Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0073 | 0.0182 | 0.0538 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0182 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0383 | 0.2123 | 0.2123 |
Chlamydia trachomatis | glutamine binding protein | 0.0049 | 0.0031 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0306 | 0.0361 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.011 | 0.0413 | 0.0488 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0306 | 0.0361 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0115 | 0.034 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.0182 | 0.0215 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.0081 | 0.024 |
Echinococcus granulosus | glutamate receptor 1 | 0.0167 | 0.0771 | 0.091 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0248 | 0.1282 | 0.1282 |
Schistosoma mansoni | glutamate receptor kainate | 0.0282 | 0.1492 | 0.1762 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.3385 | 0.3997 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.011 | 0.0413 | 0.0488 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.0032 | 0.0094 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0115 | 0.034 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0049 | 0.0031 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0492 | 0.281 | 0.281 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0325 | 0.1766 | 0.1766 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0584 | 0.3385 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.3385 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0584 | 0.3385 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0584 | 0.3385 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.3385 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0248 | 0.1282 | 0.1513 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0158 | 0.0718 | 0.0718 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0044 | 0.0052 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0448 | 0.2537 | 0.7493 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0391 | 0.2174 | 0.2174 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0306 | 0.0361 |
Onchocerca volvulus | 0.0051 | 0.0044 | 0.0129 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0062 | 0.0115 | 0.034 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.0182 | 0.0215 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0182 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.0115 | 0.034 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0049 | 0.0031 | 0.5 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0492 | 0.281 | 0.281 |
Echinococcus multilocularis | thymidylate synthase | 0.0584 | 0.3385 | 0.3385 |
Echinococcus granulosus | glutamate receptor 4 | 0.0167 | 0.0771 | 0.091 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.3385 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0771 | 0.2277 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.011 | 0.0413 | 0.0413 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1395 | 0.8469 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.011 | 0.0413 | 0.0488 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0306 | 0.0306 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0325 | 0.1766 | 0.2085 |
Echinococcus granulosus | glutamate receptor 2 | 0.0492 | 0.281 | 0.3318 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0316 | 0.1709 | 0.1709 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0282 | 0.1492 | 0.1762 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.3385 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0158 | 0.0717 | 0.0717 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.0306 | 0.0904 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0306 | 0.0306 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0584 | 0.3385 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0448 | 0.2537 | 0.7493 |
Echinococcus granulosus | thymidylate synthase | 0.0584 | 0.3385 | 0.3997 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0391 | 0.2174 | 0.2567 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.0182 | 0.0182 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1395 | 0.8469 | 0.8469 |
Mycobacterium ulcerans | thymidylate synthase | 0.0584 | 0.3385 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0062 | 0.0115 | 0.034 |
Schistosoma mansoni | glutamate receptor kainate | 0.0282 | 0.1492 | 0.1762 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0771 | 0.2277 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0325 | 0.1766 | 0.2085 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0044 | 0.0129 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0182 | 0.0215 |
Schistosoma mansoni | glutamate receptor kainate | 0.0282 | 0.1492 | 0.1762 |
Onchocerca volvulus | 0.0584 | 0.3385 | 1 | |
Echinococcus granulosus | glutamate receptor NMDA | 0.0158 | 0.0717 | 0.0847 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0306 | 0.0361 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0049 | 0.0031 | 0.5 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0282 | 0.1492 | 0.1762 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0276 | 0.1458 | 0.1721 |
Brugia malayi | hypothetical protein | 0.0248 | 0.1282 | 0.3786 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0325 | 0.1766 | 0.1766 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0044 | 0.0052 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0276 | 0.1458 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0771 | 0.2277 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0282 | 0.1492 | 0.1762 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1395 | 0.8469 | 1 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.0115 | 0.034 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0278 | 0.1467 | 0.4334 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0182 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0282 | 0.1492 | 0.4407 |
Echinococcus multilocularis | NMDA receptor | 0.011 | 0.0413 | 0.0413 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.3385 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0325 | 0.1766 | 0.2085 |
Echinococcus granulosus | glutamate receptor 2 | 0.0383 | 0.2123 | 0.2507 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0278 | 0.1467 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0484 | 0.2757 | 0.3255 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.1282 | 0.3786 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0278 | 0.1467 | 0.428 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0492 | 0.281 | 0.3318 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0325 | 0.1766 | 0.1766 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.0306 | 0.0904 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0391 | 0.2174 | 0.2567 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0202 | 0.0991 | 0.0991 |
Leishmania major | cathepsin L-like protease | 0.0062 | 0.0115 | 0.034 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.011 | 0.0413 | 0.0413 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0448 | 0.2537 | 0.2537 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0306 | 0.0361 |
Brugia malayi | hypothetical protein | 0.0278 | 0.1467 | 0.4334 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0413 | 0.0488 |
Brugia malayi | thymidylate synthase | 0.0584 | 0.3385 | 1 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0167 | 0.0771 | 0.0771 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0202 | 0.0991 | 0.117 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0448 | 0.2537 | 0.7493 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0316 | 0.1709 | 0.2018 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0182 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Binding (binding) | = 90 % | Compound (4.5 microM) was evaluated for the percent binding to the excess dTMP synthetase (3.9 microM and 7.8 microM sites) enzyme from chick embryo, 0.15 nM of CH2-H4 folate. This complex was incubated 25 degrees Centigrade for 2 hours. | ChEMBL. | 6434741 |
Dissociation (binding) | 0 | Compound was evaluated for the dissociation of the radiolabelled N4-HOdCMP by competitive binding to the excess dTMP synthetase; Active | ChEMBL. | 6434741 |
Kd (binding) | = 1 uM | Compound was evaluated for average apparent binding constant (Kd ) using Scatchard analysis to dTMP synthetase enzyme from chick embryo | ChEMBL. | 6434741 |
Ki (binding) | = 8 uM | The apparent associaton constant (Ki) of the compound with dTMP synthetase enzyme from chick embryo in the absence of CH2-H4 folate was evaluated | ChEMBL. | 6434741 |
Loss of activity (functional) | = 50 % | Compound was evaluated for time-dependent loss of activity with use of 15 nM of dTMP synthetase enzyme from chick embryo in the presence of 0.15 nM of CH2-H4 folate at about 20 seconds | ChEMBL. | 6434741 |
T1/2 (ADMET) | = 2.3 min | Dissociation time from ternary complex using nitrocellulose binding assay incubating 5.0 microM of TMP synthetase enzyme from chick embryo and 0.15 nM of CH2-H4 folate | ChEMBL. | 6434741 |
T1/2 (ADMET) | = 13 min | Dissociation time from ternary complex using nitrocellulose binding assay by incubating the compound was evaluated at 100 fold excess along with 3.8 microM of TMP synthetase enzyme from chick embryo and 0.15 nM of CH2-H4 folate. | ChEMBL. | 6434741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.