Detailed information for compound 274111

Basic information

Technical information
  • TDR Targets ID: 274111
  • Name: (2R,3R,4R,5S)-2-methyloxane-3,4,5-triol
  • MW: 148.157 | Formula: C6H12O4
  • H donors: 3 H acceptors: 3 LogP: -1.57 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H]1CO[C@@H]([C@@H]([C@@H]1O)O)C
  • InChi: 1S/C6H12O4/c1-3-5(8)6(9)4(7)2-10-3/h3-9H,2H2,1H3/t3-,4+,5+,6-/m1/s1
  • InChiKey: KBVSUNBCTPQWJL-DPYQTVNSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4R,5S)-2-methyltetrahydropyran-3,4,5-triol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase 0.0141 0.2642 0.3681
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0187 0.0113
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0187 0.0113
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.7045 1
Echinococcus multilocularis aldo keto reductase 0.0141 0.2642 0.3681
Brugia malayi nuclear hormone receptor 0.0042 0.0187 0.0216
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0405 0.0515
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0187 0.016
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Trichomonas vaginalis aldo/keto reductase, putative 0.0141 0.2642 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0076 0.0149
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.3789 0.5328
Plasmodium falciparum aldo-keto reductase, putative 0.0041 0.016 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0187 0.0113
Mycobacterium leprae Probable lipase LipE 0.0037 0.0076 0.0287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0187 0.0118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0187 0.0113
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0041 0.016 0.0121
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0405 0.1282
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0178 0.0399
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.1282
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0187 0.0216
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.5239 0.7408
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2612 0.3968
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.01 0.0093
Brugia malayi RNA, U transporter 1 0.0085 0.1252 0.2278
Mycobacterium ulcerans hypothetical protein 0.0155 0.3003 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.01 0.0082
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.01 0.0038
Onchocerca volvulus 0.0141 0.2642 1
Schistosoma mansoni pol-related 0.0141 0.2642 0.2585
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0187 0.0113
Plasmodium falciparum aldehyde reductase, putative 0.0041 0.016 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0187 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.2642 0.5207
Trichomonas vaginalis aldo/keto reductase, putative 0.0141 0.2642 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0141 0.2642 0.4015
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Loa Loa (eye worm) hypothetical protein 0.0245 0.5239 0.7408
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0178 0.0309
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.016 0.0329
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0076 0.0287
Schistosoma mansoni coup transcription factor 0.0042 0.0187 0.0113
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0405 0.0515
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0405 0.0348
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.6466 1
Trypanosoma brucei prostaglandin f synthase 0.0141 0.2642 0.4015
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0178 0.016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0187 0.016
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.1282
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.01 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0187 0.016
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0076 0.0149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0187 0.0216
Trypanosoma cruzi aldo-keto reductase 0.0141 0.2642 0.4015
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.1282
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0141 0.2642 0.497
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0187 0.0118
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.078 0.1364
Loa Loa (eye worm) oxidoreductase 0.0141 0.2642 0.3681
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0178 0.0109
Schistosoma mansoni potassium channel beta 0.0041 0.016 0.0085
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0122 0.2169 0.2109
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Mycobacterium ulcerans hypothetical protein 0.0041 0.016 0.0289
Echinococcus multilocularis tar DNA binding protein 0.0066 0.078 0.101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0187 0.016
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Schistosoma mansoni aldo-keto reductase 0.0141 0.2642 0.2585
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0141 0.2642 0.497
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0041 0.016 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0187 0.0216
Loa Loa (eye worm) hypothetical protein 0.0141 0.2642 0.3681
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0178 0.016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0076 0.0149
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0405 0.0472
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0177 0.0159
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0178 0.0399
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0258 0.0262
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0041 0.016 0.0132
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0187 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0187 0.016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0187 0.0216
Loa Loa (eye worm) inositol-1 0.0038 0.01 0.0034
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0187 0.0113
Onchocerca volvulus 0.005 0.0391 0.1227
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0187 0.016
Brugia malayi hypothetical protein 0.0245 0.5239 1
Echinococcus granulosus hypothetical protein 0.0141 0.2642 0.2718
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.3789 0.3933
Echinococcus multilocularis snurportin 1 0.0318 0.7045 1
Brugia malayi RNA binding protein 0.0066 0.078 0.1364
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0405 0.0472
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.016 0.0329
Echinococcus multilocularis aldo keto reductase 0.0141 0.2642 0.3681
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0258 0.0184
Trypanosoma cruzi aldo/keto reductase, putative 0.0041 0.016 0.0132
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.3789 0.5328
Echinococcus granulosus voltage gated potassium channel subunit 0.0041 0.016 0.009
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Onchocerca volvulus 0.0141 0.2642 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.01 0.0024
Trypanosoma brucei glucosidase, putative 0.0041 0.0178 0.016
Schistosoma mansoni survival motor neuron protein 0.005 0.0391 0.0317
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Leishmania major prostaglandin f synthase, putative 0.0141 0.2642 0.4015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.01 0.0038
Mycobacterium leprae Possible oxidoreductase 0.0041 0.016 0.0607
Leishmania major aldo-keto reductase-like protein 0.0141 0.2642 0.4015
Loa Loa (eye worm) oxidoreductase 0.0141 0.2642 0.3681
Onchocerca volvulus 0.0141 0.2642 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0076 0.0149
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.01 0.0025
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0405 0.0472
Loa Loa (eye worm) hypothetical protein 0.0122 0.2169 0.3003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0187 0.0113
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0187 0.0113
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0187 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0066 0.078 0.071
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0178 0.0399
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0405 0.0515
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0141 0.2642 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0391 0.061
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0187 0.0113
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0178 0.0399
Echinococcus multilocularis FTZ F1 alpha 0.0122 0.2169 0.3003
Echinococcus multilocularis aldehyde reductase 0.01 0.163 0.223
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0187 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Echinococcus granulosus aldo keto reductase 0.0141 0.2642 0.2718
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0187 0.0216
Mycobacterium tuberculosis Conserved protein 0.0037 0.0076 0.0149
Echinococcus granulosus tar DNA binding protein 0.0066 0.078 0.0746
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.6466 1
Schistosoma mansoni alpha-glucosidase 0.0161 0.3143 0.3091
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.016 0.0329
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0041 0.016 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0258 0.0184
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0405 0.0515
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0187 0.0216
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.1282
Trypanosoma brucei aldo-keto reductase, putative 0.0141 0.2642 0.4015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.3789 0.7193
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Onchocerca volvulus 0.0041 0.016 0.0329
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0405 0.0331
Entamoeba histolytica alcohol dehydrogenase, putative 0.0041 0.016 0.0238
Onchocerca volvulus 0.0141 0.2642 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0187 0.0118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0258 0.0262
Echinococcus granulosus aldo keto reductase 0.0141 0.2642 0.2718
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0178 0.0199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0258 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0187 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Echinococcus granulosus aldehyde reductase 0.01 0.163 0.1646
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0178 0.016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0187 0.0118
Echinococcus granulosus aldo keto reductase 0.0141 0.2642 0.2718
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0405 0.0515
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0041 0.016 0.0329
Loa Loa (eye worm) oxidoreductase 0.0141 0.2642 0.3681
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.6466 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0187 0.0118
Echinococcus multilocularis aldo keto reductase 0.0141 0.2642 0.3681
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.016 0.0329
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0141 0.2642 0.497
Loa Loa (eye worm) oxidoreductase 0.0141 0.2642 0.3681
Trichomonas vaginalis aldo-keto reductase, putative 0.0041 0.016 0.0329
Mycobacterium ulcerans oxidoreductase 0.0141 0.2642 0.8766
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0076 0.0149
Echinococcus multilocularis voltage gated potassium channel subunit 0.0041 0.016 0.0121
Echinococcus granulosus snurportin 1 0.0318 0.7045 0.7382
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0187 0.0216
Toxoplasma gondii aldose reductase, putative 0.0141 0.2642 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0178 0.0399
Giardia lamblia Aldose reductase 0.0141 0.2642 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.078 0.071
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0178 0.0399
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0402 0.0511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0187 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0187 0.016
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0041 0.016 0.009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0178 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0258 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0187 0.0216
Giardia lamblia Aldose reductase 0.0141 0.2642 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.01 0.0038
Trypanosoma cruzi aldo/keto reductase, putative 0.0141 0.2642 0.4015
Schistosoma mansoni aldo-keto reductase 0.0141 0.2642 0.2585
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0405 0.0515
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0178 0.0399
Mycobacterium tuberculosis Conserved protein 0.0041 0.016 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0187 0.0216
Loa Loa (eye worm) oxidoreductase 0.0141 0.2642 0.3681
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0141 0.2642 1
Trypanosoma brucei protein kinase, putative 0.0051 0.0405 0.0515
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.5239 0.5468
Entamoeba histolytica aldose reductase, putative 0.0141 0.2642 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Toxoplasma gondii hypothetical protein 0.0048 0.0329 0.0986
Schistosoma mansoni hypothetical protein 0.005 0.0391 0.0317
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.3003 0.592
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0187 0.0113
Brugia malayi nuclear receptor NHR-88 0.0042 0.0187 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0141 0.2642 0.2718
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0405 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0187 0.016
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.6466 1
Brugia malayi steroid hormone receptor 0.0042 0.0187 0.0216
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0076 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0187 0.016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.5073 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0076 0.0149
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0177 0.0159
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0141 0.2642 0.497
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0122 0.2169 0.3003
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0141 0.2642 0.4015
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0178 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0258 0.0184
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0405 0.0515
Entamoeba histolytica alcohol dehydrogenase, putative 0.0041 0.016 0.0238
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Plasmodium vivax aldehyde reductase, putative 0.0041 0.016 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0187 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0122 0.2169 0.4054
Schistosoma mansoni tar DNA-binding protein 0.0066 0.078 0.071
Trichomonas vaginalis aldo/keto reductase, putative 0.0141 0.2642 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Schistosoma mansoni hypothetical protein 0.008 0.113 0.1062
Loa Loa (eye worm) TAR-binding protein 0.0066 0.078 0.101
Entamoeba histolytica aldose reductase, putative 0.0141 0.2642 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.01 0.0038
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0178 0.0399
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0141 0.2642 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.078 0.101
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0177 0.0159
Brugia malayi ecdysteroid receptor 0.0042 0.0187 0.0216
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0187 0.0435
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.01 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0258 0.0193
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Schistosoma mansoni tar DNA-binding protein 0.0066 0.078 0.071
Schistosoma mansoni hypothetical protein 0.0318 0.7045 0.7023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0187 0.016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0258 0.0262
Onchocerca volvulus 0.0141 0.2642 1
Onchocerca volvulus 0.0042 0.0187 0.0435
Onchocerca volvulus 0.0141 0.2642 1
Entamoeba histolytica aldose reductase, putative 0.0141 0.2642 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0187 0.016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0178 0.0309
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0187 0.0435
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0178 0.0399
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0187 0.0113
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0076 0.0149
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0187 0.016
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2642 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0122 0.2169 0.4054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.01 0.0093
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0187 0.0435
Schistosoma mansoni alpha glucosidase 0.0041 0.0178 0.0103
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0122 0.2169 0.2217
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0141 0.2642 0.3681
Brugia malayi Inositol-1 0.0038 0.01 0.0046
Brugia malayi TAR-binding protein 0.0066 0.078 0.1364
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0187 0.016
Schistosoma mansoni alpha-glucosidase 0.0161 0.3143 0.3091
Schistosoma mansoni inositol monophosphatase 0.0038 0.01 0.0024
Schistosoma mansoni tar DNA-binding protein 0.0066 0.078 0.071
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0141 0.2642 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2612 0.3968
Mycobacterium leprae Conserved hypothetical protein 0.01 0.163 0.617
Brugia malayi NADH-dependent xylose reductase 0.0041 0.016 0.0164
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0187 0.0118
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0041 0.016 0.0329
Trypanosoma brucei aldo/keto reductase, putative 0.0041 0.016 0.0132
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.01 0.0034
Brugia malayi MAP kinase sur-1 0.0051 0.0405 0.0637
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.01 0.5
Loa Loa (eye worm) RNA binding protein 0.0066 0.078 0.101
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0187 0.016
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.2612 0.3968
Mycobacterium tuberculosis Conserved protein 0.0037 0.0076 0.0149
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0177 0.0159
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.3789 0.5328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0187 0.0118
Onchocerca volvulus 0.0108 0.1833 0.6847
Echinococcus granulosus FTZ F1 alpha 0.0418 0.9517 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0178 0.0147
Toxoplasma gondii aldo-keto reductase 0.0041 0.016 0.0329

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 42 mM Compound was evaluated for its binding affinity towards E-coli Beta-galactosidase ChEMBL. No reference
Ki (binding) = 42 mM Compound was evaluated for its binding affinity towards E-coli Beta-galactosidase ChEMBL. No reference
Ki/(Km/Kcat) (binding) = 630000 Ratio of binding affinity towards E-coli beta - galactosidase to that of km/kcat was determined ChEMBL. No reference
Ki/Km (binding) = 1.2 Ratio of binding affinity towards E-coli beta - galactosidase to that of Michaels menton constant against E-coli beta-galactosidase ChEMBL. No reference
Km (binding) = 35.9 mM Compound was evaluated for its Michaels menton constant against E-coli Beta-galactosidase ChEMBL. No reference
Km (binding) = 35.9 mM Compound was evaluated for its Michaels menton constant against E-coli Beta-galactosidase ChEMBL. No reference
Km/Kcat (binding) = 0.000067 Kinetic parameter Km/Kcat against Beta-glucosidase ChEMBL. No reference
Km/Kcat (binding) = 0.000067 Kinetic parameter Km/Kcat against Beta-glucosidase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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