Detailed information for compound 274741

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 410.897 | Formula: C22H23ClN4O2
  • H donors: 0 H acceptors: 3 LogP: 4.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ncnc(c1)N(C(=O)c1ccco1)C1CCN(CC1)CCc1ccccc1
  • InChi: 1S/C22H23ClN4O2/c23-20-15-21(25-16-24-20)27(22(28)19-7-4-14-29-19)18-9-12-26(13-10-18)11-8-17-5-2-1-3-6-17/h1-7,14-16,18H,8-13H2
  • InChiKey: PXGVJPWYBJFAQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 371 aa 27.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Onchocerca volvulus Mu opioid receptor   398 aa 356 aa 23.9 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Onchocerca volvulus Mu opioid receptor   398 aa 333 aa 26.4 %
Onchocerca volvulus Mu opioid receptor   398 aa 376 aa 26.3 %
Echinococcus granulosus allatostatin A receptor Mu opioid receptor   398 aa 346 aa 29.5 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 370 aa 27.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Mu opioid receptor   398 aa 334 aa 24.9 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Echinococcus multilocularis allatostatin A receptor Mu opioid receptor   398 aa 341 aa 29.3 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0039 0.0091 0.0284
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0791 0.2061 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0033 0.0039
Brugia malayi CXXC zinc finger family protein 0.0031 0.007 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0091 0.0084
Echinococcus multilocularis purine nucleoside phosphorylase 0.3818 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0003 0.0003
Echinococcus multilocularis GPCR, family 2 0.0017 0.0033 0.0031
Chlamydia trachomatis AMP nucleosidase 0.0791 0.2061 0.5
Onchocerca volvulus 0.0039 0.0091 0.0088
Schistosoma mansoni neuropeptide receptor 0.0005 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0791 0.2061 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.0111
Schistosoma mansoni neuropeptide receptor 0.0005 0.0003 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0091 0.0084
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.0111
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0791 0.2061 0.2056
Brugia malayi MTAP 0.0791 0.2061 0.2059
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Echinococcus multilocularis purine nucleoside phosphorylase 0.3818 1 1
Schistosoma mansoni opsin-like receptor 0.0005 0.0003 0.0003
Echinococcus granulosus GPCR family 2 0.0017 0.0033 0.0031
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0105
Toxoplasma gondii Purine nucleoside phosphorylase 0.0791 0.2061 1
Treponema pallidum pfs protein (pfs) 0.0791 0.2061 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0009 0.0009
Echinococcus multilocularis uridine phosphorylase 1 0.0791 0.2061 0.2059
Brugia malayi beta-lactamase 0.0039 0.0091 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.0111
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0003 0.0003
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0791 0.2061 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.0644 0.0613
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0091 0.0088
Plasmodium falciparum purine nucleoside phosphorylase 0.0791 0.2061 1
Schistosoma mansoni hypothetical protein 0.0037 0.0085 0.0085
Onchocerca volvulus 0.0039 0.0091 0.0088
Trypanosoma brucei uridine phosphorylase 0.0791 0.2061 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0091 0.0058
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0091 0.0058
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0791 0.2061 0.5
Mycobacterium leprae probable uridine phosphorylase 0.0791 0.2061 0.1989
Brugia malayi uridine phosphorylase family protein 0.0791 0.2061 0.2059
Echinococcus multilocularis purine nucleoside phosphorylase 0.3818 1 1
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0791 0.2061 0.2035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0005 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.0005 0.0003 0.0003
Schistosoma mansoni opsin-like receptor 0.0005 0.0003 0.0003
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0791 0.2061 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0091 0.0111
Schistosoma mansoni biogenic amine receptor 0.0005 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0091 0.0284
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.0111
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0009 0.0006
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0005 0.0003 0.0003
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0791 0.2061 0.5
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Mycobacterium ulcerans purine nucleoside phosphorylase 0.3818 1 1
Mycobacterium tuberculosis Hypothetical protein 0.0791 0.2061 0.2035
Schistosoma mansoni methylthioadenosine phosphorylase 0.0791 0.2061 0.2061
Echinococcus multilocularis cpg binding protein 0.0033 0.0075 0.0072
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0791 0.2061 0.2059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0091 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0091 0.0284
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0091 0.0284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0033 0.0031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0091 0.0091
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.013 0.0128
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0091 0.0084
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.0791 0.2061 0.2061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0791 0.2061 0.2035
Schistosoma mansoni biogenic amine receptor 0.0005 0.0003 0.0003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0005 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0005 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0005 0.0003 0.0003
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0033 0.0039
Schistosoma mansoni neuropeptide F-like receptor 0.0005 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Schistosoma mansoni growth hormone secretagogue receptor 0.0005 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0033 0.0031
Mycobacterium tuberculosis Conserved protein 0.0039 0.0091 0.0058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.013 0.0161
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0791 0.2061 0.1989
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.007 0.0085
Echinococcus granulosus dnaJ subfamily B 0.0445 0.1154 0.1152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0162 0.0162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0003 0.0003
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0791 0.2061 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0091 0.0084
Schistosoma mansoni cpg binding protein 0.0033 0.0075 0.0075
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.3818 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0143 0.0543
Loa Loa (eye worm) hypothetical protein 0.3027 0.7927 1
Schistosoma mansoni cpg binding protein 0.0031 0.007 0.007
Trichomonas vaginalis esterase, putative 0.0039 0.0091 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0033 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.3818 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0033 0.0031
Schistosoma mansoni adenoreceptor 0.0005 0.0003 0.0003
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0791 0.2061 1
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0033 0.0031
Toxoplasma gondii phosphorylase family protein 0.0791 0.2061 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0091 0.0091
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0791 0.2061 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.0111
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0791 0.2061 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.3818 1 1
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Onchocerca volvulus 0.0039 0.0091 0.0088
Echinococcus multilocularis purine nucleoside phosphorylase 0.3027 0.7927 0.7926
Schistosoma mansoni hypothetical protein 0.0005 0.0003 0.0003
Schistosoma mansoni purine nucleoside phosphorylase 0.3818 1 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0033 0.0031
Echinococcus multilocularis purine nucleoside phosphorylase 0.3027 0.7927 0.7926
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0091 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0091 0.0284
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0014 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0091 0.0084
Loa Loa (eye worm) uridine phosphorylase 0.0791 0.2061 0.2598
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Brugia malayi beta-lactamase family protein 0.0039 0.0091 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0791 0.2061 0.2056
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.3818 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0091 0.0058
Schistosoma mansoni neuropeptide receptor 0.0005 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0005 0.0003 0.0003
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0014 0.0011
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0791 0.2061 0.1989
Schistosoma mansoni opsin-like receptor 0.0005 0.0003 0.0003
Echinococcus granulosus methylthioadenosine phosphorylase 0.0791 0.2061 0.2059
Echinococcus granulosus cpg binding protein 0.0033 0.0075 0.0072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0091 0.0058
Leishmania major methylthioadenosine phosphorylase, putative 0.0791 0.2061 1
Onchocerca volvulus 0.0031 0.007 0.0068
Echinococcus multilocularis purine nucleoside phosphorylase 0.3818 1 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0033 0.0031
Echinococcus granulosus uridine phosphorylase 1 0.0791 0.2061 0.2059
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0791 0.2061 0.2598
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0091 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0091 0.0088
Schistosoma mansoni amine GPCR 0.0005 0.0003 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0033 0.0031
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Schistosoma mansoni neuropeptide receptor 0.0005 0.0003 0.0003
Schistosoma mansoni alpha-1 adrenergic receptor 0.0005 0.0003 0.0003
Loa Loa (eye worm) histone methyltransferase 0.001 0.0014 0.0014
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0791 0.2061 1
Echinococcus multilocularis dnaJ subfamily B 0.0445 0.1154 0.1152
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0085 0.0083
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Schistosoma mansoni neuropeptide f receptor 76f 0.0005 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0005 0.0003 0.0003
Brugia malayi beta-lactamase family protein 0.0039 0.0091 0.0088
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0013 0.0011
Treponema pallidum uridine phosphorylase (udp) 0.0791 0.2061 0.5
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Schistosoma mansoni purine nucleoside phosphorylase 0.3818 1 1
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0791 0.2061 0.5
Echinococcus multilocularis purine nucleoside phosphorylase 0.3818 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0005 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.0005 0.0003 0.0003
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0791 0.2061 1
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.3027 0.7927 0.7926
Schistosoma mansoni methylthioadenosine phosphorylase 0.0791 0.2061 0.2061
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.3818 1 1
Schistosoma mansoni uridine phosphorylase 0.0791 0.2061 0.2061
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0005 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0005 0.0003 0.0003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Toxoplasma gondii ABC1 family protein 0.0039 0.0091 0.0284
Schistosoma mansoni histamine h1 receptor 0.0005 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0091 0.0111
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0005 0.0003 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.013 0.0128
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0005 0.0003 0.0003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0791 0.2061 0.2056
Toxoplasma gondii phosphorylase family protein 0.0791 0.2061 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0005 0.0003 0.0003
Leishmania major nucleoside phosphorylase-like protein 0.0791 0.2061 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0005 0.0003 0.0003
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0791 0.2061 1
Schistosoma mansoni hypothetical protein 0.0005 0.0003 0.0003
Loa Loa (eye worm) beta-lactamase 0.0039 0.0091 0.0111
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0033 0.0031
Schistosoma mansoni cpg binding protein 0.0033 0.0075 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0091 0.0058
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0009 0.0006
Schistosoma mansoni uridine phosphorylase 0.0791 0.2061 0.2061
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0033 0.0031
Mycobacterium tuberculosis Conserved protein 0.0039 0.0091 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0005 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0445 0.1154 0.1154
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0033 0.0031
Echinococcus granulosus purine nucleoside phosphorylase 0.3818 1 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0791 0.2061 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0091 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0005 0.0003 0.0003
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.3818 1 1
Schistosoma mansoni myosin xvIII 0.0005 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0006

Activities

Activity type Activity value Assay description Source Reference
Analgesia (functional) = 0 % Percentage analgesia of determined by mouse hot plate assay (5 mg/kg) ChEMBL. 2563773
Analgesia (functional) = 0 % Percentage analgesia determined by mouse hot plate assay (1 mg/kg) ChEMBL. 2563773
Analgesia (functional) = 0 % Percentage analgesia of determined by mouse hot plate assay (5 mg/kg) ChEMBL. 2563773
Analgesia (functional) = 0 % Percentage analgesia determined by mouse hot plate assay (1 mg/kg) ChEMBL. 2563773
Ki (binding) = 18.5 nM Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane. ChEMBL. 2563773
Ki (binding) = 18.5 nM Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane. ChEMBL. 2563773
Reversal (functional) = 32 % Percentage of respirations per minute after treatment with morphine when compared to control in rabbit ChEMBL. 2563773
Reversal (functional) = 54 % Tested in rabbit for percentage analgesia after treatment with compound ChEMBL. 2563773
Reversal (functional) = 100 % Percentage of respirations per minute after treatment in rabbit ChEMBL. 2563773
Reversal (functional) = 100 % Tested in rabbit for percentage analgesia after treatment with morphine ChEMBL. 2563773
Reversal type (functional) = 2 Ability of compound for reversal of morphine and analgesia was determined; 2= reversal of both morphine respiratory depression and analgesia ChEMBL. 2563773

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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