Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0311 | 0.0344 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0233 | 0.2717 | 0.5 |
Toxoplasma gondii | FATC domain-containing protein | 0.0024 | 0.0053 | 0.0053 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0053 | 0.0053 |
Onchocerca volvulus | 0.0572 | 0.703 | 1 | |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0104 | 0.1072 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0443 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.001 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0295 | 0.0327 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0053 | 0.0165 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0045 | 0.0316 | 0.0449 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0311 | 0.0344 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.2027 | 0.2244 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.3932 | 0.5592 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0053 | 0.0495 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0045 | 0.0316 | 0.0349 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0416 | 0.0416 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0805 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0729 | 0.9035 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0729 | 0.9035 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0729 | 0.9035 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0572 | 0.703 | 0.7781 |
Echinococcus granulosus | dihydrofolate reductase | 0.0233 | 0.2717 | 0.3007 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0272 | 0.3212 | 0.3212 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0045 | 0.0316 | 0.0349 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.0047 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0047 | 0.0052 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0179 | 0.0255 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.0047 | 0.0052 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0311 | 0.0344 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0316 | 0.0982 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0416 | 0.0592 |
Loa Loa (eye worm) | thymidylate synthase | 0.0572 | 0.703 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0051 | 0.0396 | 0.0438 |
Echinococcus multilocularis | muscleblind protein | 0.0329 | 0.3932 | 0.4352 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.3932 | 0.5592 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0106 | 0.1092 | 0.1209 |
Brugia malayi | Muscleblind-like protein | 0.0329 | 0.3932 | 0.5592 |
Echinococcus multilocularis | geminin | 0.0179 | 0.2027 | 0.2244 |
Brugia malayi | dihydrofolate reductase family protein | 0.0233 | 0.2717 | 0.3864 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0311 | 0.0344 |
Brugia malayi | CHE-14 protein | 0.0045 | 0.0316 | 0.0449 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0805 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0572 | 0.703 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0272 | 0.3212 | 0.4569 |
Mycobacterium ulcerans | thymidylate synthase | 0.0572 | 0.703 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0311 | 0.0344 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0311 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0316 | 0.0449 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0572 | 0.703 | 1 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1257 | 0.1788 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0295 | 0.0327 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0233 | 0.2717 | 0.3864 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1257 | 0.1788 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0416 | 0.0416 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0024 | 0.0053 | 0.0059 |
Brugia malayi | thymidylate synthase | 0.0572 | 0.703 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0805 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0295 | 0.0327 |
Brugia malayi | Dihydrofolate reductase | 0.0233 | 0.2717 | 0.3864 |
Echinococcus multilocularis | expressed conserved protein | 0.0098 | 0.0992 | 0.1098 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0149 | 0.1641 | 0.1816 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0805 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0045 | 0.0316 | 0.0349 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0311 | 0.0442 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0024 | 0.0053 | 0.0059 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0805 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1257 | 0.1788 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0416 | 0.0416 |
Echinococcus granulosus | expressed conserved protein | 0.0098 | 0.0992 | 0.1098 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0179 | 0.2027 | 0.2244 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0416 | 0.0416 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0233 | 0.2717 | 0.3864 |
Schistosoma mansoni | dihydrofolate reductase | 0.0233 | 0.2717 | 0.3007 |
Echinococcus multilocularis | thymidylate synthase | 0.0572 | 0.703 | 0.7781 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0311 | 0.0344 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0149 | 0.1641 | 0.1816 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0024 | 0.0053 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1072 | 0.1525 |
Echinococcus granulosus | muscleblind protein | 0.0329 | 0.3932 | 0.4352 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0104 | 0.1072 | 0.1186 |
Schistosoma mansoni | patched 1 | 0.0045 | 0.0316 | 0.0349 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0104 | 0.1072 | 0.1186 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0295 | 0.0327 |
Brugia malayi | hypothetical protein | 0.0272 | 0.3212 | 0.4569 |
Echinococcus granulosus | serine protein kinase ATM | 0.0024 | 0.0053 | 0.0059 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0045 | 0.0316 | 0.0349 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0416 | 0.0416 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0233 | 0.2717 | 0.3864 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0233 | 0.2717 | 0.3007 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0329 | 0.3932 | 0.4352 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0104 | 0.1072 | 0.1525 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0311 | 0.0344 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0416 | 0.0416 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0053 | 0.0053 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 0.3212 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.2027 | 0.2244 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0416 | 0.0592 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0416 | 0.0416 |
Echinococcus granulosus | thymidylate synthase | 0.0572 | 0.703 | 0.7781 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Compound was measured for its inhibitory activity against Cell division cycle 25B | ChEMBL. | 10762045 |
IC50 (binding) | > 100 uM | Compound was measured for its inhibitory activity against Cell division cycle 25B | ChEMBL. | 10762045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.