Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Bos taurus | Trypsin I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin I | 246 aa | 305 aa | 23.9 % |
Drosophila melanogaster | Jonah 65Aii | Trypsin I | 246 aa | 265 aa | 34.3 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin I | 246 aa | 235 aa | 25.1 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin I | 246 aa | 223 aa | 31.8 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin I | 246 aa | 249 aa | 24.5 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin I | 246 aa | 299 aa | 21.7 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin I | 246 aa | 242 aa | 30.6 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin I | 246 aa | 235 aa | 29.8 % |
Onchocerca volvulus | Trypsin I | 246 aa | 247 aa | 21.1 % | |
Brugia malayi | Trypsin family protein | Trypsin I | 246 aa | 270 aa | 23.3 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin I | 246 aa | 269 aa | 31.6 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin I | 246 aa | 249 aa | 31.3 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin I | 246 aa | 208 aa | 23.1 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 241 aa | 27.0 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin I | 246 aa | 233 aa | 33.9 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin I | 246 aa | 209 aa | 31.1 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 262 aa | 34.0 % |
Mycobacterium tuberculosis | Membrane-associated serine protease | Trypsin I | 246 aa | 203 aa | 20.7 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 304 aa | 24.0 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin I | 246 aa | 250 aa | 23.6 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 287 aa | 27.9 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin I | 246 aa | 260 aa | 27.7 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin I | 246 aa | 272 aa | 31.6 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin I | 246 aa | 223 aa | 34.5 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin I | 246 aa | 243 aa | 28.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 241 aa | 27.0 % |
Loa Loa (eye worm) | hypothetical protein | Trypsin I | 246 aa | 217 aa | 24.0 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin I | 246 aa | 233 aa | 30.0 % |
Onchocerca volvulus | Trypsin I | 246 aa | 210 aa | 21.0 % | |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin I | 246 aa | 205 aa | 27.8 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin I | 246 aa | 235 aa | 34.9 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin I | 246 aa | 251 aa | 33.9 % |
Schistosoma japonicum | Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative | Trypsin I | 246 aa | 207 aa | 24.6 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin I | 246 aa | 261 aa | 28.0 % |
Neospora caninum | glycine cleavage T-protein domain containing protein, putative | Trypsin I | 246 aa | 203 aa | 21.7 % |
Echinococcus multilocularis | enteropeptidase | Trypsin I | 246 aa | 230 aa | 27.0 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin I | 246 aa | 246 aa | 38.2 % |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin I | 246 aa | 262 aa | 30.1 % |
Echinococcus granulosus | enteropeptidase | Trypsin I | 246 aa | 230 aa | 27.0 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin I | 246 aa | 234 aa | 32.5 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin I | 246 aa | 264 aa | 24.6 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin I | 246 aa | 301 aa | 23.9 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin I | 246 aa | 208 aa | 24.0 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin I | 246 aa | 238 aa | 28.6 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin I | 246 aa | 227 aa | 29.5 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin I | 246 aa | 299 aa | 23.4 % |
Onchocerca volvulus | Trypsin I | 246 aa | 266 aa | 22.2 % | |
Drosophila melanogaster | Jonah 99Ci | Trypsin I | 246 aa | 237 aa | 32.9 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin I | 246 aa | 267 aa | 29.2 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin I | 246 aa | 259 aa | 26.6 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin I | 246 aa | 248 aa | 28.2 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin I | 246 aa | 250 aa | 29.6 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin I | 246 aa | 233 aa | 33.5 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin I | 246 aa | 272 aa | 30.5 % |
Echinococcus multilocularis | Mastin | Trypsin I | 246 aa | 306 aa | 23.2 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin I | 246 aa | 287 aa | 27.5 % |
Echinococcus granulosus | Mastin | Trypsin I | 246 aa | 306 aa | 23.2 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 234 aa | 26.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0034 | 0.0517 | 0.0517 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0403 | 0.0403 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0403 | 0.0403 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3827 | 0.3827 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0024 | 0.0103 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0062 | 0.1643 | 0.3625 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.3141 | 0.3141 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.0097 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1864 | 0.1864 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.3123 | 0.3123 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0403 | 0.0403 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0403 | 0.0403 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0024 | 0.0103 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0103 | 0.0103 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0024 | 0.0103 | 0.0811 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0024 | 0.0103 | 0.0811 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0099 | 0.3141 | 0.3141 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.3964 | 0.3964 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0403 | 0.0403 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0024 | 0.0103 | 0.0103 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0024 | 0.0103 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0024 | 0.0103 | 0.0103 |
Brugia malayi | TAR-binding protein | 0.027 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0099 | 0.3141 | 0.3141 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.1271 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.1271 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.6031 | 0.6031 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0024 | 0.0103 | 0.0811 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.3123 | 0.3123 |
Trypanosoma brucei | beta lactamase | 0.0062 | 0.1643 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.3141 | 0.3141 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0024 | 0.0103 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0024 | 0.0103 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0403 | 0.0403 |
Onchocerca volvulus | 0.0106 | 0.3426 | 0.5511 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.3123 | 0.3123 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0024 | 0.0103 | 0.0166 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0129 | 0.435 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.6031 | 0.6031 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0099 | 0.3141 | 0.3141 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0024 | 0.0103 | 0.0811 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0024 | 0.0103 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0097 | 0.0097 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.1864 | 0.1864 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0403 | 0.0403 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0024 | 0.0103 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0176 | 0.6217 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0024 | 0.0103 | 0.0103 |
Brugia malayi | N-terminal motif family protein | 0.0176 | 0.6217 | 0.6217 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1271 | 0.1271 |
Brugia malayi | RNA recognition motif domain containing protein | 0.027 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.1271 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.1271 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0024 | 0.0103 | 0.0103 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0024 | 0.0103 | 0.0103 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0062 | 0.1643 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0403 | 0.0403 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.1271 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.3964 | 0.3964 |
Onchocerca volvulus | 0.012 | 0.3964 | 0.6376 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3827 | 0.3827 |
Loa Loa (eye worm) | RNA binding protein | 0.027 | 1 | 1 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0129 | 0.435 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0403 | 0.0403 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0403 | 0.0403 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0024 | 0.0103 | 0.5 |
Brugia malayi | hypothetical protein | 0.0053 | 0.1271 | 0.1271 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3123 | 0.3123 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.1271 | 0.7583 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0403 | 0.0403 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0403 | 0.0403 |
Schistosoma mansoni | tar DNA-binding protein | 0.027 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.027 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0403 | 0.0403 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.3141 | 0.3141 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.3964 | 0.3964 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0024 | 0.0103 | 0.0103 |
Echinococcus multilocularis | geminin | 0.0171 | 0.6031 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.6217 | 0.6217 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0403 | 0.0403 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0024 | 0.0103 | 0.0811 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0024 | 0.0103 | 0.0103 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.1271 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.1271 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1864 | 0.1864 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3827 | 0.3827 |
Echinococcus granulosus | tar DNA binding protein | 0.027 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0099 | 0.3141 | 0.3141 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.6031 | 0.6031 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.3141 | 0.3141 |
Echinococcus multilocularis | tar DNA binding protein | 0.027 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0099 | 0.3141 | 0.3141 |
Brugia malayi | Trypsin family protein | 0.012 | 0.3964 | 0.3964 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.3964 | 0.3964 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.0097 | 0.0097 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (ADMET) | = 0.49 l hr-1 kg-1 | Clearance value of compound was determined after intravenous administration of 1 mg/kg/h in dog | ChEMBL. | 10782664 |
Ki (binding) | = 2.3 nM | Inhibition of human Coagulation factor X | ChEMBL. | 10782664 |
Ki (binding) | = 2.3 nM | Inhibition of human Coagulation factor X | ChEMBL. | 10782664 |
Ki (binding) | = 180 nM | Inhibitory activity against trypsin | ChEMBL. | 10782664 |
Ki (binding) | = 180 nM | Inhibitory activity against trypsin | ChEMBL. | 10782664 |
Ki (binding) | = 5700 nM | Inhibitory activity against thrombin | ChEMBL. | 10782664 |
Ki (binding) | = 5700 nM | Inhibitory activity against thrombin | ChEMBL. | 10782664 |
T1/2 (ADMET) | = 1 hr | Half-life of the compound was determined after intravenous administration of 1 mg/kg/h in dog | ChEMBL. | 10782664 |
Vdss (ADMET) | = 0.24 l g-1 | Volume of distribution of the compound was determined after intravenous administration of 1 mg/kg/h in dog | ChEMBL. | 10782664 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.