Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 4 uM | Inhibition of cellular growth by the MTT colorimetric assay in L1210, murine leukemia cell line | ChEMBL. | 1542093 |
IC50 (functional) | > 4 uM | Inhibition of cellular growth by the MTT colorimetric assay in CCRF-CEM, human lymphoblasticof T-cell origin | ChEMBL. | 1542093 |
IC50 (functional) | > 4 uM | Inhibition of cellular growth by the MTT colorimetric assay in GC3/M TK-, a human thymidine kinase deficient adenocarcinoma line | ChEMBL. | 1542093 |
IC50 (functional) | > 4 uM | Inhibition of cellular growth by the MTT colorimetric assay in L1210, murine leukemia cell line | ChEMBL. | 1542093 |
IC50 (functional) | > 4 uM | Inhibition of cellular growth by the MTT colorimetric assay in CCRF-CEM, human lymphoblasticof T-cell origin | ChEMBL. | 1542093 |
Kii (binding) | = 2.9 uM | Inhibitory activity against thymidylate synthase from human | ChEMBL. | 1542093 |
Kii (binding) | = 2.9 uM | Inhibitory activity against thymidylate synthase from human | ChEMBL. | 1542093 |
Kii (binding) | = 16 uM | Inhibitory activity against thymidylate synthase from Escherichia coli | ChEMBL. | 1542093 |
Kii (binding) | = 16 uM | Inhibitory activity against thymidylate synthase from Escherichia coli | ChEMBL. | 1542093 |
Kis (binding) | = 3.8 uM | Inhibitory activity against thymidylate synthase from human | ChEMBL. | 1542093 |
Kis (binding) | = 3.8 uM | Inhibitory activity against thymidylate synthase from human | ChEMBL. | 1542093 |
Kis (binding) | = 22 uM | Compound was evaluated for its inhibitory activity against thymidylate synthase from Escherichia coli | ChEMBL. | 1542093 |
Kis (binding) | = 22 uM | Compound was evaluated for its inhibitory activity against thymidylate synthase from Escherichia coli | ChEMBL. | 1542093 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 1542093 | |
Homo sapiens | ChEMBL23 | 1542093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.