Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Serotonin 2a (5-HT2a) receptor | 471 aa | 422 aa | 27.5 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Serotonin 2a (5-HT2a) receptor | 471 aa | 405 aa | 25.4 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 408 aa | 21.8 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Serotonin 2a (5-HT2a) receptor | 471 aa | 435 aa | 23.0 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 462 aa | 21.2 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 417 aa | 20.6 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 416 aa | 19.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0216 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0216 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0216 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0216 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0216 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0216 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0216 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0216 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0216 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0216 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0216 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0107 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0216 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0216 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0216 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0133 | 0.2407 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0216 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0216 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0191 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0216 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0216 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0216 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0109 | 0.0151 | 0.0151 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0191 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0107 | 0 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0216 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0216 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0133 | 0.2407 | 0.2407 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 4.59 | Ability to block alpha-1 adrenergic receptor-mediated contractions of rat aorta. | ChEMBL. | 10052973 |
Kd (functional) | = 8.06 | Blocking 5-HT2A receptor-mediated contractions of rat tail artery | ChEMBL. | 10052973 |
pA2 (functional) | = 4.59 | Ability to block alpha-1 adrenergic receptor-mediated contractions of rat aorta. | ChEMBL. | 10052973 |
pA2 (functional) | = 8.06 | Blocking 5-HT2A receptor-mediated contractions of rat tail artery | ChEMBL. | 10052973 |
Specificity (functional) | = 2951 | Specificity towards 5-HT2A receptor to that of alpha-1 adrenoceptor. | ChEMBL. | 10052973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.