Detailed information for compound 273471

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.462 | Formula: C20H22N2O8S
  • H donors: 3 H acceptors: 6 LogP: 0.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1O)n1cc(C#CCCOS(=O)(=O)c2ccc(cc2)C)c(=O)[nH]c1=O
  • InChi: 1S/C20H22N2O8S/c1-13-5-7-15(8-6-13)31(27,28)29-9-3-2-4-14-11-22(20(26)21-19(14)25)18-10-16(24)17(12-23)30-18/h5-8,11,16-18,23-24H,3,9-10,12H2,1H3,(H,21,25,26)
  • InChiKey: UGJLBGMWICKKCG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0081 0.0242
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0205 0.2184
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1935 0.308
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0108 0.0816 0.1278
Trichomonas vaginalis ran, putative 0.0042 0.027 0.0416
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0836 0.8837
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.2872 0.4579
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.02 0.0303
Schistosoma mansoni hypothetical protein 0.0016 0.005 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Schistosoma mansoni importin beta-1 0.0057 0.0396 0.0386
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0036 0.0219 0.0333
Entamoeba histolytica hypothetical protein 0.0037 0.0227 0.0347
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0179 0.0169
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1219 1 1
Echinococcus multilocularis translational activator gcn1 0.0011 0.001 0.0009
Onchocerca volvulus 0.0031 0.0179 0.0592
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.033 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Echinococcus granulosus pyruvate kinase 0.0034 0.0205 0.0204
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0081 0.0113
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.0219 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Giardia lamblia Hypothetical protein 0.0273 0.2178 0.3417
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.6413 0.6413
Echinococcus granulosus pyruvate kinase 0.0018 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0227 0.0226
Echinococcus multilocularis aminopeptidase N 0.0034 0.02 0.0199
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0516 0.4189 0.8383
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0938 1
Echinococcus multilocularis dUTP pyrophosphatase 0.0331 0.2657 0.2656
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0059 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0205 0.0688
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0036 0.0219 0.0218
Entamoeba histolytica hypothetical protein 0.0331 0.2657 0.4235
Entamoeba histolytica hypothetical protein 0.0047 0.0306 0.0473
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0164 0.0164
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0119 0.0236
Brugia malayi Thioredoxin reductase 0.0049 0.0322 0.0768
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0205 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0059 0.0079
Entamoeba histolytica hypothetical protein 0.0489 0.3965 0.6328
Trichomonas vaginalis thymidine kinase, putative 0.0767 0.626 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0331 0.2657 0.4235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0081 0.0099
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.001 0.0019
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.02 0.019
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0322 0.0485
Toxoplasma gondii exonuclease III APE 0.0019 0.0081 0.0266
Echinococcus granulosus muscleblind protein 0.0154 0.1193 0.1192
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.0219 0.0333
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0089 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0205 0.0408
Schistosoma mansoni hypothetical protein 0.0026 0.0138 0.0128
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0059 0.0185
Entamoeba histolytica hypothetical protein 0.005 0.033 0.0512
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0059 0.0079
Echinococcus multilocularis protein quaking 0.0026 0.0138 0.0137
Giardia lamblia Thymidine kinase 0.0767 0.626 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.02 0.029
Leishmania major importin beta-1 subunit, putative 0.0047 0.0306 0.0473
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0012 0.0019 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.2178 0.3469
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0081 0.0113
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0179 0.0178
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0604 0.4915 0.7848
Leishmania major trypanothione reductase 0.0049 0.0322 0.0498
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.4189 0.6686
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0273 0.2178 0.2178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0309 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0179 0.0169
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.02 0.029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0479
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.0219 0.0209
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0219 0.0333
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0205 0.0408
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0396 0.0395
Schistosoma mansoni hypothetical protein 0.0338 0.2715 0.2707
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0019 0.0031
Plasmodium falciparum glutathione reductase 0.0017 0.0059 0.0185
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.0102 0.0091
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.0115 0.0871 0.3122
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.0219 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0031 0.0033
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0059 0.0079
Trypanosoma cruzi thymidine kinase, putative 0.0767 0.626 1
Onchocerca volvulus 0.0028 0.015 0.0487
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0219 0.0522
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0331 0.2657 1
Echinococcus granulosus serine protein kinase ATM 0.005 0.033 0.0329
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0516 0.4189 1
Plasmodium falciparum thioredoxin reductase 0.0017 0.0059 0.0185
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0273 0.2178 0.217
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.02 0.0303
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0108 0.0816 0.1278
Brugia malayi hypothetical protein 0.0026 0.0138 0.033
Schistosoma mansoni cpg binding protein 0.0028 0.015 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0081 0.0266
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0331 0.2657 1
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1193 0.1192
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0019 0.0036
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0306 0.0473
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0036 0.0219 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0309 0.0308
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0081 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Loa Loa (eye worm) hypothetical protein 0.0154 0.1193 0.2387
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0544
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0036 0.0219 0.032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0138 0.0275
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0273 0.2178 0.2178
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0322 0.0321
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0012 0.0019 0.0018
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0019 0.0013
Schistosoma mansoni hypothetical protein 0.0396 0.3195 0.3188
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.02 0.0303
Echinococcus granulosus transportin 1 0.0011 0.001 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0205 0.0408
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0081 0.0113
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0179 0.0636
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0614 0.4997 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.02 0.0303
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0066 0.0211
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.027 0.027
Brugia malayi Peptidase family M1 containing protein 0.0034 0.02 0.0477
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.027 0.034
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0108 0.0816 0.1278
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0205 0.0688
Loa Loa (eye worm) hypothetical protein 0.0057 0.0396 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0059 0.0142
Echinococcus multilocularis thymidine kinase 0.1219 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0219 0.0436
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0205 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0059 0.0065
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0836 0.8837
Echinococcus granulosus dUTP pyrophosphatase 0.0331 0.2657 0.2656
Leishmania major pyruvate kinase 0.0034 0.0205 0.0311
Echinococcus multilocularis pyruvate kinase 0.0018 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0034 0.0205 0.0408
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0036 0.0219 0.032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0099
Schistosoma mansoni pyruvate kinase 0.0034 0.0205 0.0195
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.0816 0.129
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.02 0.0303
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.0219 0.0218
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Plasmodium vivax importin-beta 2, putative 0.0057 0.0396 0.1457
Giardia lamblia Pyruvate kinase 0.0018 0.0066 0.0011
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0019 0.0045
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.027 0.0539
Brugia malayi dUTP diphosphatase 0.0331 0.2657 0.6343
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0081 0.0082
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0081 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0306 0.0473
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0079
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.001 0.0019
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0012 0.0019 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Loa Loa (eye worm) glutathione reductase 0.0049 0.0322 0.0642
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0036
Echinococcus multilocularis snurportin 1 0.0614 0.4997 0.4996
Echinococcus granulosus pyruvate kinase 0.0018 0.0066 0.0065
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0938 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0081 0.0034
Entamoeba histolytica aminopeptidase, putative 0.0034 0.02 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0179 0.0169
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0036 0.0219 0.0321
Brugia malayi kap beta 3 protein 0.0011 0.001 0.0025
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0331 0.2657 0.4235
Brugia malayi hypothetical protein 0.0037 0.0227 0.0542
Brugia malayi glutathione reductase 0.0049 0.0322 0.0768
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.4189 0.6686
Brugia malayi Peptidase family M1 containing protein 0.0034 0.02 0.0477
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0205 0.0311
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0176
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0309 0.0616
Onchocerca volvulus Glucosylceramidase homolog 0.0339 0.2721 1
Plasmodium falciparum importin beta, putative 0.0057 0.0396 0.1457
Mycobacterium ulcerans aminopeptidase N PepN 0.0034 0.02 0.2127
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0115 0.0871 0.9235
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.027 0.0403
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0059 0.0185
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0059 0.0079
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0331 0.2657 0.2649
Loa Loa (eye worm) tumor suppressor 0.0311 0.2495 0.4993
Brugia malayi RNA, U transporter 1 0.0164 0.1273 0.3038
Echinococcus granulosus cpg binding protein 0.0029 0.0164 0.0163
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.015 0.0299
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.4189 0.6686
Schistosoma mansoni pyruvate kinase 0.0034 0.0205 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0031 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0219 0.0787
Echinococcus multilocularis pyruvate kinase 0.0034 0.0205 0.0204
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.027 0.0982
Echinococcus granulosus importin 5 0.0011 0.001 0.0009
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0205 0.1654
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0059 0.0185
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0108 0.0816 0.129
Giardia lamblia Pyruvate kinase 0.0034 0.0205 0.0234
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.0102 0.0101
Schistosoma mansoni hypothetical protein 0.0614 0.4997 0.4992
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0306 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.2178 0.3469
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0059 0.0079
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0273 0.2178 0.3417
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0081 0.0099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0179 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.2178 0.3469
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.0219 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.2178 0.3469
Plasmodium falciparum thioredoxin reductase 0.0049 0.0322 0.1176
Echinococcus granulosus protein quaking 0.0026 0.0138 0.0137
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.0816 0.129
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0331 0.2657 1
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0205 0.0311
Entamoeba histolytica hypothetical protein 0.0489 0.3965 0.6328
Onchocerca volvulus 0.0034 0.02 0.067
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.0219 0.0333
Loa Loa (eye worm) hypothetical protein 0.0022 0.0102 0.0202
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0205 0.0311
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0205 0.0734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0309 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0089 0.0212
Brugia malayi CXXC zinc finger family protein 0.0028 0.015 0.0359
Echinococcus granulosus pyruvate kinase 0.0018 0.0066 0.0065
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0036 0.0219 0.0333
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0119 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.02 0.0303
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0059 0.0065
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Schistosoma mansoni cpg binding protein 0.0029 0.0164 0.0153
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0836 0.8837
Loa Loa (eye worm) hypothetical protein 0.0024 0.0119 0.0236
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0036 0.0219 0.0333
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0836 0.8837
Echinococcus multilocularis geminin 0.0338 0.2715 0.2714
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0012 0.0019 0.0031
Entamoeba histolytica thymidine kinase, putative 0.0767 0.626 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0012 0.0019 0.0018
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0179 0.0178
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0115 0.0871 0.1376
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0108 0.0156
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0205 0.0489
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0108 0.0816 0.129
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0115 0.0871 0.1376
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0049
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0023 0.0054
Entamoeba histolytica hypothetical protein 0.0037 0.0227 0.0347
Entamoeba histolytica hypothetical protein 0.0037 0.0227 0.0347
Brugia malayi TATA binding protein associated factor 0.0012 0.0019 0.0045
Brugia malayi Pre-SET motif family protein 0.0214 0.1691 0.4038
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Plasmodium vivax glutathione reductase, putative 0.0049 0.0322 0.1176
Echinococcus multilocularis importin 5 0.0011 0.001 0.0009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0081 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0309 0.0298
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0019 0.0008
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0219 0.032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0036
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0089 0.0078
Leishmania major pyruvate kinase 0.0034 0.0205 0.0311
Giardia lamblia GTOR 0.0036 0.0219 0.0257
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0019 0.0013
Loa Loa (eye worm) deoxynucleoside kinase 0.0273 0.2178 0.4358
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.2872 0.4579
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0019 0.0031
Trypanosoma brucei calpain, putative 0.0108 0.0816 0.129
Schistosoma mansoni hypothetical protein 0.0338 0.2715 0.2707
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.4189 0.6686
Trypanosoma brucei trypanothione reductase 0.0049 0.0322 0.0498
Trypanosoma brucei hypothetical protein 0.0108 0.0816 0.129
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.2178 0.3469
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0036 0.0219 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.4189 0.6686
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0023 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Brugia malayi Deoxynucleoside kinase family protein 0.0273 0.2178 0.52
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0019 0.0031
Trypanosoma brucei calpain-like protein, putative 0.0108 0.0816 0.129
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0036
Echinococcus granulosus snurportin 1 0.0614 0.4997 0.4996
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0938 1
Brugia malayi Temporarily assigned gene name protein 44 0.0026 0.0138 0.033
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0396 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0322 0.0642
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0836 0.8607
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.0273 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0179 0.0178
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0331 0.2657 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.02 0.0199
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0081 0.016
Echinococcus granulosus importin subunit beta 1 0.0057 0.0396 0.0395
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0205 0.0311
Leishmania major thymidine kinase, putative 0.0767 0.626 1
Entamoeba histolytica Ran family GTPase 0.0042 0.027 0.0416
Brugia malayi Importin beta-1 subunit 0.0057 0.0396 0.0945
Echinococcus granulosus dnaJ subfamily B 0.0396 0.3195 0.3195
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0108 0.0816 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0322 0.1176
Entamoeba histolytica hypothetical protein 0.0331 0.2657 0.4235
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.027 0.027
Echinococcus granulosus geminin 0.0338 0.2715 0.2714
Loa Loa (eye worm) hypothetical protein 0.0022 0.0102 0.0202
Echinococcus multilocularis serine protein kinase ATM 0.005 0.033 0.0329
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0219 0.032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0309 0.0737
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0309 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.033 0.0512
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Echinococcus granulosus thymidine kinase 0.1219 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0108 0.0156
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0059 0.0185
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.0816 0.129
Onchocerca volvulus 0.0034 0.02 0.067
Brugia malayi hypothetical protein 0.0012 0.0019 0.0045
Echinococcus multilocularis pyruvate kinase 0.0018 0.0066 0.0065
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0089 0.0088
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0059 0.0065
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.3195 0.3195
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.02 0.019
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.027 0.0982
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0418 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Schistosoma mansoni cpg binding protein 0.0029 0.0164 0.0153
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0059 0.0479
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0219 0.0436
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0108 0.0156
Loa Loa (eye worm) aminopeptidase N 0.0034 0.02 0.0398
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0036 0.0219 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0019 0.0013
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0081 0.0728
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0023 0.0108 0.0368
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0081 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0081 0.0082
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0108 0.0816 0.1278
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0938 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0205 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0108 0.0816 0.129
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Brugia malayi FAT domain containing protein 0.0016 0.005 0.0121
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0331 0.2657 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0205 0.0298
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0604 0.4915 0.7848
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0019 0.0031
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0108 0.0816 0.129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0065
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.02 0.029
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0331 0.2657 0.4235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0065
Giardia lamblia Hypothetical protein 0.0273 0.2178 0.3417
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0205 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trichomonas vaginalis thymidine kinase, putative 0.0767 0.626 1
Trichomonas vaginalis thymidine kinase, putative 0.0767 0.626 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0115 0.0871 1
Schistosoma mansoni ap endonuclease 0.0019 0.0081 0.007
Plasmodium falciparum pyruvate kinase 0.0034 0.0205 0.0734
Loa Loa (eye worm) dUTP diphosphatase 0.0331 0.2657 0.5317
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0059 0.0185
Plasmodium falciparum glutathione reductase 0.0049 0.0322 0.1176
Loa Loa (eye worm) hypothetical protein 0.0023 0.0108 0.0214
Echinococcus multilocularis muscleblind protein 0.0154 0.1193 0.1192
Echinococcus multilocularis transfer RNA-Ile 0.1219 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0836 0.8837
Echinococcus multilocularis transportin 1 0.0011 0.001 0.0009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1691 0.3384
Leishmania major GTP-binding protein, putative 0.0042 0.027 0.0416
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.0816 0.129
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0016 0.005 0.005
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0006 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0059 0.0479
Toxoplasma gondii thioredoxin reductase 0.0049 0.0322 0.1176
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0604 0.4915 0.7848
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.0219 0.0218
Onchocerca volvulus 0.0244 0.1935 0.7092
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0115 0.0871 0.1376
Echinococcus multilocularis thymidine kinase 0.1219 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0059 0.0079
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0012 0.0019 0.0036
Plasmodium vivax SET domain protein, putative 0.0031 0.0179 0.0636
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0079
Brugia malayi Muscleblind-like protein 0.0154 0.1193 0.2849
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0108 0.0816 0.129
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0227 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0227 0.0217
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0396 0.1457
Schistosoma mansoni ran 0.0042 0.027 0.026
Entamoeba histolytica hypothetical protein 0.0037 0.0227 0.0347
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.027 0.0982
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0396 0.0617
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0026 0.0138 0.0128
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0604 0.4915 0.7848
Trypanosoma cruzi thymidine kinase, putative 0.0767 0.626 1
Echinococcus multilocularis pyruvate kinase 0.0027 0.0145 0.0144
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0066 0.0211
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.027 0.0646
Toxoplasma gondii FATC domain-containing protein 0.005 0.033 0.1208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0309 0.0298
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.0816 0.129
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.0115 0.0871 0.3122
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.005 0.0064
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0019 0.0036
Giardia lamblia Deoxynucleoside kinase 0.0638 0.52 0.8291
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0179 0.0169
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0089 0.0125
Brugia malayi tumor suppressor. 0.0311 0.2495 0.5957
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0306 0.046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.027 0.0403
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0066 0.0211
Leishmania major phosphatidylinositol kinase related protein, putative 0.0036 0.0219 0.0334
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0081 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Schistosoma mansoni hypothetical protein 0.0037 0.0227 0.0217
Echinococcus granulosus hypothetical protein 0.0026 0.0138 0.0137
Trypanosoma brucei thymidine kinase 0.0767 0.626 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Loa Loa (eye worm) hypothetical protein 0.0022 0.0102 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.0219 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0089 0.0125
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0365 0.1341
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.02 0.0303
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.02 0.0199
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.005 0.033 0.0499
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0331 0.2657 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0019 0.0018
Mycobacterium tuberculosis Probable reductase 0.0111 0.0836 0.8837
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0089 0.0088
Echinococcus multilocularis cpg binding protein 0.0029 0.0164 0.0163
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0115 0.0871 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0066 0.0056
Brugia malayi Pre-SET motif family protein 0.0031 0.0179 0.0427
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0219 0.0333
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0089 0.0112
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0036 0.0219 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0309 0.0308
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0081 0.0113
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.005 0.033 0.032
Brugia malayi hypothetical protein 0.0034 0.02 0.0477
Echinococcus multilocularis pyruvate kinase 0.0018 0.0066 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Chlamydia trachomatis pyruvate kinase 0.0034 0.0205 0.0559
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0022 0.0102 0.0133
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.027 0.0416
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0019 0.0031
Loa Loa (eye worm) hypothetical protein 0.0154 0.1193 0.2387
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.005 0.033 0.0512
Schistosoma mansoni ap endonuclease 0.0019 0.0081 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.4189 0.6686
Schistosoma mansoni ran 0.0042 0.027 0.026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0322 0.0321
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0115 0.0871 0.9084
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0019 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0322 0.2985
Echinococcus granulosus translational activator gcn1 0.0011 0.001 0.0009
Schistosoma mansoni thymidine kinase 0.1219 1 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0016 0.005 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0059 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2721 0.4338
Entamoeba histolytica hypothetical protein 0.0273 0.2178 0.3469
Echinococcus granulosus pyruvate kinase 0.0034 0.0205 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0219 0.0333
Echinococcus granulosus aminopeptidase N 0.0034 0.02 0.0199
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.0219 0.032
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0205 0.0298

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 10 ug ml-1 Concentration required to reduce Vaccinia virus induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures ChEMBL. 6302254
ID50 (functional) = 13 ug ml-1 Inhibitory activity of the compound against incorpotaion of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of uninfected primary rabbit kidney (PRK) cell cultures ChEMBL. 6302254
ID50 (functional) = 33 ug ml-1 Concentration required to reduce Herpes simplex virus type 1 induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures ChEMBL. 6302254
ID50 (functional) = 44 ug ml-1 Inhibitory activity of the compound against incorpotaion of deoxy[1',2'-3H]uridine (dUrd) into the DNA of uninfected primary rabbit kidney (PRK) cell cultures ChEMBL. 6302254
ID50 (functional) = 63 ug ml-1 Concentration required to reduce Herpes simplex virus type 2 induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures ChEMBL. 6302254
ID50 (functional) = 112 ug ml-1 Inhibitory activity of the compound against incorpotaion of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of murine leukemia L1210 cell cultures ChEMBL. 6302254
ID50 (functional) = 140 ug ml-1 Inhibitory activity of the compound against incorpotaion of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of murine leukemia L1210 cell cultures ChEMBL. 6302254
ID50 (functional) > 200 ug ml-1 Concentration required to reduce leukemia L1210 cell growth in mice ChEMBL. 6302254

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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