Detailed information for compound 27521

Basic information

Technical information
  • TDR Targets ID: 27521
  • Name: 2-adamantyl N-[2,6-di(propan-2-yl)phenoxy]sul fonylcarbamate
  • MW: 435.577 | Formula: C23H33NO5S
  • H donors: 1 H acceptors: 3 LogP: 6.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cccc(c1OS(=O)(=O)NC(=O)OC1C2CC3CC1CC(C2)C3)C(C)C)C
  • InChi: 1S/C23H33NO5S/c1-13(2)19-6-5-7-20(14(3)4)22(19)29-30(26,27)24-23(25)28-21-17-9-15-8-16(11-17)12-18(21)10-15/h5-7,13-18,21H,8-12H2,1-4H3,(H,24,25)
  • InChiKey: UKESTKZJLRAXBS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-adamantyl N-(2,6-diisopropylphenoxy)sulfonylcarbamate
  • N-(2,6-diisopropylphenoxy)sulfonylcarbamic acid 2-adamantyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0207 0.1336 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi hypothetical protein 0.0123 0.073 0.171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0047 0.0111
Echinococcus granulosus intermediate filament protein 0.0028 0.0044 0.004
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0047 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis lamin dm0 0.0028 0.0044 0.004
Leishmania major hypothetical protein, conserved 0.0035 0.0096 0.053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0938 0.2199
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0214 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Loa Loa (eye worm) beta-lactamase 0.0035 0.0096 0.0225
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0127 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Brugia malayi hypothetical protein 0.007 0.0346 0.0806
Schistosoma mansoni zinc finger protein 0.0024 0.0014 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.009 0.0493 0.049
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0307
Echinococcus granulosus neuropeptide receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Loa Loa (eye worm) calcium channel 0.0541 0.3742 0.8798
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Brugia malayi calpain family protein 1 0.0059 0.0269 0.0626
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0028 0.0082
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Brugia malayi hypothetical protein 0.0029 0.0053 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0047 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Schistosoma mansoni amine GPCR 0.0784 0.55 0.5499
Giardia lamblia G2/mitotic-specific cyclin B 0.0041 0.014 0.0705
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Echinococcus granulosus biogenic amine 5HT receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0096 0.0463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0096 0.0092
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Echinococcus granulosus GPCR family 2 0.0048 0.0189 0.0186
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0056 0.0126
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0011 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0939 0.6617 0.6616
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0028 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0463 0.3182 0.3179
Trypanosoma brucei protein kinase, putative 0.0052 0.0214 0.1206
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0047 0.0103
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0112 0.0653 0.1535
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Trichomonas vaginalis hypothetical protein 0.0034 0.0088 0.0414
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0107 0.0631
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Brugia malayi ecdysteroid receptor 0.0028 0.0047 0.0103
Entamoeba histolytica cyclin, putative 0.0041 0.014 0.0882
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0635 0.0632
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.0329
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0635 0.362
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0171 0.0948
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0071 0.0357 0.2154
Onchocerca volvulus 0.0036 0.0103 0.0237
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0107 0.0104
Leishmania major ATP-NAD kinase-like protein 0.0028 0.0041 0.0216
Toxoplasma gondii hypothetical protein 0.0036 0.0103 0.0333
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0047 0.0044
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.044 0.3015 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0048 0.0187 0.0439
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0107 0.0251
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0119
Onchocerca volvulus Neuropeptide F receptor homolog 0.0463 0.3182 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0136 0.082 0.2712
Trypanosoma brucei squalene monooxygenase, putative 0.0264 0.1749 1
Schistosoma mansoni hypothetical protein 0.0062 0.029 0.0286
Echinococcus multilocularis g protein coupled receptor 0.0463 0.3182 0.3179
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0171 0.0167
Echinococcus granulosus dro:myosuppressin receptor 0.0463 0.3182 0.3179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0047 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0064 0.0305 0.1001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0148 0.091 0.5731
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0028 0.0082
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.029 0.2149
Onchocerca volvulus 0.0037 0.0107 0.025
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0463 0.3182 1
Onchocerca volvulus 0.0036 0.0103 0.0237
Onchocerca volvulus 0.0463 0.3182 1
Onchocerca volvulus 0.0029 0.0051 0.0071
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0036 0.0103 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0028 0.0044 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0493 0.3031
Loa Loa (eye worm) hypothetical protein 0.0125 0.0743 0.1747
Echinococcus multilocularis GPCR, family 2 0.0048 0.0189 0.0186
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0064 0.0305 0.1001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0214 0.1206
Plasmodium vivax SET domain protein, putative 0.003 0.006 0.0425
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0064 0.0305 0.1001
Brugia malayi neuropeptide F receptor 0.0463 0.3182 0.7478
Brugia malayi Cathepsin L-like precursor 0.0029 0.0051 0.0111
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Onchocerca volvulus 0.0463 0.3182 1
Giardia lamblia Cathepsin B precursor 0.0148 0.091 0.6691
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.006 0.0057
Toxoplasma gondii hypothetical protein 0.0079 0.041 0.1704
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0164 0.0379
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0028 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0107 0.0104
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0171 0.0637
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0024 0.0021
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0107 0.025
Echinococcus multilocularis g protein coupled receptor 0.0463 0.3182 0.3179
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0047 0.0044
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0056 0.0245
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0024 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) hypothetical protein 0.0104 0.0591 0.139
Plasmodium falciparum plasmepsin V 0.0027 0.0034 0.0073
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0047 0.0111
Echinococcus multilocularis lamin 0.0028 0.0044 0.004
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0027 0.0034 0.0026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.008
Giardia lamblia High cysteine membrane protein Group 2 0.0055 0.024 0.1483
Echinococcus multilocularis cyclin B 0.0041 0.014 0.0137
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.029 0.0286
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0028 0.0025
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0131 0.0785 0.0782
Brugia malayi endoprotease bli-4 precursor 0.0148 0.0913 0.214
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0269 0.0266
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0136 0.0821 0.0818
Brugia malayi sulfakinin receptor protein 0.0463 0.3182 0.7478
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0141 0.0861 0.0858
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0187 0.0184
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0119
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0096 0.0225
Plasmodium falciparum plasmepsin II 0.0112 0.0653 0.4794
Loa Loa (eye worm) hypothetical protein 0.0048 0.0189 0.0444
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0635 0.1493
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0028 0.0025
Echinococcus multilocularis cysteine protease 0.0037 0.0107 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0047 0.0103
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0463 0.3182 0.3179
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni growth hormone secretagogue receptor 0.0463 0.3182 0.3179
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0096 0.0337
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0164 0.0161
Brugia malayi cathepsin B-like cysteine proteinase 0.044 0.3015 0.7085
Brugia malayi Cyclin, N-terminal domain containing protein 0.0041 0.014 0.0321
Echinococcus multilocularis voltage dependent calcium channel 0.0541 0.3742 0.374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Mycobacterium tuberculosis Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) 0.0103 0.0586 0.3586
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0541 0.3742 0.374
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0047 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0047 0.0103
Schistosoma mansoni tsg101-related 0.0058 0.0263 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0157 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus granulosus orexin receptor type 2 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0152 0.0938 0.2206
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0296 0.0695
Loa Loa (eye worm) hypothetical protein 0.0059 0.0269 0.0633
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0303
Toxoplasma gondii microneme protein MIC4 0.0036 0.0103 0.0333
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) calpain family protein 1 0.0059 0.0269 0.0633
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0463
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0056 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0047 0.0103
Echinococcus granulosus tachykinin peptides receptor 99D 0.0463 0.3182 0.3179
Brugia malayi G-protein coupled receptor 0.0463 0.3182 0.7478
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0541 0.3742 0.374
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0029 0.0053 0.0049
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0635 0.4657
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0463 0.3182 0.3179
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0635 0.4657
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0047 0.0103
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Plasmodium vivax vivapain-1 0.0025 0.0024 0.0157
Echinococcus multilocularis allatostatin A receptor 0.0463 0.3182 0.3179
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0047 0.0044
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0463 0.3182 0.3179
Toxoplasma gondii kringle domain-containing protein 0.0062 0.029 0.1168
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) hypothetical protein 0.0048 0.0187 0.044
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0028 0.0041 0.0041
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0028 0.0025
Echinococcus granulosus alpha 1A adrenergic receptor 0.0463 0.3182 0.3179
Brugia malayi calpain family protein 1 0.0059 0.0269 0.0626
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0107 0.0244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0541 0.3742 0.8798
Echinococcus multilocularis orexin receptor type 2 0.0463 0.3182 0.3179
Toxoplasma gondii PAN domain-containing protein 0.0336 0.2267 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0463 0.3182 0.3179
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Echinococcus granulosus cathepsin b 0.044 0.3015 0.3012
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0028 0.0066
Onchocerca volvulus 0.0463 0.3182 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0047 0.0044
Trypanosoma cruzi GUP1, putative 0.0026 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0214 0.1279
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0207 0.1336 0.4425
Schistosoma mansoni opsin-like receptor 0.0463 0.3182 0.3179
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0136 0.082 0.4679
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0314 0.0311
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.0072 0.0363 0.036
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.1746 0.1743
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0107 0.0631
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Giardia lamblia Inorganic polyphosphate/ATP-NAD kinase, putative 0.0131 0.0785 0.5717
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.009 0.0493 0.049
Mycobacterium ulcerans hypothetical protein 0.0035 0.0096 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0189 0.0186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0463 0.3182 0.3179
Brugia malayi Dopamine receptor protein 2 0.0463 0.3182 0.7478
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.022 0.1428 0.8163
Brugia malayi 6-phosphofructokinase 0.011 0.0635 0.1486
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Plasmodium vivax vivapain-2 0.0037 0.0107 0.0778
Onchocerca volvulus 0.0029 0.0053 0.0078
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0635 0.0632
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0207 0.1336 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Echinococcus granulosus jun protein 0.0089 0.0484 0.048
Onchocerca volvulus 0.0463 0.3182 1
Trypanosoma cruzi poly(p)/ATP NAD kinase, putative 0.0028 0.0041 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0281 0.0278
Echinococcus granulosus NAD kinase 0.0131 0.0785 0.0782
Echinococcus granulosus cathepsin l1 0.0037 0.0107 0.0104
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Brugia malayi Trypsin family protein 0.0125 0.0743 0.1741
Brugia malayi PHD-finger family protein 0.0029 0.0054 0.0119
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0296 0.0292
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0028 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0107 0.0104
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0047 0.0103
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0029 0.0053 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Mycobacterium ulcerans inorganic polyphosphate/ATP-NAD kinase 0.0131 0.0785 0.5706
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0171 0.0637
Echinococcus multilocularis voltage dependent calcium channel 0.0541 0.3742 0.374
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0028 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0024 0.012
Trichomonas vaginalis esterase, putative 0.0035 0.0096 0.0463
Onchocerca volvulus 0.0463 0.3182 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Trypanosoma brucei cysteine peptidase C (CPC) 0.0148 0.091 0.5196
Echinococcus granulosus cathepsin L cysteine protease 0.0025 0.0024 0.0021
Plasmodium vivax aspartyl proteinase, putative 0.0112 0.0653 0.4875
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Schistosoma mansoni histamine h1 receptor 0.0463 0.3182 0.3179
Brugia malayi RE15519p 0.0463 0.3182 0.7478
Echinococcus granulosus neuropeptides capa receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0164 0.1026 0.2412
Schistosoma mansoni hypothetical protein 0.0026 0.0028 0.0025
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0157 0.0368
Onchocerca volvulus 0.024 0.157 0.489
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Loa Loa (eye worm) G-protein coupled receptor 0.0463 0.3182 0.748
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Entamoeba histolytica inorganic polyphosphate/ATP-NAD kinase, putative 0.0028 0.0041 0.0128
Schistosoma mansoni single-minded 0.0049 0.0195 0.0192
Echinococcus multilocularis sex peptide receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus cathepsin b 0.044 0.3015 0.3012
Schistosoma mansoni neuropeptide F-like receptor 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0028 0.0044 0.0049
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0314 0.0311
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Entamoeba histolytica hypothetical protein 0.0026 0.0028 0.0029
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0062 0.0289 0.0286
Echinococcus granulosus calpain A 0.0062 0.0289 0.0286
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi putative neuropeptide receptor NPR1 0.0463 0.3182 0.7478
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0148 0.091 0.3011
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0103 0.01
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0207 0.1336 0.4425
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0463 0.3182 0.7478
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0047 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Echinococcus granulosus serotonin receptor 0.0463 0.3182 0.3179
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0189 0.0186
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0172 0.0405
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0028 0.0025
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0011 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Toxoplasma gondii ABC1 family protein 0.0035 0.0096 0.0302
Brugia malayi G protein-coupled receptor 0.0463 0.3182 0.7478
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Schistosoma mansoni lamin 0.0028 0.0044 0.004
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Brugia malayi jmjC domain containing protein 0.0061 0.0281 0.0654
Onchocerca volvulus 0.0027 0.0034 0.0018
Schistosoma mansoni bromodomain containing protein 0.0069 0.0341 0.0337
Echinococcus multilocularis jun protein 0.0089 0.0484 0.048
Schistosoma mansoni opsin-like receptor 0.0463 0.3182 0.3179
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0056 0.0126
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0047 0.0044
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0107 0.0594
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0056 0.0398
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0127 0.0606
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Onchocerca volvulus 0.0036 0.0103 0.0237
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0187 0.0184
Plasmodium falciparum plasmepsin X 0.0027 0.0034 0.0073
Schistosoma mansoni hypothetical protein 0.0062 0.0288 0.0285
Trichomonas vaginalis porcupine, putative 0.0026 0.0028 0.0025
Brugia malayi bZIP transcription factor family protein 0.0089 0.0484 0.113
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0214 0.0699
Onchocerca volvulus 0.0463 0.3182 1
Schistosoma mansoni hypothetical protein 0.0847 0.595 0.5948
Brugia malayi hypothetical protein 0.0027 0.0034 0.0072
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0541 0.3742 0.374
Brugia malayi Pre-SET motif family protein 0.003 0.006 0.0133
Schistosoma mansoni opsin-like receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0096 0.0092
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Onchocerca volvulus 0.0037 0.0107 0.025
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Loa Loa (eye worm) hypothetical protein 0.0321 0.2156 0.5069
Echinococcus multilocularis cathepsin b 0.044 0.3015 0.3012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0143 0.0873 0.2053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0136 0.082 0.4679
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0189 0.0186
Brugia malayi larval opioid receptor 0.0463 0.3182 0.7478
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Brugia malayi aspartic protease BmAsp-2, identical 0.0027 0.0034 0.0072
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0281 0.0278
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0186 0.1232
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0027 0.0034 0.008
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0635 0.1493
Echinococcus multilocularis sodium channel protein 0.0141 0.0861 0.0858
Brugia malayi 6-phosphofructokinase 0.011 0.0635 0.1486
Trypanosoma brucei ATP-NAD kinase-like protein 0.0028 0.0041 0.0216
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Brugia malayi Dopamine receptor 0.0463 0.3182 0.7478
Echinococcus granulosus tm gpcr rhodopsin 0.0463 0.3182 0.3179
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0096 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.006 0.0057
Loa Loa (eye worm) cysteine protease 0.0037 0.0107 0.0251
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0047 0.0111
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0368
Echinococcus multilocularis neuroendocrine convertase 2 0.0093 0.0515 0.0512
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0011 0.0007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0047 0.0061
Echinococcus granulosus cysteine protease 0.0025 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni hypothetical protein 0.0074 0.0378 0.0375
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Plasmodium vivax unspecified product 0.0025 0.0024 0.0157
Schistosoma mansoni cyclin B 0.0041 0.014 0.0137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0493 0.3031
Onchocerca volvulus 0.007 0.0346 0.1007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0164 0.0161
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0028 0.0025
Echinococcus multilocularis expressed protein 0.0377 0.2565 0.2563
Onchocerca volvulus 0.0028 0.0047 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus granulosus expressed protein 0.0377 0.2565 0.2563
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0635 0.4657
Toxoplasma gondii PAN domain-containing protein 0.0336 0.2267 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.008
Loa Loa (eye worm) melatonin receptor type 1A 0.0463 0.3182 0.748
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Schistosoma mansoni cathepsin D (A01 family) 0.0331 0.2233 0.223
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0171 0.1257
Brugia malayi Pre-SET motif family protein 0.021 0.136 0.3193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0255
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0028 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Echinococcus multilocularis neuropeptides capa receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0189 0.0444
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0463 0.3182 0.7478
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0251
Giardia lamblia Cathepsin B precursor 0.0148 0.091 0.6691
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0047 0.0111
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0047 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0148 0.0913 0.2146
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0463 0.3182 0.3179
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0136 0.0821 0.193
Trypanosoma cruzi inorganic polyphosphate/ATP-NAD kinase, putative 0.0028 0.0041 0.0125
Echinococcus multilocularis 0.012 0.0706 0.0703
Echinococcus granulosus transmembrane protease serine 3 0.0029 0.0053 0.0049
Toxoplasma gondii cathepsin CPL 0.0037 0.0107 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Onchocerca volvulus 0.0463 0.3182 1
Echinococcus multilocularis cathepsin b 0.044 0.3015 0.3012
Loa Loa (eye worm) TYRA-2 protein 0.0463 0.3182 0.748
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0072 0.0358 0.1919
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0028 0.0041 0.0109
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0484 0.048
Onchocerca volvulus 0.0463 0.3182 1
Echinococcus granulosus zinc finger protein 0.0024 0.0014 0.0011
Echinococcus granulosus cyclin B 0.0041 0.014 0.0137
Brugia malayi MAP kinase sur-1 0.0052 0.0214 0.0495
Echinococcus multilocularis geminin 0.0847 0.595 0.5948
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0047 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.1746 0.1743
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0207 0.1336 1
Trypanosoma cruzi cysteine protease, putative 0.0025 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0102
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.029 0.2024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Schistosoma mansoni myosin xvIII 0.0463 0.3182 0.3179
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Entamoeba histolytica cysteine protease, putative 0.0037 0.0107 0.0631
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0025
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0635 0.4539
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0463 0.3182 0.748
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Brugia malayi proprotein convertase 2 0.0093 0.0515 0.1204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0187 0.0184
Trypanosoma cruzi cyclin, putative 0.0041 0.014 0.0454
Brugia malayi nuclear receptor NHR-88 0.0028 0.0047 0.0103
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0127 0.0785
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Onchocerca volvulus 0.0463 0.3182 1
Onchocerca volvulus 0.0036 0.0103 0.0238
Brugia malayi Cathepsin L-like precursor 0.0029 0.0051 0.0111
Schistosoma mansoni tsg101-related 0.0048 0.0186 0.0183
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0131 0.0785 0.492
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0107 0.0631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0047 0.0111
Toxoplasma gondii microneme protein MIC17C 0.0036 0.0103 0.0333
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.029 0.0286
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus 7TM GPCR rhodopsin 0.0463 0.3182 0.3179
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0463 0.3182 0.3179
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Loa Loa (eye worm) hhat protein 0.0026 0.0028 0.0066
Toxoplasma gondii microneme protein MIC17A 0.0036 0.0103 0.0333
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0064 0.0305 0.1001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi nuclear hormone receptor 0.0028 0.0047 0.0103
Echinococcus multilocularis G protein coupled receptor 139 0.0463 0.3182 0.3179
Plasmodium falciparum plasmepsin VIII, putative 0.0027 0.0034 0.0073
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0136 0.0821 0.193
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0207 0.1336 1
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0917 0.215
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0028 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0463 0.3182 0.3179
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0028 0.0029
Brugia malayi beta-lactamase family protein 0.0035 0.0096 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0107 0.0104
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0047 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0463 0.3182 0.3179
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.3015 0.3012
Brugia malayi Hhat protein 0.0026 0.0028 0.0058
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0028 0.0186
Loa Loa (eye worm) hypothetical protein 0.0079 0.041 0.0963
Echinococcus multilocularis g-protein coupled receptor 0.0463 0.3182 0.3179
Brugia malayi Melatonin receptor type 1A 0.0463 0.3182 0.7478
Plasmodium vivax aspartyl protease, putative 0.0027 0.0034 0.0229
Echinococcus multilocularis calpain A 0.0062 0.0289 0.0286
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii aspartyl protease ASP1 0.0112 0.0653 0.2791
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0047 0.0044
Loa Loa (eye worm) fibroinase 0.0037 0.0107 0.0251
Echinococcus granulosus neuropeptide receptor A26 0.0939 0.6617 0.6616
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Schistosoma mansoni hypothetical protein 0.0104 0.0591 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0938 0.2199
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) calpain 0.0022 0.0003 0.0008
Schistosoma mansoni hypothetical protein 0.0029 0.0053 0.0049
Loa Loa (eye worm) hhat protein 0.0026 0.0028 0.0066
Brugia malayi putative neuropeptide receptor 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi Trypsin family protein 0.0029 0.0053 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Echinococcus multilocularis cathepsin L 0.0025 0.0024 0.0021
Echinococcus multilocularis serotonin receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0062 0.0289 0.0286
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Plasmodium falciparum plasmepsin VII 0.0027 0.0034 0.0073
Leishmania major squalene monooxygenase-like protein 0.0264 0.1749 1
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Echinococcus granulosus Furin 1 0.0035 0.0095 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0096 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0189 0.0186
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0541 0.3742 0.374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0214 0.0503
Schistosoma mansoni tsg101-related 0.0058 0.0263 0.026
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0934 0.2196
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0107 0.0104
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0171 0.0948
Onchocerca volvulus 0.0036 0.0103 0.0237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Onchocerca volvulus 0.0029 0.0053 0.0078
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.1746 0.1743
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni biogenic amine receptor 0.0463 0.3182 0.3179
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0463 0.3182 0.3179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0164 0.0161
Onchocerca volvulus 0.0037 0.0107 0.025
Echinococcus multilocularis NAD kinase 0.0131 0.0785 0.0782
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0541 0.3742 0.374
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0064 0.0305 0.0709
Loa Loa (eye worm) acetyltransferase 0.0149 0.0917 0.2156
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0463 0.3182 0.3179
Leishmania major hypothetical protein, conserved 0.0062 0.029 0.1641
Plasmodium falciparum plasmepsin III 0.0027 0.0034 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0214 0.0211
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0207 0.1336 1
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0053 0.0049
Onchocerca volvulus 0.0035 0.0096 0.0215
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0119
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0195 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Toxoplasma gondii transporter, cation channel family protein 0.0099 0.0559 0.237
Onchocerca volvulus 0.0036 0.0103 0.0237
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0136 0.082 0.2712
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0214 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0053 0.0221 0.052
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0029 0.0049 0.0162
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0024 0.0069
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0028 0.0025
Loa Loa (eye worm) voltage-dependent calcium channel 0.0099 0.0559 0.1314
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0148 0.091 0.0907
Brugia malayi Trypsin family protein 0.0029 0.0053 0.0116
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0463 0.3182 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0047 0.0044
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.007 0.0347 0.0344
Echinococcus granulosus 7tm_1 domain containing protein 0.0463 0.3182 0.3179
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0207 0.1336 0.4425
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0164 0.0161
Plasmodium vivax vivapain-3 0.0025 0.0024 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0103 0.0395
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Brugia malayi Cyclin, N-terminal domain containing protein 0.0041 0.014 0.0321
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0051 0.0201
Echinococcus granulosus tm gpcr rhodopsin 0.1004 0.7085 0.7084
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0463 0.3182 0.7478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0463 0.3182 0.3179
Brugia malayi Trypsin-like protease protein 5 0.0029 0.0053 0.0116
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0028 0.0066
Brugia malayi Eukaryotic aspartyl protease family protein 0.0027 0.0034 0.0072
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni lamin 0.0028 0.0044 0.004
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0047 0.0044
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Onchocerca volvulus 0.0096 0.0533 0.1601
Echinococcus granulosus g protein coupled receptor 0.0463 0.3182 0.3179
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.006 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0047 0.0044
Echinococcus multilocularis transmembrane protease serine 3 0.0029 0.0053 0.0049
Echinococcus granulosus voltage dependent calcium channel 0.0099 0.0559 0.0556
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0103 0.0235
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0112 0.0653 0.2791
Brugia malayi Protein kinase domain containing protein 0.0062 0.029 0.0674
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi G protein-coupled receptor F59B2.13 0.0463 0.3182 0.7478
Trichomonas vaginalis cyclin A, putative 0.0041 0.014 0.0748
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0635 0.4642
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Echinococcus granulosus geminin 0.0847 0.595 0.5948
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0107 0.0104
Brugia malayi beta-lactamase 0.0035 0.0096 0.0218
Brugia malayi celfurPC protein 0.012 0.0706 0.1652
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis Furin 1 0.0035 0.0095 0.0092
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0028 0.0025
Echinococcus multilocularis zinc finger protein 0.0024 0.0014 0.0011
Brugia malayi Trypsin family protein 0.0029 0.0053 0.0116
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0024 0.0049
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0463 0.3182 0.3179
Echinococcus granulosus g protein coupled receptor 0.0463 0.3182 0.3179
Brugia malayi GH09647p 0.0028 0.0041 0.0089
Schistosoma mansoni jun-related protein 0.0072 0.0363 0.036
Mycobacterium leprae Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) 0.0103 0.0586 0.9088
Plasmodium falciparum plasmepsin IV 0.0112 0.0653 0.4794
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0028 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0047 0.0103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.3015 0.3012
Echinococcus multilocularis microtubule associated protein 2 0.1408 1 1
Toxoplasma gondii NAD(+)/NADH kinase domain-containing protein 0.0028 0.0041 0.0058
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Trypanosoma cruzi GUP1, putative 0.0026 0.0028 0.0082
Schistosoma mansoni voltage-gated cation channel 0.0541 0.3742 0.374
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0112 0.0653 0.4067
Echinococcus multilocularis neuropeptide receptor A26 0.0939 0.6617 0.6616
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Treponema pallidum hypothetical protein 0.0131 0.0785 0.5786
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0938 0.2206
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0484 0.048
Echinococcus granulosus g-protein coupled receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.3015 0.3012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0047 0.0044
Brugia malayi hypothetical protein 0.0074 0.0378 0.0882
Brugia malayi ORL1-like opioid receptor 0.0463 0.3182 0.7478
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0635 0.2098
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0378 0.0375
Trypanosoma cruzi squalene monooxygenase, putative 0.0264 0.1749 0.5796
Toxoplasma gondii aspartyl protease ASP3 0.0027 0.0034 0.0026
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0281 0.0278
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Onchocerca volvulus 0.0463 0.3182 1
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0028 0.0029
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0214 0.1206
Loa Loa (eye worm) hypothetical protein 0.0079 0.041 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0047 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Onchocerca volvulus 0.0037 0.0107 0.025
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Leishmania major hypothetical protein, conserved 0.0026 0.0028 0.0142
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0107 0.0535
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Trypanosoma cruzi cyclin 6, putative 0.0041 0.014 0.0454
Leishmania major cyclin 0.0041 0.014 0.0783
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0024 0.0049
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0072 0.0358 0.4863
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0037 0.0108 0.0254
Loa Loa (eye worm) hypothetical protein 0.0112 0.0653 0.1535
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0047 0.0103
Trichomonas vaginalis cyclins, putative 0.0028 0.0046 0.0139
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0066
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0136 0.0821 0.5152
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Toxoplasma gondii aspartyl protease 0.0027 0.0034 0.0026
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0004 0.0001
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0207 0.1336 0.5841
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0214 0.0211
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0035 0.0096 0.0215
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0463 0.3182 0.748
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus somatostatin receptor 0.0463 0.3182 0.3179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0187 0.0184
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0107 0.0251
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0131 0.0785 0.492
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0917 0.0914
Echinococcus multilocularis somatostatin receptor 0.0463 0.3182 0.3179
Echinococcus granulosus neuroendocrine convertase 2 0.0093 0.0515 0.0512
Echinococcus multilocularis fmrfamide receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Onchocerca volvulus 0.0036 0.0103 0.0237
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0064 0.0305 0.1001
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Schistosoma mansoni microtubule-associated protein tau 0.1408 1 1
Toxoplasma gondii subtilisin SUB12 0.0042 0.0148 0.0538
Echinococcus multilocularis fmrfamide receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis cysteine protease 0.0037 0.0107 0.0104
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Brugia malayi neuroendocrine convertase 1 precursor 0.0093 0.0515 0.1204
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0143 0.0873 0.2053
Plasmodium vivax plasmepsin IV, putative 0.0112 0.0653 0.4875
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) hypothetical protein 0.0612 0.4254 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0635 0.3946
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0056 0.0245
Brugia malayi Pepsin A precursor 0.0027 0.0034 0.0072
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0635 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.044 0.3015 0.3012
Loa Loa (eye worm) hypothetical protein 0.0099 0.0559 0.1314
Loa Loa (eye worm) hypothetical protein 0.0086 0.0466 0.1095
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0028 0.0025
Onchocerca volvulus 0.003 0.006 0.0101
Toxoplasma gondii PAN/Apple domain-containing protein 0.0036 0.0103 0.0333
Brugia malayi hypothetical protein 0.0027 0.0034 0.0072
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0025 0.0024 0.0069
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Brugia malayi intermediate filament protein 0.0028 0.0044 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0028 0.0025
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.136 0.3198
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Loa Loa (eye worm) hypothetical protein 0.0238 0.156 0.3667
Brugia malayi PAS domain containing protein 0.0049 0.0195 0.0451
Echinococcus multilocularis enteropeptidase 0.0029 0.0053 0.0049
Echinococcus multilocularis G-protein coupled receptor, putative 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0035 0.0096 0.0215
Onchocerca volvulus 0.0029 0.0053 0.0078
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0036 0.0103 0.0237
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Leishmania major hypothetical protein, conserved 0.0022 0.0004 0.0002
Loa Loa (eye worm) phosphofructokinase 0.011 0.0635 0.1493
Loa Loa (eye worm) ctsf protein 0.0037 0.0107 0.0251
Onchocerca volvulus 0.0036 0.0103 0.0237
Brugia malayi small heat shock protein 0.0612 0.4254 1
Brugia malayi follicle stimulating hormone receptor 0.0463 0.3182 0.7478
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0463 0.3182 0.3179
Echinococcus granulosus voltage dependent calcium channel 0.0541 0.3742 0.374
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1463 1
Brugia malayi GnHR receptor homolog 0.0463 0.3182 0.7478
Trypanosoma cruzi squalene monooxygenase, putative 0.0264 0.1749 0.5796
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0207 0.1336 0.5841
Plasmodium falciparum plasmepsin VI 0.0112 0.0653 0.4794
Echinococcus granulosus lamin dm0 0.0028 0.0044 0.004
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0107 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0047 0.0103
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0148 0.091 0.5196
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0541 0.3742 0.8797
Schistosoma mansoni memapsin-2 (A01 family) 0.0027 0.0034 0.0031
Echinococcus granulosus Mastin 0.0029 0.0053 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0051 0.017
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Onchocerca volvulus 0.0041 0.014 0.0355
Schistosoma mansoni cathepsin D (A01 family) 0.0331 0.2233 0.223
Schistosoma mansoni neuropeptide f receptor 76f 0.0463 0.3182 0.3179
Schistosoma mansoni furin-1 (S08 family) 0.0065 0.0308 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0463
Loa Loa (eye worm) aspartyl protease 6 0.0027 0.0034 0.008
Echinococcus granulosus g protein coupled receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Echinococcus multilocularis dro:myosuppressin receptor 0.0463 0.3182 0.3179
Schistosoma mansoni neuropeptide F-like receptor 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0463 0.3182 1
Toxoplasma gondii microneme protein, putative 0.0036 0.0103 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0047 0.0103
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0024 0.0069
Onchocerca volvulus 0.0037 0.0107 0.025
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0214 0.0699
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0025
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0029 0.0049 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0051 0.017
Echinococcus multilocularis neuropeptide Y receptor 0.0463 0.3182 0.3179
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0047 0.0044
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0136 0.0821 0.5152
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0047 0.0044
Plasmodium vivax plasmepsin V, putative 0.0027 0.0034 0.0229
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Onchocerca volvulus 0.0029 0.0053 0.0078
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0044 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0047 0.0103
Plasmodium vivax aspartyl protease, putative 0.0027 0.0034 0.0229
Echinococcus multilocularis neuropeptide receptor 0.0463 0.3182 0.3179
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0052 0.0049
Onchocerca volvulus 0.0036 0.0103 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0037 0.0107 0.025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0463 0.3182 0.3179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0028 0.0142
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0047 0.0044
Schistosoma mansoni alpha-1 adrenergic receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0041 0.014 0.0783
Schistosoma mansoni adenoreceptor 0.0463 0.3182 0.3179
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0071 0.0357 0.0833
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0214 0.0699
Echinococcus granulosus furin 0.0148 0.0913 0.091
Echinococcus multilocularis neuropeptide FF receptor 2 0.0463 0.3182 0.3179
Echinococcus granulosus hypothetical protein 0.0463 0.3182 0.3179
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0047 0.0103
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0463 0.3182 0.3179
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0096 0.053
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Plasmodium falciparum plasmepsin IX 0.0027 0.0034 0.0073
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0541 0.3742 0.374
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Onchocerca volvulus 0.0125 0.0743 0.2268
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0541 0.3742 0.374
Brugia malayi Serotonin receptor 0.0463 0.3182 0.7478
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0541 0.3742 0.374
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0463 0.3182 0.3179
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0463 0.3182 0.748
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.5757 0.5756
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0047 0.0044
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0214 0.0211
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Brugia malayi Cathepsin L-like cysteine proteinase 0.0029 0.0051 0.0111
Echinococcus multilocularis neuropeptides capa receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) cathepsin B 0.0148 0.091 0.214
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Brugia malayi hypothetical protein 0.0164 0.1026 0.2406
Onchocerca volvulus 0.0062 0.029 0.083
Loa Loa (eye worm) hypothetical protein 0.0264 0.1746 0.4104
Echinococcus multilocularis Mastin 0.0029 0.0053 0.0049
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0917 0.0914
Echinococcus granulosus enteropeptidase 0.0029 0.0053 0.0049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0164 0.0161
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0047 0.0044
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0125 0.0743 0.1747
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0051 0.0047
Brugia malayi Cytochrome P450 family protein 0.0046 0.0172 0.0397
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0066
Echinococcus granulosus neuropeptides capa receptor 0.0463 0.3182 0.3179
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0463 0.3182 0.7478
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0112 0.0653 0.065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Brugia malayi Kringle domain containing protein 0.0062 0.029 0.0674
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0029 0.0053 0.0049
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0056 0.0245
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0028 0.0025
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0028 0.0025
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0028 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0296 0.0292
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0164 0.0161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0189 0.0437
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0028 0.0041 0.0038
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0029 0.0049 0.0162
Brugia malayi Bromodomain containing protein 0.0081 0.0428 0.0999
Brugia malayi Dopamine receptor protein 1 0.0463 0.3182 0.7478
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0028 0.0025
Onchocerca volvulus 0.0029 0.0053 0.0078
Echinococcus granulosus neuropeptide Y receptor 0.0463 0.3182 0.3179
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0028 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.0463 0.3182 0.3179
Echinococcus granulosus fmrfamide receptor 0.0463 0.3182 0.3179
Echinococcus granulosus cathepsin L 0.0025 0.0024 0.0021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0047 0.0111
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0053 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0096 0.0694
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.011 0.0107
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0463 0.3182 0.748
Echinococcus granulosus single minded 2 0.0036 0.0103 0.01
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Brugia malayi neuropeptide F receptor 0.0463 0.3182 0.7478
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0056 0.0398
Loa Loa (eye worm) hypothetical protein 0.007 0.0347 0.0817
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0028 0.0029
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0296 0.0292
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Brugia malayi cathepsin L-like precursor 0.0029 0.0051 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0047 0.0111
Echinococcus multilocularis serotonin receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Brugia malayi Tachykinin-like peptides receptor 99D 0.0463 0.3182 0.7478
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0136 0.082 0.599
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0107 0.0104
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis NAD kinase domain containing protein 1 0.0028 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0094
Schistosoma mansoni hypothetical protein 0.0029 0.0053 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.0107 0.0344
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0035 0.0095 0.0092
Brugia malayi hypoxia-induced factor 1 0.0151 0.0934 0.219
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus cathepsin l1 0.0029 0.0051 0.0047
Onchocerca volvulus Cathepsin F homolog 0.0037 0.0107 0.025
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.0329
Echinococcus multilocularis musashi 0.0028 0.0044 0.004
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0107 0.025
Toxoplasma gondii cathepsin B 0.0148 0.091 0.394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0028 0.0025
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.029 0.0681
Brugia malayi hypothetical protein 0.007 0.0347 0.081
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.022 0.1428 0.4731
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0541 0.3742 0.374
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0097
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.011 0.0107
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0189 0.0437
Echinococcus multilocularis neuropeptide receptor 0.0463 0.3182 0.3179
Plasmodium falciparum plasmepsin I 0.0112 0.0653 0.4794
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0096 0.0463
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis hypothetical protein 0.0029 0.0049 0.0162
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0207 0.1336 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0635 0.0632
Echinococcus granulosus biogenic amine 5HT receptor 0.0463 0.3182 0.3179
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0024 0.0021
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0214 0.1206
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0307
Brugia malayi jmjC domain containing protein 0.0063 0.0296 0.0688
Loa Loa (eye worm) hypothetical protein 0.0062 0.029 0.0681
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Loa Loa (eye worm) hypothetical protein 0.0058 0.0262 0.0616
Toxoplasma gondii microneme protein MIC17B 0.0036 0.0103 0.0333
Plasmodium vivax aspartyl proteinase, putative 0.0027 0.0034 0.0229
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0028 0.0066
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0044 0.0102
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0028 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0378 0.0375
Brugia malayi steroid hormone receptor 0.0028 0.0047 0.0103
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Echinococcus granulosus tumor susceptibility gene 101 protein 0.007 0.0347 0.0344
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0378 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Trypanosoma cruzi CYC2-like cyclin, putative 0.0041 0.014 0.0454
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0463
Loa Loa (eye worm) neuropeptide F receptor 0.0463 0.3182 0.748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Brugia malayi beta-lactamase family protein 0.0035 0.0096 0.0218
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Onchocerca volvulus 0.0027 0.0034 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.0743 0.074
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Loa Loa (eye worm) neuropeptide F receptor 0.0463 0.3182 0.748
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0112 0.0653 0.065
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0289 0.0286
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0029 0.0051 0.0157
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0056 0.0126
Onchocerca volvulus 0.0463 0.3182 1
Trypanosoma brucei mitotic cyclin 6 0.0041 0.014 0.0783
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0207 0.1336 0.3135
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0029 0.0053 0.0116
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Plasmodium vivax vivapain-2 0.0037 0.0107 0.0778
Brugia malayi Serotonin receptor 0.0463 0.3182 0.7478
Mycobacterium ulcerans lipase LipD 0.0035 0.0096 0.0337
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0635 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.0743 0.074
Schistosoma mansoni biogenic amine receptor 0.0463 0.3182 0.3179
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0096 0.0337
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Brugia malayi G-protein coupled receptor 0.0463 0.3182 0.7478
Echinococcus granulosus neuropeptide receptor 0.0463 0.3182 0.3179
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0004 0.0002
Echinococcus granulosus sex peptide receptor 0.0463 0.3182 0.3179
Brugia malayi phosphofructokinase 0.011 0.0635 0.1486
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0107 0.0631
Echinococcus granulosus neuropeptide Y receptor 0.0463 0.3182 0.3179
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0148 0.0913 0.091
Echinococcus multilocularis neuropeptide s receptor 0.0939 0.6617 0.6616
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0214 0.083
Brugia malayi aspartic protease BmAsp-1, identical 0.0027 0.0034 0.0072
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0028 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0047 0.0044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0047 0.0044
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0463 0.3182 0.748
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0028 0.0142
Loa Loa (eye worm) trypsin family protein 0.0029 0.0053 0.0124
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1004 0.7085 0.7084
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0056 0.0208
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0463 0.3182 0.3179
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0635 0.362
Loa Loa (eye worm) proprotein convertase 2 0.0035 0.0095 0.0223
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0036 0.0103 0.0333
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Echinococcus granulosus peptide allatostatin:somatostatin 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Trypanosoma cruzi cyclin, putative 0.0041 0.014 0.0454
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.087 0.0867
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0136 0.0821 0.0818
Schistosoma mansoni intermediate filament proteins 0.0028 0.0044 0.004
Schistosoma mansoni coup transcription factor 0.0028 0.0047 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0591 0.1384
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0107 0.0631
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Loa Loa (eye worm) endoprotease bli-4 0.0148 0.0913 0.2146
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0463 0.3182 0.3179
Schistosoma mansoni biogenic amine (5HT) receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis set domain proteins, putative 0.024 0.157 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0112 0.0653 0.065
Schistosoma mansoni hypothetical protein 0.0847 0.595 0.5948
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0281 0.0278
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0207 0.1336 0.7635
Echinococcus granulosus lamin 0.0028 0.0044 0.004
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0028 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0214 0.0699
Loa Loa (eye worm) hypothetical protein 0.0136 0.0821 0.193
Echinococcus granulosus NAD kinase domain containing protein 1 0.0028 0.0041 0.0038
Mycobacterium ulcerans beta-lactamase 0.0035 0.0096 0.0337
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0028 0.0041 0.0109
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0164 0.0161
Echinococcus granulosus G protein coupled receptor 139 0.0463 0.3182 0.3179
Loa Loa (eye worm) G-protein coupled receptor 0.0463 0.3182 0.748
Schistosoma mansoni biogenic amine receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0164 0.0386
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0028 0.0025
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0053 0.0049
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0172 0.0405
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Schistosoma mansoni zinc finger protein 0.0026 0.0028 0.0025
Brugia malayi AKH receptor 0.0463 0.3182 0.7478
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0047 0.0044
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.044 0.3015 0.7087
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0028 0.0082
Brugia malayi Bromodomain containing protein 0.0043 0.0154 0.0355
Giardia lamblia Cathepsin B precursor 0.0148 0.091 0.6691
Echinococcus granulosus allatostatin A receptor 0.0463 0.3182 0.3179
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0289 0.0286
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.029 0.0951
Onchocerca volvulus 0.0036 0.0103 0.0237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0024 0.012
Toxoplasma gondii hypothetical protein 0.0036 0.0103 0.0333
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0056 0.0055
Onchocerca volvulus 0.0037 0.0107 0.025
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0024 0.0069
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0044 0.0102
Plasmodium vivax aspartyl protease, putative 0.0027 0.0034 0.0229

Activities

Activity type Activity value Assay description Source Reference
Delta TC (functional) = -36 % Acute in vivo activity measured by total plasma cholesterol concentration levels (TC) at 30 mg/kg dose ChEMBL. 8632431
IC50 (binding) = 23 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431
IC50 (binding) = 23 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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