Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | prostaglandin f synthase | 0.0224 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0224 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0224 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0159 | 0.5922 | 0.5922 |
Entamoeba histolytica | aldose reductase, putative | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0065 | 0 | 0.5 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0224 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0159 | 0.5922 | 0.5922 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0178 | 0.7122 | 0.7122 |
Giardia lamblia | Aldose reductase | 0.0224 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7122 | 0.7122 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0159 | 0.5922 | 0.5922 |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Loa Loa (eye worm) | oxidoreductase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0224 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0224 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0178 | 0.7122 | 0.7122 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0224 | 1 | 1 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0065 | 0 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0224 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0224 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0224 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0224 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0065 | 0 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7122 | 0.7122 |
Echinococcus granulosus | aldo keto reductase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0224 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0224 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0224 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0224 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0224 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0224 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0224 | 1 | 1 |
Onchocerca volvulus | 0.0224 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.19 uM | Ability to inhibit histamine-induced contractions of isolated guinea pig ileum | ChEMBL. | 7861415 |
IC50 (functional) | = 36 uM | Ability to inhibit histamine phase of platelet activating factor (PAF)-induced bronchoconstriction in vivo in pulmonary function assays in Guinea pigs dosing orally 5 hours prior was determined | ChEMBL. | 7861415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.