Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0135 | 0.7373 | 0.7373 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.7373 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.7373 | 1 |
Echinococcus multilocularis | geminin | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0135 | 0.7373 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0135 | 0.7373 | 0.7373 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.7373 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 0.7373 | 0.7373 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 0.7373 | 0.7373 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 0.7373 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0135 | 0.7373 | 0.7373 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0023 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 0.7373 | 0.7373 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0135 | 0.7373 | 0.7373 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.7373 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction of live worms (functional) | = 90 % | Antifilarial activity against L. carinii infections in the Jird at dose 3 mg/kg administered orally | ChEMBL. | 6887202 |
Reduction of live worms (functional) | = 100 % | Antifilarial activity against L. carinii infections in the Jird at dose 100 mg/kg administered orally | ChEMBL. | 6887202 |
Reduction of live worms (functional) | = 100 % | Antifilarial activity against L. carinii infections in the Jird at dose 25 mg/kg administered orally | ChEMBL. | 6887202 |
Reduction of live worms (functional) | = 100 % | Antifilarial activity against L. carinii infections in the Jird at dose 0.5 mg/kg administered orally | ChEMBL. | 6887202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.