Detailed information for compound 27237

Basic information

Technical information
  • TDR Targets ID: 27237
  • Name: Protriptyline
  • MW: 263.377 | Formula: C19H21N
  • H donors: 1 H acceptors: 0 LogP: 4.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCCCC1c2ccccc2C=Cc2c1cccc2
  • InChi: 1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
  • InChiKey: BWPIARFWQZKAIA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Protryptyline
  • 438-60-8
  • 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene
  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-
  • 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-
  • 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
  • Amimetilina
  • BRN 2217411
  • EINECS 207-119-9
  • HSDB 3391
  • N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine
  • N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine
  • Protriptilina [INN-Spanish]
  • Protriptylinum [INN-Latin]
  • PDSP1_001390
  • 1225-55-4 (HYDROCHLORIDE)
  • 3-(5H-Dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine-
  • 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine
  • AIDS-156132
  • AIDS156132
  • N-(3-(5H-Dibenzo[a,d]cyclohepten-5-yl)propyl)-N-methylamine
  • NSC169912 (HYDROCHLORIDE)
  • {5-[3-(Methylamino)propyl]-5H-dibenzo[a,d]cycloheptene} hydrochloride
  • {5H-Dibenzo[a,d]cyclohepten-5-propylamine,} N-methyl-, hydrochloride
  • {5H-Dibenzo[a,d]cycloheptene-5-propylamine,} N-methyl-, hydrochloride
  • Prestwick2_000930
  • N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
  • nchembio747-comp7
  • PDSP2_001374
  • 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-
  • 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
  • 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene
  • CHEBI:8597
  • N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine
  • Prestwick3_000930
  • BPBio1_000924
  • Lopac0_000974
  • SPBio_003019
  • C07408
  • Prestwick1_000930
  • Lopac-P-8813
  • NCGC00015851-01
  • BSPBio_000840
  • CAS-1225-55-4
  • NCGC00015851-02
  • {N-Methyl-5H-dibenzo[a,} d]cycloheptene-5-propylamine hydrochloride
  • {5H-Dibenzo[a,} d]cycloheptene-5-propanamine, N-methyl-, hydrochloride
  • Prestwick0_000930

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sodium channel, voltage-gated, type III, alpha subunit References
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens dopamine receptor D1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens sodium channel, voltage-gated, type I, alpha subunit Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens thrombopoietin Starlite/ChEMBL No references
Homo sapiens sodium channel, voltage-gated, type II, alpha subunit References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis sodium channel protein Get druggable targets OG5_126819 All targets in OG5_126819
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Leishmania major calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani calcium channel protein, putative Get druggable targets OG5_126819 All targets in OG5_126819
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum calcium channel protein, putative,ion transporter, putative Get druggable targets OG5_126819 All targets in OG5_126819
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Echinococcus granulosus orexin receptor type 2 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0037 0.0018
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0037 0.0037
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0085 0.1727 0.3337
Echinococcus multilocularis g protein coupled receptor 0.0085 0.1727 0.1727
Echinococcus granulosus g-protein coupled receptor 0.0085 0.1727 0.1727
Onchocerca volvulus 0.0085 0.1727 0.73
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0085 0.1727 0.73
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.1326 0.2535
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0217 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0142 0.32 0.4737
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Brugia malayi Dopamine receptor protein 2 0.0085 0.1727 0.3337
Schistosoma mansoni hypothetical protein 0.0085 0.1727 0.3337
Schistosoma mansoni polycystin 1-related 0.0024 0.0161 0.0263
Brugia malayi hypothetical protein 0.003 0.0331 0.0596
Schistosoma mansoni biogenic amine (5HT) receptor 0.0085 0.1727 0.3337
Schistosoma mansoni biogenic amine receptor 0.0085 0.1727 0.3337
Echinococcus multilocularis musashi 0.0033 0.0386 0.0386
Onchocerca volvulus 0.006 0.1081 0.4525
Schistosoma mansoni amine GPCR 0.0085 0.1727 0.3337
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.2355 0.6938
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0142 0.32 0.4737
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus granulosus biogenic amine 5HT receptor 0.0085 0.1727 0.1727
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0136 0.3032 0.5892
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0142 0.3197 0.6217
Brugia malayi Cytochrome P450 family protein 0.0019 0.0041 0.0027
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Echinococcus granulosus neuropeptide receptor 0.0085 0.1727 0.1727
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0062 0.1151 0.2206
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0041 0.0009
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0085 0.1727 0.3337
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0037 0.0037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.1727 0.3337
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.1727 0.1727
Schistosoma mansoni hypothetical protein 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus granulosus g protein coupled receptor 0.0085 0.1727 0.1727
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0033 0.0386 0.1136
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0085 0.1727 0.1727
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0085 0.1727 0.1727
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Echinococcus granulosus biogenic amine 5HT receptor 0.0085 0.1727 0.1727
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1326 0.1326
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0085 0.1727 0.3337
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0217 0.512 0.5
Onchocerca volvulus 0.0033 0.0386 0.1538
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0085 0.1727 0.1727
Echinococcus multilocularis G protein coupled receptor 139 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0386 0.1136
Echinococcus granulosus serotonin transporter 0.0109 0.2355 0.2355
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.3199 0.3199
Loa Loa (eye worm) hypothetical protein 0.0024 0.0161 0.0475
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.1727 0.1727
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0217 0.512 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Echinococcus multilocularis sodium channel protein 0.0136 0.3032 0.3032
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0041 0.0009
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0037 0.0037
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0161 0.0475
Brugia malayi intermediate filament protein 0.0033 0.0386 0.0703
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0037 0.0018
Echinococcus granulosus phd:f box containing protein 0.0019 0.0037 0.0037
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0386 0.0703
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.1727 0.1727
Echinococcus granulosus serotonin receptor 0.0085 0.1727 0.1727
Schistosoma mansoni rab6-interacting 0.0024 0.0161 0.0263
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Loa Loa (eye worm) serotonin transporter b 0.0109 0.2355 0.6938
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0037 0.0037
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0037 0.0018
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0085 0.1727 0.1727
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0085 0.1727 0.1727
Echinococcus granulosus hypothetical protein 0.0085 0.1727 0.1727
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Brugia malayi Serotonin receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0028 0.0081
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0217 0.512 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Echinococcus multilocularis allatostatin A receptor 0.0085 0.1727 0.1727
Schistosoma mansoni loxhd1 0.0024 0.0161 0.0263
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0075 0.1472 0.2836
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0085 0.1727 0.3337
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0161 0.0161
Brugia malayi larval opioid receptor 0.0085 0.1727 0.3337
Brugia malayi putative neuropeptide receptor NPR1 0.0085 0.1727 0.3337
Onchocerca volvulus 0.0085 0.1727 0.73
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0217 0.512 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0161 0.0263
Schistosoma mansoni neuropeptide receptor 0.0085 0.1727 0.3337
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.1326 0.2549
Leishmania major hypothetical protein, conserved 0.003 0.0331 0.0579
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.137 0.4036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.2355 0.4571
Echinococcus multilocularis fmrfamide receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Echinococcus granulosus lamin dm0 0.0033 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Brugia malayi putative neuropeptide receptor 0.0085 0.1727 0.3337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0085 0.1727 0.1727
Echinococcus multilocularis g protein coupled receptor 0.0085 0.1727 0.1727
Echinococcus granulosus allatostatin A receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0032 0.037 0.1091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0067 0.1277 0.2439
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0037 0.0108
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0067 0.1277 0.2439
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.137 0.137
Schistosoma mansoni amine GPCR 0.0085 0.1727 0.3337
Brugia malayi Serotonin receptor 0.0085 0.1727 0.3337
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Brugia malayi Dopamine receptor protein 1 0.0085 0.1727 0.3337
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.2355 0.6938
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.137 0.2637
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0217 0.512 0.512
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1326 0.2528
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1081 0.2068
Brugia malayi Dopamine receptor 0.0085 0.1727 0.3337
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0331 0.0596
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0075 0.1475 0.5
Brugia malayi Doublecortin family protein 0.0024 0.0161 0.0263
Loa Loa (eye worm) melatonin receptor type 1A 0.0085 0.1727 0.5087
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0085 0.1727 0.3337
Schistosoma mansoni lipoxygenase 0.0142 0.3199 0.6227
Brugia malayi sulfakinin receptor protein 0.0085 0.1727 0.3337
Brugia malayi G-protein coupled receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0217 0.512 0.512
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus granulosus neuropeptide receptor 0.0085 0.1727 0.1727
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0217 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0067 0.1277 0.2453
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0085 0.1727 0.3337
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0085 0.1727 0.3337
Onchocerca volvulus 0.0085 0.1727 0.73
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.137 0.137
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0142 0.32 0.32
Echinococcus multilocularis fmrfamide receptor 0.0085 0.1727 0.1727
Schistosoma mansoni rab6-interacting 0.0024 0.0161 0.0263
Schistosoma mansoni neuropeptide f receptor 76f 0.0085 0.1727 0.3337
Echinococcus granulosus dro:myosuppressin receptor 0.0085 0.1727 0.1727
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.1277 0.2439
Schistosoma mansoni neuropeptide receptor 0.0085 0.1727 0.3337
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.1326 0.2549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.1277 0.2439
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.1727 0.3337
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Brugia malayi GnHR receptor homolog 0.0085 0.1727 0.3337
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0028 0.0028
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0217 0.512 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0109 0.2355 0.6938
Schistosoma mansoni opsin-like receptor 0.0085 0.1727 0.3337
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.006 0.1081 0.3184
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0136 0.3032 0.3032
Echinococcus granulosus g protein coupled receptor 0.0085 0.1727 0.1727
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Onchocerca volvulus 0.0085 0.1727 0.73
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0217 0.512 0.5
Schistosoma mansoni opsin-like receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.015 0.3395 1
Onchocerca volvulus 0.0024 0.0161 0.0574
Echinococcus multilocularis G-protein coupled receptor, putative 0.0085 0.1727 0.1727
Echinococcus granulosus G protein coupled receptor 139 0.0085 0.1727 0.1727
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.0028 0.0028
Echinococcus granulosus sodium channel protein 0.0136 0.3032 0.3032
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0085 0.1727 0.3337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0037 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0331 0.0975
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1326 0.2528
Schistosoma mansoni growth hormone secretagogue receptor 0.0085 0.1727 0.3337
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0085 0.1727 0.1727
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0142 0.32 0.9425
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Echinococcus multilocularis somatostatin receptor 0.0085 0.1727 0.1727
Onchocerca volvulus 0.0085 0.1727 0.73
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0217 0.512 0.5
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0217 0.512 1
Brugia malayi neuropeptide F receptor 0.0085 0.1727 0.3337
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0037 0.0018
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0142 0.3197 0.6217
Brugia malayi ORL1-like opioid receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0108
Brugia malayi hypothetical protein 0.0024 0.0161 0.0263
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.1727 0.3337
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0217 0.512 1
Echinococcus granulosus somatostatin receptor 0.0085 0.1727 0.1727
Brugia malayi hypothetical protein 0.0024 0.0161 0.0263
Echinococcus granulosus 7tm_1 domain containing protein 0.0085 0.1727 0.1727
Onchocerca volvulus 0.0033 0.0386 0.1538
Schistosoma mansoni lamin 0.0033 0.0386 0.0703
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.1727 0.1727
Schistosoma mansoni adenoreceptor 0.0085 0.1727 0.3337
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.1727 0.1727
Brugia malayi hypothetical protein 0.002 0.0055 0.0053
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0037 0.0037
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.2355 0.4571
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0142 0.32 0.32
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0386 0.1136
Echinococcus multilocularis neuropeptide s receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni biogenic amine receptor 0.0085 0.1727 0.3337
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0028 0.0028
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.1727 0.1727
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Echinococcus multilocularis neuropeptide FF receptor 2 0.0085 0.1727 0.1727
Brugia malayi jmjC domain containing protein 0.0019 0.0037 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0161 0.0475
Brugia malayi follicle stimulating hormone receptor 0.0085 0.1727 0.3337
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0217 0.512 1
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.1727 0.5087
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Echinococcus granulosus intermediate filament protein 0.0033 0.0386 0.0386
Schistosoma mansoni alpha-1 adrenergic receptor 0.0085 0.1727 0.3337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.015 0.3395 1
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.2355 0.4571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Brugia malayi G protein-coupled receptor 0.0085 0.1727 0.3337
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0331 0.0579
Echinococcus multilocularis neuropeptide receptor A26 0.0085 0.1727 0.1727
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0037 0.0018
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0331 0.0579
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0041 0.0122
Schistosoma mansoni hypothetical protein 0.0024 0.0161 0.0263
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0085 0.1727 0.5087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0161 0.0161
Echinococcus multilocularis orexin receptor type 2 0.0085 0.1727 0.1727
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0217 0.512 0.512
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0037 0.0037
Brugia malayi neuropeptide F receptor 0.0085 0.1727 0.3337
Schistosoma mansoni intermediate filament proteins 0.0033 0.0386 0.0703
Echinococcus granulosus lamin 0.0033 0.0386 0.0386
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0085 0.1727 0.1727
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.1727 0.1727
Onchocerca volvulus Neuropeptide F receptor homolog 0.0085 0.1727 0.73
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.1727 0.1727
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0142 0.32 0.9425
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.1727 0.1727
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0075 0.1475 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0331 0.0596
Brugia malayi jmjC domain containing protein 0.0019 0.0037 0.0018
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0028 0.0028
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0142 0.3197 0.6217
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.1829 0.1829
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.0028 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.1727 0.1727
Echinococcus multilocularis serotonin transporter 0.0109 0.2355 0.2355
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0331 0.0579
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus multilocularis RUN 0.0024 0.0161 0.0161
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.1727 0.3337
Schistosoma mansoni jumonji domain containing protein 0.0071 0.137 0.2637
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0037 0.0018
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0142 0.32 0.9425
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.137 0.137
Brugia malayi G protein-coupled receptor F59B2.13 0.0085 0.1727 0.3337
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.1206 0.3553
Schistosoma mansoni opsin-like receptor 0.0085 0.1727 0.3337
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.3199 0.3199
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.1277 0.2439
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0217 0.512 0.512
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0085 0.1727 0.3337
Onchocerca volvulus 0.0085 0.1727 0.73
Brugia malayi jmjC domain containing protein 0.0071 0.137 0.2637
Schistosoma mansoni lipoxygenase 0.01 0.2101 0.4072
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0331 0.0596
Echinococcus multilocularis lamin dm0 0.0033 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0109 0.2355 0.6938
Echinococcus granulosus peptide allatostatin:somatostatin 0.0085 0.1727 0.1727
Echinococcus multilocularis sex peptide receptor 0.0085 0.1727 0.1727
Brugia malayi G-protein coupled receptor 0.0085 0.1727 0.3337
Onchocerca volvulus 0.0085 0.1727 0.73
Brugia malayi jmjC domain containing protein 0.0019 0.0037 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0108
Schistosoma mansoni biogenic amine receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0037 0.0108
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0041 0.0122
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0217 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni myosin xvIII 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0331 0.0596
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0217 0.512 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0085 0.1727 0.5087
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0028 0.0081
Brugia malayi Tachykinin-like peptides receptor 99D 0.0085 0.1727 0.3337
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0085 0.1727 0.3337
Schistosoma mansoni histamine h1 receptor 0.0085 0.1727 0.3337
Brugia malayi RE15519p 0.0085 0.1727 0.3337
Echinococcus granulosus 7TM GPCR rhodopsin 0.0085 0.1727 0.1727
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0217 0.512 1
Schistosoma mansoni lamin 0.0033 0.0386 0.0703
Onchocerca volvulus 0.0024 0.0161 0.0574
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.1727 0.1727
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.1727 0.3337
Echinococcus granulosus sex peptide receptor 0.0085 0.1727 0.1727
Brugia malayi jmjC domain containing protein 0.0019 0.0037 0.0018
Schistosoma mansoni neuropeptide receptor 0.0085 0.1727 0.3337
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.1727 0.1727
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.1727 0.1727
Brugia malayi AKH receptor 0.0085 0.1727 0.3337
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0037 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.1727 0.5087
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0085 0.1727 0.3337
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0085 0.1727 0.1727
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.137 0.2637
Echinococcus granulosus g protein coupled receptor 0.0085 0.1727 0.1727
Echinococcus multilocularis serotonin receptor 0.0085 0.1727 0.1727
Schistosoma mansoni amine GPCR 0.0085 0.1727 0.3337
Loa Loa (eye worm) TYRA-2 protein 0.0085 0.1727 0.5087
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0217 0.512 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0085 0.1727 0.1727
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0161 0.0161
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0037 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0161 0.0161
Leishmania major cytochrome p450-like protein 0.0019 0.0041 0.0009
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0028 0.0028
Echinococcus multilocularis g-protein coupled receptor 0.0085 0.1727 0.1727
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0217 0.512 1
Echinococcus granulosus neuropeptide receptor A26 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni neuropeptide receptor 0.0085 0.1727 0.3337
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0041 0.0122
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus multilocularis serotonin receptor 0.0085 0.1727 0.1727
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0037 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0041 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0081
Echinococcus granulosus neuropeptide s receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus granulosus alpha 1A adrenergic receptor 0.0085 0.1727 0.1727
Echinococcus granulosus neuropeptide FF receptor 2 0.0085 0.1727 0.1727
Echinococcus multilocularis neuropeptide receptor 0.0085 0.1727 0.1727
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0142 0.3197 0.6217
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.1727 0.1727
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.1829 0.1829
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0217 0.512 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0085 0.1727 0.3337
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni amine GPCR 0.0085 0.1727 0.3337
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0217 0.512 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0041 0.0027
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0217 0.512 0.5
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0217 0.512 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0085 0.1727 0.5087
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0161 0.0161
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0037 0.0037
Onchocerca volvulus 0.0085 0.1727 0.73
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0217 0.512 1
Schistosoma mansoni amine GPCR 0.0085 0.1727 0.3337
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0217 0.512 1
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0085 0.1727 0.1727
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.1727 0.1727
Onchocerca volvulus 0.0085 0.1727 0.73
Echinococcus multilocularis lamin 0.0033 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0109 0.2355 0.6938
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.0028 0.0028
Echinococcus granulosus RUN 0.0024 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0108
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.1727 0.5087
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0161 0.0263
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.1727 0.3337
Echinococcus multilocularis neuropeptide receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis g protein coupled receptor 0.0085 0.1727 0.1727
Brugia malayi Melatonin receptor type 1A 0.0085 0.1727 0.3337
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0217 0.512 1
Brugia malayi jmjC domain containing protein 0.0071 0.137 0.2637
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Onchocerca volvulus 0.0109 0.2355 1
Schistosoma mansoni hypothetical protein 0.0085 0.1727 0.3337
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0085 0.1727 0.5087
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0085 0.1727 0.1727
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.1326 0.1326
Echinococcus granulosus tachykinin peptides receptor 99D 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.137 0.137
Schistosoma mansoni biogenic amine (5HT) receptor 0.0085 0.1727 0.3337
Plasmodium vivax JmjC domain containing protein 0.0019 0.0037 0.0018
Brugia malayi hypothetical protein 0.0085 0.1727 0.3337
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.1727 0.1727
Loa Loa (eye worm) hypothetical protein 0.0085 0.1727 0.5087
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0217 0.512 1
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0217 0.512 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.981071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.981071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Activity (binding) = 12.7 % Inhibition of ASM in human H4 cells assessed as residual activity at 10 uM ChEMBL. 18027916
Activity (binding) = 12.7 % Inhibition of ASM in human H4 cells assessed as residual activity at 10 uM ChEMBL. 18027916
Binding energy (ADMET) = 10.8 kCal mol-1 Binding energy of the compound was determined by using the equation deltaG obsd = -RT ln KD ChEMBL. 6094812
delta logD (ADMET) = -0.84 Delta logD (logD6.5 - logD7.4) ChEMBL. 10891117
ED50 (functional) = 0.14 mg kg-1 Antidepressent activity was evaluated by measuring its ability to antagonize RO 4-1284-induced hypothermia in mice ChEMBL. 3373495
ED50 (functional) = 0.14 mg kg-1 Antidepressent activity was evaluated by measuring its ability to antagonize RO 4-1284-induced hypothermia in mice ChEMBL. 3373495
ED50 (functional) = 0.43 mg kg-1 Antidepressent activity was evaluated by measuring its ability to antagonize reserpine-induced ptosis in mice ChEMBL. 3373495
ED50 (functional) = 0.43 mg kg-1 Antidepressent activity was evaluated by measuring its ability to antagonize reserpine-induced ptosis in mice ChEMBL. 3373495
F (ADMET) > 80 % Oral bioavailability in human ChEMBL. 10891117
F (ADMET) = 85 % Oral bioavailability in human ChEMBL. 17870541
F (ADMET) = 85 % Oral bioavailability in human ChEMBL. 17870541
IC50 (binding) = 2.1 10'-9M Binding affinity to human norepinephrine transporter by radioligand displacement assay ChEMBL. 23466604
IC50 (binding) = 2.8 10'-9M Displacement of [3H]nisoxetine from human recombinant norepinephrine transporter expressed in CHO cells measured after 120 mins by scintillation counting method LITERATURE. 27876250
IC50 (binding) = 9.1 10'-9M Displacement of radiolabeled protriptyline from human NET ChEMBL. 18983139
IC50 (binding) = 1.1 nM Inhibitory concentration against human Adenosine A3 receptor expressed in HEK-293 cells using 0.1 nM [3H]-AB-MECA ChEMBL. 16250647
IC50 (binding) = 1.1 nM Inhibitory concentration against human Adenosine A3 receptor expressed in HEK-293 cells using 0.1 nM [3H]-AB-MECA ChEMBL. 16250647
IC50 (binding) = 2.5 nM Binding affinity to human nonepinephrine transporter by radioligand displacement assay ChEMBL. 23582449
IC50 (binding) = 2.8 nM Displacement of [3H]nisoxentine from human recombinant norepinephrine transporter expressed in CHO cells ChEMBL. 26988801
IC50 (binding) = 7.1 nM Inhibition of human NET ChEMBL. 18588282
IC50 (binding) = 17 nM Inhibition of human aorepinephrine transporter ChEMBL. 20875743
IC50 (binding) = 0.0017 uM Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation counting ChEMBL. 22420844
IC50 (binding) < 10 uM Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex ChEMBL. 2579237
IC50 (binding) < 10 uM Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex ChEMBL. 2579237
Inhibition (functional) TP_TRANSPORTER: increase in Rhodamine 123 intracellular accumulation (R123: 150 uM, Protriptyline: 0.25 ug/mL) in MDR1-expressing Caco-2 cells ChEMBL. 11082465
Inhibition (binding) < 5 % Inhibition of beta-lactamase at 100 microM. ChEMBL. 14521410
Inhibition (binding) < 5 % Inhibition of chymotrypsin at 250 microM ChEMBL. 14521410
Inhibition (binding) < 5 % Inhibition of malate dehydrogenase(MDH) at 400 microM. ChEMBL. 14521410
Inhibition (binding) < 5 % Inhibition of beta-lactamase at 100 microM. ChEMBL. 14521410
Inhibition (binding) < 5 % Inhibition of chymotrypsin at 250 microM ChEMBL. 14521410
Inhibition (binding) < 5 % Inhibition of malate dehydrogenase(MDH) at 400 microM. ChEMBL. 14521410
Inhibition (binding) = 70.3 % Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 microM ChEMBL. 2579237
Inhibition (binding) = 70.3 % Inhibition of binding of Batrachotoxinin [3H]-BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 microM ChEMBL. 2579237
Kd (binding) = 1.4 nM Inhibition of human NET ChEMBL. 20945906
Ki (binding) = 1.6 10'-9M Binding affinity to human norepinephrine transporter by radioligand displacement assay ChEMBL. 23466604
Ki (binding) = 6.8 10'-9M Displacement of radiolabeled protriptyline from human NET ChEMBL. 18983139
Ki (binding) = 2 nM Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation counting ChEMBL. 22420844
Ki (binding) = 2.3 nM Displacement of [3H]nisoxetine from human NE transporter ChEMBL. 21726069
LD50 (ADMET) = 50 mg kg-1 Acute cytotoxicity of the compound was evaluated as LD50 in mice (ip) ChEMBL. 3373495
LD50 (ADMET) = 50 mg kg-1 Acute cytotoxicity of the compound was evaluated as LD50 in mice (ip) ChEMBL. 3373495
Log Kmemb = 1 Calculated membrane partition coefficient (Kmemb) ChEMBL. 15027870
logD (ADMET) = 0.34 Partition coefficient (logD6.5) ChEMBL. 10891117
pKa = 8.2 Ionization constant (pKa) ChEMBL. 10891117
Potency (functional) = 0.0071 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.058 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0595 uM PUBCHEM_BIOASSAY: HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488989, AID488993, AID488995] ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 5.7255 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.4241 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 895 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Thrombopoietin (TPO) Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 918 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Thrombopoietin (TPO) Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 917 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488989, AID488993, AID488995] ChEMBL. No reference
Potency (functional) 12.2898 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of ATXN expression: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588349, AID588380] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 23.1093 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.8078 uM PUBCHEM_BIOASSAY: qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

21 literature references were collected for this gene.

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