Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.2747 | 0.5 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0106 | 0.5947 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0161 | 1 | 0.5 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0124 | 0.7245 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.2747 | 0.5 |
Brugia malayi | methionyl-tRNA synthetase | 0.0124 | 0.7245 | 0.7245 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0106 | 0.5947 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0107 | 0.5995 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5947 | 0.992 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.2747 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0063 | 0.2747 | 0.2747 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0063 | 0.2747 | 0.2747 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0161 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.2747 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.2112 | 0.3522 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0161 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0161 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 1 | 0.5 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0106 | 0.5947 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0161 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0161 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0161 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.2747 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0161 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.2747 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 1 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0124 | 0.7245 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.2112 | 0.2112 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 170 nM | Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
IC50 (binding) | = 170 nM | Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
MIC (functional) | = 8 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis 1 | ChEMBL. | 12639554 |
MIC (functional) | = 32 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus aureus Oxford | ChEMBL. | 12639554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.