Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0213 | 0.1928 | 0.6212 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0425 | 0.4462 | 0.4462 |
Toxoplasma gondii | hypothetical protein | 0.0075 | 0.0274 | 0.3192 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0063 | 0.0135 | 0.0618 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0163 | 0.1329 | 0.1329 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0262 | 0.2515 | 0.2515 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.02 | 0.1772 | 0.1772 |
Brugia malayi | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Brugia malayi | ecdysone receptor | 0.0163 | 0.1329 | 0.1329 |
Onchocerca volvulus | 0.0425 | 0.4462 | 0.3613 | |
Schistosoma mansoni | microtubule-associated protein tau | 0.0716 | 0.7933 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | Presenilin spe-4 | 0.0075 | 0.0274 | 0.0274 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0503 | 0.5398 | 0.675 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0262 | 0.2515 | 0.2515 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0503 | 0.5398 | 0.675 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0274 | 0.0274 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0163 | 0.1329 | 0.1532 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0213 | 0.1928 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0503 | 0.5398 | 0.675 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0425 | 0.4462 | 0.5549 |
Schistosoma mansoni | coup transcription factor | 0.0425 | 0.4462 | 0.5549 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.02 | 0.1772 | 0.1772 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0716 | 0.7933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0642 | 0.0642 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0508 | 0.5452 | 0.5452 |
Echinococcus multilocularis | sodium channel protein | 0.0214 | 0.1934 | 0.2308 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0503 | 0.5398 | 0.675 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | tailless protein | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0503 | 0.5398 | 0.675 |
Loa Loa (eye worm) | DR-78 | 0.0163 | 0.1329 | 0.1329 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0163 | 0.1329 | 0.1532 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0425 | 0.4462 | 0.5549 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | FTZ F1 alpha | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0623 | 0.0623 |
Brugia malayi | nuclear hormone receptor | 0.0163 | 0.1329 | 0.1329 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0425 | 0.4462 | 0.5549 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0425 | 0.4462 | 0.5549 |
Echinococcus granulosus | presenilin enhancer 2 | 0.02 | 0.1772 | 0.2099 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0265 | 0.2551 | 0.3098 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0105 | 0.0642 | 0.0642 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Schistosoma mansoni | thyroid hormone receptor | 0.0556 | 0.6022 | 0.755 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0163 | 0.1329 | 0.1329 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0425 | 0.4462 | 0.5549 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0425 | 0.4462 | 0.4462 |
Schistosoma mansoni | nuclear receptor | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | nuclear receptor NHR-88 | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0503 | 0.5398 | 0.675 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 0.5398 | 0.5398 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0213 | 0.1928 | 0.1395 |
Brugia malayi | steroid hormone receptor | 0.0858 | 0.9634 | 0.9634 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | conserved hypotetical protein | 0.0163 | 0.1329 | 0.1329 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.0942 | 0.1036 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0596 | 0.6501 | 0.8164 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0131 | 0.0942 | 0.1036 |
Brugia malayi | nuclear receptor NHR-88 | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0508 | 0.5452 | 0.5452 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0262 | 0.2515 | 0.2515 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Schistosoma mansoni | hypothetical protein | 0.0104 | 0.0623 | 0.0626 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0163 | 0.1329 | 0.1532 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0262 | 0.2515 | 0.3053 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0503 | 0.5398 | 0.5398 |
Schistosoma mansoni | nuclear receptor | 0.0163 | 0.1329 | 0.1532 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0163 | 0.1329 | 0.1532 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0425 | 0.4462 | 0.5549 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0303 | 0.2997 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0425 | 0.4462 | 0.5549 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | nuclear hormone receptor | 0.0425 | 0.4462 | 0.4462 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0213 | 0.1928 | 0.23 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.02 | 0.1772 | 0.2099 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0503 | 0.5398 | 0.675 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0213 | 0.1928 | 0.1395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0425 | 0.4462 | 0.5549 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0163 | 0.1329 | 0.1532 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | presenilin | 0.0213 | 0.1928 | 0.23 |
Echinococcus granulosus | Nicastrin | 0.0104 | 0.0623 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.049 | 0.049 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0503 | 0.5398 | 0.675 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0556 | 0.6022 | 0.755 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0508 | 0.5452 | 0.6819 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0425 | 0.4462 | 0.4462 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0163 | 0.1329 | 0.1532 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0105 | 0.0642 | 0.0651 |
Brugia malayi | Presenilin family protein | 0.0213 | 0.1928 | 0.1928 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1619 | 0.1619 |
Echinococcus multilocularis | presenilin | 0.0213 | 0.1928 | 0.23 |
Echinococcus multilocularis | Nicastrin | 0.0104 | 0.0623 | 0.0626 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0425 | 0.4462 | 0.4462 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0213 | 0.1928 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0858 | 0.9634 | 0.9634 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0425 | 0.4462 | 0.5549 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0213 | 0.1928 | 1 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0306 | 0.3042 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0163 | 0.1329 | 0.1532 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0075 | 0.0274 | 0.0274 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0503 | 0.5398 | 0.675 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0274 | 0.0274 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0187 | 0.1619 | 0.0334 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0163 | 0.1329 | 0.1329 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0303 | 0.2997 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0889 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0105 | 0.0642 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.4462 | 0.4462 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0262 | 0.2515 | 0.3053 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0503 | 0.5398 | 0.675 |
Schistosoma mansoni | zinc finger protein | 0.0163 | 0.1329 | 0.1532 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0425 | 0.4462 | 0.3613 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.049 | 0.049 |
Echinococcus multilocularis | Nicastrin | 0.0104 | 0.0623 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0527 | 0.5684 | 0.7116 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0503 | 0.5398 | 0.675 |
Schistosoma mansoni | voltage-gated cation channel | 0.0503 | 0.5398 | 0.675 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0425 | 0.4462 | 0.4462 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0274 | 0.0274 |
Brugia malayi | Presenilin spe-4 | 0.0075 | 0.0274 | 0.0274 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 0.049 | 0.719 |
Schistosoma mansoni | thyroid hormone receptor | 0.0556 | 0.6022 | 0.755 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0063 | 0.0135 | 0.0183 |
Schistosoma mansoni | nuclear hormone receptor | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | Presenilin spe-4 | 0.0075 | 0.0274 | 0.0274 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0508 | 0.5452 | 0.6819 |
Loa Loa (eye worm) | calcium channel | 0.0503 | 0.5398 | 0.5398 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0262 | 0.2515 | 0.3053 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0425 | 0.4462 | 0.5549 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0131 | 0.0942 | 0.1036 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0213 | 0.1928 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | nuclear receptor RXR | 0.0262 | 0.2515 | 0.2515 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0262 | 0.2515 | 0.3053 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0425 | 0.4462 | 0.4462 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0425 | 0.4462 | 0.4462 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | nuclear receptor RXR | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0508 | 0.5452 | 0.6819 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0163 | 0.1329 | 0.1329 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0198 | 0.1747 | 0.5598 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0623 | 0.0623 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0306 | 0.3042 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0163 | 0.1329 | 0.1329 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0503 | 0.5398 | 0.675 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0163 | 0.1329 | 0.1532 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0623 | 0.0623 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0163 | 0.1329 | 0.1329 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0163 | 0.1329 | 0.1532 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0425 | 0.4462 | 0.5549 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0425 | 0.4462 | 0.5549 |
Brugia malayi | N-terminal motif family protein | 0.0187 | 0.1619 | 0.1619 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0425 | 0.4462 | 0.4462 |
Schistosoma mansoni | nuclear hormone receptor | 0.0163 | 0.1329 | 0.1532 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0527 | 0.5684 | 0.7116 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0425 | 0.4462 | 0.3613 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0425 | 0.4462 | 0.4462 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0213 | 0.1928 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0425 | 0.4462 | 0.5549 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0214 | 0.1934 | 0.2308 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0716 | 0.7933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1329 | 0.1329 |
Brugia malayi | hypothetical protein | 0.0262 | 0.2515 | 0.2515 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0163 | 0.1329 | 0.1329 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0075 | 0.0274 | 0.0274 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC20 (functional) | = 56 ng ml-1 | Relative ability to increase cholinergically mediated contractions in isolated ileum of guinea pig | ChEMBL. | 8459397 |
EC20 (functional) | = 56 ng ml-1 | Relative ability to increase cholinergically mediated contractions in isolated ileum of guinea pig | ChEMBL. | 8459397 |
LAD (functional) | = 0.05 mg kg-1 | Tested against rhythmic contractile activity in a Heidenhain pouch dog preparation | ChEMBL. | 8459397 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.