Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | No references |
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | No references |
Rattus norvegicus | Thromboxane A2 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | opsin-like receptor | Thromboxane A2 receptor | 341 aa | 313 aa | 22.4 % |
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = -7.5 | In vitro inhibition of collagen-induced thromboxane A2 production in human whole blood | ChEMBL. | No reference |
Kd (functional) | = 6.1 | In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced platelet aggregation in human whole blood | ChEMBL. | No reference |
Kd (functional) | = 7.6 | In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced contraction of rat isolated thoracic aortic strip | ChEMBL. | No reference |
Log IC50 (functional) | = 7.5 | In vitro inhibition of collagen-induced thromboxane A2 production in human whole blood | ChEMBL. | No reference |
pA2 (functional) | = 6.1 | In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced platelet aggregation in human whole blood | ChEMBL. | No reference |
pA2 (functional) | = 7.6 | In vitro thromboxane A2 receptor antagonism through inhibition of U-46619 induced contraction of rat isolated thoracic aortic strip | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.