Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0288 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0013 | 0.0288 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0185 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0.0288 | 1 | |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0288 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0013 | 0.0288 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0.0288 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0288 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0185 | 1 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0013 | 0.0288 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0288 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0013 | 0.0288 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0185 | 1 | 1 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0013 | 0.0288 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0185 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0013 | 0.0288 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0013 | 0.0288 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0013 | 0.0288 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0013 | 0.0288 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0013 | 0.0288 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0013 | 0.0288 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0185 | 1 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0013 | 0.0288 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0013 | 0.0288 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0013 | 0.0288 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0013 | 0.0288 | 0.5 |
Trypanosoma brucei | pteridine reductase 1 | 0.0013 | 0.0288 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0185 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0.0288 | 1 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0013 | 0.0288 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K aps (binding) | = 590000 l M-1 | Binding to human thrombin was measured using the inhibition of thrombinhydrolysis of Bz-Phe-Val-Arg-pNA | ChEMBL. | 10201846 |
K aps (binding) | = 590000 l M-1 | Binding to human thrombin was measured using the inhibition of thrombinhydrolysis of Bz-Phe-Val-Arg-pNA | ChEMBL. | 10201846 |
K ass (binding) | = 0.61 l uM-1 | In vitro inhibitory activity against human thrombin | ChEMBL. | 10691691 |
K ass (binding) | = 0.61 l uM-1 | In vitro inhibitory activity against human thrombin | ChEMBL. | 10691691 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.