Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0078 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0078 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0078 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0078 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0078 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0078 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0078 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0078 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0078 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0078 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0078 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0078 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0078 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0078 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0078 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 9.1 uM | Compound was tested for activity against HIV-1 by syncytial plaque assay performed in duplicate using CEM-SS cells | ChEMBL. | 9548815 |
IC50 (functional) | = 9.1 uM | Compound was tested for activity against HIV-1 by syncytial plaque assay performed in duplicate using CEM-SS cells | ChEMBL. | 9548815 |
IC50 (functional) | = 19 uM | Compound was tested for antiviral activity against HIV-1 resistant to TIBO A-17 | ChEMBL. | 9548815 |
IC50 (functional) | = 30 uM | Compound was tested for antiviral activity against matched pairs of HIV-1 sensitive to AZT | ChEMBL. | 9548815 |
IC50 (functional) | > 30 uM | Compound was tested for antiviral activity against HIV-2 | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Antiviral activity against human cytomegalovirus(HCMV) by plaque reduction assay | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Antiviral activity against herpes simplex virus type-1 (HSV-1) | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Visual cytotoxicity scored on HFF cells at a time of HCMV plaque enumeration | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Inhibition of KB cell growth determined by quadruplicate assays | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Cytotoxicity against CEM-SS cells in terms of incorporation of [3H]-dThd | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Visual cytotoxicity scored on HFF cells at a time of HCMV plaque enumeration | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Inhibition of KB cell growth determined by quadruplicate assays | ChEMBL. | 9548815 |
IC50 (functional) | > 100 uM | Cytotoxicity against CEM-SS cells in terms of incorporation of [3H]-dThd | ChEMBL. | 9548815 |
IC50 (functional) | = 255 uM | Compound was tested for antiviral activity against matched pairs of HIV-1 resistant to AZT | ChEMBL. | 9548815 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9548815 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.