Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0982 | 0.6046 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0726 | 0.3226 | 0.3226 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.3226 | 0.3226 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.3414 | 0.3414 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.3414 | 0.3414 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.3414 | 0.3414 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.3414 | 0.3414 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.3226 | 0.3226 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0982 | 0.6046 | 0.5936 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1341 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0701 | 0.2956 | 0.2761 |
Onchocerca volvulus | 0.0701 | 0.2956 | 1 | |
Toxoplasma gondii | peptidase family M13 protein | 0.0982 | 0.6046 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0726 | 0.3226 | 0.3226 |
Loa Loa (eye worm) | hypothetical protein | 0.0487 | 0.0593 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.3414 | 0.3414 |
Loa Loa (eye worm) | hypothetical protein | 0.0743 | 0.3414 | 0.3414 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.107 | 0.7015 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.107 | 0.7015 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0982 | 0.6046 | 0.7611 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.6046 | 0.6046 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.6046 | 0.6046 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.107 | 0.7015 | 0.7015 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.6046 | 0.6046 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0982 | 0.6046 | 0.8466 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0982 | 0.6046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.3226 | 0.3226 |
Brugia malayi | Peptidase family M13 containing protein | 0.0982 | 0.6046 | 0.5936 |
Loa Loa (eye worm) | hypothetical protein | 0.0573 | 0.154 | 0.154 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0982 | 0.6046 | 0.7611 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0561 | 0.1416 | 0.1416 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0982 | 0.6046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 0.3226 | 0.3226 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.107 | 0.7015 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 19.3 nM | Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membrane | ChEMBL. | 11881994 |
Ki (binding) | = 19.3 nM | Inhibition of [3H]-paroxetine binding to serotonin transporter (SERT) of rat cortical membrane | ChEMBL. | 11881994 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-GBR-12,935 binding to dopamine transporter (DAT) of rat striatal membranes | ChEMBL. | 11881994 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-nisoxatine binding to norepinephrine transporter (NET) of rat cortical homogenates | ChEMBL. | 11881994 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-GBR-12,935 binding to dopamine transporter (DAT) of rat striatal membranes | ChEMBL. | 11881994 |
Ki (binding) | > 1000 nM | Inhibition of [3H]-nisoxatine binding to norepinephrine transporter (NET) of rat cortical homogenates | ChEMBL. | 11881994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.