Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.06 uM | Inhibitory activity against Prostaglandin G/H synthase 2 in human whole blood assay as LPS induced PGE-2 generation. | ChEMBL. | 12639552 |
IC50 (binding) | = 1.06 uM | Inhibitory activity against Prostaglandin G/H synthase 2 in human whole blood assay as LPS induced PGE-2 generation. | ChEMBL. | 12639552 |
IC50 (binding) | > 500 uM | Inhibitory activity against Prostaglandin G/H synthase 1 in human whole blood assay as TXB2 generation | ChEMBL. | 12639552 |
IC50 (binding) | > 500 uM | Inhibitory activity against Prostaglandin G/H synthase 1 in human whole blood assay as TXB2 generation | ChEMBL. | 12639552 |
Ratio (binding) | > 470 | Ratio for inhibition of COX-1 to that of COX-2 | ChEMBL. | 12639552 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.