Detailed information for compound 271836

Basic information

Technical information
  • TDR Targets ID: 271836
  • Name: bromo(trichloro)methane
  • MW: 198.274 | Formula: CBrCl3
  • H donors: 0 H acceptors: 0 LogP: 2.93 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1


Substructure search Similarity search

Network

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Synonyms

  • Bromotrichloromethane
  • bromo-trichloromethane
  • bromo-trichloro-methane
  • 75-62-7
  • Carbon bromotrichloride
  • Methane, bromotrichloro-
  • Monobromotrichloromethane
  • NSC8017
  • Trichlorobromomethane
  • WLN: GXGGE
  • B82251_ALDRICH
  • 18530_FLUKA
  • 4-01-00-00077 (Beilstein Handbook Reference)
  • BRN 1732543
  • CCRIS 2393
  • Carbon trichlorobromide
  • Caswell No. 118
  • EINECS 200-886-0
  • EPA Pesticide Chemical Code 008708
  • HSDB 5208
  • NSC 8017
  • Trichloromethyl bromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0219 0.2804 0.2803
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0686 0.0672
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0271 0.0257
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0472 0.0458
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0344 0.0263
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0629 0.0628
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0083 0.0069
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0629 0.0616
Mycobacterium ulcerans hypothetical protein 0.0035 0.0344 0.0263
Loa Loa (eye worm) hypothetical protein 0.0756 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1427 0.1355
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0344 0.0263
Onchocerca volvulus 0.0756 1 1
Schistosoma mansoni ran 0.0021 0.0157 0.0143
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0069
Entamoeba histolytica aldose reductase, putative 0.0756 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.2804 0.2744
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0342
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0773 0.0772
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0331 0.0331
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.037 0.0356
Trypanosoma brucei trypanothione reductase 0.0046 0.0484 0.0404
Brugia malayi beta-lactamase family protein 0.0035 0.0344 0.0344
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.022 0.0504
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.2804 0.2744
Mycobacterium leprae Possible oxidoreductase 0.0219 0.2804 0.2642
Schistosoma mansoni pol-related 0.0756 1 1
Brugia malayi hypothetical protein 0.0148 0.1857 0.1857
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0083 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0344 0.0263
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.06 0.0521
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.037 0.0356
Echinococcus multilocularis importin subunit beta 1 0.0029 0.026 0.0258
Trypanosoma cruzi aldo/keto reductase, putative 0.0756 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0219 0.2804 0.2794
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.037 0.3573
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0536 0.0534
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0026 0.0026
Trichomonas vaginalis ran, putative 0.0021 0.0157 0.0075
Echinococcus granulosus aldo keto reductase 0.0756 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.037 0.0368
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0271 0.027
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0219 0.2804 0.2744
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0256
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0629 0.0616
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1427 0.1355
Leishmania major hypothetical protein, conserved 0.0035 0.0344 0.033
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.127 0.1197
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0344 0.0263
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.037 0.1054
Echinococcus multilocularis cpg binding protein 0.003 0.0269 0.0268
Entamoeba histolytica aldose reductase, putative 0.0756 1 1
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0629 0.0616
Onchocerca volvulus 0.003 0.0271 0.0257
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0083 0.0083
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0472 0.0472
Entamoeba histolytica aldose reductase, putative 0.0756 1 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0054 0.059 0.6321
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.127 0.1197
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0756 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0544 0.0544
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0472 0.0458
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0069
Echinococcus multilocularis nmda type glutamate receptor 0.0075 0.0871 0.087
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0756 1 1
Chlamydia trachomatis glutamine binding protein 0.0054 0.059 0.6321
Loa Loa (eye worm) oxidoreductase 0.0756 1 1
Echinococcus multilocularis aldo keto reductase 0.0756 1 1
Echinococcus granulosus nmda type glutamate receptor 0.0075 0.0871 0.087
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0885 0.068
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0344 0.0342
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2993 0.2935
Trypanosoma brucei aldo/keto reductase, putative 0.0219 0.2804 0.2744
Echinococcus multilocularis snurportin 1 0.0311 0.403 0.4029
Schistosoma mansoni importin beta-1 0.0029 0.026 0.0246
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.0014 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0344 0.033
Echinococcus granulosus nmda type glutamate receptor 0.0011 0.0014 0.0013
Brugia malayi Pre-SET motif family protein 0.0205 0.2615 0.2615
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0344 0.033
Onchocerca volvulus 0.0756 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0344 0.0263
Trichomonas vaginalis aldo/keto reductase, putative 0.0756 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.88 0.8798
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0186 0.0104
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0344 0.0263
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0756 1 1
Onchocerca volvulus 0.0148 0.1857 0.1846
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0219 0.2804 0.2803
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Mycobacterium tuberculosis Conserved protein 0.0219 0.2804 0.2744
Schistosoma mansoni aldo-keto reductase 0.0756 1 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0484 0.0483
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0219 0.2804 0.2744
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.037 0.0356
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0756 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.0248 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0344 0.033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0186 0.0104
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0081
Echinococcus granulosus snurportin 1 0.0311 0.403 0.4029
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0629 0.0628
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0756 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0773 0.0772
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0157 0.0156
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.026 0.0178
Loa Loa (eye worm) hypothetical protein 0.0148 0.1857 0.1856
Schistosoma mansoni glutamate receptor NMDA 0.0067 0.0773 0.076
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0629 0.0616
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0629 0.0629
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0067 0.0773 0.0772
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0344 0.0958
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0629 0.0629
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0083 0.0082
Echinococcus multilocularis tyrosine kinase 0.0011 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Toxoplasma gondii thioredoxin reductase 0.0046 0.0484 0.0404
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.037 0.0289
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0271 0.0257
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Echinococcus granulosus geminin 0.0496 0.6515 0.6515
Onchocerca volvulus 0.0035 0.0344 0.033
Echinococcus granulosus microtubule associated protein 2 0.0667 0.88 0.88
Onchocerca volvulus 0.0233 0.2993 0.2983
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0344 0.0263
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0081
Onchocerca volvulus 0.0756 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Mycobacterium ulcerans beta-lactamase 0.0035 0.0344 0.0263
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0075
Plasmodium vivax importin-beta 2, putative 0.0029 0.026 0.065
Echinococcus granulosus voltage gated potassium channel subunit 0.0219 0.2804 0.2803
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0082
Loa Loa (eye worm) oxidoreductase 0.0756 1 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0344 0.0126
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0026 0.0026
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0269 0.0268
Brugia malayi beta-lactamase 0.0035 0.0344 0.0344
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0773 0.0772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0342
Loa Loa (eye worm) hypothetical protein 0.0029 0.026 0.0258
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0067 0.0773 0.0772
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0629 0.0628
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0885 0.0884
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0083 0.0069
Leishmania major prostaglandin f synthase, putative 0.0756 1 1
Loa Loa (eye worm) glutamate receptor 0.0011 0.0014 0.0013
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0885 0.2949
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.026 0.0178
Echinococcus multilocularis aldehyde reductase 0.0537 0.7066 0.7065
Mycobacterium ulcerans hypothetical protein 0.0219 0.2804 0.2744
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0011 0.0014 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0544 0.0542
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.037 0.0289
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.037 0.0356
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.127 0.1197
Echinococcus multilocularis NMDA receptor 0.0021 0.0151 0.015
Schistosoma mansoni hypothetical protein 0.0311 0.403 0.4022
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0344 0.0263
Toxoplasma gondii aldose reductase, putative 0.0756 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.0014 0.0013
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0492 0.0491
Brugia malayi CXXC zinc finger family protein 0.0028 0.0248 0.0248
Echinococcus granulosus glutamate receptor 2 0.0046 0.0492 0.0491
Echinococcus multilocularis aldo keto reductase 0.0756 1 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0075 0.0871 0.087
Toxoplasma gondii ABC1 family protein 0.0035 0.0344 0.0263
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0344 0.0263
Onchocerca volvulus 0.0756 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0011 0.0014 0.0013
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0082
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0773 0.0772
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0484 0.0404
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0011 0.0014 0.0013
Schistosoma mansoni hypothetical protein 0.0496 0.6515 0.651
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0344 0.0342
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0011 0.0014 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.037 0.0289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Onchocerca volvulus 0.0219 0.2804 0.2794
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0629 0.0628
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.127 0.1197
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0484 0.0483
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0021 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0342
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0186 0.0104
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0219 0.2804 0.2794
Plasmodium falciparum glutathione reductase 0.0046 0.0484 0.1474
Leishmania major importin beta-1 subunit, putative 0.0024 0.0186 0.0172
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0773 0.0772
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0344 0.0263
Loa Loa (eye worm) oxidoreductase 0.0756 1 1
Leishmania major GTP-binding protein, putative 0.0021 0.0157 0.0143
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0083 0.0082
Leishmania major trypanothione reductase 0.0046 0.0484 0.0471
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0629 0.0616
Giardia lamblia Aldose reductase 0.0756 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.88 0.88
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0248 0.0247
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.037 0.0289
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0083 0.0083
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0344 0.0263
Toxoplasma gondii hypothetical protein 0.0026 0.022 0.0138
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0021 0.0151 0.015
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.022 0.1708
Schistosoma mansoni cpg binding protein 0.003 0.0269 0.0256
Onchocerca volvulus 0.0756 1 1
Schistosoma mansoni hypothetical protein 0.0496 0.6515 0.651
Plasmodium vivax aldehyde reductase, putative 0.0219 0.2804 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.037 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0344 0.0263
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.127 0.1074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1427 0.1234
Brugia malayi Metabotropic glutamate receptor precursor. 0.0011 0.0014 0.0014
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.037 0.037
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0484 0.0471
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0271 0.0257
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0157
Toxoplasma gondii exonuclease III APE 0.0037 0.037 0.0289
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0083 0.0069
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0054 0.059 0.0511
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0219 0.2804 0.2794
Loa Loa (eye worm) hypothetical protein 0.0076 0.0885 0.0884
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0271 0.027
Trichomonas vaginalis esterase, putative 0.0035 0.0344 0.0263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0472 0.047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0271 0.0257
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 0.2949
Loa Loa (eye worm) oxidoreductase 0.0756 1 1
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0629 0.0616
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0219 0.2804 0.2744
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.027
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0472 0.047
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0157 0.0156
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0157 0.0272
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Schistosoma mansoni aldo-keto reductase 0.0756 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0472 0.047
Trypanosoma cruzi aldo/keto reductase, putative 0.0219 0.2804 0.2794
Echinococcus granulosus tyrosine kinase 0.0011 0.0014 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0248 0.0246
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0083 0.0069
Plasmodium falciparum aldehyde reductase, putative 0.0219 0.2804 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0885 0.0884
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0021 0.0151 0.015
Plasmodium vivax SET domain protein, putative 0.003 0.0271 0.0691
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.037 0.1054
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0157 0.0075
Mycobacterium leprae Conserved hypothetical protein 0.0537 0.7066 0.7
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0484 0.0483
Mycobacterium tuberculosis Probable oxidoreductase 0.0756 1 1
Loa Loa (eye worm) oxidoreductase 0.0756 1 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0536 0.0323
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0014 0.0013
Schistosoma mansoni ap endonuclease 0.0037 0.037 0.0356
Plasmodium falciparum aldo-keto reductase, putative 0.0219 0.2804 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.026 0.0258
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0021 0.0151 0.015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0157 0.0143
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0054 0.059 0.6321
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0054 0.059 0.6321
Mycobacterium ulcerans oxidoreductase 0.0756 1 1
Entamoeba histolytica hypothetical protein 0.0024 0.0186 0.0172
Onchocerca volvulus 0.0035 0.0344 0.033
Echinococcus granulosus glutamate receptor 2 0.0067 0.0773 0.0772
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0342
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0344 0.0263
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2615 0.2614
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 0.0809
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Echinococcus granulosus aldo keto reductase 0.0756 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0885 0.0809
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0544 0.0544
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Trypanosoma brucei aldo-keto reductase, putative 0.0756 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0536 0.0457
Schistosoma mansoni hypothetical protein 0.0034 0.0331 0.0317
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0021 0.0151 0.015
Echinococcus granulosus GPCR family 2 0.0016 0.0083 0.0082
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0484 0.0483
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.0014 0.0013
Toxoplasma gondii aldo-keto reductase 0.0219 0.2804 0.2744
Brugia malayi hypothetical protein 0.0011 0.0014 0.0014
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0021 0.0151 0.015
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0885 0.0809
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.037 0.3573
Mycobacterium tuberculosis Conserved protein 0.0035 0.0344 0.0263
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0083 0.0069
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0756 1 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0344 0.0126
Echinococcus granulosus aldo keto reductase 0.0756 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0773 0.0772
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0344 0.033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Loa Loa (eye worm) beta-lactamase 0.0035 0.0344 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0344 0.0342
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0756 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2895 0.2835
Giardia lamblia Aldose reductase 0.0756 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0472 0.0458
Echinococcus granulosus hypothetical protein 0.0756 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0156
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0157 0.0075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.037 0.0368
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0472 0.047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0271 0.019
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0629 0.0628
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0014 0.0013
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0344 0.0263
Brugia malayi RNA, U transporter 1 0.0083 0.0978 0.0978
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0054 0.059 0.0511
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0344 0.0344
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.403 0.4029
Echinococcus multilocularis aldo keto reductase 0.0756 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0186 0.0172
Brugia malayi Probable ClpP-like protease 0.0076 0.0885 0.0885
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0885 0.0809
Brugia malayi Importin beta-1 subunit 0.0029 0.026 0.026
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0536 0.0534
Brugia malayi Pre-SET motif family protein 0.003 0.0271 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0219 0.2804 0.2744
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.037 0.0368
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0014 0.0014
Brugia malayi metabotropic glutamate receptor type 2 0.0011 0.0014 0.0014
Brugia malayi beta-lactamase family protein 0.0035 0.0344 0.0344
Echinococcus granulosus aldehyde reductase 0.0537 0.7066 0.7065
Schistosoma mansoni hypothetical protein 0.0021 0.0151 0.0137
Brugia malayi NADH-dependent xylose reductase 0.0219 0.2804 0.2804
Plasmodium vivax glutathione reductase, putative 0.0046 0.0484 0.1474
Schistosoma mansoni potassium channel beta 0.0219 0.2804 0.2794
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0083 0.0069
Mycobacterium tuberculosis Probable reductase 0.0105 0.127 0.1197
Plasmodium falciparum importin beta, putative 0.0029 0.026 0.065
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0219 0.2804 1
Brugia malayi glutathione reductase 0.0046 0.0484 0.0484
Trypanosoma brucei prostaglandin f synthase 0.0756 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0756 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0773 0.0772
Echinococcus multilocularis nmda type glutamate receptor 0.0011 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Trichomonas vaginalis aldo-keto reductase, putative 0.0219 0.2804 0.2744
Leishmania major aldo-keto reductase-like protein 0.0756 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0344 0.0342
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0014 0.0013
Brugia malayi Thioredoxin reductase 0.0046 0.0484 0.0484
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0756 1 1
Echinococcus multilocularis geminin 0.0496 0.6515 0.6515
Plasmodium falciparum thioredoxin reductase 0.0046 0.0484 0.1474
Schistosoma mansoni ran 0.0021 0.0157 0.0143
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0069
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0157 0.0272
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0014 0.0013
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0014 0.0014
Schistosoma mansoni ap endonuclease 0.0037 0.037 0.0356
Entamoeba histolytica Ran family GTPase 0.0021 0.0157 0.0143
Echinococcus multilocularis aldo keto reductase 0.0756 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0331 0.0329
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0157 0.0143
Trichomonas vaginalis aldo-keto reductase, putative 0.0756 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0756 1 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0011 0.0014 0.0013
Trichomonas vaginalis aldo/keto reductase, putative 0.0756 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0082
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0629 0.0616
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.127 0.1197
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0536 0.0457
Mycobacterium tuberculosis Conserved protein 0.0035 0.0344 0.0263
Onchocerca volvulus 0.0035 0.0344 0.033
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0885 0.0872
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0472 0.047
Onchocerca volvulus 0.0028 0.0248 0.0234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0082
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0484 0.1474
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0271 0.027
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.022 0.0504
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0083 0.0069
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0021 0.0151 0.015
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.037 0.0289
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0082
Onchocerca volvulus 0.0756 1 1
Trypanosoma cruzi aldo-keto reductase 0.0756 1 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.026 0.0178
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0344 0.0263
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0014 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0344 0.0263
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0756 1 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0344 0.0263
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0219 0.2804 0.2804
Echinococcus multilocularis voltage gated potassium channel subunit 0.0219 0.2804 0.2803
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0756 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0544 0.0542
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1427 0.1355
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0011 0.0014 0.0013

Activities

Activity type Activity value Assay description Source Reference
Aneuploidy activty (functional) 0 Induction of aneuploidy in Aspergillus nidulans. ChEMBL. 7861411
logP (ADMET) = 3.1 Partition coefficient (logP) ChEMBL. 7861411
Potency (functional) 60.8989 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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