Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0036 | 0.0332 | 0.4473 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0241 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0169 | 0.6578 | 0.5673 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0036 | 0.0332 | 0.0617 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0036 | 0.0332 | 0.5 |
Mycobacterium ulcerans | dipeptidase PepE | 0.0073 | 0.2093 | 0.1822 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0143 | 0.5383 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0169 | 0.6578 | 0.5673 |
Onchocerca volvulus | 0.0073 | 0.2094 | 0.4394 | |
Onchocerca volvulus | 0.0121 | 0.434 | 1 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Brugia malayi | metallopeptidase family M24 containing protein | 0.012 | 0.4313 | 0.9937 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0332 | 0.0765 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0036 | 0.0332 | 0.0617 |
Echinococcus multilocularis | xaa pro aminopeptidase | 0.012 | 0.4313 | 0.4313 |
Entamoeba histolytica | aminopeptidase, putative | 0.012 | 0.4313 | 0.6373 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2668 | 0.7111 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0143 | 0.5383 | 1 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0241 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0169 | 0.6578 | 0.6461 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.0068 | 0.1852 | 0.3441 |
Trypanosoma cruzi | aminopeptidase P1, putative | 0.012 | 0.4313 | 0.8012 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24, putative | 0.012 | 0.4313 | 0.8012 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0143 | 0.5383 | 1 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0143 | 0.5383 | 1 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0036 | 0.0332 | 0.0617 |
Loa Loa (eye worm) | aminopeptidase N | 0.0036 | 0.0332 | 0.0885 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0036 | 0.0332 | 0.0617 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0241 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0169 | 0.6578 | 0.6461 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0241 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.012 | 0.4313 | 0.6373 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0169 | 0.6578 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0121 | 0.434 | 0.434 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0241 | 1 | 1 |
Treponema pallidum | aminopeptidase P | 0.012 | 0.4313 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Brugia malayi | Peptidase family M1 containing protein | 0.0121 | 0.434 | 1 |
Mycobacterium ulcerans | dipeptidase | 0.0073 | 0.2093 | 0.1822 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0036 | 0.0332 | 0.4473 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0143 | 0.5383 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0098 | 0.3256 | 0.8677 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0036 | 0.0332 | 0.0617 |
Mycobacterium ulcerans | cytoplasmic peptidase PepQ | 0.0073 | 0.2093 | 0.1822 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0036 | 0.0332 | 0.0617 |
Echinococcus granulosus | aminopeptidase N | 0.0121 | 0.434 | 0.434 |
Leishmania major | aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 | 0.012 | 0.4313 | 0.8012 |
Mycobacterium ulcerans | aminopeptidase | 0.0073 | 0.2093 | 0.1822 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0036 | 0.0332 | 0.0617 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0036 | 0.0332 | 0.0332 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0036 | 0.0332 | 0.0617 |
Trypanosoma brucei | Xaa-Pro aminopeptidase, putative | 0.012 | 0.4313 | 0.8012 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0241 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.3753 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0169 | 0.6578 | 0.5673 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0241 | 1 | 1 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0036 | 0.0332 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1852 | 0.4936 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0036 | 0.0332 | 0.5 |
Echinococcus granulosus | xaa pro aminopeptidase | 0.012 | 0.4313 | 0.4313 |
Brugia malayi | Peptidase family M1 containing protein | 0.0036 | 0.0332 | 0.0765 |
Schistosoma mansoni | aminopeptidase P1 (M24 family) | 0.0044 | 0.0743 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease (functional) | = 23 % | Antihypertensive activity as percent maximum (over 24 hr) decrease in blood pressure at 135 umol/kg,perorally (~40-50 mg/kg) in 5 spontaneously hypertensive rats (SHR) | ChEMBL. | 2435902 |
Decrease (functional) | = 27 % | Antihypertensive activity as percent maximum (0-6 hr) decrease in blood pressure at 135 umol/kg,perorally (~40-50 mg/kg) in 5 spontaneously hypertensive rats (SHR) | ChEMBL. | 2435902 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.