Detailed information for compound 275303

Basic information

Technical information
  • TDR Targets ID: 275303
  • Name: [(2R,5S)-5-(6-aminopurin-9-yl)oxolan-2-yl]met hanol
  • MW: 235.243 | Formula: C10H13N5O2
  • H donors: 2 H acceptors: 4 LogP: -0.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1CC[C@@H](O1)n1cnc2c1ncnc2N
  • InChi: 1S/C10H13N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h4-7,16H,1-3H2,(H2,11,12,13)/t6-,7+/m1/s1
  • InChiKey: WVXRAFOPTSTNLL-RQJHMYQMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R,5S)-5-(6-aminopurin-9-yl)tetrahydrofuran-2-yl]methanol
  • [(2R,5S)-5-(6-aminopurin-9-yl)-2-tetrahydrofuranyl]methanol
  • [(2R,5S)-5-adenin-9-yltetrahydrofuran-2-yl]methanol
  • Dideoxyadenosine
  • [(2R,5S)-5-(6-amino-9-purinyl)-2-tetrahydrofuranyl]methanol
  • .beta.-L-2',3'-Dideoxyadenosine
  • .beta.-L-ddA
  • AIDS-050780
  • AIDS050780
  • L-d2A
  • L-ddA
  • ZINC00040149

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adenoreceptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus kelch ECH associated protein 1 0.0206 0.5099 1
Entamoeba histolytica hypothetical protein 0.0112 0.2529 1
Toxoplasma gondii beta tubulin 0.0022 0.008 0.0406
Brugia malayi Matrixin family protein 0.0025 0.0165 0.0165
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0091 0.197 0.197
Echinococcus multilocularis dro:myosuppressin receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0108 0.243 0.243
Leishmania major beta tubulin 0.0022 0.008 1
Schistosoma mansoni opsin-like receptor 0.0108 0.243 0.4752
Leishmania major beta tubulin 0.0022 0.008 1
Schistosoma mansoni neuropeptide receptor 0.0108 0.243 0.4752
Entamoeba histolytica hypothetical protein 0.0112 0.2529 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Onchocerca volvulus 0.0108 0.243 1
Schistosoma mansoni hypothetical protein 0.0108 0.243 0.4752
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0108 0.243 0.4752
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0022 0.0087 0.0169
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108 0.243 0.4752
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.008 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) matrix metalloproteinase 0.0025 0.0165 0.0165
Echinococcus multilocularis g protein coupled receptor 0.0108 0.243 0.4752
Trypanosoma brucei beta tubulin 0.0022 0.008 1
Schistosoma mansoni amine GPCR 0.0108 0.243 0.4752
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Trypanosoma brucei beta tubulin 0.0022 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis neuropeptide FF receptor 2 0.0108 0.243 0.4752
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0024 0.013 0.0254
Schistosoma mansoni amine GPCR 0.0108 0.243 0.4752
Schistosoma mansoni neuropeptide F-like receptor 0.0108 0.243 0.4752
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0108 0.243 0.4767
Echinococcus granulosus sex peptide receptor 0.0108 0.243 0.4767
Brugia malayi Matrixin family protein 0.0025 0.0165 0.0165
Loa Loa (eye worm) tubulin beta chain 0.0022 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Toxoplasma gondii beta-1 tubulin, putative 0.0022 0.008 0.0406
Schistosoma mansoni amine GPCR 0.0108 0.243 0.4752
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.008 0.0156
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni hypothetical protein 0.0205 0.5056 0.9887
Echinococcus granulosus orexin receptor type 2 0.0108 0.243 0.4767
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.243 0.4767
Schistosoma mansoni hypothetical protein 0.0108 0.243 0.4752
Brugia malayi G protein-coupled receptor F59B2.13 0.0108 0.243 0.243
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0108 0.243 0.4752
Echinococcus granulosus fmrfamide receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Leishmania major beta tubulin 0.0022 0.008 1
Giardia lamblia Beta tubulin 0.0022 0.008 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.008 0.0157
Echinococcus granulosus kelch ECH associated protein 1 like 0.0206 0.5099 1
Schistosoma mansoni neuropeptide receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0068 0.132 0.132
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus granulosus allatostatin A receptor 0.0108 0.243 0.4767
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Onchocerca volvulus 0.0045 0.0714 0.242
Trypanosoma brucei beta tubulin 0.0022 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni tubulin subunit beta 0.0022 0.008 0.0156
Onchocerca volvulus 0.0108 0.243 1
Schistosoma mansoni tubulin subunit beta 0.0022 0.008 0.0156
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.197 0.3852
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0736 0.144
Schistosoma mansoni neuropeptide receptor 0.0108 0.243 0.4752
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0108 0.243 0.4752
Echinococcus multilocularis tubulin beta 1 chain 0.0022 0.008 0.0156
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus multilocularis neuropeptide receptor 0.0108 0.243 0.4752
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.197 0.197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Echinococcus granulosus tachykinin peptides receptor 99D 0.0108 0.243 0.4767
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0736 0.144
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) G-protein coupled receptor 0.0108 0.243 0.243
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108 0.243 0.4767
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1565 0.3059
Echinococcus multilocularis beta tubulin 0.0022 0.008 0.0156
Brugia malayi Serotonin receptor 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus beta tubulin 0.0022 0.008 0.0157
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0108 0.243 0.4752
Echinococcus granulosus neuropeptide receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0031 0.0315 0.0315
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0108 0.243 0.243
Trichomonas vaginalis tubulin alpha chain, putative 0.0022 0.008 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0108 0.243 0.243
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.008 0.5
Schistosoma mansoni myosin xvIII 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Plasmodium vivax tubulin beta chain, putative 0.0022 0.008 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0108 0.243 0.4767
Schistosoma mansoni neuropeptide receptor 0.0108 0.243 0.4752
Echinococcus multilocularis fmrfamide receptor 0.0108 0.243 0.4752
Echinococcus granulosus geminin 0.0205 0.5056 0.9917
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni hypothetical protein 0.0112 0.2529 0.4945
Loa Loa (eye worm) matrixin family protein 0.0061 0.1137 0.1137
Loa Loa (eye worm) zinc metallopeptidase 4 0.0022 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0068 0.132 0.132
Brugia malayi Dopamine receptor protein 1 0.0108 0.243 0.243
Brugia malayi neuropeptide F receptor 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis kelch ECH associated protein 1 0.0206 0.5099 0.9969
Echinococcus granulosus g protein coupled receptor 0.0108 0.243 0.4767
Schistosoma mansoni amine GPCR 0.0108 0.243 0.4752
Onchocerca volvulus Neuropeptide F receptor homolog 0.0108 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus dro:myosuppressin receptor 0.0108 0.243 0.4767
Echinococcus multilocularis G-protein coupled receptor, putative 0.0108 0.243 0.4752
Echinococcus multilocularis g-protein coupled receptor 0.0108 0.243 0.4752
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0736 0.144
Giardia lamblia Beta tubulin 0.0022 0.008 0.5
Loa Loa (eye worm) hypothetical protein 0.0091 0.197 0.197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis neuropeptide Y receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Onchocerca volvulus 0.0108 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni tubulin subunit beta 0.0022 0.008 0.0156
Echinococcus multilocularis neuropeptide s receptor 0.0108 0.243 0.4752
Brugia malayi putative neuropeptide receptor NPR1 0.0108 0.243 0.243
Echinococcus granulosus hypothetical protein 0.0108 0.243 0.4767
Brugia malayi Matrixin family protein 0.0025 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.0254
Loa Loa (eye worm) hypothetical protein 0.0091 0.197 0.197
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.197 1
Onchocerca volvulus 0.0108 0.243 1
Echinococcus granulosus g protein coupled receptor 0.0108 0.243 0.4767
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.243 0.4767
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Brugia malayi RE15519p 0.0108 0.243 0.243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1565 0.1565
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni neprilysin 0.0024 0.013 0.0254
Onchocerca volvulus 0.0108 0.243 1
Echinococcus multilocularis neuropeptide receptor A26 0.0108 0.243 0.4752
Schistosoma mansoni neuropeptide F-like receptor 0.0108 0.243 0.4752
Echinococcus multilocularis fmrfamide receptor 0.0108 0.243 0.4752
Echinococcus multilocularis neuropeptides capa receptor 0.0108 0.243 0.4752
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.197 0.3864
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108 0.243 0.4752
Toxoplasma gondii beta-tubulin, putative 0.0022 0.008 0.0406
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0087 0.0169
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis somatostatin receptor 0.0108 0.243 0.4752
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108 0.243 0.4767
Echinococcus multilocularis serotonin receptor 0.0108 0.243 0.4752
Schistosoma mansoni hypothetical protein 0.0207 0.5114 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Echinococcus multilocularis neuropeptide receptor 0.0108 0.243 0.4752
Schistosoma mansoni hypothetical protein 0.0036 0.0452 0.0884
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.132 0.132
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0108 0.243 0.243
Brugia malayi Serotonin receptor 0.0108 0.243 0.243
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108 0.243 0.4752
Brugia malayi Tachykinin-like peptides receptor 99D 0.0108 0.243 0.243
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) tubulin beta-1 chain 0.0022 0.008 0.008
Echinococcus granulosus neuropeptides capa receptor 0.0108 0.243 0.4767
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.243 0.4752
Echinococcus multilocularis allatostatin A receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0108 0.243 0.4752
Brugia malayi neuropeptide F receptor 0.0108 0.243 0.243
Brugia malayi RNA binding protein 0.0076 0.1565 0.1565
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0108 0.243 0.4752
Onchocerca volvulus 0.0108 0.243 1
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) RNA binding protein 0.0076 0.1565 0.1565
Echinococcus granulosus neuropeptide s receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) beta-tubulin 0.0022 0.008 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Onchocerca volvulus 0.0108 0.243 1
Onchocerca volvulus 0.0108 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1565 0.3059
Loa Loa (eye worm) BEN-1 protein 0.0022 0.008 0.008
Brugia malayi Tubulin beta-1 chain 0.0022 0.008 0.008
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.2529 0.4945
Brugia malayi larval opioid receptor 0.0108 0.243 0.243
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.243 0.4752
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0165
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.197 1
Brugia malayi Dopamine receptor 0.0108 0.243 0.243
Loa Loa (eye worm) peptidase family M13 containing protein 0.0068 0.132 0.132
Echinococcus multilocularis G protein coupled receptor 139 0.0108 0.243 0.4752
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.197 0.3852
Onchocerca volvulus 0.0108 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus 7tm_1 domain containing protein 0.0108 0.243 0.4767
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1565 0.1565
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0386 1 1
Brugia malayi G-protein coupled receptor 0.0108 0.243 0.243
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Brugia malayi G-protein coupled receptor 0.0108 0.243 0.243
Onchocerca volvulus 0.0036 0.0452 0.1265
Plasmodium falciparum tubulin beta chain 0.0022 0.008 1
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.2529 0.4961
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0108 0.243 0.4752
Onchocerca volvulus Matrilysin homolog 0.0056 0.1 0.3685
Leishmania major beta tubulin 0.0022 0.008 1
Leishmania major beta tubulin 0.0022 0.008 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0087 0.0169
Brugia malayi beta-tubulin, identical 0.0022 0.008 0.008
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.008 0.0156
Schistosoma mansoni biogenic amine receptor 0.0108 0.243 0.4752
Echinococcus granulosus peptide allatostatin:somatostatin 0.0108 0.243 0.4767
Echinococcus multilocularis Kelch repeat type 1 0.0207 0.5114 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0108 0.243 0.4767
Brugia malayi Melatonin receptor type 1A 0.0108 0.243 0.243
Echinococcus granulosus g protein coupled receptor 0.0108 0.243 0.4767
Leishmania major beta tubulin 0.0022 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0022 0.0087 0.0169
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Brugia malayi GnHR receptor homolog 0.0108 0.243 0.243
Schistosoma mansoni amine GPCR 0.0108 0.243 0.4752
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.2529 0.4945
Echinococcus granulosus beta tubulin 0.0022 0.008 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.1363 0.1363
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0108 0.243 0.4767
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.0254
Leishmania major beta tubulin 0.0022 0.008 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0108 0.243 0.4752
Trypanosoma cruzi beta tubulin, putative 0.0022 0.008 1
Echinococcus multilocularis tubulin subunit beta 0.0022 0.008 0.0156
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0108 0.243 0.243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0031 0.0315 0.1598
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) tubulin beta-4 chain 0.0022 0.008 0.008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni tubulin subunit beta 0.0022 0.008 0.0156
Schistosoma mansoni growth hormone secretagogue receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0069 0.1363 0.1363
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1565 0.3059
Onchocerca volvulus 0.0108 0.243 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0108 0.243 0.243
Echinococcus multilocularis serotonin receptor 0.0108 0.243 0.4752
Onchocerca volvulus 0.0108 0.243 1
Schistosoma mansoni tubulin subunit beta 0.0022 0.008 0.0156
Schistosoma mansoni hypothetical protein 0.0108 0.243 0.4752
Entamoeba histolytica hypothetical protein 0.0112 0.2529 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0108 0.243 0.243
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0736 0.144
Echinococcus granulosus neuropeptide receptor 0.0108 0.243 0.4767
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1565 0.1565
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.008 0.0157
Echinococcus granulosus tar DNA binding protein 0.0076 0.1565 0.3069
Echinococcus granulosus alpha 1A adrenergic receptor 0.0108 0.243 0.4767
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Leishmania major beta tubulin 0.0022 0.008 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.008 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Leishmania major beta tubulin 0.0022 0.008 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0108 0.243 0.4752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Echinococcus multilocularis beta tubulin 0.0022 0.008 0.0156
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni hypothetical protein 0.0205 0.5056 0.9887
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.0254
Echinococcus granulosus kelch ECH associated protein 1 like 0.0206 0.5099 1
Echinococcus granulosus neuropeptide Y receptor 0.0108 0.243 0.4767
Brugia malayi Hemopexin family protein 0.0036 0.0452 0.0452
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni biogenic amine receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0068 0.132 0.132
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.008 0.0156
Brugia malayi Dopamine receptor protein 2 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0069 0.1363 0.1363
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1565 0.3059
Toxoplasma gondii peptidase family M13 protein 0.0091 0.197 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Onchocerca volvulus 0.0108 0.243 1
Echinococcus multilocularis orexin receptor type 2 0.0108 0.243 0.4752
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0022 0.008 0.0156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Loa Loa (eye worm) neuropeptide F receptor 0.0108 0.243 0.243
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0108 0.243 0.4752
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0736 0.144
Echinococcus multilocularis g protein coupled receptor 0.0108 0.243 0.4752
Trichomonas vaginalis tubulin, putative 0.0022 0.008 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0108 0.243 0.4767
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.197 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0022 0.008 0.5
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.008 0.0157
Echinococcus granulosus somatostatin receptor 0.0108 0.243 0.4767
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.008 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0108 0.243 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0091 0.1972 0.3868
Echinococcus granulosus neuropeptide receptor A26 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis Tubulin beta 2C chain 0.0022 0.008 0.0156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.243 0.4752
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.243 0.4767
Echinococcus granulosus tubulin beta 1 chain 0.0022 0.008 0.0157
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0045 0.0714 0.0714
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0108 0.243 0.243
Echinococcus granulosus tubulin subunit beta 0.0022 0.008 0.0157
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.0254
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0069 0.1363 0.1363
Echinococcus granulosus neuropeptide FF receptor 2 0.0108 0.243 0.4767
Loa Loa (eye worm) tubulin beta-2A chain 0.0022 0.008 0.008
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.008 0.0157
Echinococcus granulosus g-protein coupled receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0165
Schistosoma mansoni opsin-like receptor 0.0108 0.243 0.4752
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0108 0.243 0.4752
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.243 0.4752
Brugia malayi putative neuropeptide receptor 0.0108 0.243 0.243
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0022 0.0087 0.0169
Brugia malayi hypothetical protein 0.0108 0.243 0.243
Brugia malayi G protein-coupled receptor 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0108 0.243 0.4752
Echinococcus multilocularis geminin 0.0205 0.5056 0.9887
Loa Loa (eye worm) neuropeptide F receptor 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis kelch ECH associated protein 1 0.0206 0.5099 0.9969
Brugia malayi hypothetical protein 0.0112 0.2529 0.2529
Brugia malayi AKH receptor 0.0108 0.243 0.243
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.0254
Loa Loa (eye worm) hypothetical protein 0.0069 0.1363 0.1363
Schistosoma mansoni opsin-like receptor 0.0108 0.243 0.4752
Schistosoma mansoni endothelin-converting enzyme-related 0.0022 0.0087 0.0169
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0108 0.243 0.4752
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Onchocerca volvulus 0.0108 0.243 1
Loa Loa (eye worm) BEN-1 protein 0.0022 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0091 0.1972 0.3856
Brugia malayi Peptidase family M13 containing protein 0.0091 0.197 0.197
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.243 0.4752
Entamoeba histolytica hypothetical protein 0.0112 0.2529 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0022 0.008 0.0157
Giardia lamblia Beta tubulin 0.0022 0.008 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0108 0.243 0.4767
Echinococcus multilocularis neuropeptides capa receptor 0.0108 0.243 0.4752
Brugia malayi ORL1-like opioid receptor 0.0108 0.243 0.243
Brugia malayi TAR-binding protein 0.0076 0.1565 0.1565
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Brugia malayi Matrixin family protein 0.0025 0.0165 0.0165
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.243 0.4767
Loa Loa (eye worm) hypothetical protein 0.0068 0.132 0.132
Echinococcus granulosus 7TM GPCR rhodopsin 0.0108 0.243 0.4767
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0108 0.243 0.243
Echinococcus multilocularis sex peptide receptor 0.0108 0.243 0.4752
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1565 0.3059
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1565 0.3059
Echinococcus granulosus Tubulin beta 2C chain 0.0022 0.008 0.0157
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0025 0.0165 0.0323
Onchocerca volvulus Matrix metalloproteinase homolog 0.0056 0.1 0.3685
Schistosoma mansoni histamine h1 receptor 0.0108 0.243 0.4752
Leishmania major beta tubulin 0.0022 0.008 1
Trypanosoma brucei beta tubulin 0.0022 0.008 1
Brugia malayi sulfakinin receptor protein 0.0108 0.243 0.243
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243
Echinococcus multilocularis neuropeptide Y receptor 0.0108 0.243 0.4752
Leishmania major beta tubulin 0.0022 0.008 1
Onchocerca volvulus 0.0108 0.243 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.243 0.4752
Onchocerca volvulus 0.0108 0.243 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0108 0.243 0.4752
Echinococcus granulosus serotonin receptor 0.0108 0.243 0.4767
Loa Loa (eye worm) matrixin family protein 0.0056 0.1 0.1
Schistosoma mansoni neuropeptide f receptor 76f 0.0108 0.243 0.4752
Loa Loa (eye worm) G-protein coupled receptor 0.0108 0.243 0.243
Echinococcus multilocularis g protein coupled receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) TYRA-2 protein 0.0108 0.243 0.243
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0108 0.243 0.4752
Brugia malayi Matrixin family protein 0.0061 0.1137 0.1137
Schistosoma mansoni biogenic amine receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) melatonin receptor type 1A 0.0108 0.243 0.243
Onchocerca volvulus 0.0108 0.243 1
Schistosoma mansoni tubulin subunit beta 0.0022 0.008 0.0156
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0031 0.0315 0.0315
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0108 0.243 0.4752
Leishmania major beta tubulin 0.0022 0.008 1
Onchocerca volvulus 0.0108 0.243 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1363 0.1363
Brugia malayi peptidase family M13 containing protein 0.0022 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.0254
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108 0.243 0.4752
Loa Loa (eye worm) hypothetical protein 0.0108 0.243 0.243

Activities

Activity type Activity value Assay description Source Reference
Toxicity (ADMET) 0 Compound was tested for cellular toxicity against HIV in CEM cells at concentration up to 100 microM; IA means inactive ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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