Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1187 | 0.1187 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0395 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0395 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0395 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0395 | 1 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.1187 | 0.1187 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.1187 | 0.1187 |
Echinococcus granulosus | histone deacetylase 1 | 0.0395 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0608 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0395 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.0608 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0206 | 0.3306 | 0.3306 |
Leishmania major | histone deacetylase, putative | 0.0395 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2483 | 0.2483 |
Echinococcus granulosus | carboxylesterase 5A | 0.0206 | 0.3306 | 0.3306 |
Echinococcus granulosus | acetylcholinesterase | 0.0206 | 0.3306 | 0.3306 |
Onchocerca volvulus | 0.013 | 0.0608 | 1 | |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0151 | 0.1374 | 0.1374 |
Echinococcus granulosus | carbonic anhydrase II | 0.0151 | 0.1374 | 0.1374 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2483 | 0.2483 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.0608 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0206 | 0.3306 | 0.3306 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0395 | 1 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0395 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0395 | 1 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0395 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0395 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0151 | 0.1374 | 0.1374 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.3306 | 0.3306 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2483 | 0.2483 |
Brugia malayi | thymidylate synthase | 0.013 | 0.0608 | 0.0608 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0206 | 0.3306 | 0.3306 |
Schistosoma mansoni | histone deacetylase | 0.0395 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0395 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0395 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.2483 | 0.2483 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0395 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0151 | 0.1374 | 0.1374 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0151 | 0.1374 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.3306 | 0.3306 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0151 | 0.1374 | 0.1374 |
Brugia malayi | Histone deacetylase 1 | 0.0395 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0608 | 0.0608 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2483 | 0.2483 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.1187 | 0.1187 |
Schistosoma mansoni | histone deacetylase | 0.0395 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0395 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0206 | 0.3306 | 0.3306 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0151 | 0.1374 | 0.1374 |
Entamoeba histolytica | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1187 | 0.1187 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0395 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.0608 | 0.0608 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0395 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0395 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0206 | 0.3306 | 0.3306 |
Echinococcus granulosus | acetylcholinesterase | 0.0206 | 0.3306 | 0.3306 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0151 | 0.1374 | 0.1374 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0206 | 0.3306 | 0.3306 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.1187 | 0.1187 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.3306 | 0.3306 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0151 | 0.1374 | 0.1374 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0151 | 0.1374 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.3306 | 0.3306 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0151 | 0.1374 | 0.1374 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.2483 | 0.2483 |
Leishmania major | carbonic anhydrase-like protein | 0.0151 | 0.1374 | 0.1374 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0395 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 58.5 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 58.5 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 85 nM | Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. | ChEMBL. | 14736247 |
Ki (binding) | = 85 nM | Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. | ChEMBL. | 14736247 |
Ki (binding) | = 121 nM | Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 121 nM | Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 549 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ki (binding) | = 549 nM | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum | ChEMBL. | 14736247 |
Ratio (binding) | = 0.7 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 1.4 | Ratio of binding affinity of compound for mutant (C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 6.5 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 0.7 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 1.4 | Ratio of binding affinity of compound for mutant (C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Ratio (binding) | = 6.5 | Ratio of binding affinity of compound for mutant (N51I+C59R+S108N+I164L) to that of wild type dihydrofolate reductase | ChEMBL. | 14736247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.