Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.011 | 0.1162 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0422 | 0.7692 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0124 | 0.1451 | 0.14 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.011 | 0.1162 | 0.1108 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.011 | 0.1162 | 0.0502 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Brugia malayi | MTAP | 0.011 | 0.1162 | 0.1162 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0088 | 0.0694 | 0.0638 |
Mycobacterium leprae | probable uridine phosphorylase | 0.011 | 0.1162 | 0.1108 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0422 | 0.7692 | 0.7678 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.011 | 0.1162 | 0.1108 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0175 | 0.251 | 1 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.011 | 0.1162 | 0.0502 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.011 | 0.1162 | 0.0502 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.1599 | 0.2079 |
Mycobacterium tuberculosis | Hypothetical protein | 0.011 | 0.1162 | 0.1108 |
Giardia lamblia | Deoxynucleoside kinase | 0.0428 | 0.783 | 0.7544 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0175 | 0.251 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.1599 | 0.1599 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.011 | 0.1162 | 0.4429 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0124 | 0.1451 | 0.0814 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Brugia malayi | Probable ClpP-like protease | 0.0088 | 0.0694 | 0.0694 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.1162 | 0.1082 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.011 | 0.1162 | 0.1108 |
Brugia malayi | thymidylate synthase | 0.0124 | 0.1451 | 0.1451 |
Loa Loa (eye worm) | uridine phosphorylase | 0.011 | 0.1162 | 0.151 |
Chlamydia trachomatis | AMP nucleosidase | 0.011 | 0.1162 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0124 | 0.1451 | 0.14 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.2574 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0532 | 1 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.011 | 0.1162 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0124 | 0.1451 | 0.0814 |
Treponema pallidum | pfs protein (pfs) | 0.011 | 0.1162 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0175 | 0.251 | 1 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.011 | 0.1162 | 0.151 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0124 | 0.1451 | 0.14 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0059 | 0.0089 | 0.003 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0175 | 0.251 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0422 | 0.7692 | 0.7678 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.4429 |
Schistosoma mansoni | uridine phosphorylase | 0.011 | 0.1162 | 0.0502 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.011 | 0.1162 | 0.2574 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0124 | 0.1451 | 0.1887 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.1162 | 0.1082 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.1599 | 0.2079 |
Entamoeba histolytica | hypothetical protein | 0.011 | 0.1162 | 0.5 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.4429 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.011 | 0.1162 | 0.2574 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.011 | 0.1162 | 0.2574 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0532 | 1 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.011 | 0.1162 | 0.0502 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0532 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.0694 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.5 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.011 | 0.1162 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0694 | 0.0902 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0175 | 0.251 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0422 | 0.7692 | 0.7678 |
Toxoplasma gondii | phosphorylase family protein | 0.011 | 0.1162 | 0.2574 |
Brugia malayi | uridine phosphorylase family protein | 0.011 | 0.1162 | 0.1162 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0532 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0124 | 0.1451 | 0.14 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0532 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0088 | 0.0694 | 0.0638 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.011 | 0.1162 | 0.4429 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0532 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.011 | 0.1162 | 0.0502 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.1082 |
Brugia malayi | hypothetical protein | 0.0059 | 0.0089 | 0.0089 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0088 | 0.0694 | 0.0638 |
Treponema pallidum | uridine phosphorylase (udp) | 0.011 | 0.1162 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.011 | 0.1162 | 0.1108 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.4429 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.011 | 0.1162 | 0.0502 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.011 | 0.1162 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0175 | 0.251 | 1 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.011 | 0.1162 | 0.1108 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Analgesia (functional) | = 20 % | Percentage analgesia determined by mouse hot plate assay (1 mg/kg) | ChEMBL. | 2563773 |
Analgesia (functional) | = 20 % | Percentage analgesia determined by mouse hot plate assay (1 mg/kg) | ChEMBL. | 2563773 |
Analgesia (functional) | = 59 % | Percentage analgesia of determined by mouse hot plate assay (5 mg/kg) | ChEMBL. | 2563773 |
Analgesia (functional) | = 59 % | Percentage analgesia of determined by mouse hot plate assay (5 mg/kg) | ChEMBL. | 2563773 |
Ki (binding) | nM | The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; ND is not determined. | ChEMBL. | 2563773 |
Ki (binding) | 0 nM | The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; ND is not determined. | ChEMBL. | 2563773 |
Reversal (functional) | = 22 % | Tested in rabbit for percentage analgesia after treatment with compound | ChEMBL. | 2563773 |
Reversal (functional) | = 53 % | Percentage of respirations per minute after treatment with morphine when compared to control in rabbit | ChEMBL. | 2563773 |
Reversal (functional) | = 100 % | Tested in rabbit for percentage analgesia after treatment with morphine | ChEMBL. | 2563773 |
Reversal (functional) | = 127 % | Percentage of respirations per minute after treatment in rabbit | ChEMBL. | 2563773 |
Reversal type (functional) | = 2 | Ability of compound for reversal of morphine and analgesia was determined; 2= reversal of both morphine respiratory depression and analgesia | ChEMBL. | 2563773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.