Detailed information for compound 273069

Basic information

Technical information
  • TDR Targets ID: 273069
  • Name: N-[2-(3,4-dichlorophenyl)ethyl]-1-[5-methoxy- 2-(2-phenylethynyl)phenyl]-N-methylpropan-2-a mine
  • MW: 452.415 | Formula: C27H27Cl2NO
  • H donors: 0 H acceptors: 0 LogP: 7.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)CC(N(CCc1ccc(c(c1)Cl)Cl)C)C)C#Cc1ccccc1
  • InChi: 1S/C27H27Cl2NO/c1-20(30(2)16-15-22-10-14-26(28)27(29)18-22)17-24-19-25(31-3)13-12-23(24)11-9-21-7-5-4-6-8-21/h4-8,10,12-14,18-20H,15-17H2,1-3H3
  • InChiKey: NZKUWWPTVYTFEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3,4-dichlorophenyl)ethyl]-1-[5-methoxy-2-(2-phenylethynyl)phenyl]-N-methyl-propan-2-amine
  • N-[2-(3,4-dichlorophenyl)ethyl]-1-[5-methoxy-2-(2-phenylethynyl)phenyl]-N-methyl-2-propanamine
  • 2-(3,4-dichlorophenyl)ethyl-[2-[5-methoxy-2-(2-phenylethynyl)phenyl]-1-methyl-ethyl]-methyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.369 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0456 0.1068
Onchocerca volvulus 0.0037 0.0657 0.1952
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0657 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0456 0.1068
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0657 0.1561
Echinococcus granulosus dihydrofolate reductase 0.0044 0.0847 0.0838
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Brugia malayi dihydrofolate reductase family protein 0.0044 0.0847 0.1263
Schistosoma mansoni rab6-interacting 0.0021 0.0145 0.0135
Loa Loa (eye worm) hypothetical protein 0.0069 0.1596 0.2368
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0261 0.0587
Schistosoma mansoni lipoxygenase 0.0057 0.1261 0.1252
Loa Loa (eye worm) hypothetical protein 0.0052 0.1102 0.163
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.805 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.1068 0.1316
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0386 0.0575
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0657 0.0966
Brugia malayi polk-prov protein 0.0031 0.0456 0.068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0657 0.0979
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.3753 0.3747
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Onchocerca volvulus 0.0037 0.0657 0.1952
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0012
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0755 0.0927
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.03 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1078 0.1069
Loa Loa (eye worm) hypothetical protein 0.0026 0.03 0.0434
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0151 0.409 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0657 0.0943
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0151 0.409 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0145 0.0135
Schistosoma mansoni intermediate filament proteins 0.0053 0.1131 0.1123
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0665 0.0644
Echinococcus multilocularis geminin 0.0347 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0558 0.1317
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0484 0.0474
Mycobacterium tuberculosis Conserved protein 0.0037 0.0657 0.0943
Onchocerca volvulus 0.0053 0.1131 0.3761
Toxoplasma gondii ABC1 family protein 0.0037 0.0657 0.1561
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0012
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0044 0.0847 0.1226
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0769 0.0944
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.1261 0.1252
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.6755 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0484 0.0707
Mycobacterium tuberculosis Conserved protein 0.0037 0.0657 0.0943
Schistosoma mansoni hypothetical protein 0.0032 0.0484 0.0474
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0657 0.0648
Mycobacterium ulcerans thymidylate synthase 0.0107 0.2768 0.6959
Echinococcus multilocularis GPCR, family 2 0.0032 0.0484 0.0474
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0665 0.0815
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0665 0.1581
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0769 0.1836
Loa Loa (eye worm) beta-lactamase 0.0037 0.0657 0.0966
Loa Loa (eye worm) acetyltransferase 0.014 0.3753 0.5587
Echinococcus multilocularis musashi 0.0053 0.1131 0.1123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1078 0.1069
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0051 0.1068 0.2571
Schistosoma mansoni lamin 0.0053 0.1131 0.1123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Schistosoma mansoni polycystin 1-related 0.0021 0.0145 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1078 0.1069
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0755 0.0746
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0145 0.0135
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0022 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0261 0.0587
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.671 0.6707
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.3278 0.4877
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Onchocerca volvulus 0.0037 0.0657 0.1952
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0107 0.2768 0.6959
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.369 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.039
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.1131 0.1686
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.1131 0.1674
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0374
Echinococcus granulosus intermediate filament protein 0.0053 0.1131 0.1123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0657 0.0966
Loa Loa (eye worm) hypothetical protein 0.0037 0.0657 0.0966
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0657 0.0805
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.001 0.0015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0657 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Brugia malayi beta-lactamase 0.0037 0.0657 0.0979
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.03 0.0291
Loa Loa (eye worm) hypothetical protein 0.0021 0.0145 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.3634 0.3628
Schistosoma mansoni hypothetical protein 0.0032 0.0484 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.3753 0.3747
Schistosoma mansoni hypothetical protein 0.0032 0.0484 0.0474
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0044 0.0847 0.0628
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0145 0.0135
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0484 0.0474
Schistosoma mansoni lamin 0.0053 0.1131 0.1123
Schistosoma mansoni lipoxygenase 0.0021 0.0145 0.0135
Schistosoma mansoni hypothetical protein 0.0049 0.0991 0.0982
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.3278 0.4877
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.001 0.0015
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0145 0.0135
Brugia malayi hypothetical protein 0.0238 0.671 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0022 0.0033
Schistosoma mansoni hypothetical protein 0.0347 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0755 0.1803
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0261 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0022 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0657 0.1561
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0769 0.1836
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0657 0.0805
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2555 0.3807
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0755 0.0324
Brugia malayi hypothetical protein 0.0021 0.0145 0.0216
Loa Loa (eye worm) hypothetical protein 0.0032 0.0484 0.0707
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0012
Schistosoma mansoni hypothetical protein 0.0021 0.0145 0.0135
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0386 0.0561
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.671 0.6707
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.369 0.5447
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0657 0.0943
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0657 0.0648
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0107 0.2768 0.276
Echinococcus granulosus GPCR family 2 0.0032 0.0484 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0156 0.0331
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0755 0.0324
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1078 0.1069
Loa Loa (eye worm) dihydrofolate reductase 0.0044 0.0847 0.125
Brugia malayi beta-lactamase family protein 0.0037 0.0657 0.0979
Schistosoma mansoni loxhd1 0.0021 0.0145 0.0135
Loa Loa (eye worm) hypothetical protein 0.0238 0.671 1
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.001 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0657 0.1561
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0484 0.0721
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0044 0.0847 0.0628
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0484 0.0474
Brugia malayi hypothetical protein 0.0024 0.0261 0.0388
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0657 0.0966
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2555 0.3807
Leishmania major hypothetical protein, conserved 0.0037 0.0657 0.1561
Echinococcus multilocularis lamin dm0 0.0053 0.1131 0.1123
Trichomonas vaginalis esterase, putative 0.0037 0.0657 0.0805
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2555 0.3798
Onchocerca volvulus 0.0049 0.0991 0.3225
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0261 0.0587
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0657 0.0805
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0261 0.0587
Echinococcus multilocularis lamin 0.0053 0.1131 0.1123
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0145 0.0303
Schistosoma mansoni hypothetical protein 0.0347 1 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0151 0.409 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.1261 0.1252
Mycobacterium tuberculosis Hypothetical protein 0.0051 0.1068 0.1553
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.805 1
Schistosoma mansoni hypothetical protein 0.0032 0.0484 0.0474
Brugia malayi intermediate filament protein 0.0053 0.1131 0.1686
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0145 0.0303
Echinococcus granulosus thymidylate synthase 0.0107 0.2768 0.276
Echinococcus granulosus lamin 0.0053 0.1131 0.1123
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0657 0.0943
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0261 0.0587
Brugia malayi beta-lactamase family protein 0.0037 0.0657 0.0979
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0022 0.0012
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0769 0.0944
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0151 0.409 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0769 0.1836
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1078 0.1594
Leishmania major hypothetical protein, conserved 0.0024 0.0261 0.0587
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0145 0.0135
Loa Loa (eye worm) thymidylate synthase 0.0107 0.2768 0.4116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0657 0.0943
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1596 0.2379
Brugia malayi hypothetical protein 0.0021 0.0145 0.0216
Schistosoma mansoni rab6-interacting 0.0021 0.0145 0.0135
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0151 0.409 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0151 0.409 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0145 0.0202
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0657 0.0805
Loa Loa (eye worm) hypothetical protein 0.0037 0.0657 0.0966
Loa Loa (eye worm) hypothetical protein 0.0031 0.0456 0.0666
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0484 0.0721
Loa Loa (eye worm) hypothetical protein 0.01 0.2555 0.3798
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0261 0.0587
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0755 0.1803
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0657 0.0648
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0657 0.0648
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.3753 0.5593
Chlamydia trachomatis dihydrofolate reductase 0.0044 0.0847 0.5
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.805 0.5
Brugia malayi Doublecortin family protein 0.0021 0.0145 0.0216
Schistosoma mansoni survival motor neuron protein 0.0049 0.0991 0.0982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.805 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0145 0.0135
Onchocerca volvulus 0.0107 0.2768 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.805 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0156 0.0331
Brugia malayi thymidylate synthase 0.0107 0.2768 0.4124
Loa Loa (eye worm) intermediate filament protein 0.0053 0.1131 0.1674
Brugia malayi Dihydrofolate reductase 0.0044 0.0847 0.1263
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0022 0.0012
Onchocerca volvulus 0.0053 0.1131 0.3761
Leishmania major DNA polymerase kappa, putative 0.0021 0.0156 0.0331
Echinococcus multilocularis thymidylate synthase 0.0107 0.2768 0.276
Echinococcus multilocularis dihydrofolate reductase 0.0044 0.0847 0.0838
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1078 0.1606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1078 0.1069
Loa Loa (eye worm) hypothetical protein 0.0053 0.1131 0.1674
Trypanosoma brucei unspecified product 0.0034 0.0558 0.1317
Loa Loa (eye worm) hypothetical protein 0.0025 0.0271 0.039
Schistosoma mansoni hypothetical protein 0.0069 0.1596 0.1588
Brugia malayi hypothetical protein 0.0051 0.1068 0.1591
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0769 0.076
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0657 0.0943
Brugia malayi MH2 domain containing protein 0.0124 0.3278 0.4885
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0156 0.02
Schistosoma mansoni dihydrofolate reductase 0.0044 0.0847 0.0838
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1078 0.1069
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0657 0.1561
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0022 0.0033
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0107 0.2768 0.4078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0991 0.1477
Mycobacterium tuberculosis Conserved protein 0.0037 0.0657 0.0943
Echinococcus granulosus lamin dm0 0.0053 0.1131 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0657 0.0943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1078 0.1069
Echinococcus granulosus RUN 0.0021 0.0145 0.0135
Echinococcus granulosus dna polymerase kappa 0.0041 0.0755 0.0746
Loa Loa (eye worm) hypothetical protein 0.0037 0.0657 0.0966
Loa Loa (eye worm) hypothetical protein 0.0037 0.0657 0.0966
Echinococcus multilocularis RUN 0.0021 0.0145 0.0135
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0755 0.0927
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0755 0.1803
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0484 0.0474

Activities

Activity type Activity value Assay description Source Reference
C175 (functional) = 0.004 uM Concentration needed to elicit a 75% increase beyond control in coronary flow in ''Langendorff'', guinea pig heart (in vitro) ChEMBL. 3346879
Control (functional) = 90 % Concentration needed to achieve a 75% increase in coronary blood flow in 'Langendorff', guinea pig heart (in vitro negative inotropic activity) ChEMBL. 3346879
Max fall in blood pressure (functional) = 67 mmHg Ability to lower blood pressure in the spontaneously hypertensive rat (SHR) at 1 mg/kg (p.o.) ChEMBL. 3346879
P (Ei) (functional) > 0.5 Concentration needed to achieve a 75% increase in coronary blood flow in 'Langendorff', guinea pig heart (in vitro Negative inotropic potency) ChEMBL. 3346879

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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