TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 519.978 | Formula: C22H18ClN3O6S2
H donors: 3 H acceptors: 5 LogP: 2.65 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc2c(c1)oc(=O)cc2CNc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)S(=O)(=O)N
InChi: 1S/C22H18ClN3O6S2/c23-15-4-9-20-14(10-22(27)32-21(20)11-15)13-25-16-5-7-18(8-6-16)34(30,31)26-17-2-1-3-19(12-17)33(24,28)29/h1-12,25-26H,13H2,(H2,24,28,29)
InChiKey: CWWNTMKCOPSSCO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase I	Starlite/ChEMBL	References
Bos taurus	Carbonic anhydrase IV	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	hypothetical protein	Carbonic anhydrase IV	312 aa	268 aa	25.4 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	322 aa	28.3 %
Echinococcus granulosus	carbonic anhydrase	Carbonic anhydrase IV	312 aa	304 aa	29.6 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	253 aa	26.9 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	Carbonic anhydrase IV	312 aa	268 aa	24.6 %
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase I	261 aa	281 aa	25.3 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Leishmania infantum	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	26.7 %
Onchocerca volvulus		Carbonic anhydrase IV	312 aa	252 aa	23.4 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	265 aa	26.0 %
Leishmania braziliensis	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	25.6 %
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Carbonic anhydrase IV	312 aa	264 aa	25.4 %
Leishmania mexicana	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	287 aa	26.8 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	264 aa	24.2 %
Echinococcus multilocularis	carbonic anhydrase	Carbonic anhydrase IV	312 aa	259 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0008	0.0034	0.0025
Echinococcus granulosus	aldo keto reductase	0.0745	0.9434	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0142	0.0114
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0006	0.0011	0.0012
Schistosoma mansoni	aldo-keto reductase	0.0745	0.9434	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0088	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0424	0.0438
Mycobacterium tuberculosis	Probable oxidoreductase	0.0745	0.9434	1
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.122	0.1283
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0135	0.1651	0.1741
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0008	0.0034	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0101	0.122	0.1283
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0142	0.0114
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0451	0.0467
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.122	0.1293
Echinococcus granulosus	traf and tnf receptor associated protein	0.0008	0.0034	0.0025
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0041	0.0032
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0451	0.0433
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1651	0.1741
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0142	0.0139
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Plasmodium vivax	aldehyde reductase, putative	0.0216	0.2688	1
Echinococcus multilocularis	synaptojanin 1	0.0008	0.0034	0.0023
Echinococcus granulosus	bloom syndrome protein	0.0023	0.0235	0.0238
Leishmania major	hypothetical protein, conserved	0.004	0.0451	0.0444
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0008	0.0034	0.0025
Schistosoma mansoni	ferritin	0.0008	0.0045	0.0047
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0008	0.0034	0.0025
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0034	0.0025
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0008	0.0034	0.0025
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0745	0.9434	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0136	0.0145
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0162	0.0161
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1651	0.175
Mycobacterium ulcerans	hypothetical protein	0.004	0.0451	0.0433
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0142	0.0139
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.122	0.121
Echinococcus granulosus	carbonic anhydrase	0.0101	0.122	0.1283
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0088	0.0081
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0006	0.0011	0.0012
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0006	0.0011	0.0012
Echinococcus granulosus	carbonic anhydrase	0.0101	0.122	0.1283
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0006	0.0011	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0142	0.0114
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0451	0.1571
Onchocerca volvulus		0.0745	0.9434	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0142	0.0405
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0162	0.0161
Loa Loa (eye worm)	hypothetical protein	0.004	0.0451	0.0467
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.006	0.0064
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0008	0.0034	0.0025
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Giardia lamblia	Aldose reductase	0.0745	0.9434	1
Schistosoma mansoni	cpg binding protein	0.003	0.0321	0.0341
Schistosoma mansoni	ferritin light chain	0.0008	0.0045	0.0047
Echinococcus granulosus	synaptojanin 1	0.0008	0.0034	0.0025
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0914	0.3315
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0008	0.0034	0.0025
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0451	0.0467
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0008	0.0034	0.0025
Loa Loa (eye worm)	hypothetical protein	0.003	0.0323	0.0331
Echinococcus granulosus	carbonic anhydrase	0.0101	0.122	0.1283
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0006	0.0011	0.0012
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0006	0.0011	0.0012
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0008	0.0034	0.0025
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0745	0.9434	1
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0418	0.0432
Schistosoma mansoni	synaptojanin	0.0008	0.0034	0.0036
Trichomonas vaginalis	helicase, putative	0.0006	0.002	0.0009
Loa Loa (eye worm)	carbonic anhydrase 3	0.0214	0.2668	0.282
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0096	0.0066
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.006	0.0028
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0008	0.0034	0.0025
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0008	0.0034	0.0025
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0914	0.0904
Brugia malayi	Thioredoxin reductase	0.0046	0.0528	0.0549
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0418	0.0408
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0216	0.2688	0.2841
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0041	0.0032
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0214	0.2668	0.282
Schistosoma mansoni	carbon catabolite repressor protein	0.0008	0.0034	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0034	0.0025
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0451	0.0467
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0142	0.015
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0528	0.0549
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0096	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0914	0.0958
Schistosoma mansoni	pol-related	0.0745	0.9434	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0323	0.0342
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0323	0.0342
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0096	0.0066
Loa Loa (eye worm)	hypothetical protein	0.015	0.1849	0.1951
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0528	0.0525
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0722	0.0765
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0216	0.2688	0.2841
Echinococcus granulosus	geminin	0.0499	0.6301	0.6675
Toxoplasma gondii	hypothetical protein	0.0026	0.0274	0.029
Echinococcus granulosus	expressed protein	0.0008	0.0045	0.0036
Schistosoma mansoni	ap endonuclease	0.0038	0.0418	0.0443
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0008	0.0034	0.0023
Mycobacterium tuberculosis	Conserved protein	0.004	0.0451	0.0444
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1651	0.1642
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.0214	0.2668	0.2802
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Mycobacterium ulcerans	lipase LipD	0.004	0.0451	0.0433
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0216	0.2688	0.268
Trypanosoma cruzi	aldo-keto reductase	0.0745	0.9434	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0162	0.0161
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0162	0.0152
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0418	0.0408
Schistosoma mansoni	ap endonuclease	0.0038	0.0418	0.0443
Schistosoma mansoni	cpg binding protein	0.003	0.0321	0.0341
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0162	0.0161
Plasmodium falciparum	aldehyde reductase, putative	0.0216	0.2688	1
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0214	0.2668	0.282
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0914	0.0926
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.122	0.1293
Plasmodium falciparum	carbonic anhydrase	0.0101	0.122	0.4468
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Entamoeba histolytica	sphingomyelinase C precursor, putative	0.0008	0.0034	0.0036
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Loa Loa (eye worm)	oxidoreductase	0.0745	0.9434	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.122	0.1283
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.2668	0.2828
Trypanosoma cruzi	aldo/keto reductase, putative	0.0745	0.9434	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0216	0.2688	0.2849
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0142	0.0104
Trypanosoma brucei	trypanothione reductase	0.0046	0.0528	0.0525
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Loa Loa (eye worm)	hypothetical protein	0.004	0.0451	0.0467
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0451	0.0441
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0451	0.0478
Brugia malayi	beta-lactamase family protein	0.004	0.0451	0.0467
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Entamoeba histolytica	aldose reductase, putative	0.0745	0.9434	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0162	0.0152
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.002	0.0009
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0258	0.3221	0.339
Loa Loa (eye worm)	RecQ helicase	0.0023	0.0235	0.0238
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.1435	0.1481
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1437	0.1513
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0006	0.0011	0.0012
Entamoeba histolytica	inositol polyphosphate-5-phosphatase, putative	0.0008	0.0034	0.0036
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0323	0.0331
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0008	0.0034	0.0036
Plasmodium vivax	SET domain protein, putative	0.003	0.0323	0.1088
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0101	0.122	0.1283
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1651	0.175
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0142	0.0405
Brugia malayi	hypothetical protein	0.015	0.1849	0.1951
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0216	0.2688	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0274	0.0902
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0008	0.0034	0.0023
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0451	0.0444
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0142	0.0114
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0041	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.002	0.0009
Schistosoma mansoni	ferritin	0.0008	0.0045	0.0047
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0008	0.0045	0.0011
Echinococcus multilocularis	aldo keto reductase	0.0745	0.9434	0.9433
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0142	0.0114
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0528	0.0518
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0649	0.0677
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0008	0.0034	0.0025
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1651	0.1741
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	0.0926
Loa Loa (eye worm)	beta-lactamase	0.004	0.0451	0.0467
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0323	0.0312
Treponema pallidum	NADH oxidase	0.0016	0.0142	0.1223
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0162	0.0161
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0451	0.0444
Schistosoma mansoni	ferritin	0.0008	0.0045	0.0047
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0745	0.9434	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.0235	0.0238
Toxoplasma gondii	ABC1 family protein	0.004	0.0451	0.0478
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.1435	0.149
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0451	0.0444
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0528	0.0525
Schistosoma mansoni	hypothetical protein	0.0038	0.0424	0.0449
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0008	0.0034	0.0025
Onchocerca volvulus		0.0008	0.0034	0.0025
Trypanosoma brucei	aldo/keto reductase, putative	0.0216	0.2688	0.2823
Schistosoma mansoni	neutral sphingomyelinase	0.0008	0.0034	0.0036
Leishmania major	carbonic anhydrase-like protein	0.0214	0.2668	0.2802
Trichomonas vaginalis	aldo/keto reductase, putative	0.0745	0.9434	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0274	0.0244
Onchocerca volvulus		0.003	0.0323	0.0331
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0323	0.0342
Mycobacterium tuberculosis	Conserved protein	0.004	0.0451	0.0444
Trichomonas vaginalis	aldo-keto reductase, putative	0.0216	0.2688	0.2841
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0418	0.0408
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0162	0.0161
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0301	0.0308
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0451	0.0444
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0142	0.0114
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0142	0.0405
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0214	0.2668	0.282
Brugia malayi	Pre-SET motif family protein	0.0207	0.2579	0.2725
Onchocerca volvulus		0.0029	0.0301	0.0308
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.1284	0.133
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0451	0.0444
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0006	0.0011	0.0012
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0451	0.0444
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0064	0.0056
Mycobacterium leprae	Possible oxidoreductase	0.0216	0.2688	0.2815
Mycobacterium ulcerans	hypothetical protein	0.0216	0.2688	0.2815
Onchocerca volvulus		0.004	0.0451	0.0467
Echinococcus multilocularis	neutral sphingomyelinase	0.0008	0.0034	0.0023
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0745	0.9434	1
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0216	0.2688	0.2823
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.1435	0.149
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0016	0.0139	0.0393
Onchocerca volvulus		0.0745	0.9434	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0528	0.186
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.002	0.0009
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0173	0.0183
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Schistosoma mansoni	hypothetical protein	0.0101	0.122	0.1293
Mycobacterium leprae	Probable lipase LipE	0.004	0.0451	0.0433
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0914	0.0969
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	1
Echinococcus granulosus	hypothetical protein	0.0745	0.9434	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.1284	0.133
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	1
Echinococcus multilocularis	aldo keto reductase	0.0745	0.9434	0.9433
Echinococcus granulosus	aldo keto reductase	0.0745	0.9434	1
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Echinococcus granulosus	cpg binding protein	0.003	0.0321	0.033
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0528	0.0549
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0142	0.0131
Trichomonas vaginalis	aldo/keto reductase, putative	0.0745	0.9434	1
Brugia malayi	beta-lactamase family protein	0.004	0.0451	0.0467
Schistosoma mansoni	nocturnin	0.0008	0.0034	0.0036
Echinococcus multilocularis	carbonic anhydrase II	0.0214	0.2668	0.266
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0418	0.0408
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0418	0.0408
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0142	0.0114
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0424	0.0438
Echinococcus multilocularis	microtubule associated protein 2	0.0684	0.8657	0.8656
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0451	0.0467
Brugia malayi	beta-lactamase	0.004	0.0451	0.0467
Mycobacterium tuberculosis	Conserved protein	0.0216	0.2688	0.2823
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Echinococcus multilocularis	aldo keto reductase	0.0745	0.9434	0.9433
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0142	0.0405
Treponema pallidum	bacterioferrin (TpF1)	0.0008	0.0045	0.0116
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.006	0.0052
Leishmania major	trypanothione reductase	0.0046	0.0528	0.0525
Schistosoma mansoni	hypothetical protein	0.0499	0.6301	0.6679
Brugia malayi	Pre-SET motif family protein	0.003	0.0323	0.0331
Loa Loa (eye worm)	hypothetical protein	0.004	0.0451	0.0467
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.0235	0.0238
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.2668	0.2802
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.001	0.006	0.0098
Schistosoma mansoni	cpg binding protein	0.0029	0.0301	0.0319
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0451	0.0444
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0008	0.0034	0.0023
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0142	0.0104
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0418	0.0408
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0274	0.2722
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0008	0.0034	0.0023
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.2943	0.3111
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0418	0.0443
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0008	0.0034	0.0025
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0528	0.186
Schistosoma mansoni	DNA helicase recq1	0.001	0.006	0.0064
Echinococcus multilocularis	ferritin	0.0008	0.0045	0.0034
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.1435	0.149
Schistosoma mansoni	microtubule-associated protein tau	0.0684	0.8657	0.9177
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0914	0.0958
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0451	0.0444
Schistosoma mansoni	synaptojanin	0.0008	0.0034	0.0036
Entamoeba histolytica	aldose reductase, putative	0.0745	0.9434	1
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0578	0.0601
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1651	0.175
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0418	0.1446
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.122	0.1293
Plasmodium falciparum	glutathione reductase	0.0016	0.0142	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0034	0.0025
Schistosoma mansoni	potassium channel beta	0.0216	0.2688	0.2849
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0008	0.0034	0.0036
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0745	0.9434	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.2579	0.2725
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0578	0.0567
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0451	0.0467
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.006	0.0052
Echinococcus multilocularis	geminin	0.0499	0.6301	0.6297
Echinococcus granulosus	GPCR family 2	0.0018	0.0162	0.0161
Toxoplasma gondii	aldose reductase, putative	0.0745	0.9434	1
Brugia malayi	glutathione reductase	0.0046	0.0528	0.0549
Onchocerca volvulus		0.0216	0.2688	0.2841
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0451	0.0444
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0578	0.0578
Echinococcus granulosus	microtubule associated protein 2	0.0684	0.8657	0.9176
Schistosoma mansoni	hypothetical protein	0.0018	0.0162	0.0172
Mycobacterium tuberculosis	Probable reductase	0.0106	0.1284	0.133
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0101	0.122	0.1283
Onchocerca volvulus		0.0745	0.9434	1
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0006	0.0011	0.0012
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0451	0.0467
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0528	0.056
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.122	0.1283
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0451	0.0467
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0142	0.015
Schistosoma mansoni	aldo-keto reductase	0.0745	0.9434	1
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Trichomonas vaginalis	ferritin, putative	0.0008	0.0045	0.0036
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0216	0.2688	0.2841
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0005	0.0003	0.0004
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.122	0.121
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0216	0.2688	0.2841
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.2668	0.2828
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0142	0.0114
Loa Loa (eye worm)	oxidoreductase	0.0745	0.9434	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0142	0.112
Toxoplasma gondii	aldo-keto reductase	0.0216	0.2688	0.2849
Plasmodium falciparum	aldo-keto reductase, putative	0.0216	0.2688	1
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0008	0.0034	0.0025
Schistosoma mansoni	apoferritin-2	0.0008	0.0045	0.0047
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0418	0.4362
Loa Loa (eye worm)	hypothetical protein	0.004	0.0451	0.0467
Schistosoma mansoni	hypothetical protein	0.0018	0.0162	0.0172
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0914	0.0969
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0323	0.0312
Toxoplasma gondii	exonuclease III APE	0.0038	0.0418	0.0443
Onchocerca volvulus		0.015	0.1849	0.1951
Loa Loa (eye worm)	hypothetical protein	0.004	0.0451	0.0467
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0418	0.0432
Trypanosoma brucei	aldo-keto reductase, putative	0.0745	0.9434	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0216	0.2688	0.2823
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0649	0.0677
Loa Loa (eye worm)	hypothetical protein	0.004	0.0451	0.0467
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.0235	0.0238
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0062	0.0054
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0301	0.0308
Mycobacterium tuberculosis	Conserved protein	0.004	0.0451	0.0444
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0041	0.0044
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0745	0.9434	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.1284	0.133
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0034	0.0025
Leishmania major	prostaglandin f synthase, putative	0.0745	0.9434	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.1284	0.1321
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Echinococcus granulosus	neutral sphingomyelinase	0.0008	0.0034	0.0025
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0745	0.9434	1
Brugia malayi	Probable ClpP-like protease	0.0077	0.0914	0.0958
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	1
Mycobacterium ulcerans	oxidoreductase	0.0745	0.9434	1
Entamoeba histolytica	aldose reductase, putative	0.0745	0.9434	1
Onchocerca volvulus		0.0745	0.9434	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0216	0.2688	0.2841
Schistosoma mansoni	apoferritin-2	0.0008	0.0045	0.0047
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.1284	0.133
Onchocerca volvulus		0.0008	0.0034	0.0025
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.006	0.0049
Plasmodium falciparum	glutathione reductase	0.0046	0.0528	0.186
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.2668	0.2802
Leishmania major	aldo-keto reductase-like protein	0.0745	0.9434	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0745	0.9434	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0745	0.9434	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0451	0.0478
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.002	0.0009
Toxoplasma gondii	hypothetical protein	0.0101	0.122	0.1293
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0418	0.0398
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.0096	0.0102
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.006	0.0064
Onchocerca volvulus		0.0236	0.2943	0.3111
Schistosoma mansoni	ferritin	0.0008	0.0045	0.0047
Schistosoma mansoni	carbonic anhydrase	0.0101	0.122	0.1293
Schistosoma mansoni	cript-related	0.0008	0.0034	0.0036
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.122	0.1283
Echinococcus granulosus	aldo keto reductase	0.0745	0.9434	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0034	0.0036
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.0235	0.0225
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0142	0.0104
Loa Loa (eye worm)	oxidoreductase	0.0745	0.9434	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.006	0.0052
Giardia lamblia	Aldose reductase	0.0745	0.9434	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0649	0.0677
Echinococcus granulosus	ferritin	0.0008	0.0045	0.0036
Echinococcus multilocularis	expressed protein	0.0008	0.0045	0.0034
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0418	0.1446
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0914	0.0969
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0418	0.0408
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0216	0.2688	0.2849
Trichomonas vaginalis	aldo-keto reductase, putative	0.0216	0.2688	0.2841
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0528	0.186
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0528	0.0549
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0216	0.2688	0.2841
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0418	0.0432
Brugia malayi	CCR4	0.0008	0.0034	0.0025
Echinococcus multilocularis	aldehyde reductase	0.0529	0.6683	0.668
Echinococcus granulosus	carbonic anhydrase II	0.0214	0.2668	0.282
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0008	0.0045	0.0011
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0745	0.9434	1
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0006	0.0011	0.0012
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0418	0.0432
Onchocerca volvulus		0.0745	0.9434	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.122	0.1283
Entamoeba histolytica	G protein alpha subunit, putative	0.0006	0.0011	0.0012
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0142	0.0114
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0064	0.0056
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.002	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0041	0.0031
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0008	0.0034	0.0023
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0008	0.0034	0.0025
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.064	0.0678
Schistosoma mansoni	hypothetical protein	0.0499	0.6301	0.6679
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0142	0.0405
Onchocerca volvulus		0.0745	0.9434	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0142	0.0139
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Trypanosoma brucei	prostaglandin f synthase	0.0745	0.9434	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0142	0.015
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.002	0.0009
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0012	0.0096	0.0066
Onchocerca volvulus		0.004	0.0451	0.0467
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.001	0.006	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0323	0.0342
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0216	0.2688	0.2849
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0745	0.9434	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.002	0.0009
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0745	0.9434	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0418	0.0432
Schistosoma mansoni	DNA helicase recq5	0.001	0.006	0.0064
Schistosoma mansoni	hypothetical protein	0.0018	0.0162	0.0172
Echinococcus granulosus	aldehyde reductase	0.0529	0.6683	0.7081
Loa Loa (eye worm)	oxidoreductase	0.0745	0.9434	1
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0006	0.0011	0.0012
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0008	0.0034	0.0025
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0418	0.4296
Entamoeba histolytica	inositol polyphosphate 5-phosphatase, putative	0.0008	0.0034	0.0036
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0006	0.0011	0.0012
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0914	0.3315
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1651	0.1642
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0216	0.2688	0.2849
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0142	0.0114
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0451	0.0433
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0578	0.0568
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0006	0.0011	0.0012
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Onchocerca volvulus		0.004	0.0451	0.0467
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0745	0.9434	0.9433
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.122	0.121
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0301	0.0308
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0008	0.0034	0.0036
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Echinococcus granulosus	voltage gated potassium channel subunit	0.0216	0.2688	0.2841
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0199	0.062
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0142	0.0139
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0323	0.0342
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0142	0.112
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0008	0.0034	0.0036
Schistosoma mansoni	hypothetical protein	0.0018	0.0162	0.0172
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0274	0.0902
Trichomonas vaginalis	esterase, putative	0.004	0.0451	0.0467
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0142	0.0114
Echinococcus multilocularis	cpg binding protein	0.003	0.0321	0.0311
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.006	0.0049
Mycobacterium leprae	Conserved hypothetical protein	0.0529	0.6683	0.707
Mycobacterium ulcerans	beta-lactamase	0.004	0.0451	0.0433
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0451	0.0444
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0451	0.0433
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0142	0.0114
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.002	0.0009
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.002	0.0009
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0745	0.9434	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0649	0.0677
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0162	0.0152
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0008	0.0034	0.0025
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0008	0.0034	0.0025
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0135	0.1651	0.1741
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0064	0.0053
Echinococcus multilocularis	aldo keto reductase	0.0745	0.9434	0.9433
Loa Loa (eye worm)	hypothetical protein	0.0101	0.122	0.1283
Trichomonas vaginalis	aldo-keto reductase, putative	0.0745	0.9434	1
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0008	0.0034	0.0025
Schistosoma mansoni	ferritin light chain	0.0008	0.0045	0.0047
Brugia malayi	NADH-dependent xylose reductase	0.0216	0.2688	0.2841
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0451	0.0467
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.1284	0.133
Loa Loa (eye worm)	oxidoreductase	0.0745	0.9434	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6 nM	Inhibition of human cloned Carbonic anhydrase II	ChEMBL.	10762051
Ki (binding)	= 6 nM	Inhibition of human cloned Carbonic anhydrase II	ChEMBL.	10762051
Ki (binding)	= 30 nM	Inhibition of bovine Carbonic anhydrase IV determined by esterase method	ChEMBL.	10762051
Ki (binding)	= 30 nM	Inhibition of bovine Carbonic anhydrase IV determined by esterase method	ChEMBL.	10762051
Ki (binding)	= 36 nM	Inhibition of human cloned Carbonic anhydrase I	ChEMBL.	10762051
Ki (binding)	= 36 nM	Inhibition of human cloned Carbonic anhydrase I	ChEMBL.	10762051

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL161658

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 274723