Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0322 | 0.0397 |
Schistosoma mansoni | lamin | 0.003 | 0.0217 | 0.0267 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0064 | 0.0079 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0217 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0064 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0059 | 0.004 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.101 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.101 | 1 | 1 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0821 | 0.8113 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0322 | 0.0397 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.101 | 1 | 1 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0821 | 0.8113 | 1 |
Echinococcus multilocularis | lamin | 0.003 | 0.0217 | 0.0267 |
Echinococcus granulosus | lamin | 0.003 | 0.0217 | 0.0267 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0217 | 0.0198 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0448 | 0.4392 | 0.5414 |
Onchocerca volvulus | 0.0031 | 0.0236 | 0.002 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0067 | 0.0588 | 0.0725 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.101 | 1 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0821 | 0.8113 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0254 | 0.0313 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.101 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0189 | 0.1808 | 0.2229 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0821 | 0.8113 | 0.8109 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0821 | 0.8113 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0821 | 0.8113 | 0.8109 |
Echinococcus granulosus | geminin | 0.0189 | 0.1808 | 0.2229 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0236 | 0.0218 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.008 | 0.0061 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0821 | 0.8113 | 0.8109 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0821 | 0.8113 | 0.805 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0217 | 0.0267 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.101 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.101 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0019 | 0.0024 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0236 | 0.0217 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0217 | 0.0198 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0217 | 0.0199 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0821 | 0.8113 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0217 | 0.0267 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0821 | 0.8113 | 0.8109 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0821 | 0.8113 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.101 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0821 | 0.8113 | 1 |
Onchocerca volvulus | 0.101 | 1 | 1 | |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.101 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0821 | 0.8113 | 1 |
Echinococcus multilocularis | musashi | 0.003 | 0.0217 | 0.0267 |
Brugia malayi | hypothetical protein | 0.004 | 0.0322 | 0.0305 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0217 | 0.0199 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0236 | 0.0291 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0322 | 0.0397 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1808 | 0.2229 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0217 | 0.0267 |
Echinococcus granulosus | dnaJ subfamily B | 0.0448 | 0.4392 | 0.5414 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0322 | 0.0397 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0821 | 0.8113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0211 | 0.0193 |
Schistosoma mansoni | lamin | 0.003 | 0.0217 | 0.0267 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0019 | 0.0024 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.101 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0448 | 0.4392 | 0.5414 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0217 | 0.0198 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.101 | 1 | 0.5 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.101 | 1 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0254 | 0.0313 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1808 | 0.2229 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0064 | 0.0079 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0254 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0059 | 0.004 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0254 | 0.0313 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0821 | 0.8113 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.008 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.96 | Inhibition of human placental microsome CYP19 | ChEMBL. | 16279787 |
IC50 (binding) | = 1.1 uM | Inhibition of human placental microsome cytochrome P450 19A1 aromatase | ChEMBL. | 11262078 |
IC50 (binding) | = 1.1 uM | Inhibition of human placental microsome cytochrome P450 19A1 aromatase | ChEMBL. | 11262078 |
IC50 (binding) | = 1.1 uM | Inhibition of human aromatase-mediated conversion of [1beta3H]androstenedione to estrone by liquid scintillation counting in presence of NADPH | ChEMBL. | 19072235 |
Inhibition (binding) | = 5 % | Inhibition of human Steroid 17-alpha-hydroxylase/17,20 lyase from human testicular microsomes at a concentration of 2.5 microM | ChEMBL. | 11262078 |
Inhibition (binding) | = 5 % | Inhibition of human Steroid 17-alpha-hydroxylase/17,20 lyase from human testicular microsomes at a concentration of 2.5 microM | ChEMBL. | 11262078 |
Inhibition (binding) | = 95 % | Inhibition of aromatase (P450) from human placental microsomes at a concentration of 25 microM | ChEMBL. | 11262078 |
Inhibition (binding) | = 95 % | Inhibition of aromatase (P450) from human placental microsomes at a concentration of 25 microM | ChEMBL. | 11262078 |
Log IC50 (binding) | = 5.96 | Inhibition of human placental microsome CYP19 | ChEMBL. | 16279787 |
Relative potency (binding) | = 17 | Potency relative to aminoglutethimide for the inhibition of human placental microsome aromatase (P450) | ChEMBL. | 11262078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.