Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0369 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.021 | 0.54 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.021 | 0.54 | 0.54 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.54 | 0.54 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 5.73 | Affinity of compound towards 5-hydroxytryptamine 1B receptor in isolated guinea-pig iliac artery | ChEMBL. | 10052973 |
Kd (functional) | = 6.12 | Ability to block alpha-1 adrenergic receptor-mediated contractions of rat aorta. | ChEMBL. | 10052973 |
Kd (functional) | = 8.5 | Blocking 5-HT2A receptor-mediated contractions of rat tail artery | ChEMBL. | 10052973 |
pA2 (functional) | = 5.73 | Affinity of compound towards 5-hydroxytryptamine 1B receptor in isolated guinea-pig iliac artery | ChEMBL. | 10052973 |
pA2 (functional) | = 6.12 | Ability to block alpha-1 adrenergic receptor-mediated contractions of rat aorta. | ChEMBL. | 10052973 |
pA2 (functional) | = 8.5 | Blocking 5-HT2A receptor-mediated contractions of rat tail artery | ChEMBL. | 10052973 |
Specificity (functional) | = 240 | Specificity towards 5-HT2A receptor to that of alpha-1 adrenoceptor. | ChEMBL. | 10052973 |
Specificity (functional) | = 589 | Specificity of compound towards 5-HT2A receptor to that of 5-HT1B receptor | ChEMBL. | 10052973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.