Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 50 % | Evaluated against tetragastrin stimulated gastric acid secretion in conscious Hiedenhain-pouch dogs at a dose of 0.32mg/kg,po | ChEMBL. | 7904648 |
Inhibition (functional) | < 70 % | Inhibition of aspirin induced gastric lesions in rats after peroral dose of 32 mg/kg | ChEMBL. | 7904648 |
Inhibition (functional) | = 72 % | H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium at 1x10E-6 g/mL. | ChEMBL. | 7904648 |
Inhibition (functional) | = 72 % | H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atrium at 1x10E-6 g/mL. | ChEMBL. | 7904648 |
Inhibition (functional) | = 81 % | Inhibition of histamine stimulated gastric acid secretion in lumen perfused anaesthetized rats after 1 mg/kg intravenous dose | ChEMBL. | 7904648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.