123	0.0451	0.0812
Brugia malayi	Cation transporter family protein	0.0038	0.0111	0.0135
Brugia malayi	hypothetical protein	0.0661	0.2604	0.3243
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Brugia malayi	hypothetical protein	0.0019	0.0037	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0047
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0123	0.0451	0.0559
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0111	0.0135
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.2511	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0123	0.0451	0.0559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Brugia malayi	ORL1-like opioid receptor	0.0123	0.0451	0.0559
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Onchocerca volvulus		0.0123	0.0451	0.0812
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0026	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0123	0.0451	0.0559
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0123	0.0451	0.0562
Brugia malayi	neuropeptide F receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	neuropeptide F-like receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Brugia malayi	putative neuropeptide receptor NPR1	0.0123	0.0451	0.0559
Trypanosoma cruzi	cytochrome P450, putative	0.0015	0.0022	0.0022
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0197	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0037	0.0047
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0346	0.1346	0.1677
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0123	0.0451	0.0559
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0015	0.0022	0.0024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0123	0.0451	0.0559
Brugia malayi	sulfakinin receptor protein	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0111	0.0135
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0111	0.0139
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0038	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0022	0.0024
Echinococcus multilocularis	cysteine protease	0.0016	0.0026	0.0028
Echinococcus granulosus	dihydrofolate reductase	0.2016	0.8023	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0123	0.0451	0.0559
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	TYRA-2 protein	0.0123	0.0451	0.0562
Echinococcus granulosus	g protein coupled receptor	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Onchocerca volvulus		0.0123	0.0451	0.0812
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.2016	0.8023	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0038	0.0111	0.0135
Echinococcus multilocularis	serotonin receptor	0.0123	0.0451	0.0559
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0038	0.0111	0.0135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Echinococcus granulosus	tm gpcr rhodopsin	0.0123	0.0451	0.0559
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.003	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Echinococcus granulosus	neuropeptides capa receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0197	0.0242
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0026	0.0028
Schistosoma mansoni	opsin-like receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0026	0.6181
Onchocerca volvulus		0.0016	0.0026	0.0041
Brugia malayi	GnHR receptor homolog	0.0123	0.0451	0.0559
Echinococcus multilocularis	RUN	0.0019	0.0037	0.0043
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0123	0.0451	0.0559
Brugia malayi	Adenylyl cyclase protein	0.0249	0.0957	0.1189
Schistosoma mansoni	amine GPCR	0.0123	0.0451	0.0562
Brugia malayi	G protein-coupled receptor F59B2.13	0.0123	0.0451	0.0559
Schistosoma mansoni	receptor-type adenylate cyclase	0.0011	0.0003	0.0004
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0197	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Schistosoma mansoni	adenylate cyclase	0.0011	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.068	0.2679	0.3339
Leishmania major	cathepsin L-like protease	0.0016	0.0026	0.0023
Onchocerca volvulus		0.0123	0.0451	0.0812
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.002	0.0042	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0026	0.6181
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0111	0.0135
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0038	0.0111	0.0135
Brugia malayi	Cation transporter family protein	0.0038	0.0111	0.0135
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0111	0.0135
Echinococcus multilocularis	sex peptide receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0026	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Onchocerca volvulus		0.0123	0.0451	0.0812
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0123	0.0451	0.0562
Onchocerca volvulus	Putative nachr subunit	0.0123	0.0453	0.0816
Echinococcus granulosus	tm gpcr rhodopsin	0.0123	0.0451	0.0559
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0038	0.0111	0.0139
Echinococcus multilocularis	adenylate cyclase 9	0.0249	0.0957	0.1189
Brugia malayi	larval opioid receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0123	0.0451	0.0559
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0123	0.0451	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0038	0.0111	0.0139
Echinococcus multilocularis	neuropeptide receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0019	0.0038	0.0047
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0123	0.0451	0.0562
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0037	0.0043
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0123	0.0451	0.0562
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0123	0.0451	0.0812
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0037	0.0043
Echinococcus multilocularis	g protein coupled receptor	0.0123	0.0451	0.0559
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0004	0.0002
Onchocerca volvulus		0.0038	0.0111	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Brugia malayi	hypothetical protein	0.0017	0.003	0.0034
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0038	0.0111	0.0135
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0026	0.0028
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Onchocerca volvulus		0.0016	0.0026	0.0041
Brugia malayi	G-protein coupled receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	neuropeptide f receptor 76f	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0004	0.0005
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0111	0.0135
Loa Loa (eye worm)	cytochrome P450 family protein	0.0015	0.0022	0.0028
Echinococcus granulosus	nAChR subunit	0.0038	0.0111	0.0135
Brugia malayi	RE15519p	0.0123	0.0451	0.0559
Echinococcus multilocularis	G protein coupled receptor 139	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Schistosoma mansoni	adenylate cyclase	0.0011	0.0003	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Brugia malayi	Serotonin receptor	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0026	0.0087
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Schistosoma mansoni	neuropeptide receptor	0.0123	0.0451	0.0562
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0003	0.0003
Schistosoma mansoni	DNA helicase recq5	0.0019	0.0038	0.0047
Schistosoma mansoni	neuropeptide F-like receptor	0.0123	0.0451	0.0562
Brugia malayi	AKH receptor	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	adenylyl cyclase 3	0.0249	0.0957	0.1193
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0026	0.0023
Onchocerca volvulus		0.0038	0.0111	0.0196
Echinococcus granulosus	neuropeptide receptor A26	0.0123	0.0451	0.0559
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.139	0.5518	0.6876
Brugia malayi	Cytochrome P450 family protein	0.0015	0.0022	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Leishmania major	cytochrome p450-like protein	0.0015	0.0022	0.0019
Schistosoma mansoni	neurotransmitter gated ion channel	0.002	0.0042	0.0052
Echinococcus multilocularis	somatostatin receptor	0.0123	0.0451	0.0559
Brugia malayi	Dihydrofolate reductase	0.2016	0.8023	1
Brugia malayi	hypothetical protein	0.0017	0.003	0.0034
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.139	0.5518	0.6876
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0156	0.0156
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0038	0.0035
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0111	0.0135
Brugia malayi	Melatonin receptor type 1A	0.0123	0.0451	0.0559
Echinococcus granulosus	g protein coupled receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0003	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0123	0.0451	0.0559
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0026	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0004	0.0002
Schistosoma mansoni	rab6-interacting	0.0019	0.0037	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Schistosoma mansoni	biogenic amine receptor	0.0123	0.0451	0.0562
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Brugia malayi	hypothetical protein	0.0017	0.003	0.0034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0123	0.0451	0.0559
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0197	0.0242
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0017	0.003	0.0034
Schistosoma mansoni	amine GPCR	0.0123	0.0451	0.0562
Schistosoma mansoni	fatty acid binding protein	0.0293	0.113	0.1409
Schistosoma mansoni	hypothetical protein	0.0019	0.0037	0.0047
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0038	0.0111	0.0135
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0038	0.0111	0.0135
Schistosoma mansoni	histamine h1 receptor	0.0123	0.0451	0.0562
Toxoplasma gondii	guanylyl cyclase	0.0011	0.0003	0.0003
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0026	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0209	0.0209
Schistosoma mansoni	lipoxygenase	0.008	0.0281	0.0351
Trichomonas vaginalis	DNA helicase recq, putative	0.0019	0.0038	0.0133
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0037	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Echinococcus granulosus	fatty acid binding protein FABP2	0.0293	0.113	0.1406
Echinococcus granulosus	somatostatin receptor	0.0123	0.0451	0.0559
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0026	0.0028
Brugia malayi	Dopamine receptor protein 2	0.0123	0.0451	0.0559
Onchocerca volvulus		0.0038	0.0111	0.0196
Echinococcus multilocularis	thymidylate synthase	0.139	0.5518	0.6876
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Onchocerca volvulus		0.0038	0.0111	0.0196
Schistosoma mansoni	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.0249	0.0957	0.1729
Loa Loa (eye worm)	guanylyl cyclase/natriuretic peptide receptor	0.0011	0.0003	0.0004
Onchocerca volvulus		0.0016	0.0026	0.0041
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.2511	1	1
Brugia malayi	hypothetical protein	0.0019	0.0037	0.0043
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0123	0.0453	0.0561
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0017	0.003	0.0034
Loa Loa (eye worm)	cysteine protease	0.0016	0.0026	0.0032
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0038	0.0111	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0038	0.0047
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0111	0.0135
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0038	0.0111	0.0139
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0123	0.0451	0.0559
Onchocerca volvulus		0.0123	0.0451	0.0812
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0111	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Echinococcus granulosus	cathepsin l1	0.0011	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.139	0.5518	0.6877
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Schistosoma mansoni	serine/threonine RGC	0.0011	0.0003	0.0004
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0111	0.0135
Toxoplasma gondii	adenylate and guanylate cyclase catalytic domain-containing protein	0.0011	0.0003	0.0003
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0017	0.003	0.0034
Onchocerca volvulus		0.0123	0.0451	0.0812
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0111	0.0135
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0123	0.0451	0.0562
Leishmania major	cathepsin L-like protease	0.0016	0.0026	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Brugia malayi	hypothetical protein	0.0017	0.003	0.0034
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0026	0.6181
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0038	0.0111	0.0135
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0111	0.0139
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Echinococcus granulosus	orexin receptor type 2	0.0123	0.0451	0.0559
Echinococcus multilocularis	neuropeptide receptor	0.0123	0.0451	0.0559
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Echinococcus multilocularis	allatostatin A receptor	0.0123	0.0451	0.0559
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0038	0.0111	0.0135
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.2016	0.8023	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0123	0.0451	0.0559
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0026	0.0032
Onchocerca volvulus		0.0038	0.0111	0.0196
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.002	0.0042	0.0048
Onchocerca volvulus		0.0017	0.003	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Echinococcus multilocularis	g-protein coupled receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0017	0.003	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0004	0.0005
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0123	0.0453	0.0561
Schistosoma mansoni	adenoreceptor	0.0123	0.0451	0.0562
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0111	0.0135
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Schistosoma mansoni	neuropeptide receptor	0.0123	0.0451	0.0562
Echinococcus granulosus	cathepsin l1	0.0016	0.0026	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Brugia malayi	Dopamine receptor	0.0123	0.0451	0.0559
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0026	0.0028
Onchocerca volvulus		0.0123	0.0451	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0123	0.0451	0.0562
Schistosoma mansoni	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	neuropeptides capa receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	nAChR subunit	0.0038	0.0111	0.0135
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Loa Loa (eye worm)	ctsf protein	0.0016	0.0026	0.0032
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0115	0.0419	0.0519
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0038	0.0111	0.0135
Leishmania major	cathepsin L-like protease	0.0016	0.0026	0.0023
Schistosoma mansoni	lipoxygenase	0.0115	0.0419	0.0523
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Onchocerca volvulus		0.0123	0.0451	0.0812
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0038	0.0111	0.0135
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0123	0.0453	0.0561
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0026	0.0028
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0026	0.0028
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0661	0.2604	0.2604
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Loa Loa (eye worm)	hypothetical protein	0.002	0.0042	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0004	0.0005
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0123	0.0451	0.0562
Brugia malayi	excitatory GABA receptor EXP-1A	0.0038	0.0111	0.0135
Echinococcus granulosus	biogenic amine 5HT receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	neuropeptides capa receptor	0.0123	0.0451	0.0559
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Onchocerca volvulus		0.0123	0.0451	0.0812
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0026	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0123	0.0451	0.0562
Trichomonas vaginalis	conserved hypothetical protein	0.0661	0.2604	1
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0197	0.0245
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0123	0.0451	0.0559
Echinococcus granulosus	g-protein coupled receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0293	0.113	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Schistosoma mansoni	fatty acid binding protein	0.0293	0.113	0.1409
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0187	0.0187
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0123	0.0451	0.0559
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0209	0.0209
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0123	0.0453	0.0561
Plasmodium vivax	adenylyl cyclase beta, putative	0.0011	0.0003	0.0003
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0017	0.003	0.0034
Onchocerca volvulus		0.0019	0.0037	0.0062
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0004	0.0005
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	growth hormone secretagogue receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	GABA receptor subunit	0.002	0.0042	0.0052
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0123	0.0451	0.0559
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Onchocerca volvulus		0.0017	0.003	0.0049
Entamoeba histolytica	hypothetical protein	0.002	0.0042	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0038	0.0038
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0123	0.0453	0.0561
Echinococcus granulosus	tm gpcr rhodopsin	0.0123	0.0451	0.0559
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.002	0.0042	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Brugia malayi	putative neuropeptide receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	cysteine protease	0.0016	0.0026	0.0028
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0026	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Loa Loa (eye worm)	thymidylate synthase	0.139	0.5518	0.6877
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0037	0.0043
Echinococcus multilocularis	g protein coupled receptor	0.0123	0.0451	0.0559
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.002	0.0042	0.0048
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0037	0.0047
Onchocerca volvulus		0.0123	0.0451	0.0812
Schistosoma mansoni	neuropeptide receptor	0.0123	0.0451	0.0562
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0026	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Plasmodium vivax	guanylyl cyclase, putative	0.0011	0.0003	0.0003
Brugia malayi	Bloom's syndrome protein homolog	0.0019	0.0038	0.0043
Loa Loa (eye worm)	acetylcholine receptor protein	0.0017	0.003	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Mycobacterium ulcerans	thymidylate synthase	0.139	0.5518	0.6876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.0004
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Echinococcus multilocularis	nAChR subunit	0.002	0.0042	0.0048
Loa Loa (eye worm)	fibroinase	0.0016	0.0026	0.0032
Giardia lamblia	Sgs1 DNA helicase, putative	0.0019	0.0038	1
Echinococcus granulosus	glycine receptor subunit beta	0.0038	0.0111	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0111	0.0135
Plasmodium vivax	vivapain-2	0.0016	0.0026	0.0026
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0017	0.003	0.0038
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0017	0.003	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0026	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Schistosoma mansoni	adenylate cyclase	0.0011	0.0003	0.0004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Echinococcus granulosus	neuropeptide FF receptor 2	0.0123	0.0451	0.0559
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Entamoeba histolytica	recQ family helicase, putative	0.0019	0.0038	0.9042
Schistosoma mansoni	polycystin 1-related	0.0019	0.0037	0.0047
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0026	0.0028
Trichomonas vaginalis	DNA helicase recq1, putative	0.0019	0.0038	0.0133
Echinococcus granulosus	biogenic amine 5HT receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	nAChR subunit	0.0017	0.003	0.0038
Onchocerca volvulus		0.0038	0.0111	0.0196
Schistosoma mansoni	DNA helicase recq1	0.0019	0.0038	0.0047
Onchocerca volvulus		0.139	0.5518	1
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Echinococcus granulosus	neuropeptide s receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	dihydrofolate reductase	0.2016	0.8023	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0003	0.0004
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Schistosoma mansoni	protein tyrosine kinase	0.0011	0.0003	0.0004
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0038	0.0043
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0111	0.0135
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0038	0.0111	0.0135
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0026	0.0028
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0123	0.0451	0.0559
Treponema pallidum	adenylate cyclase	0.0011	0.0003	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0197	0.0242
Onchocerca volvulus		0.0016	0.0026	0.0041
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0123	0.0453	0.0565
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.003	0.0034
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0017	0.003	0.0034
Schistosoma mansoni	hypothetical protein	0.0011	0.0003	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Onchocerca volvulus		0.0011	0.0004	0.0002
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0017	0.003	0.0034
Mycobacterium tuberculosis	Hypothetical protein	0.0661	0.2604	0.3243
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0111	0.0139
Echinococcus granulosus	neuropeptide Y receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	loxhd1	0.0019	0.0037	0.0047
Brugia malayi	cathepsin L-like precursor	0.0011	0.0004	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Toxoplasma gondii	adenylate cyclase, putative	0.0011	0.0003	0.0003
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.2511	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Echinococcus granulosus	sex peptide receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	RecQ helicase	0.0019	0.0038	0.0047
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Leishmania major	cathepsin L-like protease	0.0062	0.0209	0.0206
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0038	0.0111	0.0135
Brugia malayi	Doublecortin family protein	0.0019	0.0037	0.0043
Brugia malayi	neuropeptide F receptor	0.0123	0.0451	0.0559
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0038	0.0111	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0293	0.113	0.1406
Echinococcus granulosus	fatty acid binding protein FABP2	0.0293	0.113	0.1406
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0038	0.0035
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0019	0.0038	0.0043
Onchocerca volvulus		0.002	0.0042	0.007
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0019	0.0038	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	dro:myosuppressin receptor	0.0123	0.0451	0.0559
Trypanosoma brucei	cytochrome P450, putative	0.0015	0.0022	0.0019
Echinococcus multilocularis	fmrfamide receptor	0.0123	0.0451	0.0559
Brugia malayi	follicle stimulating hormone receptor	0.0346	0.1346	0.1674
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0197	0.0197
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0123	0.0451	0.0812
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0037	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0004	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Onchocerca volvulus		0.0016	0.0026	0.0041
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.003	0.0038
Echinococcus multilocularis	neuropeptide receptor A26	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0038	0.0111	0.0139
Onchocerca volvulus	Adenylate cyclase type 3 homolog	0.069	0.2721	0.4929
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0017	0.003	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Schistosoma mansoni	biogenic amine receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Echinococcus granulosus	neuropeptide receptor	0.0123	0.0451	0.0559
Toxoplasma gondii	adenylate and guanylate cyclase catalytic domain-containing protein	0.0011	0.0003	0.0003
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0003	0.0003
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0123	0.0451	0.0562
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0004	0.103
Plasmodium vivax	vivapain-2	0.0016	0.0026	0.0026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0026	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.0451	0.0562
Schistosoma mansoni	neurotransmitter gated ion channel	0.0017	0.003	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0026	0.0026
Echinococcus granulosus	allatostatin A receptor	0.0123	0.0451	0.0559
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0038	0.0038
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0026	0.0023
Onchocerca volvulus		0.0017	0.003	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Onchocerca volvulus		0.0249	0.0957	0.1729
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0453	0.0565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.2511	1	1
Brugia malayi	Dopamine receptor protein 1	0.0123	0.0451	0.0559
Loa Loa (eye worm)	LGC-31 protein	0.0038	0.0111	0.0139
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0026	0.0023
Schistosoma mansoni	myosin xvIII	0.0123	0.0451	0.0562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.002	0.0042	0.0052
Loa Loa (eye worm)	melatonin receptor type 1A	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Onchocerca volvulus		0.0123	0.0451	0.0812
Loa Loa (eye worm)	ACC-1 protein	0.0038	0.0111	0.0139
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0026	0.0028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0197	0.0242
Onchocerca volvulus		0.0123	0.0451	0.0812
Loa Loa (eye worm)	CYP4Cod1	0.0015	0.0022	0.0028
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0123	0.0451	0.0562
Echinococcus multilocularis	neuropeptide Y receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Onchocerca volvulus		0.0238	0.0914	0.1653
Echinococcus granulosus	neuropeptides capa receptor	0.0123	0.0451	0.0559
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0111	0.0135
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0017	0.003	0.0034
Plasmodium vivax	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0011	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0026	0.0087
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0209	0.0209
Toxoplasma gondii	cathepsin CPL	0.0016	0.0026	0.0026
Onchocerca volvulus		0.0016	0.0026	0.0041
Brugia malayi	Serotonin receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	serotonin receptor	0.0123	0.0451	0.0559
Echinococcus multilocularis	neuropeptide Y receptor	0.0123	0.0451	0.0559
Loa Loa (eye worm)	G-protein coupled receptor	0.0123	0.0451	0.0562
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0019	0.0038	0.0035
Echinococcus granulosus	g protein coupled receptor	0.0123	0.0451	0.0559
Leishmania major	cathepsin L-like protease	0.0016	0.0026	0.0023
Schistosoma mansoni	protein kinase	0.0011	0.0003	0.0004
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0111	0.0135
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0123	0.0451	0.0559
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0123	0.0451	0.0562
Onchocerca volvulus		0.0016	0.0026	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0019	0.0038	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0019	0.0038	0.0043
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0293	0.113	0.1409
Schistosoma mansoni	receptor-type adenylate cyclase	0.0011	0.0003	0.0004
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0123	0.0451	0.0559
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0026	0.0028
Schistosoma mansoni	hypothetical protein	0.0123	0.0451	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0026	0.0087
Schistosoma mansoni	opsin-like receptor	0.0123	0.0451	0.0562
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0026	0.0023
Echinococcus granulosus	nAChR subunit	0.002	0.0042	0.0048
Schistosoma mansoni	rab6-interacting	0.0019	0.0037	0.0047
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0003	0.0004
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0111	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	dihydrofolate reductase	0.2016	0.8023	1
Leishmania major	cathepsin L-like protease	0.0062	0.0209	0.0206
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0123	0.0451	0.0559
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0038	0.0111	0.0135
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0197	0.0194
Echinococcus multilocularis	bloom syndrome protein	0.0019	0.0038	0.0043
Brugia malayi	thymidylate synthase	0.139	0.5518	0.6876
Echinococcus multilocularis	orexin receptor type 2	0.0123	0.0451	0.0559
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Echinococcus granulosus	neuropeptide receptor	0.0123	0.0451	0.0559
Schistosoma mansoni	hypothetical protein	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Leishmania major	cathepsin L-like protease	0.0062	0.0209	0.0206
Loa Loa (eye worm)	neuropeptide F receptor	0.0123	0.0451	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0197	0.0242
Schistosoma mansoni	nAChR subunit	0.0017	0.003	0.0038
Brugia malayi	dihydrofolate reductase family protein	0.2016	0.8023	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0003	0.0004
Schistosoma mansoni	amine GPCR	0.0123	0.0451	0.0562
Echinococcus granulosus	bloom syndrome protein	0.0019	0.0038	0.0043
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0115	0.0419	0.0519
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0017	0.003	0.0034
Onchocerca volvulus		0.0123	0.0451	0.0812
Onchocerca volvulus		0.0123	0.0451	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0957	0.1193
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0003	0.0003
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0038	0.0111	0.0139
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Echinococcus granulosus	adenylate cyclase 9	0.0249	0.0957	0.1189
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0123	0.0451	0.0559
Schistosoma mansoni	neuropeptide receptor	0.0123	0.0451	0.0562
Brugia malayi	G protein-coupled receptor	0.0123	0.0451	0.0559
Brugia malayi	hypothetical protein	0.0123	0.0451	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0017	0.003	0.0038
Echinococcus granulosus	RUN	0.0019	0.0037	0.0043
Schistosoma mansoni	acetylcholine receptor-related	0.0017	0.003	0.0038
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0038	0.0111	0.0139
Echinococcus granulosus	7TM GPCR rhodopsin	0.0123	0.0451	0.0559
Schistosoma mansoni	nAChR subunit	0.0038	0.0111	0.0139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0004	0.0005
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0111	0.0135
Brugia malayi	G-protein coupled receptor	0.0123	0.0451	0.0559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0026	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0111	0.0139
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0038	0.0111	0.0139
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0026	0.0028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.0451	0.0559
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0209	0.0206
Trypanosoma cruzi	cytochrome P450, putative	0.0015	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0451	0.0562

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.97 uM	Antagonistic activity against neuronal nicotinic acetylcholine receptor (alpha3-betaX subunit) in IMR 32 cell line using 100 uM of (-)-nicotine as agonist	ChEMBL.	11266158
IC50 (functional)	= 6.97 uM	Antagonistic activity against neuronal nicotinic acetylcholine receptor (alpha3-betaX subunit) in IMR 32 cell line using 100 uM of (-)-nicotine as agonist	ChEMBL.	11266158
Ki (binding)	= 0.32 nM	In vitro ability to displace [3H]-(-)-cytisine binding to whole rat brain membranes at Nicotinic acetylcholine receptor alpha4-beta2	ChEMBL.	11266158
Ki (binding)	= 0.32 nM	In vitro ability to displace [3H]-(-)-cytisine binding to whole rat brain membranes at Nicotinic acetylcholine receptor alpha4-beta2	ChEMBL.	11266158

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 271624