Detailed information for compound 274923

Basic information

Technical information
  • TDR Targets ID: 274923
  • Name: benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-3-oxo- 1-phenyl-4-(3-phenylpropylsulfanyl)butan-2-yl ]amino]pentan-2-yl]carbamate
  • MW: 560.747 | Formula: C33H40N2O4S
  • H donors: 2 H acceptors: 3 LogP: 7.24 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N[C@H](C(=O)CSCCCc1ccccc1)Cc1ccccc1)NC(=O)OCc1ccccc1)C
  • InChi: 1S/C33H40N2O4S/c1-25(2)21-30(35-33(38)39-23-28-17-10-5-11-18-28)32(37)34-29(22-27-15-8-4-9-16-27)31(36)24-40-20-12-19-26-13-6-3-7-14-26/h3-11,13-18,25,29-30H,12,19-24H2,1-2H3,(H,34,37)(H,35,38)/t29-,30-/m0/s1
  • InChiKey: BVJMYPXCAYDMBJ-KYJUHHDHSA-N  


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Synonyms

  • benzyl N-[(1S)-1-[[(1S)-1-benzyl-2-oxo-3-(3-phenylpropylsulfanyl)propyl]carbamoyl]-3-methyl-butyl]carbamate
  • N-[(1S)-1-[[[(1S)-1-benzyl-2-oxo-3-(3-phenylpropylthio)propyl]amino]-oxomethyl]-3-methylbutyl]carbamic acid benzyl ester
  • phenylmethyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-3-oxo-1-phenyl-4-(3-phenylpropylsulfanyl)butan-2-yl]amino]pentan-2-yl]carbamate
  • N-[(1S)-1-[[(1S)-1-benzyl-2-keto-3-(3-phenylpropylthio)propyl]carbamoyl]-3-methyl-butyl]carbamic acid benzyl ester
  • phenylmethyl N-[(1S)-3-methyl-1-[[(1S)-2-oxo-1-(phenylmethyl)-3-(3-phenylpropylsulfanyl)propyl]carbamoyl]butyl]carbamate
  • N-[(1S)-3-methyl-1-[oxo-[[(1S)-2-oxo-1-(phenylmethyl)-3-(3-phenylpropylthio)propyl]amino]methyl]butyl]carbamic acid phenylmethyl ester
  • N-[(1S)-1-[[(1S)-1-(benzyl)-2-keto-3-(3-phenylpropylthio)propyl]carbamoyl]-3-methyl-butyl]carbamic acid benzyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0094 0.4182 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.1948 0.0922
Brugia malayi Cathepsin L-like precursor 0.0052 0.113 0.113
Giardia lamblia Cathepsin B precursor 0.0063 0.1948 0.5
Brugia malayi Dopamine receptor 0.0094 0.4182 0.4182
Schistosoma mansoni amine GPCR 0.0094 0.4182 0.4182
Brugia malayi G protein-coupled receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis serotonin receptor 0.0094 0.4182 0.3441
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.1948 0.1948
Onchocerca volvulus 0.0052 0.113 0.2703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.113 0.113
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.4182 0.4182
Schistosoma mansoni biogenic amine receptor 0.0094 0.4182 0.4182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.4182 0.4182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0094 0.4182 0.4182
Schistosoma mansoni amine GPCR 0.0094 0.4182 0.4182
Echinococcus granulosus 7TM GPCR rhodopsin 0.0094 0.4182 0.4182
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0094 0.4182 0.4182
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.113 0.113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.4182 0.3441
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptide s receptor 0.0094 0.4182 0.4182
Schistosoma mansoni opsin-like receptor 0.0094 0.4182 0.4182
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus multilocularis fmrfamide receptor 0.0094 0.4182 0.3441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Entamoeba histolytica cysteine protease, putative 0.0052 0.113 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0094 0.4182 0.4182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Echinococcus multilocularis somatostatin receptor 0.0094 0.4182 0.3441
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.4182 0.3441
Onchocerca volvulus 0.0094 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni amine GPCR 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus multilocularis allatostatin A receptor 0.0094 0.4182 0.3441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Giardia lamblia Cathepsin B precursor 0.0063 0.1948 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0094 0.4182 0.3441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptide receptor 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.4182 0.4182
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.113 0.5
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0094 0.4182 0.3441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.4182 0.4182
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0175 1 1
Toxoplasma gondii cathepsin B 0.0063 0.1948 1
Schistosoma mansoni biogenic amine receptor 0.0094 0.4182 0.4182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis cathepsin b 0.0175 1 1
Schistosoma mansoni neuropeptide receptor 0.0094 0.4182 0.4182
Schistosoma mansoni amine GPCR 0.0094 0.4182 0.4182
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0094 0.4182 0.4182
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0094 0.4182 0.3441
Echinococcus multilocularis serotonin receptor 0.0094 0.4182 0.3441
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.4182 0.3441
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0094 0.4182 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi Cathepsin L-like precursor 0.0052 0.113 0.113
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Echinococcus granulosus g protein coupled receptor 0.0094 0.4182 0.4182
Brugia malayi larval opioid receptor 0.0094 0.4182 0.4182
Brugia malayi putative neuropeptide receptor NPR1 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus multilocularis neuropeptides capa receptor 0.0094 0.4182 0.3441
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0094 0.4182 0.3441
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.4182 0.4182
Schistosoma mansoni opsin-like receptor 0.0094 0.4182 0.4182
Echinococcus granulosus sex peptide receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) fibroinase 0.0052 0.113 0.113
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.4182 0.3441
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0094 0.4182 0.3441
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0094 0.4182 0.3441
Schistosoma mansoni opsin-like receptor 0.0094 0.4182 0.4182
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi Serotonin receptor 0.0094 0.4182 0.4182
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0094 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptide receptor 0.0094 0.4182 0.4182
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus cathepsin b 0.0175 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0094 0.4182 0.4182
Schistosoma mansoni neuropeptide receptor 0.0094 0.4182 0.4182
Plasmodium vivax vivapain-2 0.0052 0.113 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus multilocularis sex peptide receptor 0.0094 0.4182 0.3441
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Echinococcus granulosus cathepsin b 0.0175 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0094 0.4182 0.3441
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus peptide allatostatin:somatostatin 0.0094 0.4182 0.4182
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Loa Loa (eye worm) cathepsin B 0.0063 0.1948 0.1948
Echinococcus granulosus g protein coupled receptor 0.0094 0.4182 0.4182
Brugia malayi neuropeptide F receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) ctsf protein 0.0052 0.113 0.113
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0052 0.113 0.2703
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.5248 0.4642
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0094 0.4182 0.3441
Echinococcus multilocularis G-protein coupled receptor, putative 0.0094 0.4182 0.3441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus granulosus g protein coupled receptor 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Echinococcus granulosus neuropeptide receptor A26 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.5248 0.4642
Leishmania major cathepsin L-like protease 0.0109 0.5248 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus multilocularis fmrfamide receptor 0.0094 0.4182 0.3441
Schistosoma mansoni hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Brugia malayi follicle stimulating hormone receptor 0.0094 0.4182 0.4182
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.113 0.113
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.113 1
Trypanosoma cruzi cysteine peptidase, putative 0.0109 0.5248 0.4642
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.4182 0.3441
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi Cathepsin L-like precursor 0.0052 0.113 0.113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Loa Loa (eye worm) G-protein coupled receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.113 0.113
Schistosoma mansoni growth hormone secretagogue receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.113 0.5803
Onchocerca volvulus 0.0094 0.4182 1
Onchocerca volvulus 0.0052 0.113 0.2703
Echinococcus granulosus fmrfamide receptor 0.0094 0.4182 0.4182
Plasmodium vivax vivapain-2 0.0052 0.113 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Schistosoma mansoni hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Echinococcus multilocularis neuropeptide receptor 0.0094 0.4182 0.3441
Leishmania major cathepsin L-like protease 0.0109 0.5248 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi GnHR receptor homolog 0.0094 0.4182 0.4182
Echinococcus multilocularis g-protein coupled receptor 0.0094 0.4182 0.3441
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Giardia lamblia Cathepsin B precursor 0.0063 0.1948 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0094 0.4182 0.4182
Echinococcus granulosus orexin receptor type 2 0.0094 0.4182 0.4182
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0094 0.4182 0.4182
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0094 0.4182 0.3441
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Onchocerca volvulus 0.0052 0.113 0.2703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Echinococcus granulosus cathepsin l1 0.0052 0.113 0.113
Brugia malayi ORL1-like opioid receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus somatostatin receptor 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus granulosus G protein coupled receptor 139 0.0094 0.4182 0.4182
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0094 0.4182 0.3441
Brugia malayi AKH receptor 0.0094 0.4182 0.4182
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.113 0.113
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0094 0.4182 0.4182
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0094 0.4182 0.4182
Schistosoma mansoni biogenic amine receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 1 1
Schistosoma mansoni adenoreceptor 0.0094 0.4182 0.4182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Echinococcus multilocularis g protein coupled receptor 0.0094 0.4182 0.3441
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni myosin xvIII 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.4182 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0175 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0052 0.113 0.2703
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0093 0.4118 0.3368
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Schistosoma mansoni hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni neuropeptide F-like receptor 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.113 0.113
Onchocerca volvulus 0.0094 0.4182 1
Brugia malayi Cathepsin L-like precursor 0.0052 0.113 0.113
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) cysteine protease 0.0052 0.113 0.113
Echinococcus multilocularis orexin receptor type 2 0.0094 0.4182 0.3441
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.113 0.113
Echinococcus granulosus tachykinin peptides receptor 99D 0.0094 0.4182 0.4182
Echinococcus granulosus hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus allatostatin A receptor 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.113 0.5803
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus granulosus neuropeptide FF receptor 2 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Brugia malayi neuropeptide F receptor 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Schistosoma mansoni neuropeptide receptor 0.0094 0.4182 0.4182
Brugia malayi Dopamine receptor protein 2 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Onchocerca volvulus Cathepsin L homolog 0.0052 0.113 0.2703
Leishmania major cathepsin L-like protease 0.0109 0.5248 1
Onchocerca volvulus Cathepsin L homolog 0.0052 0.113 0.2703
Echinococcus multilocularis cathepsin b 0.0175 1 1
Brugia malayi G-protein coupled receptor 0.0094 0.4182 0.4182
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0094 0.4182 0.4182
Echinococcus multilocularis neuropeptide receptor 0.0094 0.4182 0.3441
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus granulosus 7tm_1 domain containing protein 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.1948 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0094 0.4182 1
Brugia malayi putative neuropeptide receptor 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0175 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.113 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0094 0.4182 0.3441
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus multilocularis g protein coupled receptor 0.0094 0.4182 0.3441
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0052 0.113 0.2703
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0094 0.4182 0.3441
Schistosoma mansoni neuropeptide receptor 0.0094 0.4182 0.4182
Brugia malayi Cathepsin L-like precursor 0.0052 0.113 0.113
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Schistosoma mansoni hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus multilocularis dro:myosuppressin receptor 0.0094 0.4182 0.3441
Brugia malayi Cathepsin L-like precursor 0.0052 0.113 0.113
Echinococcus granulosus serotonin receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0094 0.4182 0.3441
Schistosoma mansoni amine GPCR 0.0094 0.4182 0.4182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0094 0.4182 0.3441
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptide Y receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) melatonin receptor type 1A 0.0094 0.4182 0.4182
Brugia malayi G-protein coupled receptor 0.0094 0.4182 0.4182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0094 0.4182 0.3441
Echinococcus granulosus dro:myosuppressin receptor 0.0094 0.4182 0.4182
Trypanosoma cruzi cruzipain precursor, putative 0.0109 0.5248 0.4642
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi sulfakinin receptor protein 0.0094 0.4182 0.4182
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.113 0.5
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus tm gpcr rhodopsin 0.0094 0.4182 0.4182
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.246 0.1499
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Brugia malayi Tachykinin-like peptides receptor 99D 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0052 0.113 0.2703
Loa Loa (eye worm) neuropeptide F receptor 0.0094 0.4182 0.4182
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.113 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Schistosoma mansoni biogenic amine (5HT) receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis g protein coupled receptor 0.0094 0.4182 0.3441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0094 0.4182 0.4182
Schistosoma mansoni alpha-1 adrenergic receptor 0.0094 0.4182 0.4182
Echinococcus granulosus g-protein coupled receptor 0.0094 0.4182 0.4182
Schistosoma mansoni histamine h1 receptor 0.0094 0.4182 0.4182
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.1948 0.1985
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0094 0.4182 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0109 0.5248 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.113 0.5803
Brugia malayi G protein-coupled receptor F59B2.13 0.0094 0.4182 0.4182
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0175 1 1
Brugia malayi Serotonin receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0094 0.4182 0.4182
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0094 0.4182 0.4182
Brugia malayi hypothetical protein 0.0094 0.4182 0.4182
Brugia malayi Melatonin receptor type 1A 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0094 0.4182 0.4182
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0094 0.4182 0.4182
Echinococcus granulosus neuropeptides capa receptor 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0094 0.4182 0.4182
Echinococcus multilocularis neuropeptide Y receptor 0.0094 0.4182 0.3441
Loa Loa (eye worm) TYRA-2 protein 0.0094 0.4182 0.4182
Brugia malayi RE15519p 0.0094 0.4182 0.4182
Echinococcus granulosus alpha 1A adrenergic receptor 0.0094 0.4182 0.4182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.113 0.5803
Echinococcus granulosus rhodopsin orphan GPCR 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Onchocerca volvulus 0.0094 0.4182 1
Onchocerca volvulus Cathepsin F homolog 0.0052 0.113 0.2703
Echinococcus multilocularis G protein coupled receptor 139 0.0094 0.4182 0.3441
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.113 0.113
Brugia malayi Dopamine receptor protein 1 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182
Loa Loa (eye worm) hypothetical protein 0.0094 0.4182 0.4182

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 1 nM Inhibition of Trypanosoma cruzi cruzain ChEMBL. 17996450
Ki (binding) = 1 nM Inhibitory activity against cruzain, the major cysteine protease found in T. cruzi ChEMBL. 11806719
Ki (binding) = 1 nM Inhibition of Trypanosoma cruzi cruzain ChEMBL. 17996450
Ki (binding) = 4.7 nM Inhibitory activity of the compound against human Cathepsin L ChEMBL. 11806719
Ki (binding) = 4.7 nM Inhibitory activity of the compound against human Cathepsin L ChEMBL. 11806719
Ki (binding) = 135.9 nM Inhibitory activity of the compound against human Cathepsin B ChEMBL. 11806719
Ki (binding) = 135.9 nM Inhibitory activity of the compound against human Cathepsin B ChEMBL. 11806719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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