Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1108 | 0.1108 |
Schistosoma mansoni | inositol transporter | 0.0043 | 0.089 | 0.089 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0043 | 0.089 | 0.089 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0043 | 0.089 | 0.5 |
Leishmania major | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1108 | 0.1108 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1108 | 0.1108 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.039 | 1 | 1 |
Trypanosoma brucei | thymidine kinase | 0.027 | 0.6859 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.4161 | 0.4161 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0106 | 0.2543 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.4161 | 0.4161 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0043 | 0.089 | 0.089 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1108 | 0.1108 |
Schistosoma mansoni | inositol transporter | 0.0043 | 0.089 | 0.089 |
Echinococcus multilocularis | solute carrier family 5 | 0.0043 | 0.089 | 0.089 |
Schistosoma mansoni | high-affinity choline transporter | 0.039 | 1 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0043 | 0.089 | 0.089 |
Trichomonas vaginalis | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Giardia lamblia | Thymidine kinase | 0.027 | 0.6859 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Schistosoma mansoni | kinase | 0.0054 | 0.1175 | 0.1175 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.039 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1108 | 0.1108 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0043 | 0.089 | 0.089 |
Schistosoma mansoni | hypothetical protein | 0.0154 | 0.3789 | 0.3789 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0106 | 0.2543 | 0.2543 |
Trichomonas vaginalis | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0043 | 0.089 | 0.089 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.3277 | 0.3277 |
Trypanosoma cruzi | thymidine kinase, putative | 0.027 | 0.6859 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.3277 | 0.3277 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Brugia malayi | Sodium:solute symporter family protein | 0.0043 | 0.089 | 0.089 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1108 | 0.1108 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0043 | 0.089 | 0.089 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0106 | 0.2543 | 0.2543 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0106 | 0.2543 | 0.2543 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1108 | 0.1108 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1108 | 0.1108 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1108 | 0.1108 |
Trypanosoma brucei | RNA helicase, putative | 0.0154 | 0.3789 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.4161 | 0.4161 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0106 | 0.2543 | 0.2456 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.4161 | 0.4161 |
Schistosoma mansoni | sodium/solute symporter | 0.0043 | 0.089 | 0.089 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.4161 | 0.4161 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0106 | 0.2543 | 0.2543 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.4161 | 0.4161 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.089 | 0.089 |
Echinococcus granulosus | solute carrier family 5 | 0.0043 | 0.089 | 0.089 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.3277 | 0.3277 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0043 | 0.089 | 0.089 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0106 | 0.2543 | 0.2543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes | ChEMBL. | 11844699 |
IC50 (binding) | = 5 nM | Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranes | ChEMBL. | 11844699 |
IC90 (functional) | > 300 nM | Antiviral activity against BAL strain of HIV using HeLa cell anti-infectivity assay | ChEMBL. | 11844699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.