Detailed information for compound 275207

Basic information

Technical information
  • TDR Targets ID: 275207
  • Name: 2-[cyclopentyl-[3-(2,2-dimethylpropanoylsulfa nyl)-2-methylpropanoyl]amino]acetic acid
  • MW: 329.455 | Formula: C16H27NO4S
  • H donors: 1 H acceptors: 4 LogP: 2.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(=O)N(C1CCCC1)CC(=O)O)CSC(=O)C(C)(C)C
  • InChi: 1S/C16H27NO4S/c1-11(10-22-15(21)16(2,3)4)14(20)17(9-13(18)19)12-7-5-6-8-12/h11-12H,5-10H2,1-4H3,(H,18,19)
  • InChiKey: XRKXJJYSKUIIEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[cyclopentyl-[3-(2,2-dimethylpropanoylsulfanyl)-2-methyl-propanoyl]amino]acetic acid
  • 2-[cyclopentyl-[3-[(2,2-dimethyl-1-oxopropyl)thio]-2-methyl-1-oxopropyl]amino]acetic acid
  • 2-[cyclopentyl-[3-(2,2-dimethylpropanoylsulfanyl)-2-methyl-propanoyl]amino]ethanoic acid
  • 2-[cyclopentyl-[2-methyl-3-(pivaloylthio)propanoyl]amino]acetic acid
  • pivalopril
  • 76963-39-8
  • Rhc-3659
  • Glycine, N-cyclopentyl-N-(3-((2,2-dimethyl-1-oxopropyl)thio)-2-methyl-1-oxopropyl)-
  • N-Cyclopentyl-N-(3-((2,2-dimethyl-1-oxopropyl)thio)-2-methyl-1-oxypropyl)glycine
  • Rhc 3659

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Angiotensin-converting enzyme Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Brugia malayi Angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis epidermal growth factor receptor 0.0092 0.0332 0.0332
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.003 0.0079 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0092 0.0329 0.188
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0056 0.0191
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0024 0.0056 0.0056
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0079 0.0079
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.0105 0.1014
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0079 0.0079
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0079 0.0079
Brugia malayi aspartic protease BmAsp-1, identical 0.0036 0.0105 0.0105
Trypanosoma cruzi trypanothione reductase, putative 0.0265 0.1028 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0079 0.0079
Echinococcus multilocularis muscleblind protein 0.014 0.0526 0.0526
Plasmodium falciparum plasmepsin II 0.0036 0.0105 0.1014
Plasmodium falciparum plasmepsin IV 0.0036 0.0105 0.1014
Echinococcus granulosus para nitrobenzyl esterase 0.042 0.1655 0.1655
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0056 0.027
Schistosoma mansoni two-pore calcium channel 0.003 0.0079 0.0054
Loa Loa (eye worm) hypothetical protein 0.0219 0.0843 0.0843
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.003 0.0079 0.0079
Echinococcus multilocularis glutamate synthase 0.0024 0.0056 0.0056
Echinococcus multilocularis conserved hypothetical protein 0.003 0.0079 0.0079
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0056 0.027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0092 0.0329 0.2998
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0024 0.0056 0.09
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0024 0.0056 0.0259
Schistosoma mansoni tyrosine kinase 0.0055 0.018 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0048 0.0048
Schistosoma mansoni tyrosine kinase 0.0055 0.018 0.0155
Schistosoma mansoni glutamate synthase 0.0024 0.0056 0.0031
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0715 0.2847 0.2847
Loa Loa (eye worm) voltage-gated potassium channel 0.003 0.0079 0.0079
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0092 0.0329 0.188
Loa Loa (eye worm) hypothetical protein 0.0029 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Schistosoma mansoni tyrosine kinase 0.0092 0.0332 0.0307
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0032 0.0031
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.003 0.0079 0.05
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.042 0.1655 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0105
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0024 0.0056 0.0056
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0056 0.027
Brugia malayi cation channel family protein 0.003 0.0079 0.0079
Echinococcus multilocularis insulin receptor 0.0055 0.018 0.018
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0715 0.2847 0.2846
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0249 0.0964 0.9365
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0024 0.0056 0.0166
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Mycobacterium ulcerans carboxylesterase, LipT 0.042 0.1655 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0079 0.0079
Echinococcus multilocularis sodium leak channel non selective protein 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0056 0.027
Echinococcus granulosus voltage gated potassium channel 0.003 0.0079 0.0079
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0024 0.0056 0.0213
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0024 0.0056 0.0056
Loa Loa (eye worm) programmed cell death 8 0.0024 0.0056 0.0056
Loa Loa (eye worm) voltage-gated calcium channel 0.003 0.0079 0.0079
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Brugia malayi Carboxylesterase family protein 0.042 0.1655 0.1654
Echinococcus granulosus peregrin 0.0027 0.0069 0.0069
Entamoeba histolytica thioredoxin reductase, putative 0.0024 0.0056 0.0259
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0134 0.0501 1
Schistosoma mansoni glutamate synthase 0.0024 0.0056 0.0031
Brugia malayi Carboxylesterase family protein 0.042 0.1655 0.1654
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Loa Loa (eye worm) TK/INSR protein kinase 0.0055 0.018 0.018
Echinococcus multilocularis acetylcholinesterase 0.2484 1 1
Mycobacterium ulcerans NADH dehydrogenase 0.0024 0.0056 0.0191
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0056 0.027
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0105
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.003 0.0079 0.0079
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.009 0.0321 0.0321
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0079 0.0079
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0092 0.0332 0.0332
Brugia malayi Carboxylesterase family protein 0.2484 1 1
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0079 0.0079
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0024 0.0056 0.0213
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0029 0.0029
Leishmania major trypanothione reductase 0.0265 0.1028 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Trichomonas vaginalis glutathione reductase, putative 0.0092 0.0329 0.1841
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0092 0.0329 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0056 0.027
Plasmodium vivax SET domain protein, putative 0.0029 0.0074 0.071
Echinococcus multilocularis two pore calcium channel protein 2 0.003 0.0079 0.0079
Leishmania major hypothetical protein, conserved 0.003 0.0079 0.05
Brugia malayi ion channel NompC 0.003 0.0079 0.0079
Echinococcus granulosus BC026374 protein S09 family 0.042 0.1655 0.1655
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Echinococcus multilocularis thioredoxin glutathione reductase 0.0265 0.1028 0.1028
Schistosoma mansoni transient receptor potential channel 0.003 0.0079 0.0054
Plasmodium falciparum plasmepsin III 0.0036 0.0105 0.1014
Brugia malayi Carboxylesterase family protein 0.042 0.1655 0.1654
Brugia malayi Pepsin A precursor 0.0036 0.0105 0.0105
Plasmodium vivax plasmepsin IV, putative 0.0036 0.0105 0.1014
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0024 0.0056 0.0541
Brugia malayi Bromodomain containing protein 0.0027 0.0069 0.0068
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0056 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0079 0.05
Echinococcus multilocularis BC026374 protein (S09 family) 0.042 0.1655 0.1655
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.003 0.0079 0.0079
Plasmodium falciparum plasmepsin VII 0.0036 0.0105 0.1014
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0024 0.0056 0.027
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.003 0.0079 0.0079
Toxoplasma gondii hypothetical protein 0.003 0.0079 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0056 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0048 0.014
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0092 0.0329 0.3193
Loa Loa (eye worm) thioredoxin reductase 0.0265 0.1028 0.1027
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0079 0.0079
Toxoplasma gondii aspartyl protease ASP3 0.0036 0.0105 0.0756
Echinococcus multilocularis shaker cognate 0.003 0.0079 0.0079
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.003 0.0079 0.0079
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0105 0.0105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0092 0.0329 0.1862
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0067 0.023 0.023
Trichomonas vaginalis apoptosis inducing factor, putative 0.0024 0.0056 0.0166
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0036 0.0105 0.0105
Mycobacterium tuberculosis Carboxylesterase LipT 0.042 0.1655 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0024 0.0056 0.0056
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0074 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Echinococcus granulosus neuroligin 0.042 0.1655 0.1655
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0074 0.0074
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Echinococcus multilocularis transfer RNA-Gly 0.003 0.0079 0.0079
Giardia lamblia Glutamate synthase 0.0024 0.0056 0.0259
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0056 0.0056
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0024 0.0056 0.027
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.003 0.0079 0.0079
Onchocerca volvulus 0.0027 0.0067 0.0118
Echinococcus granulosus shaker cognate 0.003 0.0079 0.0079
Echinococcus granulosus voltage dependent calcium channel 0.0249 0.0964 0.0964
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.003 0.0079 0.0054
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0092 0.0329 0.3193
Schistosoma mansoni memapsin-2 (A01 family) 0.0905 0.3618 0.3601
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0025 0.0238
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0079 0.0307
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0098 0.0098
Trichomonas vaginalis mercuric reductase, putative 0.0092 0.0329 0.1841
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Echinococcus granulosus ryanodine receptor 44f 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.0105 0.1014
Mycobacterium tuberculosis Probable reductase 0.0024 0.0056 0.0213
Echinococcus multilocularis voltage dependent calcium channel 0.0715 0.2847 0.2847
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0024 0.0056 0.0213
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0024 0.0056 0.0056
Onchocerca volvulus 0.042 0.1655 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.003 0.0079 0.0079
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0079 0.0079
Brugia malayi Eukaryotic aspartyl protease family protein 0.0036 0.0105 0.0105
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0079 0.0079
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0079 0.0079
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0024 0.0056 0.027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0079 0.0079
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0024 0.0056 0.0191
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0079 0.0079
Brugia malayi jmjC domain containing protein 0.009 0.0321 0.032
Leishmania major hypothetical protein, conserved 0.0024 0.0056 0.027
Plasmodium vivax aspartyl protease, putative 0.0036 0.0105 0.1014
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Echinococcus granulosus voltage dependent calcium channel 0.0715 0.2847 0.2847
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0048 0.0162
Toxoplasma gondii transporter, cation channel family protein 0.0249 0.0964 0.9365
Brugia malayi olfactory channel protein osm-9 0.003 0.0079 0.0079
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0092 0.0329 0.0329
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0069 0.0394
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0079 0.0079
Loa Loa (eye worm) aspartyl protease 6 0.0036 0.0105 0.0105
Echinococcus granulosus voltage gated potassium channel 0.003 0.0079 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0067 0.0067
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0024 0.0056 0.0541
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0092 0.0329 0.1862
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0024 0.0056 0.0056
Toxoplasma gondii transporter, cation channel family protein 0.003 0.0079 0.05
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0024 0.0056 0.09
Onchocerca volvulus 0.0029 0.0074 0.016
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0079 0.0054
Loa Loa (eye worm) calcium channel 0.0715 0.2847 0.2846
Echinococcus granulosus insulin receptor 0.0055 0.018 0.018
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0048 0.0048
Leishmania major calcium channel protein, putative,ion transporter, putative 0.003 0.0079 0.05
Plasmodium falciparum thioredoxin reductase 0.0092 0.0329 0.3193
Plasmodium falciparum glutathione reductase 0.0265 0.1028 1
Toxoplasma gondii hypothetical protein 0.0219 0.0843 0.8149
Echinococcus multilocularis two pore calcium channel protein 1 0.003 0.0079 0.0079
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0024 0.0056 0.027
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.003 0.0079 0.0079
Loa Loa (eye worm) voltage-gated potassium channel 0.003 0.0079 0.0079
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0079 0.0079
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0056 0.0259
Echinococcus multilocularis ryanodine receptor 44f 0.003 0.0079 0.0079
Schistosoma mansoni transient receptor potential channel 4 0.003 0.0079 0.0054
Onchocerca volvulus 0.003 0.0079 0.0195
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0092 0.0329 0.2998
Plasmodium falciparum plasmepsin VIII, putative 0.0036 0.0105 0.1014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0148 0.0147
Echinococcus granulosus calcium activated potassium channel 0.003 0.0079 0.0079
Plasmodium vivax plasmepsin V, putative 0.0036 0.0105 0.1014
Brugia malayi Transient-receptor-potential like protein 0.003 0.0079 0.0079
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0055 0.018 0.018
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0024 0.0056 0.0056
Entamoeba histolytica disulphide oxidoreductase, putative 0.0024 0.0056 0.0259
Loa Loa (eye worm) hypothetical protein 0.0715 0.2847 0.2846
Brugia malayi voltage-dependent calcium channel 0.003 0.0079 0.0079
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.003 0.0079 0.0054
Onchocerca volvulus 0.042 0.1655 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0092 0.0329 0.2998
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0092 0.0329 0.1862
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0067 0.023 0.023
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0092 0.0329 0.3193
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.0329 0.188
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.003 0.0079 0.05
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0715 0.2847 0.2847
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Echinococcus granulosus muscleblind protein 0.014 0.0526 0.0526
Treponema pallidum oxidoreductase 0.0024 0.0056 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0134 0.0501 0.2932
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Loa Loa (eye worm) hypothetical protein 0.014 0.0526 0.0525
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0036 0.0105 0.0756
Onchocerca volvulus 0.0223 0.086 0.5056
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.003 0.0079 0.0079
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0079 0.0307
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0048 0.014
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0024 0.0056 0.0184
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0715 0.2847 0.2847
Schistosoma mansoni voltage-gated ion channel 0.003 0.0079 0.0054
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0079 0.0079
Schistosoma mansoni BC026374 protein (S09 family) 0.042 0.1655 0.1633
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0074 0.0074
Giardia lamblia Thioredoxin reductase 0.0024 0.0056 0.0259
Echinococcus multilocularis carboxylesterase 5A 0.2484 1 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.003 0.0079 0.0079
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0024 0.0056 0.0213
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0056 0.0056
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0024 0.0056 0.0191
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Mycobacterium ulcerans ferredoxin reductase 0.0024 0.0056 0.0191
Brugia malayi Thioredoxin reductase 0.0265 0.1028 0.1027
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Plasmodium falciparum plasmepsin X 0.0036 0.0105 0.1014
Echinococcus granulosus two pore calcium channel protein 1 0.003 0.0079 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0067 0.0067
Loa Loa (eye worm) carboxylesterase 0.042 0.1655 0.1654
Onchocerca volvulus 0.0036 0.0105 0.0354
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0092 0.0329 0.0304
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0054
Loa Loa (eye worm) carboxylesterase 0.042 0.1655 0.1654
Schistosoma mansoni cpg binding protein 0.0029 0.0073 0.0048
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0092 0.0329 0.2998
Schistosoma mansoni 60S ribosomal protein L21 0.003 0.0079 0.0054
Brugia malayi jmjC domain containing protein 0.0035 0.0098 0.0098
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0092 0.0329 0.2998
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.003 0.0079 0.0079
Echinococcus granulosus cpg binding protein 0.0029 0.0073 0.0073
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0092 0.0329 0.3193
Echinococcus granulosus epidermal growth factor receptor 0.0092 0.0332 0.0332
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0029 0.0279
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0024 0.0056 0.0213
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0056 0.0166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0079 0.0054
Mycobacterium ulcerans glutamate synthase subunit beta 0.0024 0.0056 0.0191
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0024 0.0056 0.0213
Treponema pallidum NADH oxidase 0.0092 0.0329 0.288
Plasmodium vivax aspartyl protease, putative 0.0036 0.0105 0.1014
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0079 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0056 0.027
Schistosoma mansoni tyrosine kinase 0.0091 0.0328 0.0303
Leishmania major hypothetical protein, conserved 0.0024 0.0056 0.027
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0029 0.0048
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0079 0.0079
Schistosoma mansoni glutamate synthase 0.0024 0.0056 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0074 0.0048
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0056 0.027
Giardia lamblia PHD finger protein 15 0.0027 0.0069 0.0378
Schistosoma mansoni neuroligin 3 (S09 family) 0.042 0.1655 0.1633
Brugia malayi PHD-finger family protein 0.0027 0.0069 0.0068
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0715 0.2847 0.2847
Schistosoma mansoni hypothetical protein 0.0024 0.0056 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.042 0.1655 0.1655
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0079 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2484 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.003 0.0079 0.0079
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0069 0.0069
Schistosoma mansoni gliotactin 0.042 0.1655 0.1633
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0024 0.0056 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0024 0.0056 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0024 0.0056 0.0184
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0024 0.0056 0.0184
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.003 0.0079 0.0079
Echinococcus granulosus hypothetical protein 0.003 0.0079 0.0079
Brugia malayi aspartic protease BmAsp-2, identical 0.0036 0.0105 0.0105
Toxoplasma gondii hypothetical protein 0.003 0.0079 0.05
Schistosoma mansoni cpg binding protein 0.0029 0.0073 0.0048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0024 0.0056 0.09
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0024 0.0056 0.0541
Echinococcus multilocularis para nitrobenzyl esterase 0.042 0.1655 0.1655
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0024 0.0056 0.0541
Brugia malayi Protein kinase domain containing protein 0.0055 0.018 0.018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0092 0.0329 0.288
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0196 0.0751 0.0751
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0079 0.0079
Loa Loa (eye worm) ion channel NompC 0.003 0.0079 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0074 0.0444
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Plasmodium falciparum thioredoxin reductase 0.0265 0.1028 1
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Onchocerca volvulus 0.0024 0.0056 0.0052
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0024 0.0056 0.0056
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0079 0.0079
Mycobacterium ulcerans dehydrogenase 0.0024 0.0056 0.0191
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.003 0.0079 0.0079
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0079 0.0079
Trichomonas vaginalis spcc417.12 protein, putative 0.042 0.1655 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0056 0.0166
Schistosoma mansoni tyrosine kinase 0.0172 0.0653 0.0629
Loa Loa (eye worm) ryanodine receptor 0.003 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Echinococcus multilocularis transient receptor potential gamma protein 0.003 0.0079 0.0079
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0069 0.0069
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0024 0.0056 0.0056
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0024 0.0056 0.0191
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0056 0.0166
Plasmodium vivax aspartyl protease, putative 0.0036 0.0105 0.1014
Schistosoma mansoni tyrosine kinase 0.0091 0.0328 0.0303
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0079 0.0079
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0024 0.0056 0.0166
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0024 0.0056 0.027
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0098 0.0098
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0056 0.0166
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0079 0.0079
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0079 0.0079
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0079 0.0079
Mycobacterium ulcerans hypothetical protein 0.0022 0.0048 0.014
Schistosoma mansoni ap endonuclease 0.0018 0.0029 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Echinococcus multilocularis voltage gated potassium channel 0.003 0.0079 0.0079
Plasmodium falciparum plasmepsin I 0.0036 0.0105 0.1014
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0025 0.0238
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0056 0.0031
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0079 0.0054
Trypanosoma brucei NADH dehydrogenase 0.0024 0.0056 0.027
Loa Loa (eye worm) voltage-dependent calcium channel 0.0249 0.0964 0.0964
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0036 0.0105 0.0105
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0024 0.0056 0.027
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.0329 0.2998
Onchocerca volvulus 0.042 0.1655 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0079 0.0054
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0056 0.0166
Brugia malayi hypothetical protein 0.042 0.1655 0.1654
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0048 0.0179
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0092 0.0329 1
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 0.2984 0.2984
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.003 0.0079 0.0079
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0092 0.0329 0.0329
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0048 0.0162
Echinococcus granulosus acetylcholinesterase 0.2484 1 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0024 0.0056 0.0056
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0715 0.2847 0.2828
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0036 0.0105 0.0105
Echinococcus multilocularis sodium channel protein 0.003 0.0079 0.0079
Echinococcus granulosus sodium leak channel non selective protein 0.003 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily D 0.003 0.0079 0.0079
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0187 0.0186
Echinococcus granulosus voltage gated hydrogen channel 1 0.003 0.0079 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0048 0.0187
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0112 0.0112
Echinococcus granulosus potassium voltage gated channel subfamily H 0.003 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0056 0.027
Echinococcus granulosus carboxylesterase 5A 0.2484 1 1
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0056 0.0166
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.003 0.0079 0.0079
Onchocerca volvulus 0.042 0.1655 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.003 0.0079 0.0079
Echinococcus granulosus family S9 non peptidase ue S09 family 0.042 0.1655 0.1655
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0029 0.0279
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0092 0.0329 1
Toxoplasma gondii selenide, water dikinase 0.0024 0.0056 0.027
Echinococcus multilocularis muscleblind protein 1 0.014 0.0526 0.0526
Echinococcus granulosus potassium voltage gated channel protein 0.003 0.0079 0.0079
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0024 0.0056 0.027
Echinococcus granulosus sodium channel protein 0.003 0.0079 0.0079
Giardia lamblia Fructose-bisphosphate aldolase 0.0275 0.1069 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.0843 0.0843
Echinococcus granulosus potassium large conductance calcium activated 0.003 0.0079 0.0079
Echinococcus granulosus potassium voltage gated channel subfamily A 0.003 0.0079 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0024 0.0056 0.0191
Brugia malayi Muscleblind-like protein 0.014 0.0526 0.0525
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0249 0.0964 0.9365
Trypanosoma cruzi NADH dehydrogenase, putative 0.0024 0.0056 0.027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Trichomonas vaginalis glutamate synthase, putative 0.0024 0.0056 0.0166
Onchocerca volvulus 0.0036 0.0105 0.0354
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0715 0.2847 0.2828
Schistosoma mansoni inositol 145-trisphosphate receptor 0.003 0.0079 0.0054
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0275 0.1069 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.003 0.0079 0.0079
Schistosoma mansoni ap endonuclease 0.0018 0.0029 0.0004
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.042 0.1655 0.1633
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0029 0.0029
Treponema pallidum thioredoxin reductase (trxB) 0.0024 0.0056 0.0259
Loa Loa (eye worm) carboxylesterase 0.2484 1 1
Schistosoma mansoni hypothetical protein 0.0027 0.0069 0.0043
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Plasmodium vivax glutathione reductase, putative 0.0265 0.1028 1
Plasmodium vivax ferrodoxin reductase, putative 0.0024 0.0056 0.0541
Echinococcus multilocularis cpg binding protein 0.0029 0.0073 0.0073
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0024 0.0056 0.0213
Leishmania major NADH dehydrogenase, putative 0.0024 0.0056 0.027
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.003 0.0079 0.0079
Toxoplasma gondii transporter, cation channel family protein 0.003 0.0079 0.05
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0079 0.05
Onchocerca volvulus 0.042 0.1655 1
Schistosoma mansoni voltage-dependent calcium channel 0.003 0.0079 0.0054
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0079 0.0079
Echinococcus granulosus epidermal growth factor receptor 0.0172 0.0653 0.0653
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0715 0.2847 0.2847
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0024 0.0056 0.0184
Toxoplasma gondii histone lysine methyltransferase SET1 0.0052 0.0169 0.1397
Toxoplasma gondii aspartyl protease ASP1 0.0036 0.0105 0.0756
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Schistosoma mansoni vesicular amine transporter 0.003 0.0079 0.0054
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0024 0.0056 0.0259
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0024 0.0056 0.0259
Echinococcus multilocularis potassium large conductance calcium activated 0.003 0.0079 0.0079
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0056 0.0166
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.003 0.0079 0.0079
Plasmodium falciparum ferrodoxin reductase-like protein 0.0024 0.0056 0.0541
Chlamydia trachomatis thioredoxin reductase 0.0024 0.0056 0.1025
Schistosoma mansoni transient receptor potential channel 0.003 0.0079 0.0054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0029 0.0029
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0092 0.0329 0.6202
Schistosoma mansoni transient receptor potential channel 0.003 0.0079 0.0054
Echinococcus multilocularis neuroligin 0.042 0.1655 0.1655
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0079 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0223 0.086 0.5113
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0024 0.0056 0.0259
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0079 0.0054
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0024 0.0056 0.0184
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0025 0.0023
Brugia malayi Pre-SET motif family protein 0.0196 0.0751 0.0751
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0092 0.0329 0.2998
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0074 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Plasmodium falciparum plasmepsin VI 0.0036 0.0105 0.1014
Schistosoma mansoni tyrosine kinase 0.0091 0.0328 0.0303
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0079 0.0079
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0715 0.2847 0.2847
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0098 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0069 0.0661
Brugia malayi CXXC zinc finger family protein 0.0027 0.0067 0.0067
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0112 0.0112
Echinococcus multilocularis acetylcholinesterase 0.2484 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0172 0.0653 0.0653
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0024 0.0056 0.0166
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0036 0.0105 0.0756
Echinococcus multilocularis short transient receptor potential channel 6 0.003 0.0079 0.0079
Schistosoma mansoni ryanodine receptor related 0.003 0.0079 0.0054
Echinococcus granulosus glutamate synthase 0.0024 0.0056 0.0056
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0079 0.0079
Brugia malayi hypothetical protein 0.0036 0.0105 0.0105
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0246 0.0221
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.003 0.0079 0.0195
Echinococcus granulosus transient receptor potential gamma protein 0.003 0.0079 0.0079
Toxoplasma gondii NADPH-glutathione reductase 0.0092 0.0329 0.2998
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Echinococcus granulosus short transient receptor potential channel 6 0.003 0.0079 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0048 0.0187
Plasmodium falciparum plasmepsin V 0.0036 0.0105 0.1014
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0048 0.014
Loa Loa (eye worm) hypothetical protein 0.0249 0.0964 0.0964
Loa Loa (eye worm) TK/EGFR protein kinase 0.0172 0.0653 0.0653
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0079 0.0079
Brugia malayi Pre-SET motif family protein 0.0029 0.0074 0.0073
Echinococcus multilocularis voltage dependent calcium channel 0.0715 0.2847 0.2847
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.003 0.0079 0.0195
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0048 0.014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Echinococcus granulosus two pore calcium channel protein 2 0.003 0.0079 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0048 0.0048
Trypanosoma brucei trypanothione reductase 0.0265 0.1028 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0048 0.014
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0079 0.0079
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0762 0.3039 0.3039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0194 0.0169
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0055 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.2484 1 1
Echinococcus granulosus dnaJ subfamily B 0.0384 0.1512 0.1512
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.042 0.1655 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Echinococcus multilocularis peregrin 0.0027 0.0069 0.0069
Schistosoma mansoni voltage-gated cation channel 0.0715 0.2847 0.2828
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0069 0.0043
Schistosoma mansoni hypothetical protein 0.0384 0.1512 0.149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Echinococcus granulosus short transient receptor potential channel 6 0.003 0.0079 0.0079
Loa Loa (eye worm) acetylcholinesterase 1 0.2484 1 1
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0024 0.0056 0.027
Echinococcus granulosus thioredoxin glutathione reductase 0.0265 0.1028 0.1028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0092 0.0329 0.2998
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0068
Plasmodium falciparum phd finger protein, putative 0.0027 0.0069 0.0661
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0092 0.0329 0.0328
Echinococcus granulosus acetylcholinesterase 0.2484 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0069 0.0394
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0024 0.0056 0.0213
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0092 0.0329 0.2998
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0079 0.0054
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0134 0.0501 0.2916
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0275 0.1069 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.003 0.0079 0.0079
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.042 0.1655 0.1633
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0024 0.0056 0.0166
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0105 0.008
Schistosoma mansoni sulfide quinone reductase 0.0024 0.0056 0.0031
Mycobacterium tuberculosis Probable dehydrogenase 0.0024 0.0056 0.0213
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0024 0.0056 0.0056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0098 0.0073
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.0079 0.0079
Echinococcus multilocularis calcium activated potassium channel 0.003 0.0079 0.0079
Echinococcus multilocularis voltage gated hydrogen channel 1 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0024 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.014 0.0526 0.0525
Mycobacterium ulcerans monoxygenase 0.0024 0.0056 0.0191
Schistosoma mansoni calcium-activated potassium channel 0.003 0.0079 0.0054
Echinococcus multilocularis potassium voltage gated channel protein 0.003 0.0079 0.0079
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0079 0.0054
Brugia malayi cation channel family protein 0.003 0.0079 0.0079
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0036 0.0105 0.0105
Toxoplasma gondii thioredoxin reductase 0.0265 0.1028 1
Echinococcus multilocularis transient receptor potential cation channel 0.003 0.0079 0.0079
Plasmodium falciparum plasmepsin IX 0.0036 0.0105 0.1014
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0024 0.0056 0.027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Echinococcus multilocularis lysine specific demethylase 5A 0.0033 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0265 0.1028 0.6161
Loa Loa (eye worm) hypothetical protein 0.042 0.1655 0.1654
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.003 0.0079 0.0054
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.042 0.1655 0.1633
Schistosoma mansoni tyrosine kinase 0.0092 0.0332 0.0307
Treponema pallidum fructose-bisphosphate aldolase 0.0275 0.1069 1
Echinococcus multilocularis 0.0053 0.0173 0.0173
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0024 0.0056 0.0191
Echinococcus multilocularis short transient receptor potential channel 6 0.003 0.0079 0.0079
Onchocerca volvulus Alhambra homolog 0.0027 0.0069 0.0129
Brugia malayi glutathione reductase 0.0265 0.1028 0.1027
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0079 0.0054
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.0105 0.008
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0024 0.0056 0.0191
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0079 0.0079
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.042 0.1655 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.003 0.0079 0.0079
Mycobacterium ulcerans hypothetical protein 0.0024 0.0056 0.0191
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0024 0.0056 0.0213
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Echinococcus granulosus TRP transient receptor potential channel 0.003 0.0079 0.0079
Echinococcus granulosus transient receptor potential cation channel 0.003 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Plasmodium vivax thioredoxin reductase, putative 0.0265 0.1028 1
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Schistosoma mansoni cpg binding protein 0.0027 0.0067 0.0042
Loa Loa (eye worm) glutathione reductase 0.0265 0.1028 0.1027
Brugia malayi Angiotensin-converting enzyme family protein 0.0749 0.2984 0.2984
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0074 0.0048
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0092 0.0329 0.188
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0048 0.014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0048 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0048 0.0187
Toxoplasma gondii aspartyl protease 0.0036 0.0105 0.0756
Plasmodium falciparum glutathione reductase 0.0092 0.0329 0.3193
Schistosoma mansoni acetylcholinesterase 0.042 0.1655 0.1633
Brugia malayi hypothetical protein 0.003 0.0079 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0092 0.0329 0.2998
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0048
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0048 0.0179
Loa Loa (eye worm) hypothetical protein 0.2484 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.003 0.0079 0.0079
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0079 0.0054
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0024 0.0056 0.0056
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.0105 0.008
Schistosoma mansoni disulfide oxidoreductase 0.0024 0.0056 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.009 0.0321 0.0321
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0024 0.0056 0.0213
Echinococcus multilocularis dnaJ subfamily B 0.0384 0.1512 0.1512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0275 0.1069 0.6393
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0048 0.0179
Leishmania major hypothetical protein, unknown function 0.003 0.0079 0.05
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0092 0.0329 0.2998
Leishmania major hypothetical protein, conserved 0.0024 0.0056 0.027
Brugia malayi glutamate synthase 0.0024 0.0056 0.0056
Brugia malayi hypothetical protein 0.0036 0.0105 0.0105
Brugia malayi Furin-like cysteine rich region family protein 0.0172 0.0653 0.0653
Brugia malayi Carboxylesterase family protein 0.042 0.1655 0.1654
Echinococcus granulosus potassium voltage gated channel subfamily D 0.003 0.0079 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0074 0.0048
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0036 0.0105 0.0465
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0079
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0715 0.2847 0.2847
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025

Activities

Activity type Activity value Assay description Source Reference
Duration (functional) > 24 hr Time taken by the compound to change arterial pressure outside the control area at a dose of 30mg/kg, po ChEMBL. 3009814
Duration (functional) = 60 min The time to 50% recovery of the angiotensin I response was measured after po administration of the compound at 0.3 mg/kg ChEMBL. 3009814
I50 (binding) = 0.017 uM In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung ChEMBL. 3009814
I50 (binding) = 3.6 uM In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung ChEMBL. 3009814
IC50 (binding) = 3.6 uM In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 ChEMBL. 2981324
IC50 (binding) = 3.7 uM In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 ChEMBL. 2981324
IC50 (binding) = 3.7 uM In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 ChEMBL. 2981324
IC50 (binding) > 100 uM In vitro inhibitory activity of the compound against rabbit lung Angiotensin I converting enzyme at pH 8.3 ChEMBL. 2981324
ID50 (functional) = 0.058 mg kg-1 Peroral dose required to inhibit angiotensin I induced vasopressor response in normotensive conscious rats ChEMBL. 2981324
ID50 (functional) = 0.15 mg kg-1 Peroral dose required to inhibit angiotensin I induced vasopressor response in normotensive conscious rats ChEMBL. 2981324
ID50 (functional) = 0.15 mg kg-1 Peroral dose required to inhibit angiotensin I induced vasopressor response in normotensive conscious rats ChEMBL. 2981324
ID50 (functional) = 0.17 mg kg-1 Peroral dose required to inhibit angiotensin I induced vasopressor response in normotensive conscious dogs ChEMBL. 2981324
ID50 (functional) = 25 mg kg-1 Peroral dose required to inhibit angiotensin I induced vasopressor response in normotensive conscious rats ChEMBL. 2981324
Inhibition (functional) = 50 % Percentage inactivation of the angiotensin I induced vasopressor response in normotensive conscious rats after po administration at dose 0.058 mg/kg; 65-70 ChEMBL. 3009814
MAP (functional) = -30 % Maximum percent change in mean arterial pressure by the compound over control after po administration at 30 mg/kg dosage ChEMBL. 3009814

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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