Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | adenosine deaminase, putative | 0.0261 | 0.648 | 0.5835 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4098 | 0.3621 |
Schistosoma mansoni | adenosylhomocysteinase | 0.024 | 0.5871 | 0.5871 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1581 | 0.09 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.155 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4098 | 0.3621 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0261 | 0.648 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0387 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.2358 | 0.2358 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0387 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0387 | 1 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0387 | 1 | 1 |
Onchocerca volvulus | 0.0085 | 0.155 | 0.1398 | |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.648 | 0.6196 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0261 | 0.648 | 0.5264 |
Schistosoma mansoni | adenosylhomocysteinase | 0.024 | 0.5871 | 0.5871 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0387 | 1 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.2358 | 0.0957 |
Echinococcus granulosus | adenosine deaminase | 0.0261 | 0.648 | 0.5835 |
Mycobacterium ulcerans | adenosine deaminase | 0.0261 | 0.648 | 0.5394 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1581 | 0.09 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1525 | 0.084 |
Leishmania major | adenine aminohydrolase | 0.0261 | 0.648 | 0.5835 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0261 | 0.648 | 0.5264 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0261 | 0.648 | 0.5394 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0261 | 0.648 | 0.5835 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0387 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.024 | 0.5871 | 0.5871 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0387 | 1 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.2358 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1581 | 0.09 |
Echinococcus multilocularis | adenosine deaminase | 0.0261 | 0.648 | 0.5835 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4098 | 0.3621 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1525 | 0.084 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.1525 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2358 | 0.174 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1581 | 0.09 |
Schistosoma mansoni | AMP deaminase | 0.0085 | 0.155 | 0.155 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2358 | 0.174 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.1525 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1525 | 0.084 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0387 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.0261 | 0.648 | 0.5835 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0261 | 0.648 | 0.5394 |
Treponema pallidum | adenosine deaminase | 0.0261 | 0.648 | 0.5 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0261 | 0.648 | 0.5835 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0058 | 0.0777 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1525 | 0.084 |
Schistosoma mansoni | adenosine deaminase-related | 0.0261 | 0.648 | 0.648 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0058 | 0.0777 | 0.0777 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0387 | 1 | 1 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0058 | 0.0777 | 0.0777 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.0777 | 0.0777 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0387 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1581 | 0.09 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.0777 | 0.0777 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0387 | 1 | 1 |
Plasmodium falciparum | adenosine deaminase | 0.0261 | 0.648 | 0.5835 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1581 | 0.09 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0261 | 0.648 | 0.5835 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2358 | 0.174 |
Onchocerca volvulus | AMP deaminase 2 homolog | 0.0085 | 0.155 | 0.1398 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.2358 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4098 | 0.3621 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.2358 | 0.0957 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0261 | 0.648 | 0.5835 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0387 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.0085 | 0.155 | 0.0866 |
Schistosoma mansoni | adenosine deaminase | 0.0261 | 0.648 | 0.648 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0387 | 1 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.2358 | 0.0957 |
Schistosoma mansoni | adenosylhomocysteinase | 0.024 | 0.5871 | 0.5871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibition of Endothelin-converting enzyme of guinea pig lung membrane | ChEMBL. | No reference |
IC50 (binding) | = 25 nM | Inhibition of Endothelin-converting enzyme of guinea pig lung membrane | ChEMBL. | No reference |
Inhibition (binding) | = 13 % | Compound was tested for inhibitory activity against neutral endopeptidase(NEP) at concentration 300 nM | ChEMBL. | No reference |
Inhibition (binding) | = 13 % | Compound was tested for inhibitory activity against neutral endopeptidase(NEP) at concentration 300 nM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.