Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | histone deacetylase, putative | 0.0333 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1468 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0207 | 0.4737 | 0.4737 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0154 | 0.2483 | 0.2483 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0333 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0333 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0333 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0154 | 0.2483 | 0.2483 |
Echinococcus multilocularis | acetylcholinesterase | 0.0207 | 0.4737 | 0.4737 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1468 | 0.1468 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0333 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2259 | 0.2259 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.2259 | 0.2259 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.3695 | 0.3695 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0333 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0333 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1468 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3695 | 0.3695 |
Entamoeba histolytica | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3695 | 0.3695 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0333 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0207 | 0.4737 | 0.4737 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3695 | 0.3695 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1468 | 0.1468 |
Brugia malayi | Carboxylesterase family protein | 0.0207 | 0.4737 | 0.4737 |
Schistosoma mansoni | histone deacetylase | 0.0333 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0333 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0207 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0207 | 0.4737 | 0.4737 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.2259 | 0.2259 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0154 | 0.2483 | 0.2483 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.4737 | 0.4737 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0154 | 0.2483 | 0.2483 |
Trypanosoma brucei | histone deacetylase 1 | 0.0333 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0333 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0154 | 0.2483 | 0.2483 |
Echinococcus granulosus | carbonic anhydrase II | 0.0154 | 0.2483 | 0.2483 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.2259 | 0.2259 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0154 | 0.2483 | 0.2483 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0154 | 0.2483 | 0.2483 |
Giardia lamblia | Histone deacetylase | 0.0333 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1468 | 0.1468 |
Leishmania major | carbonic anhydrase-like protein | 0.0154 | 0.2483 | 0.2483 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3695 | 0.3695 |
Echinococcus granulosus | acetylcholinesterase | 0.0207 | 0.4737 | 0.4737 |
Echinococcus granulosus | histone deacetylase 1 | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0207 | 0.4737 | 0.4737 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0333 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1468 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0154 | 0.2483 | 0.2483 |
Echinococcus granulosus | carboxylesterase 5A | 0.0207 | 0.4737 | 0.4737 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0207 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0333 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1468 | 0.1468 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0333 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.4737 | 0.4737 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.3695 | 0.3695 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0333 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0333 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0.1468 | 1 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0154 | 0.2483 | 0.2483 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0207 | 0.4737 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.2259 | 0.2259 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.2259 | 0.2259 |
Plasmodium falciparum | histone deacetylase 1 | 0.0333 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0154 | 0.2483 | 0.2483 |
Leishmania major | histone deacetylase, putative | 0.0333 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0333 | 1 | 0.5 |
Echinococcus granulosus | histone deacetylase 3 | 0.0333 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 5 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 10.6 nM | Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. | ChEMBL. | 14736247 |
Ki (binding) | = 10.6 nM | Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. | ChEMBL. | 14736247 |
Ki (binding) | = 18 nM | Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 18 nM | Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 237 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 237 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ratio (binding) | = 22.3 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 0.5 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 1.7 | Ratio of binding affinity of compound for mutant (C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 22.3 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.